Showing BioInteractions for Isosorbide dinitrate (DB00883)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Isosorbide dinitrate is a Atrial natriuretic peptide receptor 1 agonist
1Atrial natriuretic peptide receptor 1 agonistsAmyl Nitrite, Erythrityl tetranitrate, Nitroglycerin, Nitroprusside
2Atrial natriuretic peptide receptor 1 bindersNesiritide
Interacting GroupInteracting Drugs
Isosorbide dinitrate is a Cytochrome P450 2E1 inhibitor
1Cytochrome P450 2E1 substrates1,2-dichlorobenzene, Acetaminophen, Almotriptan, Aminophylline, Aniline, Antipyrine, Benzyl alcohol, Bupropion, Caffeine, Capsaicin, Carvedilol, Chlorzoxazone, Clevidipine, Dacarbazine, Dalfampridine, Dapsone, Dexmedetomidine, Dichlorobenzene, Enflurane, Enfuvirtide, Estrone, Ethanol, Ethosuximide, Etoposide, Felbamate, Fingolimod, Fomepizole, Halothane, Iloperidone, Isoflurane, Isoniazid, Menadione, Methoxyflurane, Mexiletine, Mitoxantrone, N-Methyl-N-(Methylbenzyl)Formamide, N,N-dimethylformamide, Nicardipine, Nicotine, Nilvadipine, Ondansetron, Paramethadione, Phenacetin, Phenobarbital, Propacetamol, Quinidine, Quinine, Sevoflurane, Sildenafil, Tamoxifen, Tegafur, Thalidomide, Theobromine, Theophylline, Thiamylal, Tirapazamine, Trabectedin, Trimethadione, Zopiclone
2Cytochrome P450 2E1 inhibitorsAdemetionine, Aldesleukin, Alosetron, Azelastine, Bifonazole, Bromazepam, Chlorpromazine, Chlorzoxazone, Cimetidine, Clomifene, Clonazepam, Clotrimazole, Clozapine, Desipramine, Dexfenfluramine, Diacerein, Diazepam, Diclofenac, Diethylstilbestrol, Disulfiram, Ditiocarb, Econazole, Ellagic acid, Etoricoxib, Flunitrazepam, Fluphenazine, Flurazepam, Imipramine, Indisulam, Isoniazid, Itraconazole, Methimazole, Methotrimeprazine, Metyrapone, Miconazole, Midostaurin, Nabilone, Niacin, Nicotinamide, Nicotine, Nifedipine, Nitrazepam, Nortriptyline, Propofol, Rhein, Ritonavir, Rufinamide, Safinamide, Selegiline, Sildenafil, Sulfanilamide, Tegaserod, Thioridazine, Ticlopidine, Tioconazole, Tranylcypromine, Ursodeoxycholic acid, Vayarin, Zafirlukast, Zucapsaicin
3Cytochrome P450 2E1 inducersClofibrate, Colchicine, Delafloxacin, Dexamethasone, Ethanol, Fomepizole, Glycerin, Isoniazid, Mitoxantrone, Nicotine, Phenelzine, Phenobarbital, Piperaquine, Rifampicin, Streptozocin, Ursodeoxycholic acid