Selenium Sulfide

Identification

Name
Selenium Sulfide
Accession Number
DB00971  (APRD01323)
Type
Small Molecule
Groups
Approved
Description

Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children.

Structure
Thumb
Synonyms
  • Selenii disulfidum
  • Selenium disulfide
  • Selenium disulphide
  • Selenium sulfide, micronized
  • Selenium sulphide
  • Selenium sulphide, micronized
  • Selenium(IV) disulfide
  • Selenium(IV) disulphide
  • Selenium(IV) sulfide
  • Selenium(IV) sulphide
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Selenium SulfideLotion2.5 mg/100mLTopicalA S Medication Solutions2006-09-252017-06-20Us
Selenium SulfideLotion25 mg/mLTopicalA S Medication Solutions1983-09-012017-06-20Us
Selenium SulfideLotion25 mg/mLTopicalMorton Grove Pharmaceuticals, Inc.1983-09-01Not applicableUs
Selenium SulfideLotion2.5 mg/100mLTopicalA S Medication Solutions2006-09-252017-06-20Us
Selenium SulfideLotion2.5 g/100mLTopicalPhysicians Total Care, Inc.2006-09-25Not applicableUs
Selenium SulfideLotion2.5 mg/100mLTopicalPerrigo New York Inc.2006-09-25Not applicableUs
Selenium SulfideLotion25 mg/mLTopicalCentral Texas Community Health Centers1983-09-01Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Antidandruff MedicatedShampoo1 mL/100mLTopicalCVS Health2010-07-06Not applicableUs
Antidandruff MedicatedShampoo1 mL/100mLTopicalSafeway2010-08-05Not applicableUs
Care One MedicatedLiquid10 mg/mLTopicalAmerican Sales Company2013-08-15Not applicableUs
Care One MoisturizingLiquid10 mg/mLTopicalAmerican Sales Company2013-07-15Not applicableUs
Careone Medicated DandruffLiquid10 mg/mLTopicalAmerican Sales Company2014-11-17Not applicableUs
Careone Moisturizing DandruffShampoo1 mL/100mLTopicalAmerican Sales Company2011-08-19Not applicableUs
Careone Moisturizing DandruffLiquid10 mg/mLTopicalAmerican Sales Company2015-01-13Not applicableUs
CVS Pharmacy Dandruff Moisturizing with AloeShampoo1 mL/100mLTopicalCVS Health2010-10-15Not applicableUs
CVS Pharmacy Maximum Strength DandruffLiquid10 mg/mLTopicalCVS Health2014-11-17Not applicableUs
Cvs Pharmacy MedicatedLiquid10 mg/mLTopicalCVS Health2013-07-08Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Selenium SulfideShampoo22.5 mg/mLTopicalRochester Pharmaceuticals2011-03-30Not applicableUs
Selenium SulfideShampoo22.5 mg/mLTopicalMethod Pharmaceuticals2015-06-01Not applicableUs
Selenium SulfideShampoo22.5 mg/mLTopicalKmm Pharmaceuticals, Llc2017-11-14Not applicableUs
Selenium SulfideShampoo22.5 mg/mLTopicalAcella Pharmaceuticals, LLC2017-06-01Not applicableUs
Selenium SulfideShampoo22.5 mg/mLTopicalBi Coastal Pharma International Llc2011-06-01Not applicableUs
Selenium SulfideShampoo22.5 mg/mLTopicalNoble Pharmaceuticals, Llc2017-05-09Not applicableUs
SelRxShampoo23 mg/mLTopicalArtesa Labs, Llc2011-08-31Not applicableUs
TersiAerosol, foam1.44 g/70gTopicalQuinnova Pharmaceuticals, Inc.2009-12-01Not applicableUs
International/Other Brands
Exsel Lotion Shampoo / Glo-Sel / Head & Shoulders Intensive Treatment / Versel Lotion
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Clease and TreatSelenium Sulfide (.5 g/5g) + Benzoyl peroxide (.8 g/5g)ClothTopicalQuinnova Pharmaceuticals, Inc.2009-01-01Not applicableUs
Categories
UNII
Z69D9E381Q
CAS number
7488-56-4
Weight
Average: 143.09
Monoisotopic: 143.860663208
Chemical Formula
S2Se
InChI Key
JNMWHTHYDQTDQZ-UHFFFAOYSA-N
InChI
InChI=1S/S2Se/c1-3-2
IUPAC Name
thione
SMILES
S=[Se]=S

Pharmacology

Indication

For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp.

Structured Indications
Pharmacodynamics

Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.

Mechanism of action

Topical selenium sulfide may act by an antimitotic action, resulting in a reduction in the turnover of epidermal cells. It also has local irritant, antibacterial, and mild antifungal activity, which may contribute to its effectiveness. An antimitotic mechanism of action is suggested by data showing that selenium sulfide decreases the rate of incorporation of radioactively labeled thymidine into the DNA of dermal epithelial cells. The following organisms are generally considered susceptible to selenium sulfide in vitro: Malassezia furfur, Microsporum sp. including Microsporum audouinii and Microsporum canis, Pityrosporon sp., Trichophyton sp. including Trichophyton schoenleinii and Trichophyton tonsurans. Selenium sulfide has been shown to be sporicidal to T. tonsurans, the most common etiologic agent of tinea capitis. One in-vitro study demonstrated that 2.5% selenium sulfide was equivalent in sporicidal activity to both 1% and 2% zinc pyrithione.

Absorption

There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.

Affected organisms
  • Humans and other mammals
  • Fungi
  • Bacteria
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
No interactions found.
Food Interactions
Not Available

References

General References
  1. Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. [PubMed:10821151]
  2. Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.x. Epub 2010 Aug 24. [PubMed:20735804]
External Links
PubChem Compound
24087
PubChem Substance
46507535
ChemSpider
22519
ChEBI
135934
ChEMBL
CHEMBL1200680
PharmGKB
PA164771240
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Selenium_sulfide
ATC Codes
D01AE13 — Selenium sulfide
MSDS
Download (73.8 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
  • Allergan herbert div allergan inc
  • Actavis mid atlantic llc
  • Ivax pharmaceuticals inc
  • Perrigo new york inc
  • Taro pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
  • Chattem inc
Packagers
Dosage forms
FormRouteStrength
ClothTopical
ShampooTopical10 mg/mL
Lotion / shampooTopical1 g/100mL
ShampooTopical1 kg/100L
ShampooTopical.6 g/100mL
LiquidTopical10 mg/mL
LiquidTopical1 mL/100mL
ShampooTopical1 mL/100mL
LotionTopical2.5 mg/100mL
LotionTopical2.5 g/100mL
LotionTopical25 mg/mL
ShampooTopical22.5 mg/mL
ShampooTopical23 mg/mL
ShampooTopical1 g/100mL
ShampooTopical1 %
ShampooTopical1.0 %
ShampooTopical.025 g/mL
Aerosol, foamTopical1.44 g/70g
Prices
Unit descriptionCostUnit
Selenium Sulfide 2.5% Lotion 118ml Bottle19.99USD bottle
Selenium Sulfide 2.5% Lotion 120ml Bottle19.99USD bottle
Selenium sulfide 99% powder5.64USD g
Tersi 2.25% foam2.05USD g
Selenium sulfide 2.25% shampoo0.33USD ml
Selenium sulf 2.5% shampoo0.17USD ml
Selenium 2.5% lotion-shampoo0.1USD ml
Selenium sulfide 2.5% lotion0.1USD ml
Selsun blue shampoo x-medic0.04USD ml
Selsun blue 1% shampoo0.03USD ml
Selsun blue daily shampoo0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)100 °CNot Available
water solubilityPractically insolubleNot Available
Predicted Properties
PropertyValueSource
logP0.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity31.98 m3·mol-1ChemAxon
Polarizability9.59 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9946
Blood Brain Barrier+0.9786
Caco-2 permeable+0.6224
P-glycoprotein substrateNon-substrate0.908
P-glycoprotein inhibitor INon-inhibitor0.9531
P-glycoprotein inhibitor IINon-inhibitor0.9963
Renal organic cation transporterNon-inhibitor0.9254
CYP450 2C9 substrateNon-substrate0.8623
CYP450 2D6 substrateNon-substrate0.8451
CYP450 3A4 substrateNon-substrate0.8077
CYP450 1A2 substrateNon-inhibitor0.7526
CYP450 2C9 inhibitorNon-inhibitor0.7658
CYP450 2D6 inhibitorNon-inhibitor0.9304
CYP450 2C19 inhibitorNon-inhibitor0.8352
CYP450 3A4 inhibitorNon-inhibitor0.891
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7268
Ames testNon AMES toxic0.8363
CarcinogenicityCarcinogens 0.6874
BiodegradationNot ready biodegradable0.9612
Rat acute toxicity2.2807 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.933
hERG inhibition (predictor II)Non-inhibitor0.9694
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as other non-metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of other non-metals.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal sulfides
Direct Parent
Other non-metal sulfides
Alternative Parents
Inorganic sulfides
Substituents
Other non-metal sulfide / Inorganic sulfide
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on June 13, 2005 07:24 / Updated on December 01, 2017 14:36