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Identification
NameNeomycin
Accession NumberDB00994  (APRD00013)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionA component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Neomycin is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.
Structure
Thumb
SynonymsNot Available
External Identifiers
  • Caswell No. 595
  • USAF CB-19
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Mycifradin Sulfate Oral SolutionSolution125 mgOralPharmacia & Upjohn Inc1957-12-312000-08-02Canada
Mycifradin Sulfate Tablets 0.5 GmTablet500 mgOralPharmacia & Upjohn Inc1953-12-312000-08-02Canada
Myciguent OintmentOintment.5 %TopicalThe Upjohn Company Of Canada1951-12-311998-08-12Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Neo-fradinSolution87.5 mg/5mLOralX Gen Pharmaceuticals, Inc.2002-05-23Not applicableUs
Neomycin SulfateTablet500 mg/1OralECI Pharmaceuticals, LLC2016-01-162016-10-13Us
Neomycin SulfateTablet500 mg/1OralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Neomycin SulfateTablet500 mg/1OralHI TECH PHARMACAL CO INC2010-03-12Not applicableUs
Neomycin SulfateTablet500 mg/1OralLannett Company, Inc.2016-06-10Not applicableUs
Neomycin SulfateTablet500 mg/1OralMajor Pharmaceuticals2009-09-14Not applicableUs
Neomycin SulfateTablet500 mg/1OralBreckenridge Pharmaceutical, Inc.2011-01-032016-10-20Us
Neomycin SulfateTablet500 mg/1OralX Gen Pharmaceuticals, Inc.2010-03-12Not applicableUs
Neomycin SulfateTablet500 mg/1OralGolden State Medical Supply, Inc.2011-01-03Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AntibioticOintment3.5 mg/gTopicalPromex, LLC2013-12-05Not applicableUs
AntibioticOintment3.5 mg/gTopicalKareway Product, Inc.2011-08-11Not applicableUs
AntibioticOintment3.5 mg/gTopicalMorales Distributors Inc2012-09-25Not applicableUs
Antibiotic OintmentOintment3.5 mg/gTopicalNeo Pharm Co., Ltd.2010-08-26Not applicableUs
BaclezeneCream5 mg/.9gTopicalCurazene, Llc2014-06-19Not applicableUs
Family Care AntibioticOintment3.5 mg/gTopicalUNITED EXCHANGE CORP.2012-11-30Not applicableUs
Family Care Triple Antibiotic Pain ReliefOintment3.5 mg/gTopicalUNITED EXCHANGE CORP.2012-02-07Not applicableUs
Pomada De SulfaOintment3.5 mg/57gTopicalMenper Distributors, Inc.2012-02-21Not applicableUs
Single Antibiotic With NeomycinOintment3.5 mg/gTopicalSafetec of America2008-11-13Not applicableUs
VitacilinaOintment3.5 mg/gTopicalTeresa Cecena Dba Genesis2015-05-15Not applicableUs
Vitacilina Neomycin Sulfate First Aid AntibioticOintment3.5 mg/gTopicalCompania Internacional de Comercio, S.A. de C.V.2012-08-28Not applicableUs
Water-jel Neomycin AntibioticOintment3.5 mg/gTopicalWater Jel Technologies2010-03-31Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
MyacyneNot Available
MycifradinNot Available
MyciguentNot Available
Neo-RxNot Available
NeobioticNot Available
NivemycinNot Available
Brand mixtures
NameLabellerIngredients
10 Person AnsiGenuine First Aid LLC
25 Person AnsiGenuine First Aid LLC
50 Person AnsiGenuine First Aid LLC
Acme First Aid Contains 404 PiecesAcme United Corp.
Acme Small Cuts and BurnsAcme United Corp.
AerosootheAero Healthcare Us Llc
Aftate Triple AntibioticSabel Med Llc
American Red Cross First Aid KitTomy International
Aminoderm PoudreDesbergers LtÉe, Division Of Technilab Inc.
AntibioticRite Aid Corporation
Antibiotic and Pain ReliefRite Aid Corporation
Antibiotic and Pain Relief Maximum StrengthCVS Pharmacy
Antibiotic ApplicationCmc Group, Inc.
Antibiotic Ear (neo/polym/hc)Physicians Total Care, Inc.
Antibiotic Maximum StrengthWalgreen Company
Antibiotic Original StrengthCVS Pharmacy
Antibiotic Plus Pain ReliefSafeway
Antibiotic Plus Pain Relief Maximum StrengthRite Aid Corporation
Arc First Aid Contains 1000 PiecesAmerican Red Cross
Arc First Aid Contains 404 PiecesAmerican Red Cross
Atopalm First Aid Triple AntibioticNeoPharm Co., Ltd.
Atopalm First Aid Triple Antibiotic Protection Moisturizing and Pain ReliefNeoPharm Co., Ltd.
Bacitracin Zinc, Neomycin Sulfate and Polymyxin B SulfateGalentic Pharma (India) Private Limited
Berkley and Jensen Triple AntibioticBJWC
Biotic-plusProvision Medical
Budpak Triple Antibiotic Maximum StrengthBudpak Inc.
Cardinal Health First Aid AntibioticCardinal Health
Care One Maximum Strength First Aid AntibioticFoodhold U.S.A. Llc
Careall Triple AntibioticNew World Imports, Inc
Careone Antibiotic Plus Pain ReliefAmerican Sales Company
Careone Original Strength Triple AntibioticFoodhold U.S.A. Llc
Careone Triple AntibioticAmerican Sales Company
Childrens Double Antibiotic With Pain ReliefWalgreen Company
Cicatrin PowderGlaxosmithkline Inc
Coly-mycin SPar Pharmaceutical, Inc.
CortisporinPhysicians Total Care, Inc.
Cortisporin-TCPar Pharmaceutical, Inc.
CortomycinMajor Pharmaceuticals
CuadridermaPro Mex Llc
Cvp Triple AntibioticSalado Sales, Inc
Dg Health AntibioticDolgencorp Inc
Dg Health Triple AntibioticDolgencorp Inc
Dioptrol OintmentDioptic Pharmaceuticals Inc
Dioptrol SuspensionDioptic Pharmaceuticals Inc
Diosporin OintmentDioptic Pharmaceuticals Inc
Double Antibiotic Plus Pain Relief Maximum StrengthFred's Inc.
Dr Bells PomadeGenomma Lab Usa Inc.
Equaline Antibiotic Plus Pain ReliefSupervalu Inc
Equaline Antibiotic Plus Pain Relief for KidsSupervalu Inc
Equaline First Aid AntibioticSupervalu Inc
Equaline Triple AntibioticSupervalu Inc
Equaline Triple Antibiotic PlusSupervalu Inc
Equate Antibiotic Plus Pain ReliefWal Mart Stores Inc
Exchange Select First Aid Triple Anitbiotic Pain RelievingArmy & Air Force Exchange Service
Exchange Select Triple AntibioticArmy & Air Force Exchange Service
Face Values Triple AntibioticHarmon Stores Inc.
Family Care Triple AntibioticUNITED EXCHANGE CORP.
Family Care Triple Antibiotic Plus Pain ReliefUNITED EXCHANGE CORP.
Family Wellness Triple Antibiotic Plus Pain ReliefFamily Dollar
First Aid AntibioticGfa Production (Xiamen) Co., Ltd.
First Aid Antibiotic Pain Relief Maximum StrengthRite Aid
First Aid Antibiotic Plus Pain Relief Maximum StrengthRite Aid
First Aid Pocket Pack - 40 PiecesReady America, Inc.
First Aid Triple AntibioticRite Aid
First Aid Triple Antibiotic and Pain Relief Maximum StrengthLif Elabs, A Division Of Atico International Usa, Inc.
First Aid Triple Antibiotic With Pain RelieverCintas First Aid & Safety
First Aid Value Pack - 77 PiecesReady America, Inc.
FML-neo Oph SusAllergan Inc
Formucare Triple Antibiotic Original StrengthAccess Business Group LLC
Fulton Street Market Triple Antibiotic Original StrengthAccess Business Group LLC
Genuine First Aid - Auto First AidGenuine First Aid, LLC
Genuine First Aid - Home First AidGenuine First Aid, LLC
Genuine First Aid Emergency Preparedness Contains 167 Pieces HardcaseGenuine First Aid LLC
Genuine Triple AntibioticGenuine First Aid LLC
Gfa First Aid Kit Essentials - 33 PiecesGenuine First Aid, LLC
Good Neighbor Pharmacy Antibiotic and Pain ReliefAmerisource Bergen
Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 PiecesAmerisource Bergen
Good Neighbor Pharmacy First AidAmerisource Bergen
Good Neighbor Pharmacy Triple AntibioticAmerisource Bergen
Good Neighbor Pharmacy Triple Antibiotic Plus Pain ReliefAmerisource Bergen
Good Sense First Aid AntibioticL. Perrigo Company
Good Sense Triple AntibioticL Perrigo Company
Good Sense Triple Antibiotic and Pain ReliefL. Perrigo Company
Goodsense Antibiotic Plus Pain ReliefGeiss, Destin & Dunn, Inc.
Healthy Accents Triple AntibioticDZA Brands LLC
Kenacomb CreamWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb Mild CreamWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb Mild OintmentWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb OintmentWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb OntSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.
Large Ansi First Aid KitCmc Group, Inc.
Leader Triple AntibioticCardinal Health
Leader Triple Antibiotic PlusCardinal Health
Lidecomb CreamMedicis Canada Ltd.
LincolnLincoln Pharmaceutical Ltd.
Live Better Triple AntibioticThe Great Atlantic & Pacific Tea Company
Live Better Triple Antibiotic Plus Pain ReliefThe Great Atlantic & Pacific Tea Company
Livebetter Antibiotic Plus Pain ReliefThe Great Atlantic & Pacific Tea Company
Lucky Supersoft First AidDelta Brands, Inc
Makesense First AidCherry Hill Sales Co
Market Basket First Aid Triple AntibioticDavion, Inc.
MaxitrolAlcon Laboratories, Inc.
Maxitrol OntAlcon Canada Inc
Mecomb Crm 0.1%Medic Laboratory LtÉe
Medi-firstMedique Products
Medichoice Triple AntibioticOwens & Minor Inc.
Medpride First AidShield Line LLC
Meijer Antibiotic Plus Pain ReliefMeijer Distribution Inc
Meijer Triple AntibioticMeijer Distribution Inc
Meijer Triple Antibiotic PlusMEIJER, INC.
Meijer Triple Antibiotic Plus Pain ReliefMeijer Distribution Inc
MethedexMajor Pharmaceuticals
Mountain Series Weekender MedicalTender Corporation Dba Adventure Medical Kits
Multi Antibiotic With Pain Relief Maximum StrengthWalgreen Company
Neo PolycinPaddock Laboratories, LLC
Neo Polycin HCPaddock Laboratories, LLC
Neo-cortef 0.5% OintmentPfizer Canada Inc
Neo-cortef 1% OintmentPfizer Canada Inc
Neo-cortef Eye Ear Drops Sterile SuspensionPharmacia & Upjohn Inc
Neo-medrolPfizer Canada Inc
Neo-medrol Acne LotionPfizer Canada Inc
Neo-poly-bacButler Animal Health Supply
Neo-poly-bac HydroButler Animal Health Supply
Neo-poly-dexButler Animal Health Supply
Neo-polycinRebel Distributors Corp
Neo-polycin HCFera Pharmaceuticals
Neo-synalarMedimetriks Pharmaceuticals
NeocidinMajor Pharmaceuticals
Neodecadron Eye Ear Soln 0.1%Merck Frosst Canada & Cie, Merck Frosst Canada & Co.
Neomycin and Polymyxin B SulfatesWatson Laboratories, Inc.
Neomycin and Polymyxin B Sulfates and Bacitracin ZincRxv
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc With Hydrocortisone AcetateRebel Distributors Corp
Neomycin and Polymyxin B Sulfates and DexamethasonePaddock Laboratories, LLC
Neomycin and Polymyxin B Sulfates and GramicidinRebel Distributors Corp
Neomycin and Polymyxin B Sulfates and HydrocortisoneBlenheim Pharmacal, Inc
Neomycin and Polymyxin B Sulfates, and Bacitracin ZincHenry Schein Inc.
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and HydrocortisoneMwi/Vet One
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and HydrocortisoneHenry Schein Inc.
Neomycin Polymyxin B Sulfates and DexamethasoneMwi/Vet One
Neomycin Sulfate, Polymyxin B Sulfate and Bacitracin ZincSTAT Rx USA LLC
Neomycin Sulfate, Polymyxin B Sulfate and DexamethasoneSTAT RX LLC USA
Neomycin, Polymyxin B Sulfates and HydrocortisonePhysicians Total Care, Inc.
NeosporinPfizer Laboratories Div Pfizer Inc
Neosporin Antibiotic CreamGlaxosmithkline Inc
Neosporin Eye-ear SolutionGlaxosmithkline Inc
Neosporin G.U.Pfizer Laboratories Div Pfizer Inc
Neosporin Irrigating SolutionGlaxosmithkline Inc
Neosporin OintmentGlaxosmithkline Inc
Neosporin Ophthalmic OintmentGlaxosmithkline Inc
Neosporin OriginalJohnson & Johnson Consumer Inc.
Neosporin Pain Itch ScarJohnson & Johnson Consumer Inc.
Neosporin Plus Pain ReliefJohnson & Johnson Consumer Inc.
Neosporin Plus Pain Relief First Aid Antibiotic/pain RelievingJohnson & Johnson Consumer Inc.
Neosporin Plus Pain Relief Neo To GoJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neosporin Plus Pain Relief Neo To Go First Aid Antibiotic Pain RelievingJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Neotopic OintmentTechnilab Pharma Inc.
North Triple AntibioticNorth Safety Products
NpdPhoenix Pharmaceutical, Inc.
Odan-sporOdan Laboratories Ltd
Odan-spor-HCOdan Laboratories Ltd
Odan-trolOdan Laboratories Ltd
Optimyxin Plus Oto-opht GtteSandoz Canada Incorporated
Otizol HC LiqLab Nadeau LtÉe, Division Of Technilab Inc.
Our Family Triple AntibioticNash Finch Company
Paraid Triple AntibioticMCURE HEALTH SOLUTIONS INC
Pentrexcilina Triple AntibioticOpmx Llc
Pomada De LA Campana Triple Antibiotic Pain ReliefGenomma Lab Usa, Inc.
Premier Value Antibiotic Plus Pain ReliefChain Drug Consortium
Premier Value Triple AntibioticChain Drug Consortium
Premier Value Triple Antibiotic PlusTAI GUK PHARM. CO., LTD.
Proctosone OntTechnilab Pharma Inc.
Proctosone SupTechnilab Pharma Inc.
Procuretriple Antibiotic Triple AntibioticTWIN MED, LLC
Publix AntibioticPublix Super Markets Inc
Publix Antibiotic Plus Pain ReliefPublix Super Markets Inc
Quality Choice Maximum Strength Triple AntibioticChain Drug Marketing Association Inc
Quality Choice Triple AntibioticChain Drug Marketing Association Inc
Quality Choice Triple Antibiotic Plus Pain RelieverChain Drug Marketing Association Inc
Ratio-triacombTeva Canada Limited
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid, LLC
Ready America First Aid Pocket - 33 PiecesGenuine First Aid, LLC
Refill 2Cmc Group, Inc.
Repara Triple AntibioticPSS World Medical, Inc.
Safeway Antibiotic Plus Pain ReliefSAFEWAY INC
Sandoz CortimyxinSandoz Canada Incorporated
Schein Triple AntibioticHenry Schein, Inc.
Sheffield Triple AntibioticFaria LLC dba Sheffield Pharmaceuticals
Sheffield Triple Antibiotic Plus Pain ReliefFaria LLC dba Sheffield Pharmaceuticals
Shopko Antibiotic Plus Pain ReliefShopko Stores Operating Co., LLC
Shopko Triple AntibioticShopko Stores Operating Co., LLC
Shopko Triple Antibiotic PlusUNITED EXCHANGE CORP.
Shopko Triple Antibiotic Plus Pain ReliefShopko Stores Operating Co., LLC
Shoprite Triple AntibioticWakefern Food Corporation
Signature Care First Aid AntibioticSafeway
Signature Care Triple AntibioticSafeway
Small Cuts and BurnsGenuine First Aid LLC
Smart Sense Antibiotic Maximum StrengthKmart Corporation
Smart Sense Antibiotic Plus Pain ReliefKmart Corporation
Smart Sense Triple AntibioticKmart Corporation
Smart Sense Triple Antibitotic Plus Pain ReliefKmart Corporation
Standard Ansi First AidCmc Group, Inc.
Sunmark Antibiotic Plus Pain ReliefMc Kesson
Sunmark Triple AntibioticMc Kesson
Sunmark Triple Antibiotic Plus Pain ReliefMc Kesson
Synalar Bi-otic SolutionMedicis Canada Ltd.
Theraderm CreamBimeda Mtc Animal Health Inc
Topcare Antibiotic Plus Pain ReliefTopco Associates LLC
Topcare Triple AntibioticTopco Associates LLC
Topcare Triple Antibiotic Plus Pain ReliefTopco Associates LLC
TribioticHART Health
Tribioticlc Lc LcHART Health
Triple AntibioticE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Triple Antibiotic and Pain Relief Maximum StrengthCVS Pharmacy
Triple Antibiotic CvsCVS
Triple Antibiotic Extra StrengthPersonal Care Products, Inc.
Triple Antibiotic First AidUniversal Distribution Center LLC
Triple Antibiotic First Aid AntibioticNatureplex LLC
Triple Antibiotic HCPhoenix Pharmaceutical, Inc.
Triple Antibiotic Maximum StrengthBudpak Inc.
Triple Antibiotic OintmentG&W Laboratories, Inc.
Triple Antibiotic PlusG&W Laboratories, Inc.
Triple Antibiotic Plus Maximum StrengthH E B
Triple Antibiotic Plus Pain ReliefMeijer Distribution Inc
Triple Antibiotic Plus Pain Relief Maximum StrengthKroger Company
Triple Antibiotic With Pain Relief Maximum StrengthWalgreen Company
Triple AntiobioticDavemed Healthcare Co., Ltd.
Ultra Seal Triple AntibioticUltra Seal Corporation
Up and Up AntibioticTarget Corporation
Up and Up Antibiotic Plus Pain ReliefTarget Corporation
Up and Up First Aid Antibiotic Pain RelievingTarget Corporation
Viaderm Kc CrmTaro Pharmaceuticals Inc
Viaderm Kc OntTaro Pharmaceuticals Inc
Walgreens Maximum Strength Triple Antibiotic With Pain ReliefWALGREEN CO.
Walgreens Triple AntibioticWalgreen Company
Walgreenstriple AntibioticWalgreen Company
Water-jel 3-IN-1 AntibioticWater Jel Technologies
Well At Walg Triple Antibiotic Well At WalgreensWalgreens
Western Family Antibiotic Plus Pain ReliefWestern Family Foods Inc
Western Family Triple AntibioticWestern Family Foods Inc
Western Family Triple Antibiotic Plus Pain ReliefWestern Family Foods Inc
Winco Maximum Strength Triple AntibioticWin Co Foods, Llc
Winco Original Strength Triple AntibioticWin Co Foods, Llc
Salts
Name/CASStructureProperties
Neomycin palmitate
ThumbNot applicableDBSALT001620
Neomycin sulfate
Thumb
  • InChI Key: OIXVKQDWLFHVGR-CITJEJKVSA-N
  • Monoisotopic Mass: 712.27966483
  • Average Mass: 712.722
DBSALT000472
Categories
UNIII16QD7X297
CAS number1404-04-2
WeightAverage: 614.6437
Monoisotopic: 614.312285588
Chemical FormulaC23H46N6O13
InChI KeyPGBHMTALBVVCIT-VCIWKGPPSA-N
InChI
InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
IUPAC Name
(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol
SMILES
NC[C@@H]1O[[email protected]](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[[email protected]](N)C[[email protected]](N)[[email protected]]3O[[email protected]]3O[[email protected]](CN)[C@@H](O)[[email protected]](O)[[email protected]]3N)[C@@H]2O)[[email protected]](N)[C@@H](O)[C@@H]1O
Pharmacology
IndicationTopical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic E. coli (EPEC).
Structured Indications
PharmacodynamicsNeomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Mechanism of actionAminoglycosides like neomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
TargetKindPharmacological actionActionsOrganismUniProt ID
30S ribosomal protein S12Proteinyes
inhibitor
Escherichia coli (strain K12)P0A7S3 details
16S rRNANucleotideyes
inhibitor
Enteric bacteria and other eubacterianot applicabledetails
Related Articles
AbsorptionPoorly absorbed from the normal gastrointestinal tract. Although only approximately 3% of neomycin is absorbed through intact intestinal mucosa, significant amounts may be absorbed through ulcerated or denuded mucosa or if inflammation is present.
Volume of distributionNot Available
Protein bindingProtein binding studies have shown that the degree of aminoglycoside protein binding is low and, depending upon the methods used for testing, may be between 0% and 30%.
Metabolism

Neomycin undergoes negligible biotransformation after parenteral administration.

Route of eliminationThe small absorbed fraction is rapidly distributed in the tissues and is excreted by the kidney in keeping with the degree of kidney function.
Half life2 to 3 hours
ClearanceNot Available
ToxicityLD50 = 200 mg/kg (rat). Because of low absorption, it is unlikely that acute overdosage would occur with oral neomycin. However, prolonged administration could result in sufficient systemic drug levels to produce neurotoxicity, ototoxicity and/or nephrotoxicity. Nephrotoxicity occurs via drug accumulation in renal proximal tubular cells resulting in cellular damage. Tubular cells may regenerate despite continued exposure and nephrotoxicity is usually mild reversible. Neomycin is the most toxic aminoglycoside agent, which is thought to be due to its large number of cationic amino groups. Otoxocity occurs via drug accumulation in the endolymph and perilymph of the inner ear causing irreversible damage to hair cells in the cochlea or summit of ampullar cristae in the vestibular complex. High frequency hearing loss is followed by low frequency hearing loss. Further toxicity may cause retrograde degeneration of the auditory nerve. Vestibular toxicity may result in vertigo, nausea and vomiting, dizziness and loss of balance.
Affected organisms
  • Enteric bacteria and other eubacteria
  • Escherichia coli
  • Klebsiella
  • Enterobacter
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcarboseThe risk or severity of adverse effects can be increased when Neomycin is combined with Acarbose.Approved, Investigational
AceclofenacAceclofenac may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
AcenocoumarolNeomycin may increase the anticoagulant activities of Acenocoumarol.Approved
AcetovanilloneAcetovanillone may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be decreased when it is combined with Neomycin.Approved
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
AdapaleneAdapalene may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
Alendronic acidNeomycin may increase the hypocalcemic activities of Alendronic acid.Approved
AmdinocillinThe serum concentration of Neomycin can be decreased when it is combined with Amdinocillin.Withdrawn
AmoxicillinThe serum concentration of Neomycin can be decreased when it is combined with Amoxicillin.Approved, Vet Approved
Amphotericin BAmphotericin B may increase the nephrotoxic activities of Neomycin.Approved, Investigational
AmpicillinThe serum concentration of Neomycin can be decreased when it is combined with Ampicillin.Approved, Vet Approved
AnisodamineAnisodamine may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
AntipyrineAntipyrine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
AnvirzelThe serum concentration of Anvirzel can be decreased when it is combined with Neomycin.Investigational
ApremilastApremilast may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
Atracurium besylateNeomycin may increase the respiratory depressant activities of Atracurium besylate.Approved
AzapropazoneAzapropazone may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
AzelastineAzelastine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
AzidocillinThe serum concentration of Neomycin can be decreased when it is combined with Azidocillin.Approved
AzlocillinThe serum concentration of Neomycin can be decreased when it is combined with Azlocillin.Approved
BacampicillinThe serum concentration of Neomycin can be decreased when it is combined with Bacampicillin.Approved
BacitracinNeomycin may increase the nephrotoxic activities of Bacitracin.Approved, Vet Approved
BalsalazideBalsalazide may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Neomycin.Investigational
BenoxaprofenBenoxaprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
Benzathine benzylpenicillinThe serum concentration of Neomycin can be decreased when it is combined with Benzathine benzylpenicillin.Approved, Vet Approved
BenzylpenicillinThe serum concentration of Neomycin can be decreased when it is combined with Benzylpenicillin.Approved, Vet Approved
Benzylpenicillin PotassiumThe serum concentration of Neomycin can be decreased when it is combined with Benzylpenicillin Potassium.Approved
Benzylpenicilloyl PolylysineThe serum concentration of Neomycin can be decreased when it is combined with Benzylpenicilloyl Polylysine.Approved
Betulinic AcidBetulinic Acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
Botulinum Toxin Type ANeomycin may increase the neuromuscular blocking activities of Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BNeomycin may increase the neuromuscular blocking activities of Botulinum Toxin Type B.Approved
BromfenacBromfenac may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
BucillamineBucillamine may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Neomycin.Approved
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Neomycin.Approved
CarbenicillinThe serum concentration of Neomycin can be decreased when it is combined with Carbenicillin.Approved
CarboplatinNeomycin may increase the ototoxic activities of Carboplatin.Approved
CarindacillinThe serum concentration of Neomycin can be decreased when it is combined with Carindacillin.Approved
CarprofenCarprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may decrease the excretion rate of Neomycin which could result in a higher serum level.Experimental
CelecoxibCelecoxib may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
ChloroquineChloroquine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
Cisatracurium besylateNeomycin may increase the respiratory depressant activities of Cisatracurium besylate.Approved
CisplatinCisplatin may increase the nephrotoxic activities of Neomycin.Approved
ClodronateNeomycin may increase the hypocalcemic activities of Clodronate.Approved, Investigational, Vet Approved
ClonixinClonixin may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
CloxacillinThe serum concentration of Neomycin can be decreased when it is combined with Cloxacillin.Approved, Vet Approved
ColistimethateNeomycin may increase the nephrotoxic activities of Colistimethate.Approved, Vet Approved
CurcuminCurcumin may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
CyclacillinThe serum concentration of Neomycin can be decreased when it is combined with Cyclacillin.Approved
CyclosporineNeomycin may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
D-LimoneneD-Limonene may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
DecamethoniumNeomycin may increase the respiratory depressant activities of Decamethonium.Approved
DeslanosideThe serum concentration of Deslanoside can be decreased when it is combined with Neomycin.Approved
DiclofenacDiclofenac may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
DicloxacillinThe serum concentration of Neomycin can be decreased when it is combined with Dicloxacillin.Approved, Vet Approved
DicoumarolNeomycin may increase the anticoagulant activities of Dicoumarol.Approved
DiflunisalDiflunisal may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Neomycin.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Neomycin.Approved
Domoic AcidNeomycin may increase the respiratory depressant activities of Domoic Acid.Experimental
Doxacurium chlorideNeomycin may increase the respiratory depressant activities of Doxacurium chloride.Approved
DroxicamDroxicam may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
DuvelisibDuvelisib may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
E6201E6201 may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
EbselenEbselen may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
EpirizoleEpirizole may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Neomycin.Approved
EtanerceptEtanercept may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
Ethyl biscoumacetateNeomycin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
Etidronic acidNeomycin may increase the hypocalcemic activities of Etidronic acid.Approved
EtodolacEtodolac may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
EtoricoxibEtoricoxib may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
Evening primrose oilEvening primrose oil may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
exisulindexisulind may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
FenbufenFenbufen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
FenoprofenFenoprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
FloctafenineFloctafenine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Withdrawn
FlucloxacillinThe serum concentration of Neomycin can be decreased when it is combined with Flucloxacillin.Approved
FluindioneNeomycin may increase the anticoagulant activities of Fluindione.Investigational
FlunixinFlunixin may decrease the excretion rate of Neomycin which could result in a higher serum level.Vet Approved
FlurbiprofenFlurbiprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
FoscarnetFoscarnet may increase the nephrotoxic activities of Neomycin.Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Neomycin.Approved, Vet Approved
Gallamine TriethiodideNeomycin may increase the respiratory depressant activities of Gallamine Triethiodide.Approved
HigenamineHigenamine may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
HMPL-004HMPL-004 may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
IbandronateNeomycin may increase the hypocalcemic activities of Ibandronate.Approved, Investigational
IbuprofenIbuprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
IbuproxamIbuproxam may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
IcatibantIcatibant may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
IndomethacinIndomethacin may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
IndoprofenIndoprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
IsoxicamIsoxicam may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
KebuzoneKebuzone may decrease the excretion rate of Neomycin which could result in a higher serum level.Experimental
KetoprofenKetoprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
KetorolacKetorolac may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
LeflunomideLeflunomide may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
LisofyllineLisofylline may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
LornoxicamLornoxicam may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
LoxoprofenLoxoprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
LumiracoxibLumiracoxib may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
Magnesium salicylateMagnesium salicylate may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
MannitolMannitol may increase the nephrotoxic activities of Neomycin.Approved, Investigational
MasoprocolMasoprocol may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
MecamylamineNeomycin may increase the neuromuscular blocking activities of Mecamylamine.Approved
Meclofenamic acidMeclofenamic acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
Mefenamic acidMefenamic acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
MeloxicamMeloxicam may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
MesalazineMesalazine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
MetamizoleMetamizole may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
MeticillinThe serum concentration of Neomycin can be decreased when it is combined with Meticillin.Approved
MetocurineNeomycin may increase the respiratory depressant activities of Metocurine.Approved
Metocurine IodideNeomycin may increase the respiratory depressant activities of Metocurine Iodide.Withdrawn
MezlocillinThe serum concentration of Neomycin can be decreased when it is combined with Mezlocillin.Approved
MivacuriumNeomycin may increase the respiratory depressant activities of Mivacurium.Approved
MizoribineMizoribine may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
Mycophenolate mofetilMycophenolate mofetil may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
Mycophenolic acidMycophenolic acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
NabumetoneNabumetone may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
NafamostatNafamostat may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
NafcillinThe serum concentration of Neomycin can be decreased when it is combined with Nafcillin.Approved
NaftifineNaftifine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
NaproxenNaproxen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
NCX 4016NCX 4016 may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
NeosaxitoxinNeomycin may increase the respiratory depressant activities of Neosaxitoxin.Investigational
NepafenacNepafenac may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
Niflumic AcidNiflumic Acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
NimesulideNimesulide may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Withdrawn
NitroaspirinNitroaspirin may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
OlopatadineOlopatadine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
OlsalazineOlsalazine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
OrgoteinOrgotein may decrease the excretion rate of Neomycin which could result in a higher serum level.Vet Approved
OuabainThe serum concentration of Ouabain can be decreased when it is combined with Neomycin.Approved
OxacillinThe serum concentration of Neomycin can be decreased when it is combined with Oxacillin.Approved
OxaprozinOxaprozin may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
OxyphenbutazoneOxyphenbutazone may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
PamidronateNeomycin may increase the hypocalcemic activities of Pamidronate.Approved
PancuroniumNeomycin may increase the respiratory depressant activities of Pancuronium.Approved
ParecoxibParecoxib may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
PhenindioneNeomycin may increase the anticoagulant activities of Phenindione.Approved
PhenoxymethylpenicillinThe serum concentration of Neomycin can be decreased when it is combined with Phenoxymethylpenicillin.Approved, Vet Approved
PhenprocoumonNeomycin may increase the anticoagulant activities of Phenprocoumon.Approved
PhenylbutazonePhenylbutazone may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Neomycin.Approved
PimecrolimusPimecrolimus may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
PipecuroniumNeomycin may increase the respiratory depressant activities of Pipecuronium.Approved
PiperacillinThe serum concentration of Neomycin can be decreased when it is combined with Piperacillin.Approved
PiretanideThe risk or severity of adverse effects can be increased when Piretanide is combined with Neomycin.Experimental
PirfenidonePirfenidone may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
PiroxicamPiroxicam may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
PivampicillinThe serum concentration of Neomycin can be decreased when it is combined with Pivampicillin.Approved
PivmecillinamThe serum concentration of Neomycin can be decreased when it is combined with Pivmecillinam.Approved
Procaine benzylpenicillinThe serum concentration of Neomycin can be decreased when it is combined with Procaine benzylpenicillin.Approved, Vet Approved
PropacetamolPropacetamol may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
PTC299PTC299 may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
PyrantelNeomycin may increase the respiratory depressant activities of Pyrantel.Approved, Vet Approved
RapacuroniumNeomycin may increase the respiratory depressant activities of Rapacuronium.Withdrawn
ResveratrolResveratrol may decrease the excretion rate of Neomycin which could result in a higher serum level.Experimental, Investigational
RisedronateNeomycin may increase the hypocalcemic activities of Risedronate.Approved, Investigational
RocuroniumNeomycin may increase the respiratory depressant activities of Rocuronium.Approved
RofecoxibRofecoxib may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational, Withdrawn
SalicylamideSalicylamide may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
Salicylic acidSalicylic acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Vet Approved
SalsalateSalsalate may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
SeratrodastSeratrodast may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Neomycin.Approved, Investigational
SRT501SRT501 may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
SuccinylcholineNeomycin may increase the respiratory depressant activities of Succinylcholine.Approved
SulbactamThe serum concentration of Neomycin can be decreased when it is combined with Sulbactam.Approved
SulfasalazineSulfasalazine may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
SulindacSulindac may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
SultamicillinThe serum concentration of Neomycin can be decreased when it is combined with Sultamicillin.Investigational
SuprofenSuprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Withdrawn
TazobactamThe serum concentration of Neomycin can be decreased when it is combined with Tazobactam.Approved
Technetium tc 99m etidronateNeomycin may increase the hypocalcemic activities of Technetium tc 99m etidronate.Approved
Technetium Tc-99m MedronateNeomycin may increase the hypocalcemic activities of Technetium Tc-99m Medronate.Approved
TenofovirThe serum concentration of Neomycin can be increased when it is combined with Tenofovir.Approved, Investigational
TenoxicamTenoxicam may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
TepoxalinTepoxalin may decrease the excretion rate of Neomycin which could result in a higher serum level.Vet Approved
TeriflunomideTeriflunomide may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
Tiaprofenic acidTiaprofenic acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
TicarcillinThe serum concentration of Neomycin can be decreased when it is combined with Ticarcillin.Approved, Vet Approved
TiludronateNeomycin may increase the hypocalcemic activities of Tiludronate.Approved, Vet Approved
TinoridineTinoridine may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational
Tolfenamic AcidTolfenamic Acid may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
TolmetinTolmetin may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Neomycin.Approved
TranilastTranilast may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational
Trisalicylate-cholineTrisalicylate-choline may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
TubocurarineNeomycin may increase the respiratory depressant activities of Tubocurarine.Approved
ValdecoxibValdecoxib may decrease the excretion rate of Neomycin which could result in a higher serum level.Investigational, Withdrawn
VancomycinVancomycin may increase the nephrotoxic activities of Neomycin.Approved
VecuroniumNeomycin may increase the respiratory depressant activities of Vecuronium.Approved
WarfarinNeomycin may increase the anticoagulant activities of Warfarin.Approved
ZaltoprofenZaltoprofen may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved
ZileutonZileuton may decrease the excretion rate of Neomycin which could result in a higher serum level.Approved, Investigational, Withdrawn
Zoledronic acidNeomycin may increase the hypocalcemic activities of Zoledronic acid.Approved
ZomepiracZomepirac may decrease the excretion rate of Neomycin which could result in a higher serum level.Withdrawn
Food InteractionsNot Available
References
Synthesis Reference

Jaehoon Yu, Jongkook Lee, Miyun Kwon, Ae Pae, Hun Koh, “Heterodimeric conjugates of neomycin-oxazolidinone, their preparation and their use.” U.S. Patent US20050222055, issued October 06, 2005.

US20050222055
General ReferencesNot Available
External Links
ATC CodesA07AA51J01GB05B05CA09S01AA03D06AX04S03AA01A07AA01A01AB08R02AB01S02AA07
AHFS Codes
  • 52:04.04
  • 84:04.04
PDB Entries
FDA labelNot Available
MSDSDownload (72.9 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.8617
Blood Brain Barrier-0.9659
Caco-2 permeable-0.7502
P-glycoprotein substrateNon-substrate0.5164
P-glycoprotein inhibitor INon-inhibitor0.8023
P-glycoprotein inhibitor IINon-inhibitor0.8764
Renal organic cation transporterNon-inhibitor0.7886
CYP450 2C9 substrateNon-substrate0.8231
CYP450 2D6 substrateNon-substrate0.8041
CYP450 3A4 substrateNon-substrate0.6473
CYP450 1A2 substrateNon-inhibitor0.9157
CYP450 2C9 inhibitorNon-inhibitor0.9147
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9034
CYP450 3A4 inhibitorNon-inhibitor0.9471
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8446
Ames testNon AMES toxic0.6934
CarcinogenicityNon-carcinogens0.9505
BiodegradationNot ready biodegradable0.8587
Rat acute toxicity1.4850 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9728
hERG inhibition (predictor II)Non-inhibitor0.81
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • X gen pharmaceuticals inc
  • Pharmacia and upjohn co
  • Pfizer laboratories div pfizer inc
  • Bristol myers squibb co
  • Lannett co inc
  • Eli lilly and co
  • Oman pharmaceutical products co llc
  • Roxane laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Kit
PowderTopical
OintmentTopical3.5 mg/g
CreamTopical5 mg/.9g
SuspensionTopical
SuspensionAuricular (otic)
Suspension / dropsAuricular (otic)
OintmentOphthalmic; Topical
OintmentTopical
StickTopical
OintmentOphthalmic
SuspensionOphthalmic
Solution / dropsOphthalmic
CreamTopical
SolutionOral125 mg
TabletOral500 mg
OintmentTopical.5 %
SuspensionAuricular (otic); Ophthalmic
SolutionOral87.5 mg/5mL
LotionTopical
Suspension / dropsOphthalmic
LiquidAuricular (otic); Ophthalmic
IrrigantIrrigation
SolutionIrrigation
SolutionAuricular (otic)
Solution / dropsAuricular (otic)
TabletOral500 mg/1
SolutionOphthalmic
SolutionAuricular (otic); Ophthalmic
SolutionUrethral
LiquidOphthalmic
Solution / dropsAuricular (otic); Ophthalmic
OintmentTopical3.5 mg/57g
OintmentRectal
SuppositoryRectal
Prices
Unit descriptionCostUnit
Neomycin Sulfate 500 mg tablet1.39USD tablet
Neomycin 500 mg tablet1.25USD tablet
Neomycin sulfate powder0.84USD g
Neo-fradin 125 mg/5 ml soln0.12USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point6 mg/mL (as sulfate form)Not Available
logP-7.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility64.7 mg/mLALOGPS
logP-2.8ALOGPS
logP-8.4ChemAxon
logS-0.98ALOGPS
pKa (Strongest Acidic)12.29ChemAxon
pKa (Strongest Basic)9.97ChemAxon
Physiological Charge6ChemAxon
Hydrogen Acceptor Count19ChemAxon
Hydrogen Donor Count13ChemAxon
Polar Surface Area353.11 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity135.9 m3·mol-1ChemAxon
Polarizability60.87 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as amino sugars. These are sugars having one alcoholic hydroxy group replaced by an amino group; systematically known as x-amino-x-deoxymonosaccharides. These compounds do not include Glycosylamines.
KingdomOrganic compounds
Super ClassOrganooxygen compounds
ClassCarbohydrates and carbohydrate conjugates
Sub ClassAminosaccharides
Direct ParentAmino sugars
Alternative Parents
Substituents
  • 4,5-disubstituted 2-deoxystreptamine
  • Aminoglycoside core
  • 2-deoxystreptamine aminoglycoside
  • Neamine core
  • Glucosamine
  • Amino sugar
  • O-glycosyl compound
  • Glycosyl compound
  • Disaccharide
  • Cyclohexylamine
  • Cyclohexanol
  • Oxane
  • Oxolane
  • Cyclic alcohol
  • Secondary alcohol
  • 1,2-diol
  • 1,2-aminoalcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Acetal
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Trna binding
Specific Function:
With S4 and S5 plays an important role in translational accuracy.Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluste...
Gene Name:
rpsL
Uniprot ID:
P0A7S3
Molecular Weight:
13736.995 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Gill AE, Amyes SG: The contribution of a novel ribosomal S12 mutation to aminoglycoside resistance of Escherichia coli mutants. J Chemother. 2004 Aug;16(4):347-9. [PubMed:15332709 ]
  4. Eisenstein BI, Beachey EH, Ofek I: Influence of sublethal concentrations of antibiotics on the expression of the mannose-specific ligand of Escherichia coli. Infect Immun. 1980 Apr;28(1):154-9. [PubMed:6103875 ]
2. 16S rRNA
Kind
Nucleotide
Organism
Enteric bacteria and other eubacteria
Pharmacological action
yes
Actions
inhibitor
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Roy U, Nair D: Biodiversity of organotin resistant Pseudomonas from west coast of India. Ecotoxicology. 2007 Mar;16(2):253-61. Epub 2006 Nov 28. [PubMed:17131180 ]
  4. Wachino J, Shibayama K, Kurokawa H, Kimura K, Yamane K, Suzuki S, Shibata N, Ike Y, Arakawa Y: Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. Antimicrob Agents Chemother. 2007 Dec;51(12):4401-9. Epub 2007 Sep 17. [PubMed:17875999 ]
  5. Brown JM, Cowley KD, Manninen KI, McNeil MM: Phenotypic and molecular epidemiologic evaluation of a Nocardia farcinica mastitis epizootic. Vet Microbiol. 2007 Nov 15;125(1-2):66-72. Epub 2007 May 6. [PubMed:17553640 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23