Showing BioInteractions for Isosorbide mononitrate (DB01020)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Isosorbide mononitrate is a Guanylate cyclase soluble subunit alpha-2 activator | ||
| 1 | Guanylate cyclase soluble subunit alpha-2 inducers | Molsidomine, Nitric Oxide, Pentaerythritol tetranitrate |
| 2 | Guanylate cyclase soluble subunit alpha-2 agonists | Molsidomine, Plecanatide, Riociguat |
| 3 | Guanylate cyclase soluble subunit alpha-2 stimulators | Riociguat |
| 4 | Guanylate cyclase soluble subunit alpha-2 inhibitors | Methylene blue |
| 5 | Guanylate cyclase soluble subunit alpha-2 substrates | Magnesium gluconate |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Isosorbide mononitrate is a Glutathione S-transferase Mu 1 substrate | ||
| 1 | Glutathione S-transferase Mu 1 substrates | Acetaminophen, Azathioprine, Busulfan, Carboplatin, Cisplatin, Oxaliplatin |
| 2 | Glutathione S-transferase Mu 1 inhibitors | Chloroquine, Curcumin |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Isosorbide mononitrate is a Xanthine dehydrogenase/oxidase substrate | ||
| 1 | Xanthine dehydrogenase/oxidase inhibitors | Allopurinol, Carvedilol, Chlorphenesin, Deferoxamine, Eniluracil, Febuxostat, Spermine |
| 2 | Xanthine dehydrogenase/oxidase substrates | Adenosine, Azathioprine, Daunorubicin, Doxorubicin, Favipiravir, Inosine, Menadione, Mercaptopurine, NADH, Nitrofural, Porfiromycin, Procarbazine, Pyrazinamide |
| 3 | Xanthine dehydrogenase/oxidase conversion inhibitors | Trifluoperazine |
| 4 | Xanthine dehydrogenase/oxidase inducers | Aldesleukin, Carboplatin, Cisplatin, Inosine |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Isosorbide mononitrate is a Alcohol dehydrogenase class-3 substrate | ||
| 1 | Alcohol dehydrogenase class-3 substrates | Ethanol, NADH, Ozanimod, Polyethylene glycol 400 |