Showing BioInteractions for DB01026 (Ketoconazole)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Ketoconazole is a Lanosterol 14-alpha demethylase inhibitor
1Lanosterol 14-alpha demethylase inhibitorsBifonazole, Clotrimazole, Fluconazole, Luliconazole, Miconazole, Oxiconazole, Sertaconazole, Voriconazole
2Lanosterol 14-alpha demethylase antagonistsClotrimazole, Econazole, Posaconazole, Terconazole, Tioconazole, Voriconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Androgen receptor binder
1Androgen receptor antagonistsBicalutamide, Cyproterone acetate, Dienogest, Diethylstilbestrol, Drospirenone, Enzacamene, Eugenol, Flutamide, Homosalate, Mitotane, Nilutamide, Oxybenzone, Spironolactone
2Androgen receptor agonists1-Testosterone, Boldenone, Danazol, Drostanolone, Esculin, Fludrocortisone, Fluoxymesterone, Levonorgestrel, Methyltestosterone, Nandrolone decanoate, Nandrolone phenpropionate, Norgestrel, Oxandrolone, Oxymetholone, Prasterone, Testosterone, Testosterone Propionate
3Androgen receptor activatorsOxymetholone
4Androgen receptor inhibitorsEnzalutamide
5Androgen receptor partial agonistsNorelgestromin, Norgestimate
Interacting GroupInteracting Drugs
Ketoconazole is a Potassium voltage-gated channel subfamily H member 2 inhibitor
1Potassium voltage-gated channel subfamily H member 2 inhibitorsAmiodarone, Amsacrine, Astemizole, Bepridil, Betrixaban, Carvedilol, Cisapride, Disopyramide, Dofetilide, Doxazosin, Erythromycin, Flecainide, Fluoxetine, Halofantrine, Ibutilide, Imipramine, Miconazole, Pimozide, Prazosin, Procainamide, Propafenone, Quinidine, Sertindole, Sotalol, Tamoxifen, Terazosin, Terfenadine, Thioridazine, Verapamil
2Potassium voltage-gated channel subfamily H member 2 blockersVernakalant
3Potassium voltage-gated channel subfamily H member 2 antagonistsNefazodone
Interacting GroupInteracting Drugs
Ketoconazole is a Nuclear receptor subfamily 1 group I member 2 antagonist
1Nuclear receptor subfamily 1 group I member 2 agonistsErlotinib, Ethinyl Estradiol, Rifampicin, Rifaximin, Rilpivirine
2Nuclear receptor subfamily 1 group I member 2 inducersPaclitaxel
3Nuclear receptor subfamily 1 group I member 2 bindersDocetaxel
4Nuclear receptor subfamily 1 group I member 2 activatorsClotrimazole, Ethotoin, Mephenytoin, Methylphenobarbital, Pentobarbital, Phenobarbital, Prasterone, Quercetin, Ritonavir, Sulfinpyrazone, Troleandomycin
5Nuclear receptor subfamily 1 group I member 2 partial agonistsBezafibrate, Clonazepam, Econazole, Fenofibrate, Miconazole, Myrrh, Oxiconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A4 substrate
1Cytochrome P450 3A4 substratesAbemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Albendazole, Alclometasone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, Alprazolam, Ambrisentan, Ambroxol, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Antipyrine, Apixaban, Apremilast, Aprepitant, Argatroban, Aripiprazole, Artemether, Asenapine, Astemizole, Atazanavir, Atorvastatin, Avanafil, Axitinib, Azelastine, Azithromycin, Banoxantrone, Baricitinib, Bedaquiline, Benzphetamine, Benzyl alcohol, Bexarotene, Bezafibrate, Bicalutamide, Bisoprolol, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Carbamazepine, Carbinoxamine, Cariprazine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilostazol, Cinacalcet, Cisapride, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clofibrate, clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepate, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Cortisone acetate, Crizotinib, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delavirdine, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexchlorpheniramine maleate, Dexlansoprazole, Dextromethorphan, Dextropropoxyphene, Diazepam, Diclofenac, Dienogest, Digitoxin, Digoxin, Dihydrocodeine, Dihydroergotamine, Diltiazem, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Dutasteride, Efavirenz, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Enalapril, Enasidenib, Enzalutamide, Epinastine, Eplerenone, Ergocalciferol, Ergoloid mesylate, Ergonovine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinyl Estradiol, Ethosuximide, Ethylmorphine, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Flibanserin, Flunisolide, Flunitrazepam, Fluorometholone, Fluoxetine, Flurazepam, Flutamide, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fulvestrant, Galantamine, Gefitinib, Gemfibrozil, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halofantrine, Haloperidol, Halothane, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydromorphone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipratropium bromide, Irinotecan, Isavuconazonium, Isosorbide Dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Lansoprazole, Lapatinib, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Levobupivacaine, Levocetirizine, Levomethadyl Acetate, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lisuride, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Losartan, Lovastatin, Lumefantrine, Lurasidone, Macitentan, Maraviroc, Mebendazole, Medroxyprogesterone acetate, Mefloquine, Meloxicam, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Montelukast, Morphine, Mycophenolate mofetil, Naloxegol, Naloxone, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nicotine, Nifedipine, Nilotinib, Nilvadipine, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Norethisterone, Norgestrel, Nortriptyline, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Orphenadrine, Ospemifene, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pinacidil, Pioglitazone, Pipotiazine, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednisolone, Prednisone, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Propafenone, Propofol, Propoxyphene napsylate, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rilpivirine, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Theophylline, Thiotepa, Tiagabine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tofacitinib, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinorelbine, Vismodegib, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone
2Cytochrome P450 3A4 inhibitorsAcetaminophen, Acetazolamide, Aldesleukin, Alprazolam, Ambroxol, Amiodarone, Amlodipine, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, Atorvastatin, Azelastine, Azithromycin, Betamethasone, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brentuximab vedotin, Bromocriptine, Buprenorphine, Cabergoline, Caffeine, Capsaicin, Caspofungin, Ceritinib, Cerivastatin, Chloramphenicol, Chlorzoxazone, Cilostazol, Cimetidine, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Conivaptan, Cortisone acetate, Crizotinib, Cyclophosphamide, Cyclosporine, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Dexamethasone, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Docetaxel, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Elbasvir, Enasidenib, Epinephrine, Ergoloid mesylate, Ergonovine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Gemfibrozil, Glyburide, Glycerol Phenylbutyrate, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Indisulam, Irbesartan, Irinotecan, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Josamycin, Ketazolam, Lansoprazole, Lapatinib, Lercanidipine, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Losartan, Lovastatin, Luliconazole, Lurasidone, Manidipine, Mefloquine, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Mifepristone, Mirtazapine, Mitoxantrone, Modafinil, Nefazodone, Nelfinavir, Netupitant, Nevirapine, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Olanzapine, Olaparib, Omeprazole, Oxybutynin, Oxymetholone, Paclitaxel, Palbociclib, Paramethasone, Pazopanib, Pergolide, Phenelzine, Pilocarpine, Pimozide, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Repaglinide, Resveratrol, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rolitetracycline, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Salbutamol, Saquinavir, Sarilumab, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sitaxentan, Sorafenib, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Thiopental, Ticagrelor, Ticlopidine, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tramadol, Tranylcypromine, Troglitazone, Troleandomycin, Valproic Acid, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone, Zucapsaicin
3Cytochrome P450 3A4 inducersAcetaminophen, Alclometasone, Alimemazine, Aminoglutethimide, Armodafinil, Artemether, Atorvastatin, Azatadine, Bexarotene, Bosentan, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clofibrate, Clotrimazole, Clozapine, Colchicine, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desvenlafaxine, Dexamethasone, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Ethanol, Etoposide, Etravirine, Exemestane, Felbamate, Flucloxacillin, Fluorometholone, Fluvastatin, Fosaprepitant, Fosphenytoin, Gemfibrozil, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Idelalisib, Ifosfamide, Isavuconazonium, Lansoprazole, Lopinavir, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nicardipine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifapentine, Rifaximin, Rilpivirine, Ritonavir, Rofecoxib, Rufinamide, Seratrodast, Simvastatin, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Topiramate, Topotecan, Trametinib, Troglitazone, Vemurafenib
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A4 inhibitor
1Cytochrome P450 3A4 substratesAbemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Albendazole, Alclometasone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, Alprazolam, Ambrisentan, Ambroxol, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Antipyrine, Apixaban, Apremilast, Aprepitant, Argatroban, Aripiprazole, Artemether, Asenapine, Astemizole, Atazanavir, Atorvastatin, Avanafil, Axitinib, Azelastine, Azithromycin, Banoxantrone, Baricitinib, Bedaquiline, Benzphetamine, Benzyl alcohol, Bexarotene, Bezafibrate, Bicalutamide, Bisoprolol, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Carbamazepine, Carbinoxamine, Cariprazine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilostazol, Cinacalcet, Cisapride, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clofibrate, clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepate, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Cortisone acetate, Crizotinib, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delavirdine, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexchlorpheniramine maleate, Dexlansoprazole, Dextromethorphan, Dextropropoxyphene, Diazepam, Diclofenac, Dienogest, Digitoxin, Digoxin, Dihydrocodeine, Dihydroergotamine, Diltiazem, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Dutasteride, Efavirenz, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Enalapril, Enasidenib, Enzalutamide, Epinastine, Eplerenone, Ergocalciferol, Ergoloid mesylate, Ergonovine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinyl Estradiol, Ethosuximide, Ethylmorphine, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Flibanserin, Flunisolide, Flunitrazepam, Fluorometholone, Fluoxetine, Flurazepam, Flutamide, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fulvestrant, Galantamine, Gefitinib, Gemfibrozil, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halofantrine, Haloperidol, Halothane, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydromorphone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipratropium bromide, Irinotecan, Isavuconazonium, Isosorbide Dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Lansoprazole, Lapatinib, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Levobupivacaine, Levocetirizine, Levomethadyl Acetate, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lisuride, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Losartan, Lovastatin, Lumefantrine, Lurasidone, Macitentan, Maraviroc, Mebendazole, Medroxyprogesterone acetate, Mefloquine, Meloxicam, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Montelukast, Morphine, Mycophenolate mofetil, Naloxegol, Naloxone, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nicotine, Nifedipine, Nilotinib, Nilvadipine, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Norethisterone, Norgestrel, Nortriptyline, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Orphenadrine, Ospemifene, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pinacidil, Pioglitazone, Pipotiazine, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednisolone, Prednisone, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Propafenone, Propofol, Propoxyphene napsylate, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rilpivirine, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Theophylline, Thiotepa, Tiagabine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tofacitinib, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinorelbine, Vismodegib, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone
2Cytochrome P450 3A4 inhibitorsAcetaminophen, Acetazolamide, Aldesleukin, Alprazolam, Ambroxol, Amiodarone, Amlodipine, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, Atorvastatin, Azelastine, Azithromycin, Betamethasone, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brentuximab vedotin, Bromocriptine, Buprenorphine, Cabergoline, Caffeine, Capsaicin, Caspofungin, Ceritinib, Cerivastatin, Chloramphenicol, Chlorzoxazone, Cilostazol, Cimetidine, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Conivaptan, Cortisone acetate, Crizotinib, Cyclophosphamide, Cyclosporine, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Dexamethasone, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Docetaxel, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Elbasvir, Enasidenib, Epinephrine, Ergoloid mesylate, Ergonovine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Gemfibrozil, Glyburide, Glycerol Phenylbutyrate, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Indisulam, Irbesartan, Irinotecan, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Josamycin, Ketazolam, Lansoprazole, Lapatinib, Lercanidipine, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Losartan, Lovastatin, Luliconazole, Lurasidone, Manidipine, Mefloquine, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Mifepristone, Mirtazapine, Mitoxantrone, Modafinil, Nefazodone, Nelfinavir, Netupitant, Nevirapine, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Olanzapine, Olaparib, Omeprazole, Oxybutynin, Oxymetholone, Paclitaxel, Palbociclib, Paramethasone, Pazopanib, Pergolide, Phenelzine, Pilocarpine, Pimozide, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Repaglinide, Resveratrol, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rolitetracycline, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Salbutamol, Saquinavir, Sarilumab, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sitaxentan, Sorafenib, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Tetracycline, Thiopental, Ticagrelor, Ticlopidine, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tramadol, Tranylcypromine, Troglitazone, Troleandomycin, Valproic Acid, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone, Zucapsaicin
3Cytochrome P450 3A4 inducersAcetaminophen, Alclometasone, Alimemazine, Aminoglutethimide, Armodafinil, Artemether, Atorvastatin, Azatadine, Bexarotene, Bosentan, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clofibrate, Clotrimazole, Clozapine, Colchicine, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desvenlafaxine, Dexamethasone, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Ethanol, Etoposide, Etravirine, Exemestane, Felbamate, Flucloxacillin, Fluorometholone, Fluvastatin, Fosaprepitant, Fosphenytoin, Gemfibrozil, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Idelalisib, Ifosfamide, Isavuconazonium, Lansoprazole, Lopinavir, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nicardipine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifapentine, Rifaximin, Rilpivirine, Ritonavir, Rofecoxib, Rufinamide, Seratrodast, Simvastatin, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Topiramate, Topotecan, Trametinib, Troglitazone, Vemurafenib
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2C9 inhibitor
1Cytochrome P450 2C9 inhibitorsAbiraterone, Acenocoumarol, Agomelatine, Aminophenazone, Amiodarone, Amlodipine, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Bortezomib, Candesartan, Candesartan cilexetil, Capecitabine, Ceritinib, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Cisplatin, Clevidipine, Clopidogrel, Clotrimazole, Clozapine, Cocaine, Colchicine, Crisaborole, Cyclizine, Cyclosporine, Delavirdine, Desloratadine, Dexfenfluramine, Dextropropoxyphene, Diacerein, Diazepam, Diclofenac, Dicoumarol, Diethylstilbestrol, Diltiazem, Disulfiram, Doconexent, Dosulepin, Efavirenz, Enasidenib, Epinephrine, Eprosartan, Ethanol, Etodolac, Etoricoxib, Etravirine, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Ginkgo biloba, Glyburide, Histamine, Human Serum Albumin, Ibuprofen, Imatinib, Indinavir, Irbesartan, Isoniazid, Ketoprofen, Lansoprazole, Leflunomide, Lifitegrast, Lobeglitazone, Lopinavir, Loratadine, Lornoxicam, Losartan, Lovastatin, Lumacaftor, Manidipine, Medroxyprogesterone acetate, Mefenamic acid, Meloxicam, Methazolamide, Methimazole, Metronidazole, Miconazole, Midostaurin, Moclobemide, Modafinil, Nelfinavir, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Nilutamide, Nilvadipine, Noscapine, Olanzapine, Omeprazole, Pantoprazole, Parecoxib, Paroxetine, Phentermine, Phenylbutazone, Phenytoin, Pioglitazone, Piroxicam, Pranlukast, Pravastatin, Probenecid, Progesterone, Promethazine, Propafenone, Propofol, Pyrimethamine, Quinidine, Quinine, Rabeprazole, Regorafenib, Rhein, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Rutin, Saquinavir, Selegiline, Seratrodast, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfanilamide, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Tegaserod, Teniposide, Thioridazine, Ticagrelor, Ticlopidine, Tioconazole, Tolbutamide, Tolcapone, Topiroxostat, Tranylcypromine, Triazolam, Trimethoprim, Troglitazone, Valdecoxib, Valproic Acid, Valsartan, Verapamil, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zucapsaicin
2Cytochrome P450 2C9 substratesAceclofenac, Acenocoumarol, Acetaminophen, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amiodarone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Atazanavir, Azelastine, Bexarotene, Bortezomib, Bosentan, Brivaracetam, Brompheniramine, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Carbinoxamine, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Cisapride, Clopidogrel, Clozapine, Cyclophosphamide, Dapagliflozin, Dapsone, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diltiazem, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dopamine, Dorzolamide, Doxepin, Dronabinol, Eletriptan, Enasidenib, Epoprostenol, Estradiol, Estrone, Eszopiclone, Etodolac, Etoricoxib, Etravirine, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Gavestinel, Gliclazide, Glimepiride, Glipizide, Glyburide, Guanfacine, Haloperidol, Halothane, Hexobarbital, Histamine, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Lansoprazole, Leflunomide, Lesinurad, Licofelone, Lidocaine, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Methadone, Methoxyflurane, Metronidazole, Mirtazapine, Moclobemide, Montelukast, Naproxen, Nateglinide, Netupitant, Nevirapine, Niclosamide, Nicotine, Nortriptyline, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Oxaprozin, Paclitaxel, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Pioglitazone, Piroxicam, Pitavastatin, Prasugrel, Pravastatin, Progesterone, Proguanil, Promazine, Propofol, Quazepam, Quinidine, Quinine, Rifampicin, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Salicylic acid, Selegiline, Seratrodast, Sertraline, Sildenafil, Sitaxentan, Sulfadiazine, Sulfamethoxazole, Sulfamoxole, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Terfenadine, Testosterone, Thalidomide, Theophylline, Thiamylal, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Treprostinil, Tretinoin, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Valdecoxib, Valproic Acid, Valsartan, Venlafaxine, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Warfarin, Ximelagatran, Zafirlukast, Zalcitabine, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3Cytochrome P450 2C9 inducersAprepitant, Atorvastatin, Bosentan, Carbamazepine, Cerivastatin, Colchicine, Cyclophosphamide, Dapsone, Delafloxacin, Dexamethasone, Diclofenamide, Enzalutamide, Estrone sulfate, Fluvastatin, Fosphenytoin, Ifosfamide, Lansoprazole, Letermovir, Lovastatin, Lumacaftor, Midostaurin, Modafinil, Nicardipine, Nifedipine, Phenobarbital, Phentermine, Phenytoin, Primidone, Rifampicin, Rifapentine, Ritonavir, Secobarbital, Seratrodast, Simvastatin
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2C19 inhibitor
1Cytochrome P450 2C19 substratesAcenocoumarol, Adinazolam, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Amoxicillin, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Atomoxetine, Axitinib, Azelastine, Benzatropine, Bortezomib, Brivaracetam, Bromazepam, Brompheniramine, Bupivacaine, Carbinoxamine, Carisoprodol, Chloramphenicol, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clarithromycin, Clobazam, clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Desipramine, Dexlansoprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Dopamine, Doxazosin, Doxepin, Dronabinol, Eletriptan, Enasidenib, Enfuvirtide, Escitalopram, Esomeprazole, Estradiol, Etizolam, Etravirine, Famotidine, Flunitrazepam, Fluoxetine, Flutamide, Formoterol, Fosphenytoin, Gliclazide, Glucosamine, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Lansoprazole, Lapatinib, Levomilnacipran, Lorcaserin, Lumiracoxib, Macitentan, Melatonin, Mephenytoin, Meprobamate, Methadone, Methsuximide, Methylphenobarbital, Metoprolol, Moclobemide, Nelfinavir, Nicotine, Nilutamide, Nortriptyline, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Pentamidine, Pentobarbital, Perphenazine, Pethidine, Phenacetin, Phenobarbital, Phenytoin, Pipotiazine, Podofilox, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Ranitidine, Romidepsin, Rosuvastatin, Rupatadine, Selegiline, Seratrodast, Sertraline, Sildenafil, Tamoxifen, Tapentadol, Temazepam, Teniposide, Terbinafine, Testosterone, Thalidomide, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Trimethadione, Trimipramine, Troglitazone, Valproic Acid, Venlafaxine, Verapamil, Voriconazole, Vortioxetine, Warfarin, Zidovudine, Zolpidem
2Cytochrome P450 2C19 inhibitorsAbiraterone, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Aprepitant, Armodafinil, Atorvastatin, Azelastine, Benzbromarone, Bicalutamide, Bifonazole, Bortezomib, Buprenorphine, Carbamazepine, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Citalopram, Clarithromycin, Clevidipine, Clotrimazole, Clozapine, Cyclosporine, Delavirdine, Desipramine, Desloratadine, Dexfenfluramine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Efavirenz, Enasidenib, Eslicarbazepine acetate, Esomeprazole, Ethanol, Ethotoin, Etoricoxib, Etravirine, Felbamate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gliclazide, Idelalisib, Imipramine, Indinavir, Indomethacin, Isoniazid, Lansoprazole, Lobeglitazone, Lopinavir, Loratadine, Losartan, Lovastatin, Luliconazole, Manidipine, Memantine, Mephenytoin, Methazolamide, Methimazole, Methsuximide, Methylphenobarbital, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nelfinavir, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oxcarbazepine, Oxymetholone, Pantoprazole, Pegvisomant, Phenelzine, Phensuximide, Pimozide, Pioglitazone, Probenecid, Progesterone, Quinine, Rabeprazole, Regorafenib, Rilpivirine, Ritonavir, Rosiglitazone, Rucaparib, Saquinavir, Seratrodast, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Topiramate, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Troleandomycin, Valdecoxib, Valproic Acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3Cytochrome P450 2C19 inducersAcetylsalicylic acid, Aminoglutethimide, Artemether, Carbamazepine, Dexamethasone, Enzalutamide, Fosphenytoin, Hydroxyprogesterone caproate, Letermovir, Lopinavir, Loratadine, Lumacaftor, Midostaurin, Modafinil, Norethisterone, Phenobarbital, Phenytoin, Prednisone, Primidone, Rifampicin, Ritonavir
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A5 inhibitor
1Cytochrome P450 3A5 substratesAlfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Aprepitant, Argatroban, Aripiprazole, Artemether, Astemizole, Atorvastatin, Axitinib, Azelastine, Boceprevir, Brentuximab vedotin, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Cerivastatin, Cethromycin, Chloroquine, Chlorphenamine, Cilostazol, Cisapride, Clarithromycin, Clonidine, Clopidogrel, Cobicistat, Cocaine, Codeine, Copanlisib, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dexamethasone, Dextromethorphan, Diazepam, Diltiazem, Disulfiram, Docetaxel, Domperidone, Dutasteride, Elbasvir, Eplerenone, Erlotinib, Estradiol, Estrone, Ethosuximide, Etoposide, Felodipine, Fentanyl, Finasteride, Fluoxetine, Flutamide, Fluticasone propionate, Fluvastatin, Granisetron, Halofantrine, Haloperidol, Hydrocortisone, Hydroxyprogesterone caproate, Ibrutinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Ivacaftor, Lapatinib, Lercanidipine, Levomethadyl Acetate, Lidocaine, Losartan, Lovastatin, Methadone, Midazolam, Mifepristone, Mycophenolate mofetil, Nateglinide, Nelfinavir, Nevirapine, Nifedipine, Nimodipine, Nisoldipine, Nitrendipine, Norethisterone, Nortriptyline, Ondansetron, Oxazepam, Oxybutynin, Oxycodone, Paclitaxel, Paritaprevir, Pentamidine, Perampanel, Pimozide, Ponatinib, Pravastatin, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Sunitinib, Tacrolimus, Tamoxifen, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Testosterone, Trastuzumab emtansine, Trazodone, Tretinoin, Triazolam, Udenafil, Valbenazine, Valproic Acid, Vardenafil, Verapamil, Vicriviroc, Vincristine, Zalcitabine, Zaleplon, Ziprasidone, Zolpidem
2Cytochrome P450 3A5 inducersArmodafinil, Beclomethasone dipropionate, Carbamazepine, Cyclosporine, Daunorubicin, Dexamethasone, Etoposide, Midostaurin, Modafinil, Oxcarbazepine, Phenobarbital, Phenytoin, Reserpine, Rifampicin, Rifapentine, Ritonavir, Thalidomide, Troglitazone
3Cytochrome P450 3A5 inhibitorsAmiodarone, Aprepitant, Boceprevir, Brentuximab vedotin, Chloramphenicol, Cimetidine, Ciprofloxacin, Clarithromycin, Cobicistat, Crizotinib, Delavirdine, Diltiazem, Elbasvir, Enzalutamide, Fluconazole, Fluticasone propionate, Fluvoxamine, Gestodene, Idelalisib, Imatinib, Indinavir, Itraconazole, Mibefradil, Mifepristone, Modafinil, Nefazodone, Nelfinavir, Nicardipine, Norfloxacin, Oxymetholone, Phenelzine, Ranitidine, Ritonavir, Rosuvastatin, Rucaparib, Saquinavir, Seproxetine, Telithromycin, Temsirolimus, Troglitazone, Verapamil, Voriconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1A2 inhibitor
1Cytochrome P450 1A2 substratesAcenocoumarol, Acetaminophen, Albendazole, Almotriptan, Alosetron, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Anagrelide, Antipyrine, Apixaban, Aprepitant, Asenapine, Axitinib, Azelastine, Bendamustine, Benzyl alcohol, Betaxolol, Bortezomib, Bromazepam, Bupivacaine, Bupropion, Caffeine, Carbamazepine, Carmustine, Carvedilol, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Clenbuterol, Clevidipine, Clomipramine, Clonidine, Clopidogrel, Clozapine, Conjugated estrogens, Cyclobenzaprine, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Desipramine, Deutetrabenazine, Dexfenfluramine, Diazepam, Diclofenac, Dinoprostone, Diphenhydramine, Domperidone, Doxepin, Duloxetine, Eltrombopag, Enasidenib, Ergotamine, Erlotinib, Estradiol, Estrone, Estrone sulfate, Ethanol, Etoposide, Etoricoxib, Flunarizine, Flunitrazepam, Fluorouracil, Fluoxetine, Flutamide, Fluvoxamine, Frovatriptan, Genistein, Grepafloxacin, Guanabenz, Haloperidol, Hesperetin, Hexobarbital, Icotinib, Iloperidone, Imatinib, Imipramine, Imiquimod, Ixazomib, Leflunomide, Levobupivacaine, Lidocaine, Lomefloxacin, Lorcaserin, Lumiracoxib, Malathion, Maprotiline, Melatonin, Menadione, Mephenytoin, Methadone, Methoxyflurane, Mexiletine, Mianserin, Mirtazapine, Muraglitazar, Nabumetone, Naproxen, Nicotine, Nifedipine, Nitric Oxide, Nortriptyline, Olanzapine, Omeprazole, Ondansetron, Oxaliplatin, Oxtriphylline, Palonosetron, Pantoprazole, Pazopanib, Pentamidine, Pentoxifylline, Perphenazine, Phenacetin, Pimozide, Pipotiazine, Pomalidomide, Praziquantel, Primaquine, Progesterone, Proguanil, Promazine, Propafenone, Propofol, Propranolol, Pyrazinamide, Quinine, Ramelteon, Ranitidine, Rasagiline, Resveratrol, Rifabutin, Riluzole, Ritonavir, Rizatriptan, Rofecoxib, Ropinirole, Ropivacaine, Rotigotine, Rucaparib, Selegiline, Sertraline, Stiripentol, Tacrine, Tamoxifen, Telithromycin, Temafloxacin, Terbinafine, Thalidomide, Theobromine, Theophylline, Thiabendazole, Thioridazine, Thiothixene, Tizanidine, Tolperisone, Toremifene, Triamterene, Trifluoperazine, Ulipristal, Vadimezan, Verapamil, Voxilaprevir, Warfarin, Zileuton, Ziprasidone, Zolmitriptan, Zolpidem
2Cytochrome P450 1A2 inhibitorsAbiraterone, Aciclovir, Agomelatine, Albendazole, Alitretinoin, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Anastrozole, Apomorphine, Atazanavir, Atropine, Azithromycin, Bortezomib, Bromocriptine, Buprenorphine, Caffeine, Carbamazepine, Carbimazole, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clobetasol propionate, Clomifene, Clotrimazole, Clozapine, Conjugated estrogens, Crisaborole, Delavirdine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Diacerein, Diazepam, Diclofenac, Disulfiram, Dopamine, Dosulepin, Edetic Acid, Efavirenz, Eltrombopag, Enasidenib, Enoxacin, Entacapone, Epinephrine, Erythromycin, Estradiol, Etoricoxib, Fluconazole, Fluoxetine, Fluphenazine, Flutamide, Fluvastatin, Fluvoxamine, Gemfibrozil, Glecaprevir, Glycerol Phenylbutyrate, Imipramine, Interferon Alfa-2b, Recombinant, Interferon gamma-1b, Irbesartan, Isoniazid, Levofloxacin, Lidocaine, Lobeglitazone, Lomefloxacin, Lopinavir, Losartan, Manidipine, Meclizine, Melatonin, Mestranol, Methimazole, Methotrimeprazine, Methoxsalen, Mexiletine, Mibefradil, Miconazole, Midostaurin, Mifepristone, Mirtazapine, Moclobemide, Modafinil, Nefazodone, Nelfinavir, Nevirapine, Niclosamide, Nifedipine, Nilvadipine, Nisoldipine, Nitroprusside, Norepinephrine, Norfloxacin, Obeticholic acid, Ofloxacin, Olanzapine, Omeprazole, Ondansetron, Orphenadrine, Oxymetholone, Paroxetine, Pefloxacin, Peginterferon alfa-2a, Peginterferon alfa-2b, Pentoxifylline, Perphenazine, Phentermine, Phenylbutyric acid, Phenylpropanolamine, Pibrentasvir, Primaquine, Propafenone, Propofol, Propranolol, Quinidine, Quinine, Ranitidine, Resveratrol, Rhein, Rofecoxib, Ropinirole, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Selegiline, Sertraline, Simeprevir, Sorafenib, Sulconazole, Sulindac, Synthetic Conjugated Estrogens, A, Tegaserod, Temafloxacin, Tenofovir disoproxil, Theophylline, Thiabendazole, Thioridazine, Ticlopidine, Tioconazole, Tocainide, Topiroxostat, Tranylcypromine, Triamterene, Valaciclovir, Valproic Acid, Vemurafenib, Verapamil, Zafirlukast, Zileuton, Zucapsaicin
3Cytochrome P450 1A2 inducersAlbendazole, Aminoglutethimide, Armodafinil, Belinostat, beta-Naphthoflavone, Capsaicin, Carbamazepine, Danthron, Griseofulvin, Insulin Aspart, Insulin Beef, Insulin Detemir, Insulin Glargine, Insulin Glulisine, Insulin Human, Insulin Lispro, Insulin Pork, Lansoprazole, Menadione, Midostaurin, Modafinil, Nafcillin, Nicotine, Omeprazole, Osimertinib, Pantoprazole, Phenobarbital, Phenylephrine, Primaquine, Primidone, Quinine, Rabeprazole, Resveratrol, Rifampicin, Rilpivirine, Ritonavir, Rucaparib, Secobarbital, Streptozocin
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2C8 inhibitor
1Cytochrome P450 2C8 substratesAcetaminophen, Acetylsalicylic acid, Almotriptan, Aminophenazone, Amiodarone, Amitriptyline, Amodiaquine, Amprenavir, Antipyrine, Apixaban, Atorvastatin, Azelastine, Benzyl alcohol, Beraprost, Brigatinib, Brompheniramine, Buprenorphine, Bupropion, Cabazitaxel, Caffeine, Carbamazepine, Carbinoxamine, Cerivastatin, Chloroquine, Cisapride, Clozapine, Cyclophosphamide, Dabrafenib, Dapsone, Dasabuvir, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Domperidone, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Estradiol, Eszopiclone, Fluorouracil, Fluvastatin, Fosphenytoin, Halofantrine, Ibuprofen, Ifosfamide, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Lansoprazole, Lapatinib, Levomilnacipran, Licofelone, Lidocaine, Loperamide, Loratadine, Losartan, Mefenamic acid, Meloxicam, Mephenytoin, Methadone, Mirtazapine, Morphine, Muraglitazar, Mycophenolate mofetil, Naloxone, Naproxen, Nicardipine, Nicotine, Odanacatib, Olodaterol, Ombitasvir, Omeprazole, Paclitaxel, Paramethadione, Pazopanib, Pentamidine, Perospirone, Perphenazine, Phenprocoumon, Phenytoin, Pioglitazone, Piroxicam, Pitavastatin, Ponatinib, Progesterone, Propofol, Quinidine, Quinine, Repaglinide, Rifampicin, Riociguat, Rofecoxib, Rosiglitazone, Selegiline, Selexipag, Seratrodast, Simvastatin, Sitagliptin, Sorafenib, Sulfadiazine, Sulfinpyrazone, Tazarotene, Temazepam, Terbinafine, Testosterone, Theophylline, Tolbutamide, Torasemide, Tretinoin, Trimethadione, Trimethoprim, Troglitazone, Velpatasvir, Verapamil, Vortioxetine, Voxilaprevir, Warfarin, Zafirlukast, Zidovudine, Zopiclone
2Cytochrome P450 2C8 inducersCarbamazepine, Colchicine, Cyclophosphamide, Dexamethasone, Fosphenytoin, Gemfibrozil, Hydrocortisone, Ifosfamide, Lumacaftor, Midostaurin, Phenobarbital, Phenytoin, Primidone, Probenecid, Rifampicin, Rifapentine, Ritonavir, Secobarbital
3Cytochrome P450 2C8 inhibitorsAbiraterone, Amitriptyline, Amlodipine, Atorvastatin, Belinostat, Bezafibrate, Candesartan, Candesartan cilexetil, Celecoxib, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Clopidogrel, Clotrimazole, Cocaine, Colchicine, Crisaborole, Cyclosporine, Delavirdine, Dextropropoxyphene, Diethylstilbestrol, Efavirenz, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Ethinyl Estradiol, Etoposide, Felodipine, Fenofibrate, Fluvastatin, Gemfibrozil, Idelalisib, Irbesartan, Isoniazid, Ketoprofen, Lansoprazole, Lapatinib, Letermovir, Levothyroxine, Licofelone, Liotrix, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Medroxyprogesterone acetate, Mefenamic acid, Meloxicam, Metronidazole, Midostaurin, Mometasone, Montelukast, Nicardipine, Nifedipine, Nilotinib, Nilutamide, Nilvadipine, Oxybutynin, Paroxetine, Phenelzine, Pioglitazone, Piroxicam, Ponatinib, Pravastatin, Propafenone, Propoxyphene napsylate, Pyrimethamine, Quercetin, Quinine, Rabeprazole, Raloxifene, Regorafenib, Rifampicin, Ritonavir, Rosiglitazone, Rucaparib, Rutin, Salmeterol, Saquinavir, Simvastatin, Sorafenib, Spironolactone, Sulfamethoxazole, Sulfaphenazole, Tamoxifen, Tegaserod, Terfenadine, Teriflunomide, Thioridazine, Ticlopidine, Tioconazole, Tolbutamide, Topiroxostat, Trametinib, Triazolam, Trimethoprim, Troglitazone, Troleandomycin, Valproic Acid, Vismodegib, Warfarin, Zafirlukast
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1A1 inhibitor
1Cytochrome P450 1A1 substratesAcetaminophen, Amiodarone, Amodiaquine, Azelastine, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Diclofenac, Dronabinol, Erlotinib, Estradiol, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Lorcaserin, Melatonin, Menadione, Nicotine, Oxaliplatin, Pentamidine, Perospirone, Phenacetin, Prazosin, Progesterone, Resveratrol, Riluzole, Riociguat, Romidepsin, Tamoxifen, Tesmilifene, Testosterone, Thalidomide, Theophylline, Toremifene, Tretinoin, Troglitazone, Warfarin
2Cytochrome P450 1A1 inducersAlbendazole, Bezafibrate, Clofibrate, Clomifene, Clozapine, Dexamethasone, Dicyclomine, Ellagic Acid, Fluorescein, Itraconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Picrotoxin, Primaquine, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Vitamin A
3Cytochrome P450 1A1 inhibitorsAmlodipine, Arsenic trioxide, Caffeine, Cholecalciferol, Clobetasol propionate, Dexamethasone, Dexmedetomidine, Ellagic Acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Manidipine, Melatonin, Methoxsalen, Mibefradil, Nifedipine, Nitroprusside, Norfloxacin, Ouabain, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Sildenafil, Sulindac, Theophylline, Ticlopidine, Topiroxostat, Vitamin A
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1A1 inducer
1Cytochrome P450 1A1 substratesAcetaminophen, Amiodarone, Amodiaquine, Azelastine, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Diclofenac, Dronabinol, Erlotinib, Estradiol, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Lorcaserin, Melatonin, Menadione, Nicotine, Oxaliplatin, Pentamidine, Perospirone, Phenacetin, Prazosin, Progesterone, Resveratrol, Riluzole, Riociguat, Romidepsin, Tamoxifen, Tesmilifene, Testosterone, Thalidomide, Theophylline, Toremifene, Tretinoin, Troglitazone, Warfarin
2Cytochrome P450 1A1 inducersAlbendazole, Bezafibrate, Clofibrate, Clomifene, Clozapine, Dexamethasone, Dicyclomine, Ellagic Acid, Fluorescein, Itraconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Picrotoxin, Primaquine, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Vitamin A
3Cytochrome P450 1A1 inhibitorsAmlodipine, Arsenic trioxide, Caffeine, Cholecalciferol, Clobetasol propionate, Dexamethasone, Dexmedetomidine, Ellagic Acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Manidipine, Melatonin, Methoxsalen, Mibefradil, Nifedipine, Nitroprusside, Norfloxacin, Ouabain, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Sildenafil, Sulindac, Theophylline, Ticlopidine, Topiroxostat, Vitamin A
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2D6 inhibitor
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, Acetaminophen, Acetylcholine, Ajmaline, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Amsacrine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Artemether, Astemizole, Atomoxetine, Azelastine, Benzatropine, Benzyl alcohol, Bepridil, Betaxolol, Bisoprolol, Bortezomib, Brexpiprazole, Brompheniramine, Bufuralol, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Caffeine, Captopril, Cariprazine, Carteolol, Carvedilol, Cephalexin, Cevimeline, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Clozapine, Codeine, Cyclobenzaprine, Cyclophosphamide, Dapagliflozin, Darifenacin, Dasabuvir, Debrisoquin, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmethylphenidate, Dextroamphetamine, Dextromethorphan, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dopamine, Doxazosin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Epinastine, Erlotinib, Escitalopram, Esmirtazapine, Ethylmorphine, Etoricoxib, Fesoterodine, Fingolimod, Flecainide, Flunarizine, Fluoxetine, Fluphenazine, Fluvastatin, Fluvoxamine, Formoterol, Galantamine, Gefitinib, Granisetron, Halofantrine, Haloperidol, Halothane, Hydrocodone, Hydromorphone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Ipratropium bromide, Ixazomib, Labetalol, Letermovir, Levodopa, Levomilnacipran, Lidocaine, Lisuride, Lomustine, Loperamide, Loratadine, Lorcaserin, Maprotiline, Mephenytoin, Mequitazine, Mesoridazine, Methadone, Methamphetamine, Methotrimeprazine, Methoxyflurane, Methylphenidate, Methyprylon, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Morphine, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicardipine, Nicergoline, Nicotine, Nifedipine, Nitrofural, Nortriptyline, Olanzapine, Ondansetron, Oxycodone, Oxymorphone, Palonosetron, Paroxetine, Pazopanib, Pentamidine, Perhexiline, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenformin, Pindolol, Piperazine, Pipotiazine, Ponatinib, Procainamide, Prochlorperazine, Progesterone, Promethazine, Propafenone, Propofol, Propranolol, Protriptyline, Pseudoephedrine, Quetiapine, Quinine, Ranitidine, Remoxipride, Repinotan, Risperidone, Ritonavir, Ropivacaine, Rotigotine, Rucaparib, Rupatadine, Saquinavir, Sertindole, Sertraline, Sildenafil, Simvastatin, Sparteine, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Trimipramine, Umeclidinium, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Vortioxetine, Yohimbine, Zalcitabine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitorsAbiraterone, Acebutolol, Ajmaline, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amphetamine, Antipyrine, Aripiprazole, Artemether, Asenapine, Atomoxetine, Atorvastatin, Azelastine, Betaxolol, Bicalutamide, Biperiden, Bortezomib, Brompheniramine, Buprenorphine, Bupropion, Carbinoxamine, Carteolol, Celecoxib, Cerivastatin, Chloroquine, Chlorphenamine, Chlorpromazine, Cholecalciferol, Cimetidine, Cinacalcet, Cisapride, Citalopram, Clemastine, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Codeine, Cyclosporine, Cyproterone acetate, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Dexmethylphenidate, Dextroamphetamine, Dextromethorphan, Dextropropoxyphene, Diacerein, Diltiazem, Dimethyl sulfoxide, Diphenhydramine, Disulfiram, Dolasetron, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Eliglustat, Enasidenib, Entacapone, Enzalutamide, Epinastine, Escitalopram, Etoricoxib, Felodipine, Fenfluramine, Fexofenadine, Flecainide, Fluoxetine, Fluphenazine, Fluvastatin, Fluvoxamine, Gefitinib, Glycerol Phenylbutyrate, Granisetron, Halofantrine, Haloperidol, Histamine, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Idarubicin, Imatinib, Imipramine, Indinavir, Indisulam, Irbesartan, Isoniazid, Itraconazole, Labetalol, Lansoprazole, Lercanidipine, Levosalbutamol, Lidocaine, Lomustine, Lopinavir, Loratadine, Lorcaserin, Lovastatin, Lumefantrine, Manidipine, Mefloquine, Mepyramine, Methadone, Methamphetamine, Methazolamide, Methimazole, Methotrimeprazine, Methoxsalen, Methylnaltrexone, Methylphenidate, Metoclopramide, Metoprolol, Mianserin, Mibefradil, Miconazole, Midodrine, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Moclobemide, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Ondansetron, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pentamidine, Pergolide, Perhexiline, Perphenazine, Phentermine, Phenylbutyric acid, Pimozide, Pindolol, Pioglitazone, Pipotiazine, Pravastatin, Praziquantel, Primaquine, Proguanil, Promazine, Promethazine, Propafenone, Propofol, Propoxyphene napsylate, Propranolol, Pyrimethamine, Quetiapine, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Risperidone, Ritonavir, Rivastigmine, Rolapitant, Ropinirole, Rosiglitazone, Rotigotine, Rucaparib, Rutin, Saquinavir, Selegiline, Sertraline, Sildenafil, Simvastatin, Sorafenib, Sparteine, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Telithromycin, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Timolol, Tioconazole, Tipranavir, Tramadol, Tranylcypromine, Tripelennamine, Triprolidine, Trospium, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Yohimbine, Zafirlukast, Ziprasidone, Zucapsaicin
3Cytochrome P450 2D6 inducersAripiprazole, Dexamethasone, Glutethimide, Granisetron, Haloperidol, Loratadine, Mirtazapine, Moclobemide, Pindolol, Reboxetine, Rifapentine
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A7 inhibitor
1Cytochrome P450 3A7 substratesAlfentanil, Alprazolam, Aminophenazone, Amlodipine, Aprepitant, Aripiprazole, Astemizole, Atorvastatin, Buprenorphine, Buspirone, Caffeine, Carbamazepine, Cerivastatin, Chlorphenamine, Cilostazol, Cisapride, Clarithromycin, Cobicistat, Cocaine, Codeine, Copanlisib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dexamethasone, Dextromethorphan, Diazepam, Diltiazem, Docetaxel, Domperidone, Elbasvir, Eplerenone, Erythromycin, Estradiol, Ethosuximide, Ethylmorphine, Felodipine, Fentanyl, Finasteride, Fluticasone propionate, Haloperidol, Hydrocortisone, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imipramine, Indinavir, Irinotecan, Lercanidipine, Levomethadyl Acetate, Lidocaine, Lovastatin, Methadone, Midazolam, Nateglinide, Nelfinavir, Nifedipine, Nisoldipine, Nitrendipine, Norethisterone, Ondansetron, Oxazepam, Oxycodone, Paclitaxel, Pimozide, Prasterone, Prasterone sulfate, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Risperidone, Ritonavir, Salmeterol, Saquinavir, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sunitinib, Tacrolimus, Tamoxifen, Telithromycin, Temsirolimus, Terfenadine, Testosterone, Trazodone, Tretinoin, Triazolam, Verapamil, Vincristine, Zalcitabine, Zaleplon, Ziprasidone, Zolpidem
2Cytochrome P450 3A7 inhibitorsAmiodarone, Aprepitant, Chloramphenicol, Cimetidine, Ciprofloxacin, Clarithromycin, Cobicistat, Delavirdine, Diltiazem, Elbasvir, Erythromycin, Fluconazole, Fluvoxamine, Gestodene, Idelalisib, Imatinib, Indinavir, Itraconazole, Mibefradil, Midazolam, Mifepristone, Nefazodone, Nelfinavir, Norfloxacin, Oxymetholone, Phenelzine, Prasterone, Progesterone, Propoxyphene napsylate, Ritonavir, Rucaparib, Saquinavir, Seproxetine, Telithromycin, Troglitazone, Verapamil, Voriconazole
3Cytochrome P450 3A7 inducersClotrimazole, Cyclosporine, Dexamethasone, Dextropropoxyphene, Midostaurin, Phenobarbital, Phenytoin, Rifampicin, Rifapentine, Ritonavir, Troglitazone
Interacting GroupInteracting Drugs
Ketoconazole is a Cholesterol side-chain cleavage enzyme, mitochondrial inhibitor
1Cholesterol side-chain cleavage enzyme, mitochondrial inhibitorsAminoglutethimide, Clomifene, Clotrimazole, Dexamethasone, Digoxin, Glutethimide, Omeprazole, Terbinafine, Testosterone
2Cholesterol side-chain cleavage enzyme, mitochondrial substratesCholecalciferol, Dinoprostone, Saquinavir, Stanolone
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 11B1, mitochondrial inhibitor
1Cytochrome P450 11B1, mitochondrial inducersMitotane, Spironolactone
2Cytochrome P450 11B1, mitochondrial inhibitorsCimetidine, Clotrimazole, Etomidate, Fluconazole, Metoclopramide, Metyrapone, Mibefradil, Miconazole, Phenytoin, Spironolactone
3Cytochrome P450 11B1, mitochondrial substratesAldosterone, Hydrocortisone
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1B1 inhibitor
1Cytochrome P450 1B1 substratesAmodiaquine, Caffeine, Dasatinib, Docetaxel, Erlotinib, Estradiol, Estrone, Flutamide, Melatonin, Oxaliplatin, Procarbazine, Progesterone, Tamoxifen, Testosterone, Theophylline
2Cytochrome P450 1B1 inhibitorsArsenic trioxide, Daunorubicin, Docetaxel, Doxorubicin, Flutamide, Melatonin, Mitoxantrone, Paclitaxel, Propofol, Resveratrol, Tamoxifen
3Cytochrome P450 1B1 inducersBiotin, Clozapine, Dexamethasone, Docetaxel, Lansoprazole, Omeprazole, Phenobarbital, Primaquine
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 26A1 inhibitor
1Cytochrome P450 26A1 substratesAcitretin, Etretinate
2Cytochrome P450 26A1 inducersVitamin A
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2A6 inhibitor
1Cytochrome P450 2A6 substratesAcetaminophen, Antipyrine, Arformoterol, Bupropion, Chlorzoxazone, Cinnarizine, Cisapride, clomethiazole, Clozapine, Cyclophosphamide, Dapagliflozin, Dronabinol, Flunarizine, Flunitrazepam, Fluorouracil, Flurazepam, Formoterol, Halothane, Ifosfamide, Letrozole, Lidocaine, Lorcaserin, Methoxsalen, Methoxyflurane, Montelukast, Nevirapine, Nicotine, Nifedipine, Phenacetin, Pilocarpine, Progesterone, Propofol, Rifampicin, Selegiline, Sevoflurane, Tamoxifen, Tegafur, Tretinoin, Valproic Acid, Vortioxetine, Zidovudine
2Cytochrome P450 2A6 inhibitorsAmiodarone, Amlodipine, Amphetamine, Azelastine, Azithromycin, Buprenorphine, Clofibrate, Clomifene, Clotrimazole, Desipramine, Dexfenfluramine, Diethylstilbestrol, Ezogabine, Fomepizole, Isoniazid, Letrozole, Memantine, Menadione, Methimazole, Methoxsalen, Metyrapone, Miconazole, Nicotine, Nilvadipine, Norfloxacin, Phenobarbital, Pilocarpine, Prednisolone, Rifampicin, Rosiglitazone, Seratrodast, Sulfaphenazole, Tranylcypromine, Troleandomycin
3Cytochrome P450 2A6 inducersAmobarbital, Dexamethasone, Eletriptan, Pentobarbital, Phenobarbital, Rifampicin, Valproic Acid
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2B6 inhibitor
1Cytochrome P450 2B6 substratesAmitriptyline, Antipyrine, Artemether, Banoxantrone, Benzphetamine, Benzyl alcohol, Brivaracetam, Brompheniramine, Bupropion, Carbinoxamine, Cinnarizine, Cisapride, Clobazam, clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dextromethorphan, Diazepam, Diclofenac, Diphenhydramine, Domperidone, Efavirenz, Enasidenib, Epinastine, Erythromycin, Estrone, Ethylmorphine, Flunarizine, Flunitrazepam, Fluoxetine, Halothane, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Lorcaserin, Malathion, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Midazolam, Nevirapine, Nicotine, Ospemifene, Perhexiline, Permethrin, Perphenazine, Pethidine, Prasugrel, Promethazine, Propofol, Ritonavir, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Sorafenib, Tamoxifen, Temazepam, Testosterone, Tramadol, Tretinoin, Valproic Acid, Velpatasvir, Verapamil, Vortioxetine
2Cytochrome P450 2B6 inducersArmodafinil, Artemether, Atorvastatin, Carbamazepine, Cerivastatin, Clofibrate, Clotrimazole, Cyclophosphamide, Dexamethasone, Efavirenz, Enasidenib, Fluvastatin, Fosphenytoin, Idelalisib, Isoflurane, Letermovir, Lumacaftor, Metamizole, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Orphenadrine, Permethrin, Phenobarbital, Phenytoin, Primidone, Rifampicin, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone, Troglitazone, Verapamil
3Cytochrome P450 2B6 inhibitorsAmlodipine, Amprenavir, Antipyrine, Azelastine, Bupropion, Cholecalciferol, Cisplatin, Citalopram, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Desipramine, Doxorubicin, Efavirenz, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Lopinavir, Manidipine, Memantine, Methimazole, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Phencyclidine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rilpivirine, Ritonavir, Roxithromycin, Sertraline, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Venlafaxine
Interacting GroupInteracting Drugs
Ketoconazole is a Lanosterol 14-alpha demethylase inhibitor
1Lanosterol 14-alpha demethylase inhibitorsItraconazole, Sertaconazole, Tioconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Bile salt export pump inhibitor
1Bile salt export pump inhibitorsBosentan, Chlorpromazine, Cholic Acid, Cimetidine, Clofazimine, Cyclosporine, Ethinyl Estradiol, Fusidic Acid, Glyburide, Glycochenodeoxycholic Acid, Letermovir, Novobiocin, Paclitaxel, Ponatinib, Progesterone, Quinidine, Reserpine, Rifampicin, Simeprevir, Tamoxifen, Troglitazone, Ursodeoxycholic acid, Verapamil, Vinblastine
2Bile salt export pump substratesCholic Acid, Daunorubicin, Digoxin, Doxorubicin, Fluorescein, Glycochenodeoxycholic Acid, Paclitaxel, Pravastatin, Rosuvastatin, Taurocholic Acid, Ursodeoxycholic acid, Vinblastine, Vincristine
3Bile salt export pump inducersCholic Acid, Deoxycholic Acid, Dexamethasone, Ethinyl Estradiol, Phenobarbital, Taurocholic Acid, Ursodeoxycholic acid
Interacting GroupInteracting Drugs
Ketoconazole is a Multidrug resistance protein 1 substrate
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Apixaban, Arsenic trioxide, Atazanavir, Atenolol, Axitinib, Baricitinib, Belinostat, Betamethasone, Bosutinib, Brentuximab vedotin, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carbamazepine, Carfilzomib, Ceritinib, Cerivastatin, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxorubicin, Edoxaban, Elbasvir, Eletriptan, Enasidenib, Epinastine, Erlotinib, Estradiol, Estriol, Estrone, Ethinyl Estradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluciclovine (18F), Fluticasone furoate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Osimertinib, Paclitaxel, Panobinostat, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Reserpine, Rifampicin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Salicylic acid, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Ulipristal, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Albendazole, Alectinib, Alfentanil, Amantadine, Aminohippuric acid, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Amsacrine, Astemizole, Atazanavir, Atenolol, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Biperiden, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carbamazepine, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorpropamide, Chlorprothixene, Cholesterol, Cilazapril, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Dexamethasone, Dextromethorphan, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Etravirine, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Glycerin, Gramicidin D, Grepafloxacin, Haloperidol, Hydrocortisone, Idelalisib, Imatinib, Imipramine, Indinavir, Indomethacin, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ketamine, Lansoprazole, Lapatinib, Letermovir, Levofloxacin, Lidocaine, Lomitapide, Loperamide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Maprotiline, Mebendazole, Mefloquine, Megestrol acetate, Meprobamate, Methadone, Metoprolol, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitomycin, Mitoxantrone, Morphine, Naltrexone, Naringenin, Nelfinavir, Neostigmine, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrazepam, Nitrendipine, Omeprazole, P-Nitrophenol, Paclitaxel, Palmitic Acid, Pantoprazole, Paroxetine, Perindopril, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Pravastatin, Prazosin, Prednisone, Probenecid, Progesterone, Promethazine, Propafenone, Propranolol, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Rifampicin, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Spironolactone, Staurosporine, Sulfinpyrazone, Sumatriptan, Sunitinib, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Trimipramine, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersBetrixaban, Ledipasvir
Interacting GroupInteracting Drugs
Ketoconazole is a Multidrug resistance protein 1 inhibitor
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Apixaban, Arsenic trioxide, Atazanavir, Atenolol, Axitinib, Baricitinib, Belinostat, Betamethasone, Bosutinib, Brentuximab vedotin, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carbamazepine, Carfilzomib, Ceritinib, Cerivastatin, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxorubicin, Edoxaban, Elbasvir, Eletriptan, Enasidenib, Epinastine, Erlotinib, Estradiol, Estriol, Estrone, Ethinyl Estradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluciclovine (18F), Fluticasone furoate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Osimertinib, Paclitaxel, Panobinostat, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Reserpine, Rifampicin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Salicylic acid, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Ulipristal, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Albendazole, Alectinib, Alfentanil, Amantadine, Aminohippuric acid, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Amsacrine, Astemizole, Atazanavir, Atenolol, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Biperiden, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carbamazepine, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorpropamide, Chlorprothixene, Cholesterol, Cilazapril, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Dexamethasone, Dextromethorphan, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Etravirine, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Glycerin, Gramicidin D, Grepafloxacin, Haloperidol, Hydrocortisone, Idelalisib, Imatinib, Imipramine, Indinavir, Indomethacin, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ketamine, Lansoprazole, Lapatinib, Letermovir, Levofloxacin, Lidocaine, Lomitapide, Loperamide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Maprotiline, Mebendazole, Mefloquine, Megestrol acetate, Meprobamate, Methadone, Metoprolol, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitomycin, Mitoxantrone, Morphine, Naltrexone, Naringenin, Nelfinavir, Neostigmine, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrazepam, Nitrendipine, Omeprazole, P-Nitrophenol, Paclitaxel, Palmitic Acid, Pantoprazole, Paroxetine, Perindopril, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Pravastatin, Prazosin, Prednisone, Probenecid, Progesterone, Promethazine, Propafenone, Propranolol, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Rifampicin, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Spironolactone, Staurosporine, Sulfinpyrazone, Sumatriptan, Sunitinib, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Trimipramine, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersBetrixaban, Ledipasvir
Interacting GroupInteracting Drugs
Ketoconazole is a Solute carrier organic anion transporter family member 1A2 inhibitor
1Solute carrier organic anion transporter family member 1A2 substratesAminohippuric acid, Bilastine, Bumetanide, Cholic Acid, Conjugated estrogens, Deoxycholic Acid, Digoxin, Dinoprostone, Enalapril, Fexofenadine, Glycochenodeoxycholic Acid, Indomethacin, Lifitegrast, Liothyronine, Liotrix, Methotrexate, Mirabegron, Ouabain, Rocuronium, Taurocholic Acid, Ursodeoxycholic acid
2Solute carrier organic anion transporter family member 1A2 inhibitorsAldosterone, Atorvastatin, Cholic Acid, Conjugated estrogens, Cyclosporine, Deoxycholic Acid, Dexamethasone, Digitoxin, Estradiol, Estriol, Estrone, Glyburide, Glycochenodeoxycholic Acid, Hydrocortisone, Ibuprofen, Indinavir, Indomethacin, Ketoprofen, Lovastatin, Methyltestosterone, Naloxone, Naproxen, Nelfinavir, Ouabain, Pravastatin, Prednisolone, Prednisone, Probenecid, Quinidine, Quinine, Rifampicin, Ritonavir, Saquinavir, Simvastatin, Spironolactone, Taurocholic Acid, Testosterone, Tolbutamide, Ursodeoxycholic acid, Verapamil
3Solute carrier organic anion transporter family member 1A2 inducersCholic Acid, Methyltestosterone, Sumatriptan, Taurocholic Acid, Testosterone, Ursodeoxycholic acid