Showing BioInteractions for Ketoconazole (DB01026)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Ketoconazole is a Lanosterol 14-alpha demethylase inhibitor
1Lanosterol 14-alpha demethylase inhibitorsBifonazole, Clotrimazole, Fluconazole, Luliconazole, Miconazole, Oxiconazole, Sertaconazole, Voriconazole
2Lanosterol 14-alpha demethylase antagonistsClotrimazole, Econazole, Posaconazole, Terconazole, Tioconazole, Voriconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Androgen receptor binder
1Androgen receptor antagonistsApalutamide, Bicalutamide, Cyproterone acetate, Dienogest, Diethylstilbestrol, Drospirenone, Enzacamene, Eugenol, Flutamide, Gestrinone, Homosalate, Ligandrol, Mitotane, Nilutamide, Oxybenzone, Spironolactone
2Androgen receptor agonists1-Testosterone, Boldenone, Danazol, Drostanolone, Esculin, Fludrocortisone, Fluoxymesterone, Levonorgestrel, Ligandrol, Methyltestosterone, Nandrolone decanoate, Nandrolone phenpropionate, Norgestrel, Oxandrolone, Oxymetholone, Prasterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate
3Androgen receptor activatorsOxymetholone
4Androgen receptor inhibitorsDimethylcurcumin, Enzalutamide
5Androgen receptor partial agonistsNorelgestromin, Norgestimate
Interacting GroupInteracting Drugs
Ketoconazole is a 17-hydroxylase inhibitor
Interacting GroupInteracting Drugs
Ketoconazole is a Steroid 21-hydroxylase inhibitor
Interacting GroupInteracting Drugs
Ketoconazole is a 11-hydroxylase inhibitor
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 19A1 inhibitor
1Cytochrome P450 19A1 inhibitorsAminoglutethimide, Anastrozole, Bifonazole, Carbimazole, Clomifene, Clotrimazole, Cyproterone acetate, Danazol, Drostanolone, Econazole, Etomidate, Etretinate, Exemestane, Letrozole, Levonorgestrel, Mefloquine, Melatonin, Miconazole, Naringenin, Nicotine, Norgestrel, Paclitaxel, Raloxifene, substance P, Tamoxifen, Terbinafine, Testolactone, Tioconazole, Trastuzumab, Troglitazone
2Cytochrome P450 19A1 antagonistsLetrozole
3Cytochrome P450 19A1 substratesBetamethasone, Edetic Acid, Endostatin, Letrozole, Levomethadyl acetate, Methadone, Nandrolone phenpropionate, Stanolone, Stanolone acetate, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
4Cytochrome P450 19A1 inducersBetamethasone, Buserelin, Chlorotrianisene, Chlorphenesin, Dexamethasone, Diethylstilbestrol, Dinoprostone, Methyltestosterone, Nandrolone decanoate, Prasterone sulfate, Sulfathiazole
Interacting GroupInteracting Drugs
Ketoconazole is a Potassium voltage-gated channel subfamily H member 2 inhibitor
1Potassium voltage-gated channel subfamily H member 2 inhibitorsAlfuzosin, Amiodarone, Amsacrine, Astemizole, Bepridil, Betrixaban, Carvedilol, Chlorpromazine, Cisapride, Disopyramide, Dofetilide, Doxazosin, Doxepin, Erythromycin, Flecainide, Fluoxetine, Halofantrine, Ibutilide, Imipramine, Isavuconazole, Miconazole, Pentoxyverine, Pimozide, Prazosin, Procainamide, Propafenone, Quinidine, Sertindole, Sotalol, Tamoxifen, Terazosin, Terfenadine, Thioridazine, Verapamil
2Potassium voltage-gated channel subfamily H member 2 blockersPitolisant, Vernakalant
3Potassium voltage-gated channel subfamily H member 2 antagonistsNefazodone
4Potassium voltage-gated channel subfamily H member 2 agonistsPotassium nitrate
Interacting GroupInteracting Drugs
Ketoconazole is a Nuclear receptor subfamily 1 group I member 2 antagonist
1Nuclear receptor subfamily 1 group I member 2 agonistsErlotinib, Ethinylestradiol, Rifampicin, Rifaximin, Rilpivirine
2Nuclear receptor subfamily 1 group I member 2 inducersPaclitaxel
3Nuclear receptor subfamily 1 group I member 2 bindersDocetaxel
4Nuclear receptor subfamily 1 group I member 2 activatorsClotrimazole, Ethotoin, Mephenytoin, Methylphenobarbital, Pentobarbital, Phenobarbital, Prasterone, Quercetin, Ritonavir, Sulfinpyrazone, Troleandomycin
5Nuclear receptor subfamily 1 group I member 2 partial agonistsBezafibrate, Clonazepam, Econazole, Fenofibrate, Fenofibric acid, Miconazole, Myrrh, Oxiconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A4 substrate
1Cytochrome P450 3A4 substrates(S)-Warfarin, 16-Bromoepiandrosterone, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azithromycin, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzphetamine, Benzyl alcohol, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Cannabidiol, Carbamazepine, Carbinoxamine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofazimine, Clofibrate, clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepate, Clorindione, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone Pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dicoumarol, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Digoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Dotarizine, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Drospirenone, Dutasteride, Dydrogesterone, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Emopamil, Enalapril, Enasidenib, Encorafenib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Ergocalciferol, Ergoloid mesylate, Ergonovine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fendiline, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Fish oil, Flibanserin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fosnetupitant, Fostamatinib, Fulvestrant, Gabapentin, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydromorphone, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipecac, Ipratropium, Irinotecan, Isavuconazole, Isavuconazonium, Isosorbide dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Lacidipine, Lamotrigine, Lansoprazole, Lapatinib, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levetiracetam, Levobupivacaine, Levocetirizine, Levomethadyl acetate, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lidoflazine, Liothyronine, Liotrix, Lisuride, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic Acid Diethylamide, Macimorelin, Macitentan, Magnesium sulfate, Manidipine, Maraviroc, Mebendazole, Medical Cannabis, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Menthol, Meprednisone, Mestranol, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylergometrine, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Naloxone, Naltrexone, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Ospemifene, Otilonium, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Penfluridol, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisone, Prednylidene, Pregabalin, Pregnenolone, Prenylamine, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Promegestone, Propafenone, Propiverine, Propofol, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Seletracetam, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic Acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Valproic Acid, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine
2Cytochrome P450 3A4 inducersAcetaminophen, Alimemazine, Aminoglutethimide, Apalutamide, Armodafinil, Artemether, Asunaprevir, Atorvastatin, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clofibrate, Clotrimazole, Clozapine, Colchicine, Corticotropin, Cortisone acetate, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desonide, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Fludrocortisone, Flunisolide, Fluocinolone acetonide, Fluvastatin, Formestane, Fosaprepitant, Fosphenytoin, Glycerol phenylbutyrate, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Lansoprazole, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Methylprednisolone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Seratrodast, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, Acetaminophen, Acetazolamide, Acetyl sulfisoxazole, Aldesleukin, Ambroxol, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, AVE9633, Azelastine, Azithromycin, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Caffeine, Candicidin, Capsaicin, Carbomycin, Caspofungin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Cimicifuga racemosa, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Coltuximab ravtansine, Conivaptan, Cortisone acetate, Crizotinib, Curcumin, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desogestrel, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Docetaxel, Doramectin, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Efonidipine, Elbasvir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergonovine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Glyburide, GPI-1485, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Imatinib, Indinavir, Indisulam, Irbesartan, Irinotecan, Isavuconazole, Isavuconazonium, Isoniazid, Itraconazole, Ivacaftor, Ivermectin, Ixabepilone, Josamycin, Ketazolam, Kitasamycin, KOS-1584, Lansoprazole, Lapatinib, Lercanidipine, Letermovir, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Mefloquine, Mepartricin, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Mifepristone, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Mitoxantrone, Modafinil, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Oxetacaine, Oxybutynin, Oxymetholone, Paclitaxel, Palbociclib, Paramethasone, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Regorafenib, Repaglinide, Resveratrol, Ridaforolimus, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rokitamycin, Rolitetracycline, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Sarilumab, Selamectin, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sitaxentan, Solithromycin, Sorafenib, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Thiopental, Ticlopidine, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tramadol, Tranylcypromine, Trastuzumab emtansine, Troglitazone, Troleandomycin, Tylosin, Tylvalosin, Valproic Acid, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A4 inhibitor
1Cytochrome P450 3A4 substrates(S)-Warfarin, 16-Bromoepiandrosterone, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azithromycin, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzphetamine, Benzyl alcohol, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Cannabidiol, Carbamazepine, Carbinoxamine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofazimine, Clofibrate, clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepate, Clorindione, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone Pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dicoumarol, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Digoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Dotarizine, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Drospirenone, Dutasteride, Dydrogesterone, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Emopamil, Enalapril, Enasidenib, Encorafenib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Ergocalciferol, Ergoloid mesylate, Ergonovine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fendiline, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Fish oil, Flibanserin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fosnetupitant, Fostamatinib, Fulvestrant, Gabapentin, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydromorphone, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipecac, Ipratropium, Irinotecan, Isavuconazole, Isavuconazonium, Isosorbide dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Lacidipine, Lamotrigine, Lansoprazole, Lapatinib, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levetiracetam, Levobupivacaine, Levocetirizine, Levomethadyl acetate, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lidoflazine, Liothyronine, Liotrix, Lisuride, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic Acid Diethylamide, Macimorelin, Macitentan, Magnesium sulfate, Manidipine, Maraviroc, Mebendazole, Medical Cannabis, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Menthol, Meprednisone, Mestranol, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylergometrine, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Naloxone, Naltrexone, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Ospemifene, Otilonium, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Penfluridol, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisone, Prednylidene, Pregabalin, Pregnenolone, Prenylamine, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Promegestone, Propafenone, Propiverine, Propofol, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Seletracetam, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic Acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Valproic Acid, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine
2Cytochrome P450 3A4 inducersAcetaminophen, Alimemazine, Aminoglutethimide, Apalutamide, Armodafinil, Artemether, Asunaprevir, Atorvastatin, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clofibrate, Clotrimazole, Clozapine, Colchicine, Corticotropin, Cortisone acetate, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desonide, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Fludrocortisone, Flunisolide, Fluocinolone acetonide, Fluvastatin, Formestane, Fosaprepitant, Fosphenytoin, Glycerol phenylbutyrate, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Lansoprazole, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Methylprednisolone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Seratrodast, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, Acetaminophen, Acetazolamide, Acetyl sulfisoxazole, Aldesleukin, Ambroxol, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, AVE9633, Azelastine, Azithromycin, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Caffeine, Candicidin, Capsaicin, Carbomycin, Caspofungin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Cimicifuga racemosa, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Coltuximab ravtansine, Conivaptan, Cortisone acetate, Crizotinib, Curcumin, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desogestrel, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Docetaxel, Doramectin, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Efonidipine, Elbasvir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergonovine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Glyburide, GPI-1485, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Imatinib, Indinavir, Indisulam, Irbesartan, Irinotecan, Isavuconazole, Isavuconazonium, Isoniazid, Itraconazole, Ivacaftor, Ivermectin, Ixabepilone, Josamycin, Ketazolam, Kitasamycin, KOS-1584, Lansoprazole, Lapatinib, Lercanidipine, Letermovir, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Mefloquine, Mepartricin, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Mifepristone, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Mitoxantrone, Modafinil, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Oxetacaine, Oxybutynin, Oxymetholone, Paclitaxel, Palbociclib, Paramethasone, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Regorafenib, Repaglinide, Resveratrol, Ridaforolimus, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rokitamycin, Rolitetracycline, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Sarilumab, Selamectin, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sitaxentan, Solithromycin, Sorafenib, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Thiopental, Ticlopidine, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tramadol, Tranylcypromine, Trastuzumab emtansine, Troglitazone, Troleandomycin, Tylosin, Tylvalosin, Valproic Acid, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2C9 inhibitor
1Cytochrome P450 2C9 inhibitorsAbiraterone, Acenocoumarol, Acetyl sulfisoxazole, Agomelatine, Aminophenazone, Amiodarone, Amlodipine, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Bortezomib, Candesartan, Candesartan cilexetil, Capecitabine, Ceritinib, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Cimicifuga racemosa, Cisplatin, Clevidipine, Clopidogrel, Clotrimazole, Clozapine, Cocaine, Colchicine, Crisaborole, Curcumin, Cyclizine, Cyclosporine, Delavirdine, Desloratadine, Dexfenfluramine, Dextropropoxyphene, Diacerein, Diazepam, Diclofenac, Dicoumarol, Diethylstilbestrol, Diltiazem, Disulfiram, Doconexent, Dosulepin, Efavirenz, Enasidenib, Epinephrine, Eprosartan, Ethanol, Etodolac, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Ginkgo biloba, Glyburide, Histamine, Ibuprofen, Imatinib, Indinavir, Irbesartan, Isavuconazole, Isoniazid, Ketoprofen, Lansoprazole, Leflunomide, Lifitegrast, Lobeglitazone, Lopinavir, Loratadine, Lornoxicam, Losartan, Lovastatin, Lumacaftor, Manidipine, Medroxyprogesterone acetate, Mefenamic acid, Meloxicam, Methazolamide, Methimazole, Metronidazole, Miconazole, Midostaurin, Moclobemide, Modafinil, Nabilone, Nelfinavir, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Nilutamide, Nilvadipine, Noscapine, Olanzapine, Omeprazole, Pantoprazole, Parecoxib, Paroxetine, Phentermine, Phenylbutazone, Phenytoin, Pioglitazone, Piperine, Piroxicam, Pranlukast, Pravastatin, Probenecid, Progesterone, Promethazine, Propafenone, Propofol, Pyrimethamine, Quinidine, Quinine, Rabeprazole, Regorafenib, Rhein, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Rutin, Saquinavir, Selegiline, Seratrodast, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfanilamide, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Tegaserod, Teniposide, Thioridazine, Ticagrelor, Ticlopidine, Tioconazole, Tolcapone, Topiroxostat, Tranylcypromine, Triazolam, Trimethoprim, Troglitazone, Valdecoxib, Valproic Acid, Valsartan, Verapamil, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zucapsaicin
2Cytochrome P450 2C9 substratesAceclofenac, Acenocoumarol, Acetaminophen, Acetyl sulfisoxazole, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Azelastine, Bexarotene, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Brompheniramine, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Carbinoxamine, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Cisapride, Clopidogrel, Clozapine, Cyclophosphamide, Dapagliflozin, Dapsone, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diltiazem, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dopamine, Dorzolamide, Doxepin, Dronabinol, Eletriptan, Enasidenib, Epoprostenol, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Eszopiclone, Etodolac, Etoricoxib, Etravirine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Gavestinel, Gliclazide, Glimepiride, Glipizide, Glyburide, Guanfacine, Haloperidol, Halothane, Hexobarbital, Histamine, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Lansoprazole, Leflunomide, Lesinurad, Licofelone, Lidocaine, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Methadone, Methoxyflurane, Metronidazole, Mirtazapine, Moclobemide, Montelukast, Nabiximols, Naproxen, Nateglinide, Netupitant, Nevirapine, Niclosamide, Nicotine, Nortriptyline, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Oxaprozin, Paclitaxel, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Pioglitazone, Piperaquine, Piroxicam, Pitavastatin, Prasugrel, Pravastatin, Progesterone, Proguanil, Promazine, Propofol, Quazepam, Quinidine, Quinine, Rifampicin, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Salicylic acid, Selegiline, Seratrodast, Sertraline, Sildenafil, Sitaxentan, Sulfamethoxazole, Sulfamoxole, Sulfinpyrazone, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Theophylline, Thiamylal, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Treprostinil, Tretinoin, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Valdecoxib, Valproic Acid, Valsartan, Venlafaxine, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Warfarin, Ximelagatran, Zafirlukast, Zalcitabine, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3Cytochrome P450 2C9 inducersApalutamide, Aprepitant, Atorvastatin, Avatrombopag, Bosentan, Carbamazepine, Cerivastatin, Colchicine, Cyclophosphamide, Dapsone, Delafloxacin, Dexamethasone, Diclofenamide, Enzalutamide, Estrone sulfate, Fluvastatin, Fosphenytoin, Ifosfamide, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lovastatin, Lumacaftor, Midostaurin, Modafinil, Nicardipine, Nifedipine, Nilotinib, Phenobarbital, Phentermine, Phenytoin, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, Seratrodast, Simvastatin
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2C19 inhibitor
1Cytochrome P450 2C19 substratesAcenocoumarol, Adinazolam, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Amoxicillin, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Benzatropine, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Brompheniramine, Bupivacaine, Cannabidiol, Carbinoxamine, Carisoprodol, Chloramphenicol, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clarithromycin, Clobazam, clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Desipramine, Dexlansoprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Dopamine, Doxazosin, Doxepin, Dronabinol, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Famotidine, Flunitrazepam, Fluoxetine, Flutamide, Formoterol, Fosphenytoin, Gliclazide, Glucosamine, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lorcaserin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Mephenytoin, Meprobamate, Methadone, Methohexital, Methsuximide, Methylphenobarbital, Metoprolol, Moclobemide, Nabiximols, Nelfinavir, Nicotine, Nilutamide, Nortriptyline, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Pentamidine, Pentobarbital, Perphenazine, Pethidine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Podofilox, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Ranitidine, Romidepsin, Rosuvastatin, Rupatadine, Selegiline, Seratrodast, Sertraline, Sildenafil, Tamoxifen, Tapentadol, Temazepam, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Trimethadione, Trimipramine, Troglitazone, Valproic Acid, Venlafaxine, Verapamil, Voriconazole, Vortioxetine, Warfarin, Zidovudine, Zolpidem
2Cytochrome P450 2C19 inhibitorsAbiraterone, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Azelastine, Benzbromarone, Bicalutamide, Bifonazole, Bortezomib, Buprenorphine, Carbamazepine, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Citalopram, Clarithromycin, Clevidipine, Clotrimazole, Clozapine, Cyclosporine, Delavirdine, Desipramine, Desloratadine, Dexfenfluramine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Efavirenz, Enasidenib, Eslicarbazepine acetate, Esomeprazole, Ethanol, Ethotoin, Etoricoxib, Etravirine, Felbamate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gliclazide, Idelalisib, Imipramine, Indinavir, Indomethacin, Isavuconazole, Isoniazid, Lansoprazole, Lobeglitazone, Lopinavir, Loratadine, Losartan, Lovastatin, Luliconazole, Manidipine, Memantine, Mephenytoin, Methazolamide, Methimazole, Methsuximide, Methylphenobarbital, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nelfinavir, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Opicapone, Oxcarbazepine, Oxymetholone, Pantoprazole, Pegvisomant, Phenelzine, Phensuximide, Pimozide, Pioglitazone, Piperaquine, Probenecid, Progesterone, Quinine, Rabeprazole, Regorafenib, Rilpivirine, Ritonavir, Rosiglitazone, Rucaparib, Saquinavir, Seratrodast, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tolbutamide, Topiramate, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Troleandomycin, Valdecoxib, Valproic Acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3Cytochrome P450 2C19 inducersAcetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Carbamazepine, Dexamethasone, Enzalutamide, Hydroxyprogesterone caproate, Letermovir, Lopinavir, Loratadine, Lumacaftor, Midostaurin, Modafinil, Norethisterone, Phenobarbital, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A5 inhibitor
1Cytochrome P450 3A5 substratesAlfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Aprepitant, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Astemizole, Asunaprevir, Atorvastatin, Axitinib, Azelastine, Benidipine, Boceprevir, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Cerivastatin, Cethromycin, Chloroquine, Chlorphenamine, Cilostazol, Cisapride, Clarithromycin, Clonidine, Clopidogrel, Cobicistat, Cocaine, Codeine, Copanlisib, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dexamethasone, Dextromethorphan, Diazepam, Diltiazem, Disulfiram, Docetaxel, Domperidone, Dutasteride, Elbasvir, Eplerenone, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Ethosuximide, Etoposide, Felodipine, Fentanyl, Finasteride, Fluoxetine, Flutamide, Fluticasone propionate, Fluvastatin, Granisetron, Halofantrine, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxyprogesterone caproate, Ibrutinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Isavuconazole, Ivacaftor, Lapatinib, Lercanidipine, Levomethadyl acetate, Lidocaine, Losartan, Lovastatin, Methadone, Midazolam, Mifepristone, Mycophenolate mofetil, Nateglinide, Nelfinavir, Nevirapine, Nifedipine, Nimodipine, Nisoldipine, Nitrendipine, Norethisterone, Nortriptyline, Ondansetron, Oxazepam, Oxybutynin, Oxycodone, Paclitaxel, Paritaprevir, Pentamidine, Perampanel, Pimozide, Ponatinib, Pravastatin, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Sunitinib, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Trastuzumab emtansine, Trazodone, Tretinoin, Triazolam, Udenafil, Valbenazine, Valproic Acid, Vardenafil, Verapamil, Vicriviroc, Vincristine, Zalcitabine, Zaleplon, Ziprasidone, Zolpidem
2Cytochrome P450 3A5 inducersArmodafinil, Beclomethasone dipropionate, Budesonide, Carbamazepine, Cyclosporine, Daunorubicin, Dexamethasone, Efavirenz, Etoposide, Midostaurin, Modafinil, Oxcarbazepine, Phenobarbital, Phenytoin, Reserpine, Rifampicin, Rifapentine, Ritonavir, Thalidomide, Troglitazone
3Cytochrome P450 3A5 inhibitorsAmiodarone, Aprepitant, Boceprevir, Chloramphenicol, Cimetidine, Ciprofloxacin, Clarithromycin, Cobicistat, Crizotinib, Delavirdine, Diltiazem, Efavirenz, Elbasvir, Enzalutamide, Erythromycin, Fluconazole, Fluticasone propionate, Fluvoxamine, Gestodene, Idelalisib, Imatinib, Indinavir, Isavuconazole, Itraconazole, Letermovir, Mibefradil, Mifepristone, Modafinil, Nefazodone, Nelfinavir, Nicardipine, Norfloxacin, Oxymetholone, Phenelzine, Ranitidine, Ritonavir, Rosuvastatin, Rucaparib, Saquinavir, Seproxetine, Telithromycin, Temsirolimus, Troglitazone, Troleandomycin, Verapamil, Voriconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1A2 inhibitor
1Cytochrome P450 1A2 substratesAcenocoumarol, Acetaminophen, Albendazole, Almotriptan, Alosetron, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Anagrelide, Antipyrine, Apixaban, Aprepitant, Asenapine, Axitinib, Azelastine, Bendamustine, Benzyl alcohol, Betaxolol, Binimetinib, Bortezomib, Bromazepam, Bupivacaine, Bupropion, Caffeine, Carbamazepine, Carmustine, Carvedilol, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Clenbuterol, Clevidipine, Clomipramine, Clonidine, Clopidogrel, Clozapine, Conjugated estrogens, Cyclobenzaprine, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Desipramine, Deutetrabenazine, Dexfenfluramine, Diazepam, Diclofenac, Dicoumarol, Dinoprostone, Diphenhydramine, Domperidone, Doxepin, Duloxetine, Eltrombopag, Enasidenib, Ergotamine, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Ethanol, Etoposide, Etoricoxib, Flunarizine, Flunitrazepam, Fluorouracil, Fluoxetine, Flutamide, Fluvoxamine, Frovatriptan, Genistein, Grepafloxacin, Guanabenz, Haloperidol, Hesperetin, Hexobarbital, Icotinib, Iloperidone, Imatinib, Imipramine, Imiquimod, Ixazomib, Leflunomide, Levobupivacaine, Lidocaine, Lofexidine, Lomefloxacin, Lorcaserin, Lumiracoxib, Malathion, Maprotiline, Melatonin, Menadione, Mephenytoin, Methadone, Methoxyflurane, Mexiletine, Mianserin, Mirtazapine, Muraglitazar, Nabumetone, Naproxen, Nicotine, Nifedipine, Nitric Oxide, Nortriptyline, Olanzapine, Omeprazole, Ondansetron, Oxaliplatin, Oxtriphylline, Palonosetron, Pantoprazole, Pazopanib, Pentamidine, Pentoxifylline, Perphenazine, Phenacetin, Pimozide, Pipotiazine, Pomalidomide, Praziquantel, Primaquine, Progesterone, Proguanil, Promazine, Propafenone, Propofol, Propranolol, Pyrazinamide, Quinine, Ramelteon, Ranitidine, Rasagiline, Resveratrol, Rifabutin, Riluzole, Ritonavir, Rizatriptan, Rofecoxib, Ropinirole, Ropivacaine, Rotigotine, Rucaparib, Selegiline, Sertraline, Stiripentol, Tacrine, Tamoxifen, Telithromycin, Temafloxacin, Terbinafine, Thalidomide, Theobromine, Theophylline, Thiabendazole, Thioridazine, Thiothixene, Tizanidine, Tolperisone, Toremifene, Triamterene, Trifluoperazine, Ulipristal, Vadimezan, Verapamil, Voxilaprevir, Warfarin, Zileuton, Ziprasidone, Zolmitriptan, Zolpidem, Zotepine
2Cytochrome P450 1A2 inhibitorsAbiraterone, Acyclovir, Agomelatine, Albendazole, Alitretinoin, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Anastrozole, Apomorphine, Artenimol, Atazanavir, Atropine, Azithromycin, Bortezomib, Bromocriptine, Buprenorphine, Caffeine, Carbamazepine, Carbimazole, Cimetidine, Cimicifuga racemosa, Ciprofloxacin, Citalopram, Clarithromycin, Clobetasol propionate, Clomifene, Clotrimazole, Clozapine, Conjugated estrogens, Crisaborole, Curcumin, Delavirdine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Diacerein, Diazepam, Diclofenac, Disulfiram, Dopamine, Dosulepin, Edetic Acid, Efavirenz, Eltrombopag, Enasidenib, Enoxacin, Entacapone, Epinephrine, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etoricoxib, Fluconazole, Fluoxetine, Fluphenazine, Flutamide, Fluvastatin, Fluvoxamine, Gemfibrozil, Genistein, Glecaprevir, Glycerol phenylbutyrate, Imipramine, Interferon Alfa-2b, Recombinant, Interferon gamma-1b, Irbesartan, Isoniazid, Levofloxacin, Lidocaine, Lobeglitazone, Lomefloxacin, Lopinavir, Losartan, Manidipine, Meclizine, Melatonin, Mestranol, Methimazole, Methotrimeprazine, Methoxsalen, Mexiletine, Mibefradil, Miconazole, Midostaurin, Mifepristone, Mirtazapine, Moclobemide, Modafinil, Nefazodone, Nelfinavir, Niclosamide, Nifedipine, Nilvadipine, Nisoldipine, Nitroprusside, Norepinephrine, Norfloxacin, Obeticholic acid, Ofloxacin, Olanzapine, Omeprazole, Ondansetron, Orphenadrine, Oxymetholone, Paroxetine, Pefloxacin, Peginterferon alfa-2a, Peginterferon alfa-2b, Pentoxifylline, Peppermint oil, Perphenazine, Phentermine, Phenylbutyric acid, Phenylpropanolamine, Pibrentasvir, Primaquine, Propafenone, Propofol, Propranolol, Quinidine, Quinine, Ranitidine, Resveratrol, Rhein, Rofecoxib, Ropinirole, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Selegiline, Sertraline, Simeprevir, Sorafenib, Sulconazole, Sulindac, Synthetic Conjugated Estrogens, A, Tegaserod, Temafloxacin, Tenofovir disoproxil, Theophylline, Thiabendazole, Thioridazine, Ticlopidine, Tioconazole, Tocainide, Topiroxostat, Tranylcypromine, Triamterene, Valaciclovir, Valproic Acid, Vemurafenib, Verapamil, Zafirlukast, Zileuton, Zucapsaicin
3Cytochrome P450 1A2 inducersAlbendazole, Aminoglutethimide, Armodafinil, Belinostat, beta-Naphthoflavone, Capsaicin, Carbamazepine, Danthron, Griseofulvin, Insulin Aspart, Insulin Beef, Insulin Detemir, Insulin Glargine, Insulin Glulisine, Insulin Human, Insulin Lispro, Insulin Pork, Lansoprazole, Menadione, Midostaurin, Modafinil, Nafcillin, Nicotine, Omeprazole, Osimertinib, Pantoprazole, Phenobarbital, Phenylephrine, Pitolisant, Primaquine, Primidone, Quinine, Rabeprazole, Resveratrol, Rifampicin, Rilpivirine, Ritonavir, Rucaparib, Secobarbital, Streptozocin
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2C8 inhibitor
1Cytochrome P450 2C8 substratesAcetaminophen, Acetylsalicylic acid, Almotriptan, Aminophenazone, Amiodarone, Amitriptyline, Amodiaquine, Amprenavir, Antipyrine, Apalutamide, Apixaban, Atorvastatin, Azelastine, Benzyl alcohol, Beraprost, Bioallethrin, Brigatinib, Brompheniramine, Buprenorphine, Bupropion, Cabazitaxel, Caffeine, Carbamazepine, Carbinoxamine, Cerivastatin, Chloroquine, Cisapride, Clozapine, Cyclophosphamide, Dabrafenib, Dapsone, Dasabuvir, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Domperidone, Elagolix, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Eszopiclone, Fluorouracil, Fluvastatin, Halofantrine, Ibuprofen, Ifosfamide, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Lansoprazole, Lapatinib, Levomilnacipran, Licofelone, Lidocaine, Loperamide, Loratadine, Losartan, Mefenamic acid, Meloxicam, Mephenytoin, Methadone, Mirtazapine, Morphine, Muraglitazar, Mycophenolate mofetil, Naloxone, Naproxen, Nicardipine, Nicotine, Odanacatib, Olodaterol, Ombitasvir, Omeprazole, Paclitaxel, Paramethadione, Pazopanib, Pentamidine, Perospirone, Perphenazine, Phenprocoumon, Phenytoin, Pioglitazone, Piroxicam, Pitavastatin, Ponatinib, Progesterone, Propofol, Quinidine, Quinine, Repaglinide, Rifampicin, Riociguat, Rofecoxib, Rosiglitazone, Selegiline, Selexipag, Seratrodast, Simvastatin, Sitagliptin, Sorafenib, Sulfadiazine, Sulfinpyrazone, Tazarotene, Temazepam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline, Tolbutamide, Torasemide, Tretinoin, Trimethadione, Trimethoprim, Troglitazone, Velpatasvir, Verapamil, Vortioxetine, Voxilaprevir, Warfarin, Zafirlukast, Zidovudine, Zopiclone
2Cytochrome P450 2C8 inhibitorsAbiraterone, Amitriptyline, Amlodipine, Atorvastatin, Belinostat, Bezafibrate, Candesartan, Candesartan cilexetil, Celecoxib, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Clopidogrel, Clotrimazole, Cocaine, Colchicine, Crisaborole, Cyclosporine, Delavirdine, Dextropropoxyphene, Diethylstilbestrol, Efavirenz, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Ethinylestradiol, Etoposide, Felodipine, Fenofibrate, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Gemfibrozil, Idelalisib, Irbesartan, Isavuconazole, Isoniazid, Ketoprofen, Lansoprazole, Lapatinib, Letermovir, Levothyroxine, Licofelone, Liotrix, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Medroxyprogesterone acetate, Mefenamic acid, Meloxicam, Metronidazole, Midostaurin, Mometasone, Montelukast, Nabilone, Nicardipine, Nifedipine, Nilotinib, Nilutamide, Nilvadipine, Opicapone, Oxybutynin, Paroxetine, Phenelzine, Pioglitazone, Piroxicam, Ponatinib, Pravastatin, Propafenone, Pyrimethamine, Quercetin, Quinine, Rabeprazole, Raloxifene, Regorafenib, Ritonavir, Rosiglitazone, Rucaparib, Rutin, Salmeterol, Saquinavir, Simvastatin, Sorafenib, Spironolactone, Sulfamethoxazole, Sulfaphenazole, Tamoxifen, Tegaserod, Terfenadine, Teriflunomide, Thioridazine, Ticlopidine, Tioconazole, Topiroxostat, Trametinib, Triazolam, Trimethoprim, Troglitazone, Troleandomycin, Valproic Acid, Vismodegib, Warfarin, Zafirlukast
3Cytochrome P450 2C8 inducersAvatrombopag, Carbamazepine, Colchicine, Cyclophosphamide, Dexamethasone, Gemfibrozil, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Ifosfamide, Isavuconazole, Ivosidenib, Lumacaftor, Midostaurin, Nilotinib, Phenobarbital, Primidone, Probenecid, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1A1 inhibitor
1Cytochrome P450 1A1 substratesAcetaminophen, Amiodarone, Amodiaquine, Azelastine, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Diclofenac, Dronabinol, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Lorcaserin, Melatonin, Menadione, Nicotine, Oxaliplatin, Pentamidine, Perospirone, Phenacetin, Prazosin, Progesterone, Resveratrol, Riluzole, Riociguat, Romidepsin, Tamoxifen, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Theophylline, Toremifene, Tretinoin, Troglitazone, Warfarin
2Cytochrome P450 1A1 inducersAlbendazole, Bezafibrate, Clofibrate, Clomifene, Clozapine, Dexamethasone, Dicyclomine, Ellagic Acid, Fluorescein, Itraconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Picrotoxin, Primaquine, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Triclocarban, Vitamin A
3Cytochrome P450 1A1 inhibitorsAmlodipine, Arsenic trioxide, Caffeine, Cannabidiol, Cholecalciferol, Clobetasol propionate, Dexamethasone, Dexmedetomidine, Ellagic Acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Manidipine, Melatonin, Methoxsalen, Mibefradil, Nifedipine, Nitroprusside, Norfloxacin, Ouabain, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Sildenafil, Sulindac, Theophylline, Ticlopidine, Topiroxostat, Vitamin A
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1A1 inducer
1Cytochrome P450 1A1 substratesAcetaminophen, Amiodarone, Amodiaquine, Azelastine, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Diclofenac, Dronabinol, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Lorcaserin, Melatonin, Menadione, Nicotine, Oxaliplatin, Pentamidine, Perospirone, Phenacetin, Prazosin, Progesterone, Resveratrol, Riluzole, Riociguat, Romidepsin, Tamoxifen, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Theophylline, Toremifene, Tretinoin, Troglitazone, Warfarin
2Cytochrome P450 1A1 inducersAlbendazole, Bezafibrate, Clofibrate, Clomifene, Clozapine, Dexamethasone, Dicyclomine, Ellagic Acid, Fluorescein, Itraconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Picrotoxin, Primaquine, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Triclocarban, Vitamin A
3Cytochrome P450 1A1 inhibitorsAmlodipine, Arsenic trioxide, Caffeine, Cannabidiol, Cholecalciferol, Clobetasol propionate, Dexamethasone, Dexmedetomidine, Ellagic Acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Manidipine, Melatonin, Methoxsalen, Mibefradil, Nifedipine, Nitroprusside, Norfloxacin, Ouabain, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Sildenafil, Sulindac, Theophylline, Ticlopidine, Topiroxostat, Vitamin A
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2D6 inhibitor
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, Acebutolol, Acetaminophen, Acetylcholine, Ajmaline, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Amsacrine, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Artemether, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Befunolol, Benzatropine, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bisoprolol, Bopindolol, Bortezomib, Brexpiprazole, Brompheniramine, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Bupropion, Buspirone, Caffeine, Captopril, Cariprazine, Carteolol, Carvedilol, Celiprolol, Cephalexin, Cevimeline, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Cyclophosphamide, Dapagliflozin, Darifenacin, Dasabuvir, Debrisoquin, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmethylphenidate, Dextroamphetamine, Dextromethorphan, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dopamine, Doxazosin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Etoricoxib, Fesoterodine, Fingolimod, Flecainide, Flunarizine, Fluoxetine, Fluphenazine, Fluvastatin, Fluvoxamine, Formoterol, Galantamine, Gefitinib, Granisetron, Halofantrine, Haloperidol, Halothane, Hydrocodone, Hydromorphone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Ipratropium, Ixazomib, Labetalol, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levodopa, Levomilnacipran, Lidocaine, Lisuride, Lofexidine, Lomustine, Loperamide, Loratadine, Lorcaserin, Lorpiprazole, Lysergic Acid Diethylamide, Maprotiline, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Methadone, Methamphetamine, Methotrimeprazine, Methoxyflurane, Methylphenidate, Methyprylon, Metipranolol, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Morphine, Nadolol, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicardipine, Nicergoline, Nicotine, Nifedipine, Nitrofural, Nortriptyline, Olanzapine, Ondansetron, Opium, Oxprenolol, Oxycodone, Oxymorphone, Palonosetron, Paroxetine, Pazopanib, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenformin, Pindolol, Piperazine, Pipotiazine, Pitolisant, Ponatinib, Practolol, Procainamide, Prochlorperazine, Progesterone, Promethazine, Propafenone, Propofol, Propranolol, Protriptyline, Pseudoephedrine, Quetiapine, Quinine, Ranitidine, Remoxipride, Repinotan, Risperidone, Ritonavir, Ropivacaine, Rotigotine, Rucaparib, Rupatadine, Saquinavir, Sertindole, Sertraline, Sildenafil, Simvastatin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Trimipramine, Umeclidinium, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Vortioxetine, Yohimbine, Zalcitabine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitorsAbiraterone, Acebutolol, Ajmaline, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amphetamine, Antipyrine, Aripiprazole, Artemether, Artenimol, Asenapine, Asunaprevir, Atomoxetine, Atorvastatin, Azelastine, Betaxolol, Bicalutamide, Biperiden, Brompheniramine, Buprenorphine, Bupropion, Carbinoxamine, Carteolol, Celecoxib, Cerivastatin, Chloroquine, Chlorphenamine, Chlorpromazine, Cholecalciferol, Cimetidine, Cimicifuga racemosa, Cinacalcet, Cisapride, Citalopram, Clemastine, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Cyclosporine, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Dexmethylphenidate, Dextroamphetamine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Diphenhydramine, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Eliglustat, Enasidenib, Entacapone, Enzalutamide, Epinastine, Escitalopram, Etoricoxib, Felodipine, Fenfluramine, Fexofenadine, Fluoxetine, Fluphenazine, Fluvoxamine, Glycerol phenylbutyrate, Granisetron, Halofantrine, Haloperidol, Histamine, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Idarubicin, Imatinib, Imipramine, Indinavir, Indisulam, Isavuconazole, Isoniazid, Itraconazole, Labetalol, Lansoprazole, Lercanidipine, Levosalbutamol, Lidocaine, Lopinavir, Loratadine, Lorcaserin, Lovastatin, Lumefantrine, Manidipine, Mefloquine, Melperone, Mepyramine, Methadone, Methamphetamine, Methazolamide, Methimazole, Methotrimeprazine, Methylnaltrexone, Methylphenidate, Metoclopramide, Metoprolol, Mianserin, Mibefradil, Miconazole, Midodrine, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Moclobemide, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pergolide, Perhexiline, Perphenazine, Phentermine, Phenylbutyric acid, Pimozide, Pindolol, Pioglitazone, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promazine, Promethazine, Propafenone, Propranolol, Pyrimethamine, Quetiapine, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Risperidone, Ritonavir, Rivastigmine, Rolapitant, Ropinirole, Rosiglitazone, Rotigotine, Rucaparib, Rutin, Saquinavir, Selegiline, Sertraline, Sildenafil, Sorafenib, Sparteine, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Telithromycin, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Tipranavir, Tramadol, Tranylcypromine, Tripelennamine, Trospium, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Yohimbine, Ziprasidone
3Cytochrome P450 2D6 inducersAripiprazole, Dexamethasone, Glutethimide, Granisetron, Haloperidol, Loratadine, Mirtazapine, Moclobemide, Pindolol, Reboxetine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 3A7 inhibitor
1Cytochrome P450 3A7 substratesAlfentanil, Alprazolam, Aminophenazone, Amlodipine, Aprepitant, Aripiprazole, Aripiprazole lauroxil, Astemizole, Atorvastatin, Buprenorphine, Buspirone, Caffeine, Carbamazepine, Cerivastatin, Chlorphenamine, Cilostazol, Cisapride, Clarithromycin, Cobicistat, Cocaine, Codeine, Copanlisib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dexamethasone, Dextromethorphan, Diazepam, Diltiazem, Docetaxel, Domperidone, Elbasvir, Eplerenone, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethosuximide, Ethylmorphine, Felodipine, Fentanyl, Finasteride, Fluticasone propionate, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imipramine, Indinavir, Irinotecan, Lercanidipine, Levomethadyl acetate, Lidocaine, Lovastatin, Methadone, Midazolam, Nateglinide, Nelfinavir, Nifedipine, Nisoldipine, Nitrendipine, Norethisterone, Ondansetron, Oxazepam, Oxycodone, Paclitaxel, Pimozide, Prasterone, Prasterone sulfate, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Risperidone, Ritonavir, Salmeterol, Saquinavir, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sunitinib, Tacrolimus, Tamoxifen, Telithromycin, Temsirolimus, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Trazodone, Tretinoin, Triazolam, Verapamil, Vincristine, Zalcitabine, Zaleplon, Ziprasidone, Zolpidem
2Cytochrome P450 3A7 inhibitorsAmiodarone, Aprepitant, Chloramphenicol, Cimetidine, Ciprofloxacin, Cobicistat, Delavirdine, Diltiazem, Efavirenz, Elbasvir, Erythromycin, Fluconazole, Fluvoxamine, Gestodene, Idelalisib, Imatinib, Indinavir, Itraconazole, Letermovir, Mibefradil, Midazolam, Mifepristone, Nelfinavir, Norfloxacin, Oxymetholone, Phenelzine, Prasterone, Progesterone, Ritonavir, Rucaparib, Saquinavir, Seproxetine, Telithromycin, Troglitazone, Troleandomycin, Verapamil, Voriconazole
3Cytochrome P450 3A7 inducersClotrimazole, Cyclosporine, Dexamethasone, Dextropropoxyphene, Efavirenz, Midostaurin, Phenobarbital, Phenytoin, Rifampicin, Rifapentine, Ritonavir, Troglitazone
Interacting GroupInteracting Drugs
Ketoconazole is a Cholesterol side-chain cleavage enzyme, mitochondrial inhibitor
1Cholesterol side-chain cleavage enzyme, mitochondrial inhibitorsAminoglutethimide, Clomifene, Clotrimazole, Dexamethasone, Digoxin, Glutethimide, Omeprazole, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
2Cholesterol side-chain cleavage enzyme, mitochondrial substratesCholecalciferol, Dinoprostone, Saquinavir, Stanolone, Stanolone acetate
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 11B1, mitochondrial inhibitor
1Cytochrome P450 11B1, mitochondrial inducersMitotane, Spironolactone
2Cytochrome P450 11B1, mitochondrial inhibitorsCimetidine, Clotrimazole, Etomidate, Fluconazole, Metoclopramide, Metyrapone, Mibefradil, Miconazole, Phenytoin, Spironolactone
3Cytochrome P450 11B1, mitochondrial substratesAldosterone, Hydrocortisone, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 1B1 inhibitor
1Cytochrome P450 1B1 substratesAmodiaquine, Caffeine, Dasatinib, Docetaxel, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flutamide, Melatonin, Oxaliplatin, Procarbazine, Progesterone, Tamoxifen, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline
2Cytochrome P450 1B1 inhibitorsArsenic trioxide, Daunorubicin, Docetaxel, Doxorubicin, Flutamide, Melatonin, Mitoxantrone, Paclitaxel, Propofol, Resveratrol, Tamoxifen
3Cytochrome P450 1B1 inducersBiotin, Clozapine, Dexamethasone, Docetaxel, Lansoprazole, Omeprazole, Phenobarbital, Primaquine, Triclocarban
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 26A1 inhibitor
1Cytochrome P450 26A1 substratesAcitretin, Etretinate
2Cytochrome P450 26A1 inducersVitamin A
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2A6 inhibitor
1Cytochrome P450 2A6 substratesAcetaminophen, Antipyrine, Arformoterol, Asunaprevir, Bupropion, Chlorzoxazone, Cinnarizine, Cisapride, clomethiazole, Clozapine, Cyclophosphamide, Dapagliflozin, Dronabinol, Flunarizine, Flunitrazepam, Fluorouracil, Flurazepam, Formoterol, Halothane, Ifosfamide, Letrozole, Lidocaine, Lorcaserin, Methoxsalen, Methoxyflurane, Montelukast, Nevirapine, Nicotine, Nifedipine, Phenacetin, Pilocarpine, Progesterone, Propofol, Rifampicin, Selegiline, Sevoflurane, Tamoxifen, Tegafur, Tegafur-uracil, Tretinoin, Valproic Acid, Vortioxetine, Zidovudine
2Cytochrome P450 2A6 inhibitorsAmiodarone, Amlodipine, Amphetamine, Azelastine, Azithromycin, Buprenorphine, Clofibrate, Clomifene, Clotrimazole, Desipramine, Dexfenfluramine, Diethylstilbestrol, Ezogabine, Fomepizole, Isoniazid, Letrozole, Memantine, Menadione, Methimazole, Methoxsalen, Metyrapone, Miconazole, Nicotine, Nilvadipine, Norfloxacin, Phenobarbital, Pilocarpine, Prednisolone, Rifampicin, Rosiglitazone, Seratrodast, Sulfaphenazole, Tranylcypromine, Troleandomycin
3Cytochrome P450 2A6 inducersAmobarbital, Dexamethasone, Eletriptan, Pentobarbital, Phenobarbital, Rifampicin, Valproic Acid
Interacting GroupInteracting Drugs
Ketoconazole is a Cytochrome P450 2B6 inhibitor
1Cytochrome P450 2B6 substratesAmitriptyline, Antipyrine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Benzyl alcohol, Brivaracetam, Brompheniramine, Bupropion, Carbinoxamine, Cinnarizine, Cisapride, Clobazam, clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dextromethorphan, Diazepam, Diclofenac, Diphenhydramine, Domperidone, Efavirenz, Enasidenib, Epinastine, Erythromycin, Estrone, Ethylmorphine, Flunarizine, Flunitrazepam, Fluoxetine, Halothane, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Lorcaserin, Malathion, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Midazolam, Nevirapine, Nicotine, Ospemifene, Perhexiline, Permethrin, Perphenazine, Pethidine, Prasugrel, Promethazine, Propofol, Ritonavir, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Sorafenib, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Valproic Acid, Velpatasvir, Verapamil, Vortioxetine
2Cytochrome P450 2B6 inducersArmodafinil, Artemether, Atorvastatin, Carbamazepine, Cerivastatin, Clofibrate, Clotrimazole, Cyclophosphamide, Dexamethasone, Efavirenz, Enasidenib, Fluvastatin, Fosphenytoin, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Letermovir, Lumacaftor, Metamizole, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Orphenadrine, Permethrin, Phenobarbital, Phenytoin, Pitolisant, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Verapamil
3Cytochrome P450 2B6 inhibitorsAmlodipine, Amprenavir, Antipyrine, Azelastine, Bupropion, Cholecalciferol, Cisplatin, Citalopram, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Desipramine, Doxorubicin, Efavirenz, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Lopinavir, Manidipine, Memantine, Methimazole, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rilpivirine, Ritonavir, Roxithromycin, Selegiline, Sertraline, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Venlafaxine, Voriconazole
Interacting GroupInteracting Drugs
Ketoconazole is a Lanosterol 14-alpha demethylase inhibitor
1Lanosterol 14-alpha demethylase inhibitorsItraconazole, Sertaconazole, Tioconazole
Interacting GroupInteracting Drugs
Ketoconazole is a UDP-glucuronosyltransferase 1-1 inhibitor
1UDP-glucuronosyltransferase 1-1 substratesAbacavir, Acetaminophen, Alvocidib, Amitriptyline, Atorvastatin, Axitinib, Bictegravir, Binimetinib, Buprenorphine, Carvedilol, Cerivastatin, Codeine, Cyclobenzaprine, Delafloxacin, Diclofenac, Dolutegravir, Eltrombopag, Enasidenib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Ezogabine, Fenofibrate, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Gavestinel, Gemfibrozil, Glipizide, Ibuprofen, Indacaterol, Indomethacin, Irinotecan, Ketoprofen, Lamotrigine, Letermovir, Levothyroxine, Losartan, Lovastatin, Metronidazole, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Naproxen, Olanzapine, Oxcarbazepine, Propofol, Raloxifene, Raltegravir, Simvastatin, Suprofen, Tiagabine, Tramadol, Troglitazone, Valproic Acid, Zidovudine, Zonisamide
2UDP-glucuronosyltransferase 1-1 inhibitorsAdenine, Atazanavir, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Indomethacin, Nilotinib, Pazopanib, Pibrentasvir, Propofol, Regorafenib, Rucaparib, Silibinin A, Sodium aurothiomalate, Sorafenib, Valproic Acid
3UDP-glucuronosyltransferase 1-1 inducersCarbamazepine, Efavirenz, Ethinylestradiol, Lamotrigine, Nelfinavir, Oxcarbazepine, Phenobarbital, Phenytoin, Primidone, Rifampicin, Ritonavir, Testosterone propionate, Tipranavir, Zidovudine
Interacting GroupInteracting Drugs
Ketoconazole is a UDP-glucuronosyltransferase 2B7 inhibitor
1UDP-glucuronosyltransferase 2B7 substratesAcemetacin, Ambrisentan, Artenimol, Atorvastatin, Carbamazepine, Codeine, Dapagliflozin, Diclofenac, Enasidenib, Epirubicin, Ertugliflozin, Etodolac, Ezetimibe, Flurbiprofen, Fluvastatin, Ibuprofen, Indomethacin, Losartan, Lovastatin, Mitiglinide, Morphine, Mycophenolate mofetil, Mycophenolic acid, Nalmefene, Naproxen, Oxazepam, Pitavastatin, Silodosin, Simvastatin, Suprofen, Tapentadol, Troglitazone, Vadimezan, Valproic Acid, Zaltoprofen, Zidovudine
2UDP-glucuronosyltransferase 2B7 inhibitorsChenodeoxycholic acid, Flunitrazepam, Indomethacin
Interacting GroupInteracting Drugs
Ketoconazole is a Bile salt export pump inhibitor
1Bile salt export pump inhibitorsBosentan, Cholic Acid, Clofazimine, Clotrimazole, Cyclosporine, Ethinylestradiol, Fusidic Acid, Glyburide, Glycochenodeoxycholic Acid, Letermovir, Progesterone, Reserpine, Rifampicin, Simeprevir, Tipranavir, Troglitazone, Ursodeoxycholic acid, Vinblastine
2Bile salt export pump substratesCholic Acid, Daunorubicin, Digoxin, Doxorubicin, Fluorescein, Glycochenodeoxycholic Acid, Paclitaxel, Pravastatin, Rosuvastatin, Taurocholic Acid, Ursodeoxycholic acid, Vinblastine, Vincristine
3Bile salt export pump inducersCholic Acid, Deoxycholic Acid, Dexamethasone, Ethinylestradiol, Phenobarbital, Taurocholic Acid, Ursodeoxycholic acid
Interacting GroupInteracting Drugs
Ketoconazole is a Multidrug resistance protein 1 substrate
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Apalutamide, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Amprenavir, Apixaban, Arsenic trioxide, Asunaprevir, Atazanavir, Atenolol, Avatrombopag, Axitinib, Baricitinib, Belinostat, Betamethasone, Bosutinib, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carfilzomib, Ceritinib, Cerivastatin, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxorubicin, Edoxaban, Elagolix, Elbasvir, Eletriptan, Epinastine, Erlotinib, Ertugliflozin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluciclovine (18F), Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Moxidectin, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Osimertinib, Paclitaxel, Panobinostat, Paritaprevir, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Regorafenib, Reserpine, Rifampicin, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Testosterone propionate, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Trimipramine, Ubidecarenone, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Albendazole, Alectinib, Alfentanil, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Atazanavir, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Concanamycin A, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Emopamil, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Lansoprazole, Lapatinib, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Mefloquine, Megestrol acetate, Methadone, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitoxantrone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrendipine, Omeprazole, ONT-093, Paclitaxel, Pantoprazole, Paroxetine, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersalpha-Tocopherol acetate, Betrixaban, Ledipasvir, Tocopherol
5Multidrug resistance protein 1 bindersTechnetium Tc-99m tetrofosmin
6Multidrug resistance protein 1 antagonistsTocofersolan
Interacting GroupInteracting Drugs
Ketoconazole is a Multidrug resistance protein 1 inhibitor
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Apalutamide, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Amprenavir, Apixaban, Arsenic trioxide, Asunaprevir, Atazanavir, Atenolol, Avatrombopag, Axitinib, Baricitinib, Belinostat, Betamethasone, Bosutinib, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carfilzomib, Ceritinib, Cerivastatin, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxorubicin, Edoxaban, Elagolix, Elbasvir, Eletriptan, Epinastine, Erlotinib, Ertugliflozin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluciclovine (18F), Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Moxidectin, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Osimertinib, Paclitaxel, Panobinostat, Paritaprevir, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Regorafenib, Reserpine, Rifampicin, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Testosterone propionate, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Trimipramine, Ubidecarenone, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Albendazole, Alectinib, Alfentanil, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Atazanavir, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Concanamycin A, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Emopamil, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Lansoprazole, Lapatinib, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Mefloquine, Megestrol acetate, Methadone, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitoxantrone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrendipine, Omeprazole, ONT-093, Paclitaxel, Pantoprazole, Paroxetine, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersalpha-Tocopherol acetate, Betrixaban, Ledipasvir, Tocopherol
5Multidrug resistance protein 1 bindersTechnetium Tc-99m tetrofosmin
6Multidrug resistance protein 1 antagonistsTocofersolan
Interacting GroupInteracting Drugs
Ketoconazole is a Solute carrier organic anion transporter family member 1A2 inhibitor
1Solute carrier organic anion transporter family member 1A2 substratesAminohippuric acid, Bilastine, Bumetanide, Cholic Acid, Conjugated estrogens, Deoxycholic Acid, Digoxin, Dinoprostone, Enalapril, Fexofenadine, Glycochenodeoxycholic Acid, Indomethacin, Lifitegrast, Liothyronine, Liotrix, Methotrexate, Mirabegron, Ouabain, Rocuronium, Taurocholic Acid, Ursodeoxycholic acid
2Solute carrier organic anion transporter family member 1A2 inhibitorsAldosterone, Atorvastatin, Cholic Acid, Conjugated estrogens, Cyclosporine, Deoxycholic Acid, Dexamethasone, Digitoxin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Everolimus, Glyburide, Glycochenodeoxycholic Acid, Hydrocortisone, Ibuprofen, Indinavir, Indomethacin, Ketoprofen, Levothyroxine, Lovastatin, Methyltestosterone, Naloxone, Naproxen, Nelfinavir, Ouabain, Pravastatin, Prednisolone, Prednisone, Probenecid, Quinidine, Quinine, Rifampicin, Ritonavir, Saquinavir, Simvastatin, Spironolactone, Taurocholic Acid, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tolbutamide, Ursodeoxycholic acid, Verapamil
3Solute carrier organic anion transporter family member 1A2 inducersCholic Acid, Methyltestosterone, Sumatriptan, Taurocholic Acid, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid
Interacting GroupInteracting Drugs
Ketoconazole is a Solute carrier organic anion transporter family member 1B1 inhibitor
1Solute carrier organic anion transporter family member 1B1 substratesAmbrisentan, Asunaprevir, Atorvastatin, Axitinib, Benzylpenicillin, Cerivastatin, Cholecystokinin, Cholic Acid, Cobimetinib, Conjugated estrogens, Digoxin, Dinoprostone, Elagolix, Eluxadoline, Erythromycin, Ezetimibe, Fluvastatin, Gadoxetic acid, Gimatecan, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Lovastatin, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paritaprevir, Penicillamine, Pitavastatin, Pravastatin, Repaglinide, Rosuvastatin, Selexipag, Simeprevir, Simvastatin, Sumatriptan, Taurocholic Acid, Technetium Tc-99m mebrofenin, Valsartan, Voxilaprevir
2Solute carrier organic anion transporter family member 1B1 inhibitorsAcetylcysteine, Aminohippuric acid, Amprenavir, Asunaprevir, Atazanavir, Atorvastatin, Axitinib, Benzbromarone, Bezafibrate, Cabazitaxel, Candesartan, Caspofungin, Cerivastatin, Cholecystokinin, Cholic Acid, Cobicistat, Conjugated estrogens, Cyclosporine, Dabrafenib, Daclatasvir, Darunavir, Diclofenac, Diethylstilbestrol, Digoxin, Dipyridamole, Elacridar, Eltrombopag, Eluxadoline, Enasidenib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Everolimus, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Gemfibrozil, Genistein, Glecaprevir, Hyperforin, Idelalisib, Indinavir, Indomethacin, Irinotecan, Ivermectin, L-Carnitine, Levothyroxine, Lobeglitazone, Lopinavir, Lovastatin, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Novobiocin, Nystatin, Ouabain, Pantoprazole, Paritaprevir, Pazopanib, Pibrentasvir, Pioglitazone, Pitavastatin, Posizolid, Pravastatin, Progesterone, Quercetin, Quinidine, Quinine, Reserpine, Rifampicin, Rilpivirine, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Sacubitril, Saquinavir, Semaglutide, Sildenafil, Silibinin A, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Tacrolimus, Taurocholic Acid, Telaprevir, Telithromycin, Tipranavir, Troglitazone, Valsartan, Valspodar, Velpatasvir, Verapamil, Vinblastine, Vincristine, Voxilaprevir, Zosuquidar
3Solute carrier organic anion transporter family member 1B1 inducersApalutamide, Cholic Acid, Taurocholic Acid
4Solute carrier organic anion transporter family member 1B1 weak inhibitorsCobimetinib
5Solute carrier organic anion transporter family member 1B1 transportersVelpatasvir