Showing BioInteractions for Abacavir (DB01048)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 1
Enzyme Mediated Interactions 3

	Interacting Group	Interacting Drugs
	Abacavir is a Reverse transcriptase/RNaseH inhibitor
1	Reverse transcriptase/RNaseH inhibitors	Apricitabine, Delavirdine, Didanosine, Doravirine, Efavirenz, Emtricitabine, Lamivudine, Nevirapine, Rilpivirine, Sennosides, Stavudine, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Zalcitabine, Zidovudine
2	Reverse transcriptase/RNaseH antagonists	Bictegravir

	Interacting Group	Interacting Drugs
	Abacavir is a Alcohol dehydrogenase 6 substrate
1	Alcohol dehydrogenase 6 substrates	Ethanol, NADH
2	Alcohol dehydrogenase 6 activators	NADH

	Interacting Group	Interacting Drugs
	Abacavir is a UDP-glucuronosyltransferase 1-1 substrate
1	UDP-glucuronosyltransferase 1-1 substrates	Acetaminophen, Alvocidib, Atorvastatin, Axitinib, Belinostat, Bictegravir, Binimetinib, Cabotegravir, Carvedilol, Cerivastatin, Deferasirox, Delafloxacin, Dexibuprofen, Dolutegravir, Eltrombopag, Elvitegravir, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Ezogabine, Febuxostat, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Fusidic acid, Gavestinel, Gemfibrozil, Glipizide, Indacaterol, Indomethacin, Irinotecan, Ketoprofen, Labetalol, Letermovir, Levothyroxine, Liothyronine, Losartan, Lovastatin, Metronidazole, Migalastat, Minoxidil, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Nintedanib, Norgestimate, Phenytoin, Propacetamol, Propofol, Raloxifene, Raltegravir, Sacituzumab govitecan, Selumetinib, Simvastatin, Suprofen, Tecovirimat, Tiagabine, Tramadol, Troglitazone, Valproic acid, Vericiguat, Zidovudine, Zonisamide
2	UDP-glucuronosyltransferase 1-1 inhibitors	Adenine, Atazanavir, Dacomitinib, Dasabuvir, Deferasirox, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Indomethacin, Ketoconazole, Nilotinib, Ombitasvir, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Probenecid, Propofol, Regorafenib, Rucaparib, Silibinin, Sodium aurothiomalate, Sorafenib, Ubrogepant, Valproic acid
3	UDP-glucuronosyltransferase 1-1 inducers	Carbamazepine, Desogestrel, Efavirenz, Ethinylestradiol, Nelfinavir, Phenobarbital, Phenytoin, Rifampicin, Testosterone propionate, Tipranavir, Zidovudine

	Interacting Group	Interacting Drugs
	Abacavir is a Adenosine kinase substrate
1	Adenosine kinase substrates	Adenosine, ATP
2	Adenosine kinase activators	Ribavirin