Showing BioInteractions for Diphenhydramine (DB01075)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Diphenhydramine is a Histamine H1 receptor antagonist
1Histamine H1 receptor antagonistsAceprometazine, Acrivastine, Alcaftadine, Alimemazine, Amitriptyline, Amoxapine, Antazoline, Aripiprazole, Aripiprazole lauroxil, Asenapine, Astemizole, Azatadine, Azelastine, Benzatropine, Benzquinamide, Bepotastine, Bilastine, Bromodiphenhydramine, Brompheniramine, Buclizine, Butriptyline, Carbinoxamine, Cariprazine, Cetirizine, Chlorcyclizine, Chloropyramine, Chlorphenamine, Chlorpromazine, Chlorprothixene, Cinnarizine, Clemastine, Clofedanol, Clozapine, Cyclizine, Cyproheptadine, Desipramine, Desloratadine, Dexbrompheniramine, Dexchlorpheniramine maleate, Dimenhydrinate, Dimetindene, Diphenylpyraline, Dosulepin, Doxepin, Doxylamine, Emedastine, Epinastine, Escitalopram, Fexofenadine, Flunarizine, Hydroxyzine, Iloperidone, Imipramine, Isothipendyl, Ketotifen, Levocabastine, Levocetirizine, Loratadine, Lorpiprazole, Maprotiline, Meclizine, Mepyramine, Mequitazine, Methdilazine, Methotrimeprazine, Mianserin, Mirtazapine, Nortriptyline, Olanzapine, Olopatadine, Orphenadrine, Phenindamine, Pheniramine, Pizotifen, Promazine, Promethazine, Propiomazine, Quetiapine, Risperidone, Rupatadine, Terfenadine, Tesmilifene, Thonzylamine, Trazodone, Trimipramine, Tripelennamine, Triprolidine, Ziprasidone, Zuclopenthixol
2Histamine H1 receptor agonistsBetahistine, Histamine, Paliperidone, Tolazoline
3Histamine H1 receptor bindersCitalopram, Loxapine
4Histamine H1 receptor inverse agonistsEsmirtazapine, Perospirone
5Histamine H1 receptor inhibitorsLamotrigine, Levocetirizine
Interacting GroupInteracting Drugs
Diphenhydramine is a Muscarinic acetylcholine receptor M2 antagonist
1Muscarinic acetylcholine receptor M2 antagonistsAclidinium, Amitriptyline, Anisotropine Methylbromide, Aripiprazole, Atropine, Benzquinamide, Brompheniramine, Butylscopolamine, Chlorprothixene, Clozapine, Cocaine, Cryptenamine, Cyproheptadine, Darifenacin, Desipramine, Dicyclomine, Dimetindene, Diphenidol, Disopyramide, Dosulepin, Doxacurium, Doxepin, Ethopropazine, Fesoterodine, Flavoxate, Gallamine Triethiodide, Hexocyclium, Homatropine, Homatropine Methylbromide, Hyoscyamine, Imidafenacin, Imipramine, Ipratropium, Maprotiline, Methotrimeprazine, Methylscopolamine bromide, Metixene, Metocurine, Mivacurium, Nicardipine, Nortriptyline, Olanzapine, Oxybutynin, Oxyphencyclimine, Pancuronium, Paroxetine, Pipecuronium, Pizotifen, Procyclidine, Promazine, Promethazine, Propiomazine, Propiverine, Quetiapine, Rapacuronium, Rociverine, Rocuronium, Scopolamine, Solifenacin, Thonzylamine, Tiotropium, Tolterodine, Tridihexethyl, Triflupromazine, Trihexyphenidyl, Trimebutine, Tropicamide, Umeclidinium, Ziprasidone
2Muscarinic acetylcholine receptor M2 agonistsBethanechol, Carbamoylcholine, Pilocarpine, Succinylcholine
3Muscarinic acetylcholine receptor M2 partial agonistsMivacurium
4Muscarinic acetylcholine receptor M2 bindersGlycopyrronium, Loxapine, Terfenadine
Interacting GroupInteracting Drugs
Diphenhydramine is a Cytochrome P450 2D6 substrate
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, Acebutolol, Acetaminophen, Acetylcholine, Ajmaline, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Amsacrine, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Artemether, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Befunolol, Benzatropine, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bisoprolol, Bopindolol, Bortezomib, Brexpiprazole, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Bupropion, Buspirone, Caffeine, Captopril, Cariprazine, Carteolol, Carvedilol, Celiprolol, Cephalexin, Cevimeline, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Cyclophosphamide, Dapagliflozin, Dapoxetine, Darifenacin, Dasabuvir, Debrisoquin, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmethylphenidate, Dextroamphetamine, Dextromethorphan, Dihydrocodeine, Diltiazem, Dolasetron, Domperidone, Donepezil, Dopamine, Dosulepin, Doxazosin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Etoricoxib, Fesoterodine, Fingolimod, Flecainide, Flunarizine, Fluoxetine, Fluphenazine, Fluvastatin, Fluvoxamine, Formoterol, Fusidic Acid, Galantamine, Gefitinib, Granisetron, Halofantrine, Haloperidol, Halothane, Hydrocodone, Hydromorphone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Ipratropium, Ixazomib, Labetalol, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levodopa, Levomilnacipran, Lidocaine, Lisuride, Lofexidine, Lomustine, Loperamide, Loratadine, Lorcaserin, Lorpiprazole, Lysergic Acid Diethylamide, Maprotiline, Meperidine, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Methadone, Methamphetamine, Methotrimeprazine, Methoxyflurane, Methylphenidate, Methyprylon, Metipranolol, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Morphine, Nadolol, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicardipine, Nicergoline, Nicotine, Nifedipine, Nitrofural, Nortriptyline, Olanzapine, Ondansetron, Opium, Oxprenolol, Oxycodone, Oxymorphone, Paliperidone, Palonosetron, Paroxetine, Pazopanib, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenformin, Pimozide, Pindolol, Piperazine, Pipotiazine, Pitolisant, Ponatinib, Practolol, Procainamide, Prochlorperazine, Progesterone, Promethazine, Propacetamol, Propafenone, Propranolol, Protriptyline, Pseudoephedrine, Quetiapine, Quinine, Ranitidine, Remoxipride, Repinotan, Risperidone, Ritonavir, Ropivacaine, Rotigotine, Rucaparib, Rupatadine, Saquinavir, Sertindole, Sertraline, Sildenafil, Simvastatin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Trimipramine, Umeclidinium, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Vortioxetine, Yohimbine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitorsAbiraterone, Acebutolol, Ajmaline, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amphetamine, Antipyrine, Aripiprazole, Artemether, Artenimol, Asenapine, Asunaprevir, Atomoxetine, Atorvastatin, Azelastine, Betaxolol, Bicalutamide, Biperiden, Buprenorphine, Bupropion, Carbinoxamine, Carteolol, Celecoxib, Cerivastatin, Chloroquine, Chlorphenamine, Chlorpromazine, Cholecalciferol, Cimetidine, Cimicifuga racemosa, Cinacalcet, Cisapride, Citalopram, Clemastine, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Cyclosporine, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Dexmethylphenidate, Dextroamphetamine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Eliglustat, Enasidenib, Entacapone, Enzalutamide, Epinastine, Escitalopram, Etoricoxib, Felodipine, Fenfluramine, Fexofenadine, Fluoxetine, Fluphenazine, Fluvoxamine, Fusidic Acid, Glycerol phenylbutyrate, Granisetron, Halofantrine, Haloperidol, Histamine, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Idarubicin, Imatinib, Imipramine, Indinavir, Indisulam, Iproniazid, Isavuconazole, Isoniazid, Itraconazole, Ketoconazole, Labetalol, Lansoprazole, Lenvatinib, Lercanidipine, Levosalbutamol, Lidocaine, Lopinavir, Loratadine, Lorcaserin, Lovastatin, Lumefantrine, Manidipine, Mefloquine, Melperone, Mepyramine, Methadone, Methamphetamine, Methazolamide, Methimazole, Methotrimeprazine, Methylnaltrexone, Methylphenidate, Metoclopramide, Metoprolol, Mianserin, Mibefradil, Miconazole, Midodrine, Midostaurin, Mifepristone, Mirabegron, Moclobemide, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pergolide, Perhexiline, Perphenazine, Phenelzine, Phentermine, Phenylbutyric acid, Pindolol, Pioglitazone, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promazine, Promethazine, Propafenone, Propranolol, Pyrimethamine, Quetiapine, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Rilpivirine, Risperidone, Ritanserin, Ritonavir, Rivastigmine, Rolapitant, Ropinirole, Rosiglitazone, Rotigotine, Rucaparib, Rutin, Safinamide, Saquinavir, Selegiline, Sertraline, Sildenafil, Sorafenib, Sparteine, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Telithromycin, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Tipranavir, Tranylcypromine, Tripelennamine, Trospium, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Yohimbine, Ziprasidone
3Cytochrome P450 2D6 inducersAripiprazole, Dexamethasone, Fosphenytoin, Glutethimide, Granisetron, Griseofulvin, Haloperidol, Loratadine, Moclobemide, Oritavancin, Phenytoin, Pindolol, Reboxetine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin
Interacting GroupInteracting Drugs
Diphenhydramine is a Cytochrome P450 2D6 inhibitor
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, Acebutolol, Acetaminophen, Acetylcholine, Ajmaline, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Amsacrine, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Artemether, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Befunolol, Benzatropine, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bisoprolol, Bopindolol, Bortezomib, Brexpiprazole, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Bupropion, Buspirone, Caffeine, Captopril, Cariprazine, Carteolol, Carvedilol, Celiprolol, Cephalexin, Cevimeline, Chlordiazepoxide, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Cyclophosphamide, Dapagliflozin, Dapoxetine, Darifenacin, Dasabuvir, Debrisoquin, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmethylphenidate, Dextroamphetamine, Dextromethorphan, Dihydrocodeine, Diltiazem, Dolasetron, Domperidone, Donepezil, Dopamine, Dosulepin, Doxazosin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Etoricoxib, Fesoterodine, Fingolimod, Flecainide, Flunarizine, Fluoxetine, Fluphenazine, Fluvastatin, Fluvoxamine, Formoterol, Fusidic Acid, Galantamine, Gefitinib, Granisetron, Halofantrine, Haloperidol, Halothane, Hydrocodone, Hydromorphone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Ipratropium, Ixazomib, Labetalol, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levodopa, Levomilnacipran, Lidocaine, Lisuride, Lofexidine, Lomustine, Loperamide, Loratadine, Lorcaserin, Lorpiprazole, Lysergic Acid Diethylamide, Maprotiline, Meperidine, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Methadone, Methamphetamine, Methotrimeprazine, Methoxyflurane, Methylphenidate, Methyprylon, Metipranolol, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Morphine, Nadolol, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicardipine, Nicergoline, Nicotine, Nifedipine, Nitrofural, Nortriptyline, Olanzapine, Ondansetron, Opium, Oxprenolol, Oxycodone, Oxymorphone, Paliperidone, Palonosetron, Paroxetine, Pazopanib, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenformin, Pimozide, Pindolol, Piperazine, Pipotiazine, Pitolisant, Ponatinib, Practolol, Procainamide, Prochlorperazine, Progesterone, Promethazine, Propacetamol, Propafenone, Propranolol, Protriptyline, Pseudoephedrine, Quetiapine, Quinine, Ranitidine, Remoxipride, Repinotan, Risperidone, Ritonavir, Ropivacaine, Rotigotine, Rucaparib, Rupatadine, Saquinavir, Sertindole, Sertraline, Sildenafil, Simvastatin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Trimipramine, Umeclidinium, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Vortioxetine, Yohimbine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitorsAbiraterone, Acebutolol, Ajmaline, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amphetamine, Antipyrine, Aripiprazole, Artemether, Artenimol, Asenapine, Asunaprevir, Atomoxetine, Atorvastatin, Azelastine, Betaxolol, Bicalutamide, Biperiden, Buprenorphine, Bupropion, Carbinoxamine, Carteolol, Celecoxib, Cerivastatin, Chloroquine, Chlorphenamine, Chlorpromazine, Cholecalciferol, Cimetidine, Cimicifuga racemosa, Cinacalcet, Cisapride, Citalopram, Clemastine, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Cyclosporine, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desloratadine, Dexfenfluramine, Dexmedetomidine, Dexmethylphenidate, Dextroamphetamine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Eliglustat, Enasidenib, Entacapone, Enzalutamide, Epinastine, Escitalopram, Etoricoxib, Felodipine, Fenfluramine, Fexofenadine, Fluoxetine, Fluphenazine, Fluvoxamine, Fusidic Acid, Glycerol phenylbutyrate, Granisetron, Halofantrine, Haloperidol, Histamine, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Idarubicin, Imatinib, Imipramine, Indinavir, Indisulam, Iproniazid, Isavuconazole, Isoniazid, Itraconazole, Ketoconazole, Labetalol, Lansoprazole, Lenvatinib, Lercanidipine, Levosalbutamol, Lidocaine, Lopinavir, Loratadine, Lorcaserin, Lovastatin, Lumefantrine, Manidipine, Mefloquine, Melperone, Mepyramine, Methadone, Methamphetamine, Methazolamide, Methimazole, Methotrimeprazine, Methylnaltrexone, Methylphenidate, Metoclopramide, Metoprolol, Mianserin, Mibefradil, Miconazole, Midodrine, Midostaurin, Mifepristone, Mirabegron, Moclobemide, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pergolide, Perhexiline, Perphenazine, Phenelzine, Phentermine, Phenylbutyric acid, Pindolol, Pioglitazone, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promazine, Promethazine, Propafenone, Propranolol, Pyrimethamine, Quetiapine, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Rilpivirine, Risperidone, Ritanserin, Ritonavir, Rivastigmine, Rolapitant, Ropinirole, Rosiglitazone, Rotigotine, Rucaparib, Rutin, Safinamide, Saquinavir, Selegiline, Sertraline, Sildenafil, Sorafenib, Sparteine, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Telithromycin, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Tipranavir, Tranylcypromine, Tripelennamine, Trospium, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vilazodone, Vinblastine, Vinorelbine, Yohimbine, Ziprasidone
3Cytochrome P450 2D6 inducersAripiprazole, Dexamethasone, Fosphenytoin, Glutethimide, Granisetron, Griseofulvin, Haloperidol, Loratadine, Moclobemide, Oritavancin, Phenytoin, Pindolol, Reboxetine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin
Interacting GroupInteracting Drugs
Diphenhydramine is a Cytochrome P450 2C9 substrate
1Cytochrome P450 2C9 inhibitorsAbiraterone, Acenocoumarol, Acetyl sulfisoxazole, Agomelatine, Aminophenazone, Amiodarone, Amlodipine, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Bortezomib, Candesartan, Candesartan cilexetil, Capecitabine, Ceritinib, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Cimicifuga racemosa, Cisplatin, Clevidipine, Clopidogrel, Clotrimazole, Clozapine, Cocaine, Colchicine, Crisaborole, Curcumin, Cyclizine, Cyclosporine, Delavirdine, Desloratadine, Dexfenfluramine, Dextropropoxyphene, Diacerein, Diazepam, Diclofenac, Dicoumarol, Diethylstilbestrol, Diltiazem, Disulfiram, Doconexent, Dosulepin, Efavirenz, Enasidenib, Epinephrine, Eprosartan, Ethanol, Etodolac, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Histamine, Ibuprofen, Imatinib, Indinavir, Iproniazid, Irbesartan, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Lifitegrast, Lobeglitazone, Lopinavir, Loratadine, Lornoxicam, Losartan, Lovastatin, Lumacaftor, Manidipine, Medroxyprogesterone acetate, Mefenamic acid, Meloxicam, Methazolamide, Methimazole, Metronidazole, Miconazole, Midostaurin, Moclobemide, Modafinil, Nabilone, Nelfinavir, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Nilutamide, Nilvadipine, Noscapine, Olanzapine, Omeprazole, Oritavancin, Pantoprazole, Parecoxib, Paroxetine, Phentermine, Phenylbutazone, Phenytoin, Pioglitazone, Piperine, Piroxicam, Pranlukast, Pravastatin, Probenecid, Progesterone, Promethazine, Propafenone, Propofol, Pyrimethamine, Quinidine, Quinine, Rabeprazole, Regorafenib, Rhein, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Rutin, Safinamide, Saquinavir, Selegiline, Seratrodast, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfanilamide, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Tegaserod, Teniposide, Thioridazine, Ticagrelor, Ticlopidine, Tioconazole, Tolcapone, Topiroxostat, Tranylcypromine, Triazolam, Trimethoprim, Troglitazone, Valdecoxib, Valproic Acid, Valsartan, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zucapsaicin
2Cytochrome P450 2C9 substrates(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetaminophen, Acetohexamide, Acetyl sulfisoxazole, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Azelastine, Bexarotene, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Brompheniramine, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Carbinoxamine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Cisapride, Clopidogrel, Clozapine, Cyclophosphamide, Dapagliflozin, Dapsone, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diltiazem, Doconexent, Dolasetron, Donepezil, Dopamine, Dorzolamide, Doxepin, Dronabinol, Eletriptan, Enasidenib, Enzalutamide, Epoprostenol, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Eszopiclone, Etodolac, Etoricoxib, Etravirine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Gavestinel, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Guanfacine, Haloperidol, Halothane, Hexobarbital, Histamine, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Lacosamide, Lansoprazole, Leflunomide, Lesinurad, Licofelone, Lidocaine, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Metronidazole, Mirtazapine, Moclobemide, Montelukast, Nabiximols, Naproxen, Nateglinide, Netupitant, Nevirapine, Niclosamide, Nicotine, Nortriptyline, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Oxaprozin, Paclitaxel, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Pioglitazone, Piperaquine, Piroxicam, Pitavastatin, Prasugrel, Pravastatin, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Rifampicin, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Salicylic acid, Selegiline, Seratrodast, Sertraline, Sildenafil, Sitaxentan, Sulfamethoxazole, Sulfamoxole, Sulfinpyrazone, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Theophylline, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Treprostinil, Tretinoin, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Valdecoxib, Valproic Acid, Valsartan, Venlafaxine, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3Cytochrome P450 2C9 inducersApalutamide, Aprepitant, Atorvastatin, Avatrombopag, Bosentan, Carbamazepine, Cerivastatin, Colchicine, Cyclophosphamide, Dapsone, Delafloxacin, Dexamethasone, Diclofenamide, Enzalutamide, Estrone sulfate, Fluvastatin, Fosaprepitant, Fosphenytoin, Ifosfamide, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lovastatin, Lumacaftor, Midostaurin, Modafinil, Nicardipine, Nifedipine, Nilotinib, Peginterferon alfa-2b, Phenobarbital, Phentermine, Phenytoin, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, Seratrodast, Simvastatin, Vigabatrin
Interacting GroupInteracting Drugs
Diphenhydramine is a Cytochrome P450 2C19 substrate
1Cytochrome P450 2C19 substrates(R)-warfarin, Acenocoumarol, Adinazolam, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Amoxicillin, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Benzatropine, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Brompheniramine, Bupivacaine, Cannabidiol, Carbinoxamine, Carisoprodol, Chloramphenicol, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clarithromycin, Clobazam, clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Desipramine, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Dopamine, Doxazosin, Doxepin, Dronabinol, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Famotidine, Flunitrazepam, Fluoxetine, Flutamide, Formoterol, Fosphenytoin, Gliclazide, Glucosamine, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Lorcaserin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Meprobamate, Methadone, Methohexital, Methsuximide, Methylphenobarbital, Metoprolol, Moclobemide, Nabiximols, Nelfinavir, Nicotine, Nilutamide, Nortriptyline, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Ranitidine, Rilpivirine, Romidepsin, Rosuvastatin, Rupatadine, Selegiline, Seratrodast, Sertraline, Sildenafil, Simvastatin, Tamoxifen, Tapentadol, Temazepam, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Trimethadione, Trimipramine, Troglitazone, Valproic Acid, Venlafaxine, Verapamil, Voriconazole, Vortioxetine, Warfarin, Zolpidem, Zonisamide
2Cytochrome P450 2C19 inhibitorsAbiraterone, Aminophenazone, Amiodarone, Amitriptyline, Amprenavir, Antipyrine, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Chloramphenicol, Cimetidine, Citalopram, Clevidipine, Clozapine, Cyclosporine, Delavirdine, Desloratadine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Efavirenz, Enasidenib, Eslicarbazepine acetate, Esomeprazole, Ethanol, Etoricoxib, Etravirine, Felbamate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gliclazide, Idelalisib, Imipramine, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Lobeglitazone, Lopinavir, Loratadine, Losartan, Luliconazole, Manidipine, Memantine, Mephenytoin, Methazolamide, Methimazole, Methsuximide, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nelfinavir, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Oxcarbazepine, Pantoprazole, Phenelzine, Piperaquine, Probenecid, Progesterone, Quinine, Rabeprazole, Ritonavir, Rucaparib, Safinamide, Sertraline, Sildenafil, Sitaxentan, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Topiramate, Topiroxostat, Tranylcypromine, Troglitazone, Valproic Acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3Cytochrome P450 2C19 inducersAcetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Carbamazepine, Dexamethasone, Enzalutamide, Hydroxyprogesterone caproate, Letermovir, Loratadine, Lumacaftor, Midostaurin, Norethisterone, Opicapone, Phenobarbital, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
Interacting GroupInteracting Drugs
Diphenhydramine is a Cytochrome P450 2C18 substrate
1Cytochrome P450 2C18 substrates(R)-warfarin, (S)-Warfarin, Aminophenazone, Antipyrine, Buprenorphine, Clobazam, Clotiazepam, Cyclophosphamide, Dapsone, Desipramine, Diazepam, Diclofenac, Etizolam, Ifosfamide, Imipramine, Lansoprazole, Lidocaine, Methadone, Omeprazole, Perphenazine, Phenytoin, Propofol, Tolbutamide, Tretinoin, Verapamil, Vilazodone, Warfarin
2Cytochrome P450 2C18 inhibitorsPegvisomant, Troleandomycin, Valproic Acid
3Cytochrome P450 2C18 inducersPhenobarbital
Interacting GroupInteracting Drugs
Diphenhydramine is a Prostaglandin G/H synthase 1 substrate
1Prostaglandin G/H synthase 1 inhibitorsAceclofenac, Acetaminophen, Acetylsalicylic acid, Antipyrine, Antrafenine, Balsalazide, Bromfenac, Bufexamac, Carprofen, Choline magnesium trisalicylate, Dexibuprofen, Dexketoprofen, Diclofenac, Diethylcarbamazine, Diflunisal, Dihomo-gamma-linolenic acid, Droxicam, Etodolac, Fenoprofen, Flurbiprofen, Hyperforin, Ibuprofen, Icosapent, Indomethacin, Ketoprofen, Ketorolac, Lornoxicam, Lumiracoxib, Magnesium salicylate, Meclofenamic acid, Mefenamic acid, Meloxicam, Mesalazine, Nabumetone, Naproxen, Nepafenac, Nitroaspirin, Oxaprozin, Phenylbutazone, Piroxicam, Resveratrol, Salicylic acid, Salsalate, Sulfasalazine, Sulindac, Suprofen, Talniflumate, Tenoxicam, Tiaprofenic acid, Tolmetin, Trolamine salicylate
2Prostaglandin G/H synthase 1 inducersDesmopressin, Minoxidil
3Prostaglandin G/H synthase 1 substratesCandesartan, Candesartan cilexetil, Carvedilol, Chlorpropamide, Dapsone, Diazepam, Diclofenac, Dronabinol, Eletriptan, Eszopiclone, Etoposide, Hexobarbital, Hydromorphone, Ifosfamide, Imatinib, Irbesartan, Ketamine, Ketobemidone, Loxoprofen, Montelukast, Nateglinide, Nortriptyline, Pioglitazone, Rofecoxib, Rosiglitazone, Seratrodast, Sulfamethoxazole, Terbinafine, Thalidomide, Torasemide, Trabectedin, Valproic Acid, Voriconazole, Zafirlukast, Zaltoprofen, Zileuton, Zolpidem, Zopiclone
4Prostaglandin G/H synthase 1 antagonistsAcemetacin, Dexketoprofen, Glycol salicylate, Loxoprofen, Menthyl salicylate, Phenyl salicylate, Propacetamol, Talniflumate, Tolfenamic Acid, Triflusal
Interacting GroupInteracting Drugs
Diphenhydramine is a Solute carrier family 22 member 2 inhibitor
1Solute carrier family 22 member 2 inhibitorsAmantadine, Amiloride, Aminohippuric acid, Apalutamide, Baricitinib, Bupropion, Chlorphenamine, Choline, Choline salicylate, Cimetidine, Cisplatin, Cocaine, Desipramine, Dexchlorpheniramine maleate, Dinoprostone, Disopyramide, Dolutegravir, Dopamine, Enasidenib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Famotidine, Flurazepam, Grepafloxacin, Guanidine, Histamine, Imatinib, Imipramine, Isavuconazole, Lenvatinib, Levofloxacin, Metformin, Metoprolol, Nicotine, Norepinephrine, Oxprenolol, Phenformin, Phenoxybenzamine, Pimagedine, Prazosin, Probenecid, Procainamide, Progesterone, Propranolol, Quinacrine, Quinidine, Quinine, Tafenoquine, Thiamine, Varenicline
2Solute carrier family 22 member 2 substratesAgmatine, Choline, Choline salicylate, Cimetidine, Cisplatin, Dalfampridine, Dopamine, Epinephrine, Histamine, Lamivudine, Memantine, Metformin, Nafamostat, Norepinephrine, Oxaliplatin, Pramipexole, Prazosin, Ranitidine, Reserpine, Tetraethylammonium, Varenicline
3Solute carrier family 22 member 2 carriersTipiracil
Interacting GroupInteracting Drugs
Diphenhydramine is a Solute carrier family 22 member 1 inhibitor
1Solute carrier family 22 member 1 inhibitorsAcebutolol, Acepromazine, Acyclovir, Amantadine, Amiloride, Aminohippuric acid, Baricitinib, Bilastine, Brigatinib, Caspofungin, Chlorphenamine, Chlorpromazine, Choline, Choline salicylate, Cimetidine, Clonidine, Deoxythymidine, Desipramine, Dexchlorpheniramine maleate, Dinoprostone, Disopyramide, Dopamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone sulfate, Ganciclovir, Gentian violet cation, Guanidine, Histamine, Imatinib, Imipramine, Indinavir, Lenvatinib, Metformin, Midazolam, Nelfinavir, Nicotine, Pancuronium, Phenformin, Phenoxybenzamine, Pitolisant, Prazosin, Probenecid, Procainamide, Progesterone, Quinidine, Quinine, Ranitidine, Reserpine, Rocuronium, Rucaparib, Saquinavir, Taurocholic Acid, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamine, Thioproperazine, Vecuronium, Verapamil
2Solute carrier family 22 member 1 substratesAcetylcholine, Agmatine, Buformin, Choline, Choline salicylate, Cimetidine, Cladribine, Codeine, Cytarabine, Dexchlorpheniramine maleate, Dopamine, Epinephrine, Histamine, Imatinib, Lamivudine, Latanoprostene Bunod, Metformin, Nafamostat, Norepinephrine, Oxaliplatin, Pancuronium, Phenformin, Pramipexole, Quinidine, Quinine, Spermidine, Spermine, Tubocurarine
Interacting GroupInteracting Drugs
Diphenhydramine is a Solute carrier family 22 member 5 inhibitor
1Solute carrier family 22 member 5 inhibitorsAcetylcholine, Aldosterone, Aminohippuric acid, Amphetamine, Ampicillin, Azidocillin, Benzylpenicillin, Cefadroxil, Cefalotin, Cefdinir, Cefepime, Cefixime, Cefradine, Ceftazidime, Cephalexin, Cephaloglycin, Choline, Choline salicylate, Cimetidine, Clonidine, Creatine, Cyclacillin, Dactinomycin, Desipramine, Dopamine, Furosemide, Grepafloxacin, Guanidine, Histamine, L-Arginine, Lidocaine, Lomefloxacin, Methamphetamine, Niacin, Nicotine, Norepinephrine, Norfloxacin, Ofloxacin, Probenecid, Procainamide, Quinidine, Quinine, Sparfloxacin, Thiamine, Valproic Acid, Verapamil
2Solute carrier family 22 member 5 substratesIpratropium, L-Carnitine, Tiotropium