Showing BioInteractions for Iloprost (DB01088)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 7
Transporter Mediated Interactions 3

	Interacting Group	Interacting Drugs
	Iloprost is a Prostacyclin receptor agonist
1	Prostacyclin receptor antagonists	Dinoprost tromethamine
2	Prostacyclin receptor agonists	Epoprostenol, Selexipag, Treprostinil

	Interacting Group	Interacting Drugs
	Iloprost is a cAMP-specific 3',5'-cyclic phosphodiesterase 4A inducer
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitors	Crisaborole, Dipyridamole, Drotaverine, Dyphylline, Enprofylline, Ibudilast, Oxtriphylline, Roflumilast, Theophylline, Tofisopam

	Interacting Group	Interacting Drugs
	Iloprost is a cAMP-specific 3',5'-cyclic phosphodiesterase 4B inducer
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitors	(R)-Rolipram, (S)-Rolipram, Caffeine, Cilomilast, Crisaborole, Dyphylline, Enprofylline, Filaminast, Ibudilast, Papaverine, Roflumilast, Theobromine, Theophylline

	Interacting Group	Interacting Drugs
	Iloprost is a cAMP-specific 3',5'-cyclic phosphodiesterase 4C inducer
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4C inhibitors	Crisaborole, Dyphylline, Ibudilast, Roflumilast

	Interacting Group	Interacting Drugs
	Iloprost is a cAMP-specific 3',5'-cyclic phosphodiesterase 4D inducer
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitors	Cilomilast, Crisaborole, Dyphylline, Ibudilast, Roflumilast

	Interacting Group	Interacting Drugs
	Iloprost is a Prostaglandin E2 receptor EP1 subtype agonist
1	Prostaglandin E2 receptor EP1 subtype agonists	Alprostadil, Bimatoprost, Carboprost tromethamine, Dinoprostone, Limaprost, Misoprostol

	Interacting Group	Interacting Drugs
	Iloprost is a Prostaglandin D2 receptor 2 agonist
1	Prostaglandin D2 receptor 2 antagonists	Sulindac
2	Prostaglandin D2 receptor 2 agonists	Alprostadil, Dinoprost, Dinoprostone

	Interacting Group	Interacting Drugs
	Iloprost is a Solute carrier organic anion transporter family member 2B1 substrate
1	Solute carrier organic anion transporter family member 2B1 inhibitors	Acetic acid, Alprostadil, Asunaprevir, Atazanavir, Benzbromarone, Benzoic acid, Bilastine, Cholecystokinin, Citric acid, Dipyridamole, Dovitinib, Erlotinib, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Gemfibrozil, Genistein, Indinavir, Itraconazole, Lactic acid, Levothyroxine, Naringenin, Nefazodone, Nelfinavir, Niacin, Novobiocin, Oxalic Acid, Pexidartinib, Phthalic Acid, Piroxicam, Quercetin, Reserpine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Silibinin, Sulfasalazine, Telaprevir, Tetracycline, Tipranavir, Valproic acid, Velpatasvir
2	Solute carrier organic anion transporter family member 2B1 substrates	Acetic acid, Asunaprevir, Atorvastatin, Benzylpenicillin, Conjugated estrogens, Diethylstilbestrol, Dinoprostone, Fexofenadine, Glyburide, Ibuprofen, Lactic acid, Latanoprostene bunod, Lifitegrast, Montelukast, Opicapone, Pitavastatin, Prasterone, Pravastatin, Salicylic acid, Simeprevir, Taurocholic acid, Tolbutamide
3	Solute carrier organic anion transporter family member 2B1 transporters	Velpatasvir

	Interacting Group	Interacting Drugs
	Iloprost is a Solute carrier organic anion transporter family member 2A1 substrate
1	Solute carrier organic anion transporter family member 2A1 inducers	Phenobarbital
2	Solute carrier organic anion transporter family member 2A1 inhibitors	beta-D-fructofuranose 1,6-bisphosphate, D-glyceraldehyde 3-phosphate, Furosemide, Glucose-6-Phosphate, Lactic acid, Phosphoenolpyruvate, Pyruvic acid, Rifamycin
3	Solute carrier organic anion transporter family member 2A1 substrates	Alprostadil, Arachidonic Acid, Dinoprostone, Latanoprost

	Interacting Group	Interacting Drugs
	Iloprost is a Solute carrier organic anion transporter family member 3A1 substrate
1	Solute carrier organic anion transporter family member 3A1 inhibitors	Alprostadil, Aminohippuric acid, Lobeglitazone, Taurocholic acid
2	Solute carrier organic anion transporter family member 3A1 substrates	Benzylpenicillin, Conjugated estrogens, Dinoprostone, Methotrexate, Safinamide, Thyroid, porcine