Showing BioInteractions for Sertraline (DB01104)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Sertraline is a Sodium-dependent serotonin transporter inhibitor
1Sodium-dependent serotonin transporter inhibitors4-Methoxyamphetamine, Amitriptyline, Amoxapine, Benzatropine, Butriptyline, Chlorpheniramine, Citalopram, Clomipramine, Cocaine, Cyclobenzaprine, Desipramine, Desvenlafaxine, Dexfenfluramine, Dexmethylphenidate, Dextromethorphan, Dopamine, Dosulepin, Doxepin, Duloxetine, Escitalopram, Etoperidone, Fenfluramine, Fluoxetine, Fluvoxamine, Imipramine, Levomilnacipran, Lumateperone, Mazindol, Mianserin, Milnacipran, Minaprine, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Phentermine, Protriptyline, Pseudoephedrine, Sibutramine, Tapentadol, Tegaserod, Tramadol, Trazodone, Trimipramine, Venlafaxine, Vilazodone, Vortioxetine
2Sodium-dependent serotonin transporter bindersAmphetamine, Atomoxetine, Loxapine
3Sodium-dependent serotonin transporter negative modulatorsEphedra sinica root, Metamfetamine, Midomafetamine, MMDA
4Sodium-dependent serotonin transporter substratesMirtazapine, Tegaserod
5Sodium-dependent serotonin transporter bindingsMeperidine
6Sodium-dependent serotonin transporter antagonistsButriptyline, Lorpiprazole, Zotepine
7Sodium-dependent serotonin transporter modulatorsAripiprazole
Interacting GroupInteracting Drugs
Sertraline is a Sodium-dependent serotonin transporter binder
1Sodium-dependent serotonin transporter inhibitors4-Methoxyamphetamine, Amitriptyline, Amoxapine, Benzatropine, Butriptyline, Chlorpheniramine, Citalopram, Clomipramine, Cocaine, Cyclobenzaprine, Desipramine, Desvenlafaxine, Dexfenfluramine, Dexmethylphenidate, Dextromethorphan, Dopamine, Dosulepin, Doxepin, Duloxetine, Escitalopram, Etoperidone, Fenfluramine, Fluoxetine, Fluvoxamine, Imipramine, Levomilnacipran, Lumateperone, Mazindol, Mianserin, Milnacipran, Minaprine, Mirtazapine, Nefazodone, Nortriptyline, Paroxetine, Phentermine, Protriptyline, Pseudoephedrine, Sibutramine, Tapentadol, Tegaserod, Tramadol, Trazodone, Trimipramine, Venlafaxine, Vilazodone, Vortioxetine
2Sodium-dependent serotonin transporter bindersAmphetamine, Atomoxetine, Loxapine
3Sodium-dependent serotonin transporter negative modulatorsEphedra sinica root, Metamfetamine, Midomafetamine, MMDA
4Sodium-dependent serotonin transporter substratesMirtazapine, Tegaserod
5Sodium-dependent serotonin transporter bindingsMeperidine
6Sodium-dependent serotonin transporter antagonistsButriptyline, Lorpiprazole, Zotepine
7Sodium-dependent serotonin transporter modulatorsAripiprazole
Interacting GroupInteracting Drugs
Sertraline is a Sodium-dependent dopamine transporter inhibitor
1Sodium-dependent dopamine transporter inhibitors4-Methoxyamphetamine, Armodafinil, Benzatropine, Benzphetamine, Bupropion, Chloroprocaine, Chlorpheniramine, Cocaine, Desvenlafaxine, Dexmethylphenidate, Diethylpropion, Diphenylpyraline, Duloxetine, Escitalopram, Etoperidone, Fencamfamin, Imipramine, Mazindol, Meperidine, Methylphenidate, Modafinil, Nefazodone, Phenmetrazine, Phentermine, Procaine, Pseudoephedrine, Sibutramine, Trimipramine, Venlafaxine
2Sodium-dependent dopamine transporter negative modulatorsAmphetamine, Dextroamphetamine, Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA
3Sodium-dependent dopamine transporter bindersAmoxapine, Loxapine, Mianserin
4Sodium-dependent dopamine transporter inducersDopamine
5Sodium-dependent dopamine transporter antagonistsArmodafinil
6Sodium-dependent dopamine transporter modulatorsAripiprazole
Interacting GroupInteracting Drugs
Sertraline is a Sodium-dependent dopamine transporter binder
1Sodium-dependent dopamine transporter inhibitors4-Methoxyamphetamine, Armodafinil, Benzatropine, Benzphetamine, Bupropion, Chloroprocaine, Chlorpheniramine, Cocaine, Desvenlafaxine, Dexmethylphenidate, Diethylpropion, Diphenylpyraline, Duloxetine, Escitalopram, Etoperidone, Fencamfamin, Imipramine, Mazindol, Meperidine, Methylphenidate, Modafinil, Nefazodone, Phenmetrazine, Phentermine, Procaine, Pseudoephedrine, Sibutramine, Trimipramine, Venlafaxine
2Sodium-dependent dopamine transporter negative modulatorsAmphetamine, Dextroamphetamine, Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA
3Sodium-dependent dopamine transporter bindersAmoxapine, Loxapine, Mianserin
4Sodium-dependent dopamine transporter inducersDopamine
5Sodium-dependent dopamine transporter antagonistsArmodafinil
6Sodium-dependent dopamine transporter modulatorsAripiprazole
Interacting GroupInteracting Drugs
Sertraline is a Sigma receptor inhibitor
1Sigma receptor bindersNortriptyline
Interacting GroupInteracting Drugs
Sertraline is a Sigma receptor binder
1Sigma receptor bindersNortriptyline
Interacting GroupInteracting Drugs
Sertraline is a Sodium-dependent noradrenaline transporter inhibitor
1Sodium-dependent noradrenaline transporter inhibitorsAmitriptyline, Amoxapine, Atomoxetine, Benzatropine, Bupropion, Chlorpheniramine, Clomipramine, Cocaine, Cyclobenzaprine, Desipramine, Desvenlafaxine, Dexmethylphenidate, Dextromethorphan, Diethylpropion, Dopamine, Dosulepin, Doxepin, Duloxetine, Ergotamine, Escitalopram, Etoperidone, Ginkgo biloba, Imipramine, Ketamine, Levomilnacipran, Maprotiline, Mazindol, Meperidine, Methylphenidate, Mianserin, Milnacipran, Nefazodone, Netarsudil, Nortriptyline, Orphenadrine, Paroxetine, Phenmetrazine, Phentermine, Protriptyline, Pseudoephedrine, Rauwolfia serpentina root, Reboxetine, Sibutramine, Tapentadol, Tramadol, Trimipramine, Venlafaxine, Viloxazine
2Sodium-dependent noradrenaline transporter partial agonistsGuanadrel
3Sodium-dependent noradrenaline transporter inducersDebrisoquine, Guanethidine
4Sodium-dependent noradrenaline transporter negative modulatorsDextroamphetamine, Ephedra sinica root, Metamfetamine, Midomafetamine, MMDA, Phendimetrazine
5Sodium-dependent noradrenaline transporter inverse agonistsEphedrine
6Sodium-dependent noradrenaline transporter substratesDroxidopa, Iobenguane, Iobenguane sulfate I-123, Norepinephrine
7Sodium-dependent noradrenaline transporter bindersLoxapine
8Sodium-dependent noradrenaline transporter stimulatorsAmphetamine
9Sodium-dependent noradrenaline transporter blockersVortioxetine
10Sodium-dependent noradrenaline transporter antagonistsZotepine
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2B6 substrate
1Cytochrome P450 2B6 substratesAmitriptyline, Amlodipine, Antipyrine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Ritonavir, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2Cytochrome P450 2B6 inducersArmodafinil, Artemether, Artemisinin, Atorvastatin, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dabrafenib, Dexamethasone, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Pexidartinib, Phenobarbital, Phenytoin, Pitolisant, Prednisone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Vemurafenib, Zanubrutinib
3Cytochrome P450 2B6 inhibitorsAbemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Desipramine, Doxorubicin, Efavirenz, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Methimazole, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Pexidartinib, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Safinamide, Selegiline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Triclabendazole, Voriconazole
4Cytochrome P450 2B6 activatorsVerapamil
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2B6 inhibitor
1Cytochrome P450 2B6 substratesAmitriptyline, Amlodipine, Antipyrine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Ritonavir, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2Cytochrome P450 2B6 inducersArmodafinil, Artemether, Artemisinin, Atorvastatin, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dabrafenib, Dexamethasone, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Pexidartinib, Phenobarbital, Phenytoin, Pitolisant, Prednisone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Vemurafenib, Zanubrutinib
3Cytochrome P450 2B6 inhibitorsAbemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Desipramine, Doxorubicin, Efavirenz, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Methimazole, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Pexidartinib, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Safinamide, Selegiline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Triclabendazole, Voriconazole
4Cytochrome P450 2B6 activatorsVerapamil
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2C19 substrate
1Cytochrome P450 2C19 substrates(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Flunitrazepam, Fluoxetine, Flutamide, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Loratadine, Lorcaserin, Lorlatinib, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methohexital, Methsuximide, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Seratrodast, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Valproic acid, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2Cytochrome P450 2C19 inhibitorsAbiraterone, Alpelisib, Aminophenazone, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Efavirenz, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Lobeglitazone, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Mephenytoin, Methimazole, Methsuximide, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Oxcarbazepine, Pantoprazole, Paroxetine, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Ritonavir, Rucaparib, Safinamide, Seproxetine, Sildenafil, Sitaxentan, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Valproic acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3Cytochrome P450 2C19 inducersAcetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Budesonide, Carbamazepine, Dexamethasone, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2C19 inhibitor
1Cytochrome P450 2C19 substrates(R)-warfarin, (S)-Warfarin, Acenocoumarol, Adinazolam, Albendazole, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Bupivacaine, Cannabidiol, Capravirine, Carisoprodol, Cenobamate, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clobazam, Clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Dexibuprofen, Dexlansoprazole, Dexrabeprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Doxazosin, Doxepin, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esketamine, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Fedratinib, Flunitrazepam, Fluoxetine, Flutamide, Formoterol, Fosphenytoin, Gliclazide, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Hydrocodone, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lacosamide, Lansoprazole, Lapatinib, Levomilnacipran, Lofexidine, Loratadine, Lorcaserin, Lorlatinib, Lovastatin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Meperidine, Mephenytoin, Methadone, Methohexital, Methsuximide, Methylphenobarbital, Moclobemide, Nabiximols, Nebivolol, Nelfinavir, Nicotine, Nilutamide, Norethisterone, Nortriptyline, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Paroxetine, Pentamidine, Pentobarbital, Perphenazine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Rilpivirine, Romidepsin, Rupatadine, Selegiline, Seratrodast, Sildenafil, Simvastatin, St. John's Wort, Stiripentol, Tamoxifen, Tapentadol, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Triclabendazole, Trimethadione, Trimipramine, Valproic acid, Verapamil, Vilazodone, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Zolpidem, Zonisamide
2Cytochrome P450 2C19 inhibitorsAbiraterone, Alpelisib, Aminophenazone, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Avasimibe, Azelastine, Benzbromarone, Bicalutamide, Bortezomib, Buprenorphine, Carbamazepine, Cenobamate, Chloramphenicol, Cimetidine, Cisapride, Citalopram, Clevidipine, Clinafloxacin, Clozapine, Curcumin sulfate, Cyclosporine, Delavirdine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Dovitinib, Efavirenz, Elexacaftor, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Esomeprazole, Ethanol, Ethinylestradiol, Etoricoxib, Etravirine, Felbamate, Fenofibrate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gestodene, Idelalisib, Imipramine, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lenvatinib, Lobeglitazone, Lopinavir, Loratadine, Losartan, Luliconazole, Lynestrenol, Manidipine, Memantine, Mephenytoin, Methimazole, Methsuximide, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Oritavancin, Oxcarbazepine, Pantoprazole, Paroxetine, Phenelzine, Piperaquine, Progesterone, Quinine, Rabeprazole, Rifamycin, Ritonavir, Rucaparib, Safinamide, Seproxetine, Sildenafil, Sitaxentan, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Topiramate, Topiroxostat, Tranylcypromine, Triclabendazole, Troglitazone, Ubrogepant, Valproic acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3Cytochrome P450 2C19 inducersAcetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Budesonide, Carbamazepine, Dexamethasone, Efavirenz, Enzalutamide, Hydrocortisone, Hydroxyprogesterone caproate, Letermovir, Lumacaftor, Methylprednisolone, Midostaurin, Nelfinavir, Norethisterone, Opicapone, Phenobarbital, Phenytoin, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital, St. John's Wort
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2C9 substrate
1Cytochrome P450 2C9 inhibitorsAbemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Cisplatin, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Methimazole, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Oritavancin, Oxandrolone, Paroxetine, Pexidartinib, Phenylbutazone, Phenytoin, Piperine, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rucaparib, Safinamide, Seproxetine, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Valproic acid, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2Cytochrome P450 2C9 substrates(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amiodarone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Etodolac, Etoricoxib, Etravirine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Salicylic acid, Selegiline, Seratrodast, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Valdecoxib, Valproic acid, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3Cytochrome P450 2C9 inducersAlpelisib, Apalutamide, Aprepitant, Avatrombopag, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Etravirine, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2C9 inhibitor
1Cytochrome P450 2C9 inhibitorsAbemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Cisplatin, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Methimazole, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Oritavancin, Oxandrolone, Paroxetine, Pexidartinib, Phenylbutazone, Phenytoin, Piperine, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rucaparib, Safinamide, Seproxetine, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Valproic acid, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2Cytochrome P450 2C9 substrates(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amiodarone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Etodolac, Etoricoxib, Etravirine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Salicylic acid, Selegiline, Seratrodast, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Valdecoxib, Valproic acid, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3Cytochrome P450 2C9 inducersAlpelisib, Apalutamide, Aprepitant, Avatrombopag, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Etravirine, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2D6 substrate
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, 5-methoxy-N,N-dimethyltryptamine, Acebutolol, Acetaminophen, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Asenapine, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Azimilide, Befunolol, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bicifadine, Bopindolol, Bortezomib, Brexpiprazole, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Buspirone, Butyrfentanyl, Caffeine, Cannabidiol, Cariprazine, Carteolol, Carvedilol, Celecoxib, Celiprolol, Cevimeline, Chloroquine, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Ciclesonide, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Dacomitinib, Dapagliflozin, Dapoxetine, Darifenacin, Dasabuvir, Debrisoquine, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dextroamphetamine, Dextromethorphan, Dextropropoxyphene, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dosulepin, Doxazosin, Doxepin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Fesoterodine, Flecainide, Flunarizine, Fluoxetine, Fluvastatin, Fluvoxamine, Formoterol, Fusidic acid, Galantamine, Gefitinib, Haloperidol, Hydrocodone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Istradefylline, Ixazomib, Labetalol, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levomilnacipran, Lidocaine, Lisdexamfetamine, Lofexidine, Loperamide, Loratadine, Lorcaserin, Lorpiprazole, Lysergic acid diethylamide, Maprotiline, Meclizine, Meperidine, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Metamfetamine, Methadone, Methotrimeprazine, Methoxyflurane, Metipranolol, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Midodrine, Midomafetamine, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Nabiximols, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicergoline, Nicotine, Nortriptyline, Olanzapine, Ondansetron, Opium, Oxamniquine, Oxprenolol, Oxycodone, Oxymorphone, Paliperidone, Palonosetron, Paroxetine, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenformin, Phenytoin, Pindolol, Piperazine, Pipotiazine, Pitolisant, Ponatinib, Practolol, Procainamide, Prochlorperazine, Progesterone, Promazine, Promethazine, Propacetamol, Propafenone, Propranolol, Quetiapine, Quinidine, Quinine, Ranolazine, Remoxipride, Repinotan, Revefenacin, Risperidone, Ritonavir, Rotigotine, Rucaparib, Rupatadine, Selegiline, Sertindole, Sildenafil, Simvastatin, Solifenacin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Triclabendazole, Trimipramine, Umeclidinium, Upadacitinib, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vortioxetine, Yohimbine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitors1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine, Abemaciclib, Abiraterone, Acebutolol, Amiodarone, Amlodipine, Amodiaquine, Amoxapine, Artenimol, Asenapine, Asunaprevir, Atorvastatin, Azelastine, Bepridil, Bicalutamide, Biperiden, Black cohosh, Buprenorphine, Bupropion, Cannabidiol, Celecoxib, Cerivastatin, Chloroquine, Chlorpheniramine, Chlorpromazine, Cimetidine, Cinacalcet, Cisapride, Citalopram, Clemastine, Clinafloxacin, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Curcumin sulfate, Cyclosporine, Dacomitinib, Dapoxetine, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desvenlafaxine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmedetomidine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Diphenhydramine, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Elexacaftor, Eliglustat, Enasidenib, Entacapone, Epinastine, Escitalopram, Etoricoxib, Everolimus, Felodipine, Fenfluramine, Flecainide, Fluoxetine, Fluphenazine, Fluvoxamine, Fusidic acid, Gefitinib, Glycerol phenylbutyrate, Halofantrine, Haloperidol, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Imatinib, Imipramine, Indinavir, Indisulam, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Labetalol, Lansoprazole, Lasmiditan, Lenvatinib, Lercanidipine, Levosalbutamol, Lidocaine, Lisdexamfetamine, Lomustine, Lopinavir, Loratadine, Lorcaserin, Lumefantrine, Manidipine, Medical Cannabis, Melperone, Mepyramine, Methadone, Methimazole, Methotrimeprazine, Metoclopramide, Metoprolol, Mibefradil, Miconazole, Midostaurin, Mifepristone, Mirabegron, Mizolastine, Moclobemide, Nabiximols, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Oritavancin, Orphenadrine, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pergolide, Perhexiline, Perphenazine, Phenelzine, Phenylbutyric acid, Pimozide, Pindolol, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promethazine, Propafenone, Propranolol, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Rilpivirine, Risperidone, Ritanserin, Ritonavir, Rolapitant, Rosiglitazone, Rotigotine, Rucaparib, Safinamide, Saquinavir, Selegiline, Sorafenib, Sparteine, St. John's Wort, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Tipranavir, Tranylcypromine, Trazodone, Triclabendazole, Tripelennamine, Trospium, Ubrogepant, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vinblastine, Vinorelbine
3Cytochrome P450 2D6 inducersOritavancin
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2D6 inhibitor
1Cytochrome P450 2D6 substrates4-Methoxyamphetamine, 5-methoxy-N,N-dimethyltryptamine, Acebutolol, Acetaminophen, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amiodarone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Asenapine, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Azimilide, Befunolol, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bicifadine, Bopindolol, Bortezomib, Brexpiprazole, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Buspirone, Butyrfentanyl, Caffeine, Cannabidiol, Cariprazine, Carteolol, Carvedilol, Celecoxib, Celiprolol, Cevimeline, Chloroquine, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Ciclesonide, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Dacomitinib, Dapagliflozin, Dapoxetine, Darifenacin, Dasabuvir, Debrisoquine, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dextroamphetamine, Dextromethorphan, Dextropropoxyphene, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dosulepin, Doxazosin, Doxepin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Fesoterodine, Flecainide, Flunarizine, Fluoxetine, Fluvastatin, Fluvoxamine, Formoterol, Fusidic acid, Galantamine, Gefitinib, Haloperidol, Hydrocodone, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Istradefylline, Ixazomib, Labetalol, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levomilnacipran, Lidocaine, Lisdexamfetamine, Lofexidine, Loperamide, Loratadine, Lorcaserin, Lorpiprazole, Lysergic acid diethylamide, Maprotiline, Meclizine, Meperidine, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Metamfetamine, Methadone, Methotrimeprazine, Methoxyflurane, Metipranolol, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Midodrine, Midomafetamine, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Nabiximols, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicergoline, Nicotine, Nortriptyline, Olanzapine, Ondansetron, Opium, Oxamniquine, Oxprenolol, Oxycodone, Oxymorphone, Paliperidone, Palonosetron, Paroxetine, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenformin, Phenytoin, Pindolol, Piperazine, Pipotiazine, Pitolisant, Ponatinib, Practolol, Procainamide, Prochlorperazine, Progesterone, Promazine, Promethazine, Propacetamol, Propafenone, Propranolol, Quetiapine, Quinidine, Quinine, Ranolazine, Remoxipride, Repinotan, Revefenacin, Risperidone, Ritonavir, Rotigotine, Rucaparib, Rupatadine, Selegiline, Sertindole, Sildenafil, Simvastatin, Solifenacin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Triclabendazole, Trimipramine, Umeclidinium, Upadacitinib, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vortioxetine, Yohimbine, Zolpidem, Zuclopenthixol
2Cytochrome P450 2D6 inhibitors1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine, Abemaciclib, Abiraterone, Acebutolol, Amiodarone, Amlodipine, Amodiaquine, Amoxapine, Artenimol, Asenapine, Asunaprevir, Atorvastatin, Azelastine, Bepridil, Bicalutamide, Biperiden, Black cohosh, Buprenorphine, Bupropion, Cannabidiol, Celecoxib, Cerivastatin, Chloroquine, Chlorpheniramine, Chlorpromazine, Cimetidine, Cinacalcet, Cisapride, Citalopram, Clemastine, Clinafloxacin, Clobazam, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Curcumin sulfate, Cyclosporine, Dacomitinib, Dapoxetine, Darifenacin, Delavirdine, Deramciclane, Desipramine, Desvenlafaxine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmedetomidine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Diphenhydramine, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Elexacaftor, Eliglustat, Enasidenib, Entacapone, Epinastine, Escitalopram, Etoricoxib, Everolimus, Felodipine, Fenfluramine, Flecainide, Fluoxetine, Fluphenazine, Fluvoxamine, Fusidic acid, Gefitinib, Glycerol phenylbutyrate, Halofantrine, Haloperidol, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Imatinib, Imipramine, Indinavir, Indisulam, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Labetalol, Lansoprazole, Lasmiditan, Lenvatinib, Lercanidipine, Levosalbutamol, Lidocaine, Lisdexamfetamine, Lomustine, Lopinavir, Loratadine, Lorcaserin, Lumefantrine, Manidipine, Medical Cannabis, Melperone, Mepyramine, Methadone, Methimazole, Methotrimeprazine, Metoclopramide, Metoprolol, Mibefradil, Miconazole, Midostaurin, Mifepristone, Mirabegron, Mizolastine, Moclobemide, Nabiximols, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Oritavancin, Orphenadrine, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Pergolide, Perhexiline, Perphenazine, Phenelzine, Phenylbutyric acid, Pimozide, Pindolol, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promethazine, Propafenone, Propranolol, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Rilpivirine, Risperidone, Ritanserin, Ritonavir, Rolapitant, Rosiglitazone, Rotigotine, Rucaparib, Safinamide, Saquinavir, Selegiline, Sorafenib, Sparteine, St. John's Wort, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticagrelor, Ticlopidine, Tipranavir, Tranylcypromine, Trazodone, Triclabendazole, Tripelennamine, Trospium, Ubrogepant, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vinblastine, Vinorelbine
3Cytochrome P450 2D6 inducersOritavancin
Interacting GroupInteracting Drugs
Sertraline is a CYP2B protein inducer
1CYP2B protein inhibitorsNefazodone
2CYP2B protein inducersDoxylamine, Fluoxetine
3CYP2B protein substratesMoxidectin
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 3A4 substrate
1Cytochrome P450 3A4 substrates(R)-warfarin, (S)-Warfarin, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, 6-O-benzylguanine, 7-ethyl-10-hydroxycamptothecin, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Almotriptan, Alogliptin, Alosetron, Alpelisib, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Artesunate, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Avapritinib, Axitinib, Azelastine, Azelnidipine, Azimilide, Azithromycin, Balaglitazone, Baloxavir marboxil, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzodiazepine, Benzphetamine, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bimatoprost, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromocriptine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Buspirone, Busulfan, Butyrfentanyl, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calanolide A, Calcitriol, Canagliflozin, Cannabidiol, Capravirine, Carbamazepine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Cenobamate, Ceritinib, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clorindione, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desipramine, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexloxiglumide, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Doxycycline, Dronabinol, Dronedarone, Drospirenone, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Elvitegravir, Emopamil, Enasidenib, Encorafenib, Enfortumab vedotin, Entrectinib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Erdafitinib, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esketamine, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Fedratinib, Felbamate, Felodipine, Fendiline, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Flucloxacillin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Fluprednisolone acetate, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fulvestrant, Fusidic acid, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxychloroquine, Hydroxyprogesterone, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Ibuprofen, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Irinotecan, Isavuconazole, Isavuconazonium, Isotretinoin, Isradipine, Istradefylline, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lefamulin, Lemborexant, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levacetylmethadol, Levamlodipine, Levobupivacaine, Levocetirizine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Metoclopramide, Metoprolol, Mexazolam, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osimertinib, Ospemifene, Otilonium, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Paroxetine, Pazopanib, Penfluridol, Perampanel, Pergolide, Perhexiline, Perospirone, Perphenazine, Pexidartinib, Phenacetin, Phenprocoumon, Phentermine, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Plitidepsin, Polatuzumab vedotin, Pomalidomide, Ponatinib, Posaconazole, Pranlukast, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisone, Prednylidene, Pregnenolone, Prenylamine, Pretomanid, Primaquine, Progesterone, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifalazil, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropivacaine, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Selinexor, Seratrodast, Sertindole, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Siponimod, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, St. John's Wort, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Tazemetostat, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Tenapanor, Teniposide, Tenofovir, Tenofovir alafenamide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab deruxtecan, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Triclabendazole, Trifarotene, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Troleandomycin, Ubrogepant, Udenafil, Ulipristal, Upadacitinib, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vitamin E, Vorapaxar, Voriconazole, Vortioxetine, Voxelotor, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zaleplon, Zanubrutinib, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2Cytochrome P450 3A4 inducersAcetaminophen, Amcinonide, Aminoglutethimide, Amprenavir, Apalutamide, Aprepitant, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cenobamate, Cerivastatin, Chlorphenesin, Chlorpromazine, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clocortolone acetate, Clofazimine, Clofibrate, Cloprednol, Clotrimazole, Clozapine, Corticotropin, Cortisone, Cortisone acetate, Cortivazol, Cyclophosphamide, Dabrafenib, Deferasirox, Deflazacort, Delafloxacin, Desonide, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Difluocortolone, Echinacea, Efavirenz, Enasidenib, Enzalutamide, Esketamine, Eslicarbazepine, Eslicarbazepine acetate, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Halometasone, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivermectin, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Lesinurad, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Medrysone, Melengestrol acetate, Meperidine, Meprednisone, Metamizole, Methadone, Methylprednisolone, Methylprednisolone hemisuccinate, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Mometasone, Mometasone furoate, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Paramethasone, Pegvisomant, Pentobarbital, Perampanel, Pexidartinib, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Primidone, Probenecid, Progesterone, Propacetamol, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamylal, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine, Vitamin E, Warfarin
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, 7-ethyl-10-hydroxycamptothecin, Abemaciclib, Abiraterone, Acalabrutinib, Acetazolamide, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, AVE9633, Azelastine, Azithromycin, Barnidipine, Benidipine, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Caspofungin, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clofazimine, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Curcumin sulfate, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diclofenac, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Ditiocarb, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Econazole, Edetate disodium anhydrous, Efavirenz, Efonidipine, Elbasvir, Elexacaftor, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergotamine, Erlotinib, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Ginkgo biloba, Glecaprevir, Glyburide, GPI-1485, Haloperidol, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isradipine, Itraconazole, Ivacaftor, Ixabepilone, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levofloxacin, Levosalbutamol, Linagliptin, Lomustine, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Medical Cannabis, Mefloquine, Mepartricin, Mequitazine, Methadone, Methimazole, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitric Oxide, Norfloxacin, Noscapine, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Osimertinib, Oxcarbazepine, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Pexidartinib, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Piperine, Posaconazole, Primaquine, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Remacemide, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Ritonavir, Rokitamycin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Saracatinib, Sarilumab, Selamectin, Seproxetine, Simeprevir, Sitaxentan, Solithromycin, Somatostatin, Sorafenib, Stiripentol, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Toremifene, Trastuzumab emtansine, Triclabendazole, Troleandomycin, Tylosin, Tylvalosin, Valproic acid, Vapreotide, Venetoclax, Verapamil, Vinblastine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine
Interacting GroupInteracting Drugs
Sertraline is a Amine oxidase [flavin-containing] B substrate
1Amine oxidase [flavin-containing] B antagonistsMoclobemide, Phenelzine, Phentermine, Safinamide
2Amine oxidase [flavin-containing] B inhibitors4-Methoxyamphetamine, Amantadine, Amphetamine, Ephedra sinica root, Farnesol, Furazolidone, Iproniazid, Isatin, Isocarboxazid, Linezolid, Metamfetamine, MMDA, Moclobemide, N-Propargyl-1(S)-Aminoindan, Nandrolone decanoate, Nicotine, Pargyline, Pioglitazone, Rasagiline, Selegiline, Tranylcypromine, Zimelidine, Zonisamide
3Amine oxidase [flavin-containing] B ligands5-Hydroxy-N-Propargyl-1(R)-Aminoindan, Lauryl Dimethylamine-N-Oxide
4Amine oxidase [flavin-containing] B substratesBicifadine, Dopamine, Phenelzine, Phenylephrine
Interacting GroupInteracting Drugs
Sertraline is a Amine oxidase [flavin-containing] A substrate
1Amine oxidase [flavin-containing] A inhibitors4-Methoxyamphetamine, Brofaromine, Capsaicin, Ephedra sinica root, Furazolidone, Iproniazid, Isocarboxazid, Linezolid, Metamfetamine, Minaprine, MMDA, Moclobemide, Nandrolone decanoate, Nicotine, Pargyline, Phenylpropanolamine, Pirlindole, Propranolol, Pseudoephedrine, Safinamide, Selegiline, Toloxatone, Tranylcypromine, Ubrogepant, Zimelidine, Zonisamide
2Amine oxidase [flavin-containing] A antagonistsMoclobemide, Phenelzine, Phentermine, Pirlindole, Toloxatone
3Amine oxidase [flavin-containing] A substratesAlmotriptan, Bicifadine, Bufotenine, Dopamine, Eravacycline, Naratriptan, Phenelzine, Phenylephrine, Rizatriptan, Sumatriptan, Zolmitriptan
4Amine oxidase [flavin-containing] A cofactorsRiboflavin
5Amine oxidase [flavin-containing] A inducersOxymetholone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
Interacting GroupInteracting Drugs
Sertraline is a Cytochrome P450 2E1 substrate
1Cytochrome P450 2E1 substrates1,2-dichlorobenzene, Acetaminophen, Almotriptan, Aminophylline, Aniline, Antipyrine, Benzyl alcohol, Bupropion, Caffeine, Capsaicin, Carvedilol, Cenobamate, Chlorzoxazone, Clevidipine, Dacarbazine, Dalfampridine, Dapsone, Dexloxiglumide, Dexmedetomidine, Dichlorobenzene, Enflurane, Enfuvirtide, Estrone, Ethanol, Ethosuximide, Etoposide, Felbamate, Fingolimod, Fomepizole, GTS-21, Halothane, Iloperidone, Isoflurane, Isoniazid, Methoxyflurane, Mexiletine, Mitoxantrone, N-Methyl-N-(Methylbenzyl)Formamide, N,N-dimethylformamide, Nicardipine, Nicotinamide, Nicotine, Nilvadipine, Ondansetron, Paramethadione, Phenacetin, Phenobarbital, Phenytoin, Plitidepsin, Primidone, Propacetamol, Quinidine, Quinine, Sevoflurane, Sildenafil, Tamoxifen, Tegafur, Thalidomide, Theobromine, Theophylline, Thiamylal, Tirapazamine, Trabectedin, Trimethadione, Verapamil, Zopiclone
2Cytochrome P450 2E1 inhibitorsAdemetionine, Aldesleukin, Alosetron, Azelastine, Bifonazole, Bromazepam, Chlorpromazine, Chlorzoxazone, Cimetidine, Clonazepam, Clotrimazole, Desipramine, Dexfenfluramine, Diacerein, Diazepam, Diclofenac, Diethylstilbestrol, Disulfiram, Ditiocarb, Econazole, Ellagic acid, Etoricoxib, Flunitrazepam, Fluphenazine, Flurazepam, Imipramine, Indisulam, Isoniazid, Isosorbide dinitrate, Itraconazole, Methimazole, Methotrimeprazine, Metyrapone, Miconazole, Midostaurin, Nabilone, Niacin, Nicotinamide, Nicotine, Nifedipine, Nitrazepam, Nortriptyline, Orphenadrine, Propofol, Rhein, Ritonavir, Rufinamide, Safinamide, Selegiline, Sildenafil, Sulfanilamide, Tegaserod, Thioridazine, Ticlopidine, Tioconazole, Tranylcypromine, Ursodeoxycholic acid, Vayarin, Zafirlukast, Zucapsaicin
3Cytochrome P450 2E1 inducersClofibrate, Colchicine, Delafloxacin, Dexamethasone, Ethanol, Fomepizole, Glycerin, Isoniazid, Mitoxantrone, Nicotine, Phenelzine, Phenobarbital, Piperaquine, Primidone, Rifampicin, Streptozocin, Ursodeoxycholic acid
Interacting GroupInteracting Drugs
Sertraline is a P-glycoprotein 1 inhibitor
1P-glycoprotein 1 inducersAcetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Beclomethasone dipropionate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Hydrocortisone, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Methylprednisolone, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Phenobarbital, Platelet Activating Factor, Prednisone, Progesterone, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Vinblastine, Vincristine
2P-glycoprotein 1 substratesAbemaciclib, Acebutolol, Acenocoumarol, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Alpelisib, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Arsenic trioxide, Asunaprevir, Atazanavir, Atorvastatin, Avatrombopag, Axitinib, Azathioprine, Azithromycin, Beclomethasone dipropionate, Belinostat, Betamethasone, Betrixaban, Bisoprolol, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Camptothecin, Canagliflozin, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cetirizine, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dacomitinib, Dactinomycin, Dapagliflozin, Darolutamide, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Donepezil, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Enfortumab vedotin, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Flecainide, Fluciclovine (18F), Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Hydroxyzine, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lasmiditan, Ledipasvir, Lefamulin, Lemborexant, Lenalidomide, Lenvatinib, Letermovir, Levamlodipine, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Loratadine, Losartan, Lusutrombopag, Mannitol, Methotrexate, Methylprednisolone, Metoclopramide, Metoprolol, Mirabegron, Mitoxantrone, Morphine, Moxidectin, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Osimertinib, Oxcarbazepine, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Reserpine, Revefenacin, Rifamycin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Tamoxifen, Taurocholic acid, Tazemetostat, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tolvaptan, Topiramate, Topotecan, Toremifene, Tramadol, Trastuzumab deruxtecan, Trastuzumab emtansine, Trimipramine, Ubidecarenone, Ubrogepant, Umeclidinium, Upadacitinib, Vardenafil, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Vismodegib, Voxilaprevir, Zanubrutinib, Zidovudine
3P-glycoprotein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Azelastine, Azithromycin, Benzocaine, Bepridil, Bisoprolol, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carvedilol, Caspofungin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Crizotinib, Curcumin, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erythromycin, Esomeprazole, Estramustine, Etoposide, Fedratinib, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Istradefylline, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ketoconazole, Lansoprazole, Lapatinib, Lasmiditan, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Lusutrombopag, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Mitoxantrone, Naproxen, Nefazodone, Nelfinavir, Neratinib, Nicardipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Norethisterone, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pibrentasvir, Pimozide, Piperine, Polyethylene glycol 400, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Sarecycline, Scopolamine, Selegiline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Troleandomycin, Upadacitinib, Vardenafil, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine
4P-glycoprotein 1 modulatorsAcetylsalicylic acid, Avapritinib, Prazosin
5P-glycoprotein 1 transportersLedipasvir, Tocopherol
6P-glycoprotein 1 bindersTechnetium Tc-99m tetrofosmin
7P-glycoprotein 1 antagonistsTocofersolan