|Accession Number||DB01187 (APRD01312, DB13498)|
Iophendylate is a mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization. Iophendylate is a myelographic oil-ester (U.S. Patent 2,348,231). Iophendylate, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors. It next appeared on the world scene for high volume (12-15cc), routine use, in diagnosing disc herniations. A number of clinicians have published on the dangers of oil myelography. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected".
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|Product Ingredients||Not Available|
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|Weight||Average: 416.3368 |
Iophendylate is used as a contrast agent to locate spinal tumors.
|Structured Indications||Not Available|
Iophendylate is a myelographic oil-ester initially introduced for use in small amounts (1-2cc) for locating spinal tumors. Later, it was found to cause adhesive arachnoiditis. Because these substances are hyperbaric once they were placed in the subarachnoid space they would migrate to the distal portion, where they remained, producing progressive scarring.
|Mechanism of action|
Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec.
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U.S. Patent 2,348,231.
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|ATC Codes||V08AD04 — Iofendylate|
|AHFS Codes||Not Available|
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|Description||This compound belongs to the class of chemical entities known as iodobenzenes. These are aromatic compounds containing one or more iodine atoms attached to a benzene.|
|Super Class||Organic compounds|
|Sub Class||Benzene and substituted derivatives|
|Alternative Parents||Fatty acid esters / Aryl iodides / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organoiodides / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds|
|Substituents||Fatty acid ester / Iodobenzene / Aryl halide / Aryl iodide / Fatty acyl / Carboxylic acid ester / Carboxylic acid derivative / Monocarboxylic acid or derivatives / Organoiodide / Organooxygen compound|
|Molecular Framework||Aromatic homomonocyclic compounds|
|External Descriptors||Not Available|