Identification

Name
Desflurane
Accession Number
DB01189  (APRD00907)
Type
Small Molecule
Groups
Approved
Description

Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.

Structure
Thumb
Synonyms
  • (+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether
  • 1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane
  • Desflurane
  • Desflurano
  • Desfluranum
  • Difluoromethyl 1,2,2,2-tetrafluoroethyl ether
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SupraneLiquid100 %Respiratory (inhalation)Baxter Laboratories1996-12-23Not applicableCanada
SupraneLiquid240 mL/240mLRespiratory (inhalation)Baxter Laboratories1992-09-18Not applicableUs
SupraneLiquid240 mL/240mLRespiratory (inhalation)Baxter Laboratories1992-09-18Not applicableUs
SupraneLiquid240 mL/240mLRespiratory (inhalation)General Injectables & Vaccines2012-04-25Not applicableUs
SupraneLiquid240 mL/240mLRespiratory (inhalation)Baxter Laboratories1992-09-18Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DesfluraneLiquid1 mL/mLRespiratory (inhalation)Piramal Critical Care Inc2017-01-01Not applicableUs
International/Other Brands
Suprane
Categories
UNII
CRS35BZ94Q
CAS number
57041-67-5
Weight
Average: 168.0378
Monoisotopic: 168.000983916
Chemical Formula
C3H2F6O
InChI Key
DPYMFVXJLLWWEU-UHFFFAOYSA-N
InChI
InChI=1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H
IUPAC Name
2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
SMILES
FC(F)OC(F)C(F)(F)F

Pharmacology

Indication

For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.

Structured Indications
Not Available
Pharmacodynamics

Desflurane is a general inhalation anesthetic. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Mechanism of action

Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Desflurane also binds to and agonizes the GABA receptor, the large conductance Ca2+ activated potassium channel, the glycine receptors, and antagonizes the glutamate receptors.

TargetActionsOrganism
AGABA-A receptor (anion channel)
positive allosteric modulator
Human
AGlycine receptor subunit alpha-1
agonist
Human
AGlutamate receptor 1
antagonist
Human
APotassium voltage-gated channel subfamily A member 1
inducer
Human
ACalcium-transporting ATPase type 2C member 1
inhibitor
Human
UATP synthase subunit delta, mitochondrial
other/unknown
Human
UNADH-ubiquinone oxidoreductase chain 1
unknown
Human
Absorption

Rapidly absorbed into the circulation via the lungs following inhalation.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed).

Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Voltage-dependent L-type calcium channel subunit alpha-1S---Not Availablec.3257G>A / c.520C>TADR InferredMalignant hyperthermia.Details
Ryanodine receptor 1---Not Availablec.103T>C / c.487C>T  … show all ADR InferredMalignant hyperthermia.Details

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when Desflurane is combined with 7-Nitroindazole.Experimental
AcebutololThe risk or severity of adverse effects can be increased when Desflurane is combined with Acebutolol.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Aceprometazine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Desflurane is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Desflurane is combined with Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Desflurane is combined with Alaproclate.Experimental
AldesleukinThe risk or severity of adverse effects can be increased when Desflurane is combined with Aldesleukin.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Desflurane is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Desflurane.Approved, Illicit
AliskirenThe risk or severity of adverse effects can be increased when Desflurane is combined with Aliskiren.Approved, Investigational
AllopregnanoloneThe risk or severity of adverse effects can be increased when Desflurane is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Desflurane is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Desflurane is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Desflurane.Approved, Illicit, Investigational
AmifostineThe risk or severity of adverse effects can be increased when Amifostine is combined with Desflurane.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Desflurane is combined with Amiloride.Approved
AmiodaroneDesflurane may increase the QTc-prolonging activities of Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Desflurane is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Desflurane is combined with Amitriptyline.Approved
AmlodipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Amlodipine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Desflurane is combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Desflurane is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Desflurane is combined with Amperozide.Experimental
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Desflurane.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Desflurane is combined with Amyl Nitrite.Approved
AnagrelideDesflurane may increase the QTc-prolonging activities of Anagrelide.Approved
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Desflurane.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Apraclonidine.Approved
AripiprazoleAripiprazole may increase the hypotensive activities of Desflurane.Approved, Investigational
ArotinololThe risk or severity of adverse effects can be increased when Arotinolol is combined with Desflurane.Approved, Investigational
Arsenic trioxideDesflurane may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherDesflurane may increase the QTc-prolonging activities of Artemether.Approved
ArticaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Articaine.Approved
AsenapineDesflurane may increase the QTc-prolonging activities of Asenapine.Approved
AtenololThe risk or severity of adverse effects can be increased when Desflurane is combined with Atenolol.Approved
Atracurium besylateDesflurane may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Azaperone.Investigational, Vet Approved
AzelastineDesflurane may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Desflurane is combined with Azilsartan medoxomil.Approved
AzithromycinDesflurane may increase the QTc-prolonging activities of Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Desflurane is combined with Baclofen.Approved
BarbexacloneBarbexaclone may increase the hypotensive activities of Desflurane.Experimental
BarbitalThe risk or severity of adverse effects can be increased when Desflurane is combined with Barbital.Illicit
BarnidipineThe risk or severity of adverse effects can be increased when Barnidipine is combined with Desflurane.Approved
BedaquilineDesflurane may increase the QTc-prolonging activities of Bedaquiline.Approved
BenazeprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Benazepril.Approved, Investigational
BendroflumethiazideThe risk or severity of adverse effects can be increased when Desflurane is combined with Bendroflumethiazide.Approved
BenperidolThe risk or severity of adverse effects can be increased when Desflurane is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Benzocaine.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Desflurane is combined with Benzyl alcohol.Approved
BepridilThe risk or severity of adverse effects can be increased when Bepridil is combined with Desflurane.Approved, Withdrawn
BetaxololThe risk or severity of adverse effects can be increased when Desflurane is combined with Betaxolol.Approved
BisoprololThe risk or severity of adverse effects can be increased when Desflurane is combined with Bisoprolol.Approved
BortezomibThe risk or severity of adverse effects can be increased when Bortezomib is combined with Desflurane.Approved, Investigational
BretyliumThe risk or severity of adverse effects can be increased when Desflurane is combined with Bretylium.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Desflurane is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
BromazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Bromazepam.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Desflurane is combined with Bromisoval.Experimental
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Desflurane.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Desflurane is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Desflurane is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Desflurane is combined with Brotizolam.Approved, Investigational, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Desflurane is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Bupivacaine.Approved, Investigational
BuprenorphineDesflurane may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Desflurane.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Desflurane.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Desflurane is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Desflurane is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Desflurane is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Desflurane.Approved, Illicit, Vet Approved
CanagliflozinThe risk or severity of adverse effects can be increased when Desflurane is combined with Canagliflozin.Approved
Candesartan cilexetilThe risk or severity of adverse effects can be increased when Desflurane is combined with Candesartan cilexetil.Approved
CanertinibThe risk or severity of adverse effects can be increased when Desflurane is combined with Canertinib.Investigational
CaptoprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Captopril.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Desflurane.Approved, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Desflurane.Approved
CarbinoxamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Desflurane is combined with Carfentanil.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Desflurane is combined with Carisoprodol.Approved
CarteololThe risk or severity of adverse effects can be increased when Desflurane is combined with Carteolol.Approved
CarvedilolThe risk or severity of adverse effects can be increased when Desflurane is combined with Carvedilol.Approved, Investigational
CeritinibDesflurane may increase the QTc-prolonging activities of Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Desflurane is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Desflurane is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Desflurane.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlormezanone.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Chloroprocaine.Approved
ChloroquineDesflurane may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorphenamine.Approved
ChlorpromazineDesflurane may increase the QTc-prolonging activities of Chlorpromazine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorzoxazone.Approved
CilazaprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Cilnidipine is combined with Desflurane.Approved, Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Cinchocaine.Approved, Vet Approved
CiprofloxacinDesflurane may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideDesflurane may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CitalopramDesflurane may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinDesflurane may increase the QTc-prolonging activities of Clarithromycin.Approved
ClemastineThe risk or severity of adverse effects can be increased when Desflurane is combined with Clemastine.Approved
ClevidipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Clevidipine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Desflurane is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Desflurane is combined with Clobazam.Approved, Illicit
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Desflurane.Approved, Investigational
clomethiazoleThe risk or severity of adverse effects can be increased when Desflurane is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Desflurane is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Desflurane is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Desflurane.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Desflurane is combined with Clothiapine.Experimental
ClozapineDesflurane may increase the QTc-prolonging activities of Clozapine.Approved
CocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Cocaine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Desflurane.Approved, Illicit
ConivaptanThe risk or severity of adverse effects can be increased when Conivaptan is combined with Desflurane.Approved, Investigational
CrizotinibDesflurane may increase the QTc-prolonging activities of Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Desflurane is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Desflurane.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Desflurane is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Desflurane is combined with Dantrolene.Approved
DapagliflozinThe risk or severity of adverse effects can be increased when Desflurane is combined with Dapagliflozin.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Desflurane is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Desflurane is combined with Deramciclane.Investigational
DesipramineThe risk or severity of adverse effects can be increased when Desflurane is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Desflurane is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desflurane is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Desflurane is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Desflurane is combined with Dextropropoxyphene.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dezocine.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Desflurane.Approved, Illicit, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Desflurane is combined with Diclofenamide.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Desflurane is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Desflurane is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dihydromorphine.Experimental, Illicit
DiltiazemThe risk or severity of adverse effects can be increased when Desflurane is combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Desflurane is combined with Dimenhydrinate.Approved
DinutuximabThe risk or severity of adverse effects can be increased when Desflurane is combined with Dinutuximab.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Desflurane.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Desflurane.Approved, Illicit
DipyridamoleThe risk or severity of adverse effects can be increased when Desflurane is combined with Dipyridamole.Approved
DisopyramideDesflurane may increase the QTc-prolonging activities of Disopyramide.Approved
DixyrazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dixyrazine.Experimental
DofetilideDesflurane may increase the QTc-prolonging activities of Dofetilide.Approved
DolasetronDesflurane may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneDesflurane may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DopamineDesflurane may increase the arrhythmogenic activities of Dopamine.Approved
DoramectinThe risk or severity of adverse effects can be increased when Desflurane is combined with Doramectin.Vet Approved
DoxazosinThe risk or severity of adverse effects can be increased when Desflurane is combined with Doxazosin.Approved
DoxepinThe risk or severity of adverse effects can be increased when Desflurane is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Desflurane is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved, Illicit
DronedaroneDesflurane may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Desflurane is combined with Drotebanol.Experimental, Illicit
DuloxetineDesflurane may increase the orthostatic hypotensive activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Desflurane is combined with Dyclonine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Desflurane is combined with Ecgonine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Desflurane is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Desflurane is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Efonidipine.Approved, Investigational
EliglustatDesflurane may increase the QTc-prolonging activities of Eliglustat.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Desflurane is combined with Eltanolone.Investigational
EmpagliflozinThe risk or severity of adverse effects can be increased when Desflurane is combined with Empagliflozin.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Desflurane is combined with Enalaprilat.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Enflurane.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Desflurane is combined with Entacapone.Approved, Investigational
EphedraEphedra may increase the arrhythmogenic activities of Desflurane.Approved, Nutraceutical, Withdrawn
EphedrineEphedrine may increase the arrhythmogenic activities of Desflurane.Approved
EpinephrineDesflurane may increase the arrhythmogenic activities of Epinephrine.Approved, Vet Approved
EplerenoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Eplerenone.Approved
EpoprostenolThe risk or severity of adverse effects can be increased when Desflurane is combined with Epoprostenol.Approved
EprosartanThe risk or severity of adverse effects can be increased when Desflurane is combined with Eprosartan.Approved
ErythromycinDesflurane may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramDesflurane may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
EsmololThe risk or severity of adverse effects can be increased when Desflurane is combined with Esmolol.Approved
EstazolamThe risk or severity of adverse effects can be increased when Desflurane is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Desflurane.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Desflurane is combined with Etacrynic acid.Approved
EthanolDesflurane may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Desflurane is combined with Ethchlorvynol.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Desflurane is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Desflurane is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Desflurane is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Desflurane is combined with Ethyl chloride.Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Desflurane is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Desflurane is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Desflurane is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Desflurane is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Desflurane is combined with Etomidate.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Desflurane is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Desflurane is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Desflurane is combined with Felbamate.Approved
FelodipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Fencamfamine.Approved, Illicit, Withdrawn
FenoldopamThe risk or severity of adverse effects can be increased when Desflurane is combined with Fenoldopam.Approved
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Desflurane.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Desflurane is combined with Fexofenadine.Approved
FimasartanThe risk or severity of adverse effects can be increased when Desflurane is combined with Fimasartan.Approved, Investigational
FlecainideDesflurane may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe risk or severity of adverse effects can be increased when Desflurane is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Desflurane is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Flunitrazepam.Approved, Illicit
FluoxetineDesflurane may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FlupentixolDesflurane may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Desflurane.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Desflurane.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Desflurane is combined with Fluspirilene.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Desflurane is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Fluvoxamine.Approved, Investigational
FormoterolDesflurane may increase the arrhythmogenic activities of Formoterol.Approved, Investigational
FosinoprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Fosinopril.Approved
FosphenytoinThe risk or severity of adverse effects can be increased when Desflurane is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Desflurane is combined with Fospropofol.Approved, Illicit, Investigational
FurosemideThe risk or severity of adverse effects can be increased when Desflurane is combined with Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Desflurane.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Desflurane is combined with Gabapentin Enacarbil.Approved
Gadobenic acidDesflurane may increase the QTc-prolonging activities of Gadobenic acid.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Desflurane is combined with Gamma Hydroxybutyric Acid.Approved, Illicit, Investigational
GemifloxacinDesflurane may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GepironeThe risk or severity of adverse effects can be increased when Desflurane is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Desflurane is combined with Glutethimide.Approved, Illicit
GoserelinDesflurane may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronDesflurane may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GuanfacineThe risk or severity of adverse effects can be increased when Desflurane is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Halazepam.Approved, Illicit, Withdrawn
HaloperidolDesflurane may increase the QTc-prolonging activities of Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Desflurane is combined with Halothane.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Desflurane is combined with Heroin.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Desflurane is combined with Hexobarbital.Approved
HydralazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Hydralazine.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Desflurane is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneDesflurane may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Desflurane is combined with Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Desflurane.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
IbutilideDesflurane may increase the QTc-prolonging activities of Ibutilide.Approved
IloperidoneDesflurane may increase the QTc-prolonging activities of Iloperidone.Approved
IloprostThe risk or severity of adverse effects can be increased when Desflurane is combined with Iloprost.Approved, Investigational
ImidaprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Imidapril.Investigational
ImipramineThe risk or severity of adverse effects can be increased when Desflurane is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Desflurane is combined with Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Desflurane is combined with Indapamide.Approved
IndiplonThe risk or severity of adverse effects can be increased when Desflurane is combined with Indiplon.Investigational
IndoraminThe risk or severity of adverse effects can be increased when Desflurane is combined with Indoramin.Withdrawn
IrbesartanThe risk or severity of adverse effects can be increased when Desflurane is combined with Irbesartan.Approved, Investigational
IsocarboxazidThe risk or severity of adverse effects can be increased when Desflurane is combined with Isocarboxazid.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Desflurane.Approved, Vet Approved
IsoprenalineDesflurane may increase the arrhythmogenic activities of Isoprenaline.Approved
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Desflurane is combined with Isosorbide Dinitrate.Approved
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Desflurane is combined with Isosorbide Mononitrate.Approved
IsoxsuprineThe risk or severity of adverse effects can be increased when Desflurane is combined with Isoxsuprine.Approved, Withdrawn
IsradipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Isradipine.Approved
KetamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Desflurane is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Ketobemidone.Approved, Investigational
LabetalolThe risk or severity of adverse effects can be increased when Desflurane is combined with Labetalol.Approved
LacidipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Lacidipine.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Desflurane is combined with Lamotrigine.Approved, Investigational
LenvatinibDesflurane may increase the QTc-prolonging activities of Lenvatinib.Approved
LercanidipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Lercanidipine.Approved, Investigational
LeuprolideDesflurane may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Desflurane is combined with Levetiracetam.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Desflurane is combined with Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Levobupivacaine.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Desflurane is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Desflurane is combined with Levocetirizine.Approved
LevodopaDesflurane may increase the orthostatic hypotensive activities of Levodopa.Approved
LevofloxacinDesflurane may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Desflurane is combined with Levomethadyl Acetate.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Desflurane is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Desflurane.Approved
LevosimendanThe risk or severity of adverse effects can be increased when Desflurane is combined with Levosimendan.Approved, Investigational
LidocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Lidocaine.Approved, Vet Approved
LisinoprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Lisinopril.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Desflurane is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Desflurane is combined with Lofentanil.Illicit
LofexidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Lofexidine.Approved, Investigational
LopinavirDesflurane may increase the QTc-prolonging activities of Lopinavir.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Desflurane is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Desflurane is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desflurane.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Lormetazepam.Approved
LosartanThe risk or severity of adverse effects can be increased when Desflurane is combined with Losartan.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Desflurane.Approved
LumefantrineDesflurane may increase the QTc-prolonging activities of Lumefantrine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Desflurane is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Desflurane is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Desflurane is combined with Mebicar.Experimental
MecamylamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Mecamylamine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Desflurane is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Desflurane is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Melperone.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Desflurane.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Desflurane is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Mesoridazine.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Desflurane is combined with Metaxalone.Approved
MethadoneDesflurane may increase the QTc-prolonging activities of Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Desflurane is combined with Methadyl Acetate.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Desflurane is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Desflurane is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Desflurane is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Desflurane.Approved
MethotrimeprazineDesflurane may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Methoxyflurane.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Desflurane is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Desflurane is combined with Methyclothiazide.Approved
MethyldopaThe risk or severity of adverse effects can be increased when Desflurane is combined with Methyldopa.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Desflurane is combined with Methylecgonine.Experimental
MethylphenidateMethylphenidate may increase the hypertensive activities of Desflurane.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Desflurane is combined with Methylphenobarbital.Approved
MetipranololThe risk or severity of adverse effects can be increased when Desflurane is combined with Metipranolol.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Metolazone.Approved
MetoprololThe risk or severity of adverse effects can be increased when Desflurane is combined with Metoprolol.Approved, Investigational
MetyrosineDesflurane may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Desflurane.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Desflurane.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Desflurane is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved, Investigational
MinoxidilThe risk or severity of adverse effects can be increased when Desflurane is combined with Minoxidil.Approved
MirtazapineDesflurane may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MivacuriumDesflurane may increase the neuromuscular blocking activities of Mivacurium.Approved
MoexiprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Moexipril.Approved
MolindoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Molindone.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Desflurane.Approved, Investigational
MoxifloxacinDesflurane may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
MoxonidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Moxonidine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved, Investigational
NadololThe risk or severity of adverse effects can be increased when Desflurane is combined with Nadolol.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Desflurane.Approved
NebivololThe risk or severity of adverse effects can be increased when Desflurane is combined with Nebivolol.Approved, Investigational
NefazodoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Nefazodone.Approved, Withdrawn
NesiritideThe risk or severity of adverse effects can be increased when Desflurane is combined with Nesiritide.Approved, Investigational
NicardipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Nicardipine.Approved
NicorandilNicorandil may increase the hypotensive activities of Desflurane.Approved, Investigational
NifedipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Nifedipine.Approved
NilotinibDesflurane may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NilvadipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Nilvadipine.Approved, Investigational
NimodipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Nimodipine.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Nisoldipine.Approved
NitrazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitrazepam.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitrendipine.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitric Oxide.Approved
NitroglycerinThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitroglycerin.Approved, Investigational
NitroprussideThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitroprusside.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Desflurane is combined with Nitrous oxide.Approved, Vet Approved
NorepinephrineDesflurane may increase the arrhythmogenic activities of Norepinephrine.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Desflurane is combined with Nortriptyline.Approved
ObinutuzumabThe risk or severity of adverse effects can be increased when Desflurane is combined with Obinutuzumab.Approved
OfloxacinDesflurane may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Desflurane.Approved, Investigational
OlmesartanThe risk or severity of adverse effects can be increased when Desflurane is combined with Olmesartan.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Desflurane is combined with Olopatadine.Approved
OndansetronDesflurane may increase the QTc-prolonging activities of Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Desflurane is combined with Opium.Approved, Illicit
OrphenadrineDesflurane may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Desflurane is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Desflurane.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Oxethazaine.Approved, Investigational
OxprenololThe risk or severity of adverse effects can be increased when Desflurane is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Oxybuprocaine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Desflurane.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Oxymorphone.Approved, Investigational, Vet Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Desflurane is combined with Paclitaxel.Approved, Vet Approved
PaliperidoneDesflurane may increase the QTc-prolonging activities of Paliperidone.Approved
PanobinostatDesflurane may increase the QTc-prolonging activities of Panobinostat.Approved, Investigational
PapaverineThe risk or severity of adverse effects can be increased when Desflurane is combined with Papaverine.Approved
ParaldehydeDesflurane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Desflurane is combined with Paroxetine.Approved, Investigational
PazopanibDesflurane may increase the QTc-prolonging activities of Pazopanib.Approved
PenbutololThe risk or severity of adverse effects can be increased when Desflurane is combined with Penbutolol.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Desflurane is combined with Penfluridol.Experimental
PentamidineDesflurane may increase the QTc-prolonging activities of Pentamidine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Desflurane.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Desflurane.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
PerazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Perazine.Investigational
PerflutrenDesflurane may increase the QTc-prolonging activities of Perflutren.Approved
PerindoprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Perindopril.Approved
PerospironeThe risk or severity of adverse effects can be increased when Desflurane is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Desflurane.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Desflurane.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenazocine.Experimental
PhenelzineThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenelzine.Approved
PhenibutThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenibut.Experimental
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Desflurane.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenoperidine.Experimental
PhenoxybenzamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenoxybenzamine.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenoxyethanol.Approved
PhentolamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Phentolamine.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Desflurane is combined with Phenytoin.Approved, Vet Approved
PimozideDesflurane may increase the QTc-prolonging activities of Pimozide.Approved
PindololThe risk or severity of adverse effects can be increased when Desflurane is combined with Pindolol.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Pipamperone.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Pipotiazine.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Desflurane is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Desflurane is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Desflurane is combined with Pomalidomide.Approved
PramipexoleDesflurane may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Prazepam.Approved, Illicit
PrazosinThe risk or severity of adverse effects can be increased when Desflurane is combined with Prazosin.Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Desflurane.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Prilocaine.Approved
PrimaquineDesflurane may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Primidone.Approved, Vet Approved
ProcainamideDesflurane may increase the QTc-prolonging activities of Procainamide.Approved
ProcaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Desflurane.Approved, Vet Approved
PromazineDesflurane may increase the QTc-prolonging activities of Promazine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Promethazine.Approved
PropafenoneDesflurane may increase the QTc-prolonging activities of Propafenone.Approved
PropanididThe risk or severity of adverse effects can be increased when Desflurane is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Proparacaine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Desflurane.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Propoxycaine.Approved
PropranololThe risk or severity of adverse effects can be increased when Desflurane is combined with Propranolol.Approved, Investigational
ProtriptylineThe risk or severity of adverse effects can be increased when Desflurane is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Desflurane is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Desflurane is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Quazepam.Approved, Illicit
QuetiapineDesflurane may increase the QTc-prolonging activities of Quetiapine.Approved
QuinaprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Quinapril.Approved, Investigational
QuinidineDesflurane may increase the QTc-prolonging activities of Quinidine.Approved
QuinineDesflurane may increase the QTc-prolonging activities of Quinine.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Desflurane is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Desflurane is combined with Ramelteon.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Ramipril.Approved
RapacuroniumDesflurane may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
RasagilineThe risk or severity of adverse effects can be increased when Desflurane is combined with Rasagiline.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Desflurane.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Desflurane is combined with Remoxipride.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Desflurane.Approved, Investigational
RiociguatThe risk or severity of adverse effects can be increased when Desflurane is combined with Riociguat.Approved
RisperidoneDesflurane may increase the hypotensive activities of Risperidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Desflurane is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Romifidine.Vet Approved
RopiniroleDesflurane may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Ropivacaine.Approved
RotigotineDesflurane may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Desflurane.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Desflurane is combined with Sacubitril.Approved
SaquinavirDesflurane may increase the QTc-prolonging activities of Saquinavir.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Desflurane.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Desflurane is combined with Selegiline.Approved, Investigational, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Desflurane is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Desflurane is combined with Sertindole.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Desflurane is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Sevoflurane.Approved, Vet Approved
Sodium NitriteThe risk or severity of adverse effects can be increased when Desflurane is combined with Sodium Nitrite.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
SotalolDesflurane may increase the QTc-prolonging activities of Sotalol.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Spironolactone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Desflurane is combined with Stiripentol.Approved
StreptokinaseThe risk or severity of adverse effects can be increased when Desflurane is combined with Streptokinase.Approved, Investigational
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Desflurane.Approved, Investigational
SulfisoxazoleDesflurane may increase the QTc-prolonging activities of Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Desflurane is combined with Sulpiride.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Desflurane is combined with Sultopride.Experimental
SuvorexantDesflurane may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TamsulosinThe risk or severity of adverse effects can be increased when Desflurane is combined with Tamsulosin.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Desflurane is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Desflurane.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Desflurane is combined with Tasimelteon.Approved
TelavancinDesflurane may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinDesflurane may increase the QTc-prolonging activities of Telithromycin.Approved
TelmisartanThe risk or severity of adverse effects can be increased when Desflurane is combined with Telmisartan.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Desflurane.Approved
TerazosinThe risk or severity of adverse effects can be increased when Desflurane is combined with Terazosin.Approved
TetrabenazineDesflurane may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Desflurane is combined with Tetrodotoxin.Investigational
ThalidomideDesflurane may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Desflurane is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Desflurane is combined with Thiopental.Approved, Vet Approved
ThioridazineDesflurane may increase the QTc-prolonging activities of Thioridazine.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Desflurane is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Desflurane is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tilidine.Experimental
TimololThe risk or severity of adverse effects can be increased when Desflurane is combined with Timolol.Approved
TizanidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tizanidine.Approved
TolazolineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tolazoline.Approved, Vet Approved
TolcaponeThe risk or severity of adverse effects can be increased when Desflurane is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Desflurane is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Desflurane is combined with Torasemide.Approved
ToremifeneDesflurane may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Desflurane.Approved, Investigational
TrandolaprilThe risk or severity of adverse effects can be increased when Desflurane is combined with Trandolapril.Approved
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Desflurane is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Desflurane is combined with Tranylcypromine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Desflurane is combined with Trazodone.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Desflurane is combined with Tretinoin.Approved, Investigational, Nutraceutical
TriamtereneThe risk or severity of adverse effects can be increased when Desflurane is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Desflurane.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Desflurane is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Desflurane is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Desflurane.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Desflurane is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Triflupromazine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Desflurane is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Desflurane is combined with Valproic Acid.Approved, Investigational
ValsartanThe risk or severity of adverse effects can be increased when Desflurane is combined with Valsartan.Approved, Investigational
VandetanibDesflurane may increase the QTc-prolonging activities of Vandetanib.Approved
VemurafenibDesflurane may increase the QTc-prolonging activities of Vemurafenib.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Desflurane is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Desflurane is combined with Veralipride.Experimental
VerapamilThe risk or severity of adverse effects can be increased when Desflurane is combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Desflurane is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Desflurane is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Desflurane is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Desflurane is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Desflurane is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Desflurane.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Desflurane is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Desflurane is combined with Zimelidine.Withdrawn
ZiprasidoneDesflurane may increase the QTc-prolonging activities of Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Desflurane is combined with Zolazepam.Vet Approved
ZolpidemDesflurane may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Desflurane is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Desflurane is combined with Zopiclone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Desflurane is combined with Zotepine.Approved, Investigational
ZuclopenthixolDesflurane may increase the QTc-prolonging activities of Zuclopenthixol.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Leonid A. Rozov, Chialang Huang, Gerald G. Vernice, "Synthesis of desflurane." U.S. Patent US5205914, issued June, 1991.

US5205914
General References
Not Available
External Links
Human Metabolome Database
HMDB15320
KEGG Drug
D00546
KEGG Compound
C07519
PubChem Compound
42113
PubChem Substance
46505270
ChemSpider
38403
ChEBI
4445
ChEMBL
CHEMBL1200733
Therapeutic Targets Database
DAP000693
PharmGKB
PA164749136
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Desflurane
ATC Codes
N01AB07 — Desflurane
AHFS Codes
  • 28:04.16 — Inhalation Anesthetics
FDA label
Download (174 KB)
MSDS
Download (51.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedTreatmentPostoperative Cognitive Dysfunction1
2CompletedSupportive CareColorectal Cancers1
2CompletedTreatmentKnee Replacement Surgery / Orthopedic Procedures / Total Hip Prosthesis1
2CompletedTreatmentTransplant; Failure, Kidney1
2RecruitingSupportive CareDown Syndrome (DS)1
2, 3CompletedTreatmentAnaesthesia therapy1
3CompletedHealth Services ResearchBaxter Anaesthesia Brand of Desflurane / Cystoscopes / Sevoflurane1
3CompletedPreventionOrthopedic Disorders1
3CompletedTreatmentAnesthesia With Use of LMA (Laryngeal Mask Airway)1
3CompletedTreatmentHepatectomy1
3RecruitingPreventionAnaesthesia therapy2
3RecruitingPreventionAdjunct to general anesthesia therapy1
4CompletedNot AvailableAnaesthesia therapy1
4CompletedDiagnosticAnaesthesia1
4CompletedHealth Services ResearchEmergence Agitation1
4CompletedPreventionPostoperative Cognitive Functions1
4CompletedPreventionPostreperfusion Syndrome / Transplantation, Liver1
4CompletedPreventionProstate Cancer1
4CompletedPreventionAdjunct to general anesthesia therapy / Strabismus1
4CompletedSupportive CareCalculi / Excessive Repair / Exposure Laser / Injury of Bladder / Ureteral Stent Occlusion / Ureterostomy; Functional Disturbance / Vaginal Diseases1
4CompletedSupportive CareCoronary Artery Disease1
4CompletedSupportive CareEnd Stage Renal Disease (ESRD) / Healthy Volunteers1
4CompletedSupportive CareNausea / Tiredness1
4CompletedTreatmentAirway Reflexes, Protective / Anesthetic Recovery / Recovery After Neuromuscular Block1
4CompletedTreatmentArthritis / BMI >30 kg/m21
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentDeep Extubation1
4CompletedTreatmentDelayed Emergence From Anesthesia1
4CompletedTreatmentPulmonary Aspiration1
4CompletedTreatmentThoracic Surgery1
4Not Yet RecruitingSupportive CareCognition Disorders in Old Age1
4RecruitingBasic ScienceAnesthesia; Bariatric Surgery1
4RecruitingDiagnosticAnesthesia; Adverse Effect / Laryngeal Masks / Respiratory System Abnormalities1
4RecruitingDiagnosticOxygen Saturation1
4RecruitingDiagnosticPostoperative Delirium1
4RecruitingPreventionCholangiocarcinomas / Gallbladder Neoplasms / Hepatocellular,Carcinoma1
4RecruitingPreventionCoronary Artery Bypass Graft Redo / General Anesthetic Drug Adverse Reaction1
4RecruitingPreventionSleep Apnea Syndromes / Sleep Apnea, Obstructive1
4RecruitingTreatmentAdenocarcinomas / Circulating Tumor Cells / Circulating Tumor Cells in Pancreatic Cancer Surgery / Neoplasms, Pancreatic1
4RecruitingTreatmentAnesthetic Complication Spinal / Microcirculation1
4RecruitingTreatmentCoronary Artery Bypass Graft / Coronary Artery Bypass Grafting (CABG) Surgery / Surgery, Cardiac1
4TerminatedDiagnosticVentricular Dysfunction / Young Healthy Adults1
4Unknown StatusSupportive CarePectus Excavatum1
4Unknown StatusTreatmentAortic Valve Stenosis1
4Unknown StatusTreatmentPatients Undergoing Elective Craniotomy1
Not AvailableActive Not RecruitingNot AvailableLung Cancers1
Not AvailableActive Not RecruitingPreventionIschemic Optic Neuropathy1
Not AvailableCompletedNot AvailableAnaesthesia therapy / General Surgery1
Not AvailableCompletedNot AvailableDepth of Anesthesia (DOA)1
Not AvailableCompletedNot AvailableNephrectomy,Kidney Donation1
Not AvailableCompletedNot AvailableRhytidoplasty1
Not AvailableCompletedNot AvailableAdjunct to general anesthesia therapy1
Not AvailableCompletedBasic SciencePharmacokinetics of Inhaled Anesthetics1
Not AvailableCompletedDiagnosticCancer, Ovarian / Cervical Cancers / Gallbladder Inflammation / Ovarian Cysts / Uterine Leiomyomas1
Not AvailableCompletedHealth Services ResearchDelayed Recovery From Anaesthesia1
Not AvailableCompletedHealth Services ResearchUnconscious State1
Not AvailableCompletedOtherEntropion1
Not AvailableCompletedOtherObese1
Not AvailableCompletedPreventionAmbulation Difficulty / Children / Urologic Diseases1
Not AvailableCompletedPreventionAnaesthesia therapy / Catheter Site Discomfort / Complications / Urinary Bladder Neoplasms1
Not AvailableCompletedPreventionDesflurane Anesthesia1
Not AvailableCompletedPreventionIdiopathic Scoliosis1
Not AvailableCompletedPreventionIschemia, Cerebral1
Not AvailableCompletedPreventionVitrectomy Operation Under General Anesthesia1
Not AvailableCompletedSupportive CareAirway Complications1
Not AvailableCompletedSupportive CareIdiopathic Scoliosis1
Not AvailableCompletedSupportive CareIntraocular Pressure1
Not AvailableCompletedTreatmentAmnesia / Cognition Disorders / Coronary Artery Bypass Graft / Delirium / Dementias / Morbidity1
Not AvailableCompletedTreatmentEar Deformities, Acquired1
Not AvailableCompletedTreatmentGeneral Anesthetic Drug Adverse Reaction1
Not AvailableCompletedTreatmentMechanical Ventilation Complication1
Not AvailableCompletedTreatmentPostoperative pain1
Not AvailableCompletedTreatmentStatus;Splenectomy1
Not AvailableCompletedTreatmentAdjunct to general anesthesia therapy1
Not AvailableEnrolling by InvitationScreeningAnaesthesia therapy / General Surgery / Ophthalmic1
Not AvailableNot Yet RecruitingPreventionHip Arthroplasty1
Not AvailableNot Yet RecruitingTreatmentAdjunct to general anesthesia therapy1
Not AvailableRecruitingNot AvailableAnesthetics, Inhalation1
Not AvailableRecruitingNot AvailableHealthy Volunteers1
Not AvailableRecruitingNot AvailablePituitary Adenomas1
Not AvailableRecruitingNot AvailableShort Stature1
Not AvailableRecruitingBasic ScienceTransient ischemia attacks1
Not AvailableRecruitingPreventionAcute Lung Injury (ALI)1
Not AvailableRecruitingPreventionArterial Hypotension1
Not AvailableRecruitingPreventionNeoplasms, Thyroid1
Not AvailableRecruitingPreventionProphylaxis against postoperative nausea and vomiting1
Not AvailableUnknown StatusNot AvailableHemifacial Spasm1
Not AvailableUnknown StatusScreeningAnesthesia Recovery Period / Delirium, Dementia, Cognitive Disorders / Mental Competency / Neurobehavioural Manifestation1
Not AvailableUnknown StatusSupportive CareAdjunct to general anesthesia therapy1
Not AvailableWithdrawnNot AvailableOptic Nerve Sheath1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Dosage forms
FormRouteStrength
LiquidRespiratory (inhalation)1 mL/mL
LiquidRespiratory (inhalation)100 %
LiquidRespiratory (inhalation)240 mL/240mL
Prices
Unit descriptionCostUnit
Suprane inhalation liquid0.76USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5617906No1994-10-082014-10-08Us

Properties

State
Liquid
Experimental Properties
PropertyValueSource
boiling point (°C)23.5 °CNot Available
water solubilityNegligibleNot Available
logP1.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility3.54 mg/mLALOGPS
logP2.19ALOGPS
logP2.4ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)18.87ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area9.23 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity18.12 m3·mol-1ChemAxon
Polarizability7.89 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9974
Blood Brain Barrier+0.9941
Caco-2 permeable+0.626
P-glycoprotein substrateNon-substrate0.883
P-glycoprotein inhibitor INon-inhibitor0.9415
P-glycoprotein inhibitor IINon-inhibitor0.9027
Renal organic cation transporterNon-inhibitor0.9311
CYP450 2C9 substrateNon-substrate0.8676
CYP450 2D6 substrateNon-substrate0.919
CYP450 3A4 substrateNon-substrate0.7556
CYP450 1A2 substrateNon-inhibitor0.6194
CYP450 2C9 inhibitorNon-inhibitor0.836
CYP450 2D6 inhibitorNon-inhibitor0.9466
CYP450 2C19 inhibitorNon-inhibitor0.707
CYP450 3A4 inhibitorNon-inhibitor0.9604
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8921
Ames testNon AMES toxic0.9042
CarcinogenicityCarcinogens 0.7045
BiodegradationNot ready biodegradable0.9566
Rat acute toxicity1.2690 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9724
hERG inhibition (predictor II)Non-inhibitor0.909
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as organofluorides. These are compounds containing a chemical bond between a carbon atom and a fluorine atom.
Kingdom
Organic compounds
Super Class
Organohalogen compounds
Class
Organofluorides
Sub Class
Not Available
Direct Parent
Organofluorides
Alternative Parents
Organooxygen compounds / Hydrocarbon derivatives / Alkyl fluorides
Substituents
Organic oxygen compound / Hydrocarbon derivative / Organooxygen compound / Organofluoride / Alkyl halide / Alkyl fluoride / Aliphatic acyclic compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organofluorine compound (CHEBI:4445)

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Positive allosteric modulator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...

Components:
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Transmitter-gated ion channel activity
Specific Function
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Gene Name
GLRA1
Uniprot ID
P23415
Uniprot Name
Glycine receptor subunit alpha-1
Molecular Weight
52623.35 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Grasshoff C, Antkowiak B: Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats. Br J Anaesth. 2006 Nov;97(5):687-94. Epub 2006 Sep 13. [PubMed:16973644]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Pdz domain binding
Specific Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a co...
Gene Name
GRIA1
Uniprot ID
P42261
Uniprot Name
Glutamate receptor 1
Molecular Weight
101505.245 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Dildy-Mayfield JE, Eger EI 2nd, Harris RA: Anesthetics produce subunit-selective actions on glutamate receptors. J Pharmacol Exp Ther. 1996 Mar;276(3):1058-65. [PubMed:8786535]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inducer
General Function
Voltage-gated potassium channel activity
Specific Function
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:1990381...
Gene Name
KCNA1
Uniprot ID
Q09470
Uniprot Name
Potassium voltage-gated channel subfamily A member 1
Molecular Weight
56465.01 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Matchett GA, Allard MW, Martin RD, Zhang JH: Neuroprotective effect of volatile anesthetic agents: molecular mechanisms. Neurol Res. 2009 Mar;31(2):128-34. doi: 10.1179/174313209X393546. [PubMed:19298752]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Signal transducer activity
Specific Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Gene Name
ATP2C1
Uniprot ID
P98194
Uniprot Name
Calcium-transporting ATPase type 2C member 1
Molecular Weight
100576.42 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Other/unknown
General Function
Transporter activity
Specific Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport comp...
Gene Name
ATP5D
Uniprot ID
P30049
Uniprot Name
ATP synthase subunit delta, mitochondrial
Molecular Weight
17489.755 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Kosk-Kosicka D, Roszczynska G: Inhibition of plasma membrane Ca(2+)-ATPase activity by volatile anesthetics. Anesthesiology. 1993 Oct;79(4):774-80. [PubMed:8214757]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Unknown
General Function
Nadh dehydrogenase (ubiquinone) activity
Specific Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the tra...
Gene Name
MT-ND1
Uniprot ID
P03886
Uniprot Name
NADH-ubiquinone oxidoreductase chain 1
Molecular Weight
35660.055 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Sawas AH, Pentyala SN, Rebecchi MJ: Binding of volatile anesthetics to serum albumin: measurements of enthalpy and solvent contributions. Biochemistry. 2004 Oct 5;43(39):12675-85. [PubMed:15449957]

Drug created on June 13, 2005 07:24 / Updated on December 10, 2017 17:18