Showing BioInteractions for Levodopa (DB01235)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Levodopa is a Dopamine D1 receptor agonist | ||
| 1 | Dopamine D1 receptor antagonists | Acepromazine, Amoxapine, Aripiprazole, Asenapine, Carphenazine, Chlorpromazine, Chlorprothixene, Clozapine, Flupentixol, Fluphenazine, Haloperidol, Iloperidone, Lisuride, Loxapine, Methotrimeprazine, Methylergometrine, Olanzapine, Paliperidone, Periciazine, Perphenazine, Pipamperone, Pipotiazine, Quetiapine, Risperidone, Tetrahydropalmatine, Thioproperazine, Thioridazine, Thiothixene, Triflupromazine, Ziprasidone, Zuclopenthixol |
| 2 | Dopamine D1 receptor agonists | Apomorphine, Bromocriptine, Cabergoline, Dopamine, Fenoldopam, Minaprine, Pergolide, Rotigotine |
| 3 | Dopamine D1 receptor partial agonists | Aripiprazole, Phenylpropanolamine |
| 4 | Dopamine D1 receptor ligands | Aripiprazole |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Levodopa is a Dopamine D3 receptor agonist | ||
| 1 | Dopamine D3 receptor antagonists | Amisulpride, Amoxapine, Aripiprazole, AS-8112, Asenapine, Blonanserin, Buspirone, Chlorprothixene, Clozapine, Domperidone, Flupentixol, Iloperidone, Methotrimeprazine, Olanzapine, Paliperidone, Pimozide, Remoxipride, Sulpiride, Yohimbine, Ziprasidone |
| 2 | Dopamine D3 receptor agonists | Apomorphine, Bromocriptine, Cabergoline, Captodiame, Cariprazine, Dopamine, Lisuride, Pergolide, Pramipexole, Ropinirole, Rotigotine, Tianeptine |
| 3 | Dopamine D3 receptor partial agonists | Aripiprazole, Cariprazine, Dihydro-alpha-ergocryptine |
| 4 | Dopamine D3 receptor inverse agonists | Haloperidol |
| 5 | Dopamine D3 receptor ligands | Quetiapine, Sarizotan |
| 6 | Dopamine D3 receptor inhibitors | Chlorpromazine |
| 7 | Dopamine D3 receptor binders | Loxapine, Mianserin |
| 8 | Dopamine D3 receptor blockers | Tiapride |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Levodopa is a Dopamine D4 receptor agonist | ||
| 1 | Dopamine D4 receptor antagonists | Amoxapine, Aripiprazole, Asenapine, Bromocriptine, Buspirone, Clozapine, Flibanserin, Flupentixol, Iloperidone, Methotrimeprazine, Olanzapine, Paliperidone, Perospirone, Pipamperone, Remoxipride, Sulpiride, Ziprasidone |
| 2 | Dopamine D4 receptor agonists | Apomorphine, Cabergoline, Dopamine, Flibanserin, Lisuride, Pergolide, Pramipexole, Ropinirole, Rotigotine |
| 3 | Dopamine D4 receptor partial agonists | Aripiprazole |
| 4 | Dopamine D4 receptor ligands | Quetiapine |
| 5 | Dopamine D4 receptor binders | Chlorpromazine, Loxapine |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Levodopa is a Dopamine D5 receptor agonist | ||
| 1 | Dopamine D5 receptor agonists | Apomorphine, Bromocriptine, Cabergoline, Dopamine, Fenoldopam, Pergolide, Rotigotine |
| 2 | Dopamine D5 receptor antagonists | Aripiprazole, Carphenazine, Lisuride, Methotrimeprazine, Olanzapine, Ziprasidone, Zuclopenthixol |
| 3 | Dopamine D5 receptor partial agonists | Aripiprazole |
| 4 | Dopamine D5 receptor ligands | Aripiprazole, Quetiapine |
| 5 | Dopamine D5 receptor inhibitors | Chlorpromazine |
| 6 | Dopamine D5 receptor binders | Loxapine |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Levodopa is a Aromatic-L-amino-acid decarboxylase substrate | ||
| 1 | Aromatic-L-amino-acid decarboxylase cofactors | Pyridoxal phosphate |
| 2 | Aromatic-L-amino-acid decarboxylase inhibitors | Benserazide, Carbidopa, Cycloserine, Methyldopa |
| 3 | Aromatic-L-amino-acid decarboxylase substrates | Droxidopa, Fluorodopa (18F), Tryptophan |
| 4 | Aromatic-L-amino-acid decarboxylase inducers | Amantadine, Flupentixol |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Levodopa is a Solute carrier family 15 member 1 inhibitor | ||
| 1 | Solute carrier family 15 member 1 inhibitors | Aminolevulinic acid, Amoxicillin, Ampicillin, Azidocillin, Benzylpenicillin, Captopril, Cefaclor, Cefadroxil, Cefalotin, Cefdinir, Cefepime, Cefixime, Cefmetazole, Cefotaxime, Cefradine, Ceftazidime, Ceftibuten, Ceftriaxone, Cefuroxime, Cephalexin, Chlorpropamide, Cloxacillin, Cyclacillin, Dicloxacillin, Enalapril, Fluvastatin, Glyburide, Lisinopril, Loracarbef, Methyldopa, Nateglinide, Oxacillin, Tolbutamide, Ubenimex, Valaciclovir |
| 2 | Solute carrier family 15 member 1 substrates | Benazepril, Benzylpenicillin, Cefadroxil, Cefdinir, Cefixime, Cefradine, Ceftibuten, Ceftizoxime, Cephalexin, Cilazapril, Enalapril, Fluvastatin, Fosinopril, Lisdexamfetamine, Lisinopril, Methotrexate, Moexipril, Oseltamivir, Perindopril, Quinapril, Ramipril, Spirapril, Taurine, Trandolapril, Valaciclovir |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Levodopa is a Monocarboxylate transporter 10 inhibitor | ||
| 1 | Monocarboxylate transporter 10 inhibitors | Alanine, Arginine, Asparagine, Aspartic acid, Cysteine, Cystine, D-Alanine, D-Leucine, D-Phenylalanine, D-Serine, D-Tryptophan, D-Tyrosine, Droxidopa, Glutamic acid, Glycine, Histidine, Isoleucine, L-Glutamine, Lactic acid, Leucine, Liothyronine, Liotrix, Lysine, Methionine, Phenylalanine, Proline, Pyruvic acid, Serine, Threonine, Tryptophan, Tyrosine, Valine |
| 2 | Monocarboxylate transporter 10 substrates | 2-aminoisobutyric acid, beta-Alanine, D-Phenylalanine, Glutamic acid, Glycine, Histidine, Lactic acid, Lysine, Pyruvic acid |