Showing BioInteractions for Lapatinib (DB01259)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Lapatinib is a Epidermal growth factor receptor antagonist
1Epidermal growth factor receptor antagonistsCetuximab, Erlotinib, Gefitinib, Icotinib, Lidocaine, Necitumumab, Zalutumumab
2Epidermal growth factor receptor suppressorsPanitumumab
3Epidermal growth factor receptor inhibitorsAfatinib, Brigatinib, Fostamatinib, Neratinib, Olmutinib, Osimertinib, Vandetanib
4Epidermal growth factor receptor agonistsForeskin keratinocyte (neonatal)
Interacting GroupInteracting Drugs
Lapatinib is a Receptor tyrosine-protein kinase erbB-2 antagonist
1Receptor tyrosine-protein kinase erbB-2 inhibitorsAfatinib, Brigatinib, Fostamatinib
Interacting GroupInteracting Drugs
Lapatinib is a Cytochrome P450 3A4 substrate
1Cytochrome P450 3A4 substrates(S)-Warfarin, 16-Bromoepiandrosterone, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azithromycin, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzphetamine, Benzyl alcohol, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Cannabidiol, Carbamazepine, Carbinoxamine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofazimine, Clofibrate, clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepate, Clorindione, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone Pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dicoumarol, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Digoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Dotarizine, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Drospirenone, Dutasteride, Dydrogesterone, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Emopamil, Enalapril, Enasidenib, Encorafenib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Ergocalciferol, Ergoloid mesylate, Ergonovine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fendiline, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Fish oil, Flibanserin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fosnetupitant, Fostamatinib, Fulvestrant, Gabapentin, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydromorphone, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipecac, Ipratropium, Irinotecan, Isavuconazole, Isavuconazonium, Isosorbide dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lamotrigine, Lansoprazole, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levetiracetam, Levobupivacaine, Levocetirizine, Levomethadyl acetate, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lidoflazine, Liothyronine, Liotrix, Lisuride, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic Acid Diethylamide, Macimorelin, Macitentan, Magnesium sulfate, Manidipine, Maraviroc, Mebendazole, Medical Cannabis, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Menthol, Meprednisone, Mestranol, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylergometrine, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Naloxone, Naltrexone, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Ospemifene, Otilonium, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Penfluridol, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisone, Prednylidene, Pregabalin, Pregnenolone, Prenylamine, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Promegestone, Propafenone, Propiverine, Propofol, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Seletracetam, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic Acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Valproic Acid, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine
2Cytochrome P450 3A4 inducersAcetaminophen, Alimemazine, Aminoglutethimide, Apalutamide, Armodafinil, Artemether, Asunaprevir, Atorvastatin, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clofibrate, Clotrimazole, Clozapine, Colchicine, Corticotropin, Cortisone acetate, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desonide, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Fludrocortisone, Flunisolide, Fluocinolone acetonide, Fluvastatin, Formestane, Fosaprepitant, Fosphenytoin, Glycerol phenylbutyrate, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Lansoprazole, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Methylprednisolone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Seratrodast, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, Acetaminophen, Acetazolamide, Acetyl sulfisoxazole, Aldesleukin, Ambroxol, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, AVE9633, Azelastine, Azithromycin, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Caffeine, Candicidin, Capsaicin, Carbomycin, Caspofungin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Cimicifuga racemosa, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Coltuximab ravtansine, Conivaptan, Cortisone acetate, Crizotinib, Curcumin, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desogestrel, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Docetaxel, Doramectin, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Efonidipine, Elbasvir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergonovine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Glyburide, GPI-1485, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Imatinib, Indinavir, Indisulam, Irbesartan, Irinotecan, Isavuconazole, Isavuconazonium, Isoniazid, Itraconazole, Ivacaftor, Ivermectin, Ixabepilone, Josamycin, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lansoprazole, Lercanidipine, Letermovir, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Mefloquine, Mepartricin, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Mifepristone, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Mitoxantrone, Modafinil, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Oxetacaine, Oxybutynin, Oxymetholone, Paclitaxel, Palbociclib, Paramethasone, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Regorafenib, Repaglinide, Resveratrol, Ridaforolimus, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rokitamycin, Rolitetracycline, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Sarilumab, Selamectin, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sitaxentan, Solithromycin, Sorafenib, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Thiopental, Ticlopidine, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tramadol, Tranylcypromine, Trastuzumab emtansine, Troglitazone, Troleandomycin, Tylosin, Tylvalosin, Valproic Acid, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone
Interacting GroupInteracting Drugs
Lapatinib is a Cytochrome P450 3A4 inhibitor
1Cytochrome P450 3A4 substrates(S)-Warfarin, 16-Bromoepiandrosterone, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azithromycin, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzphetamine, Benzyl alcohol, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Cannabidiol, Carbamazepine, Carbinoxamine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Celiprolol, Cephalexin, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorphenamine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofazimine, Clofibrate, clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepate, Clorindione, Clotiazepam, Clozapine, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone Pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dicoumarol, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Digoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Dorzolamide, Dotarizine, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Drospirenone, Dutasteride, Dydrogesterone, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Emopamil, Enalapril, Enasidenib, Encorafenib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Ergocalciferol, Ergoloid mesylate, Ergonovine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrogens, esterified, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fendiline, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fingolimod, Fish oil, Flibanserin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fosamprenavir, Fosnetupitant, Fostamatinib, Fulvestrant, Gabapentin, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydromorphone, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indapamide, Indinavir, Ipecac, Ipratropium, Irinotecan, Isavuconazole, Isavuconazonium, Isosorbide dinitrate, Isosorbide Mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lamotrigine, Lansoprazole, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levetiracetam, Levobupivacaine, Levocetirizine, Levomethadyl acetate, Levomilnacipran, Levonorgestrel, Levothyroxine, Lidocaine, Lidoflazine, Liothyronine, Liotrix, Lisuride, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic Acid Diethylamide, Macimorelin, Macitentan, Magnesium sulfate, Manidipine, Maraviroc, Mebendazole, Medical Cannabis, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Menthol, Meprednisone, Mestranol, Methadone, Methaqualone, Methoxsalen, Methoxyflurane, Methylergometrine, Methylprednisolone, Methyltestosterone, Metronidazole, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Naloxone, Naltrexone, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Ospemifene, Otilonium, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Penfluridol, Pentamidine, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Pethidine, Phenacetin, Phenoxybenzamine, Phenprocoumon, Phenytoin, Pilocarpine, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Podofilox, Pomalidomide, Ponatinib, Posaconazole, Prasterone, Prasugrel, Pravastatin, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisone, Prednylidene, Pregabalin, Pregnenolone, Prenylamine, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Promegestone, Propafenone, Propiverine, Propofol, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Raloxifene, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rofecoxib, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Selegiline, Seletracetam, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic Acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Valproic Acid, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zalcitabine, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine
2Cytochrome P450 3A4 inducersAcetaminophen, Alimemazine, Aminoglutethimide, Apalutamide, Armodafinil, Artemether, Asunaprevir, Atorvastatin, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clofibrate, Clotrimazole, Clozapine, Colchicine, Corticotropin, Cortisone acetate, Cyclophosphamide, Dabrafenib, Deferasirox, Delafloxacin, Desonide, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Fludrocortisone, Flunisolide, Fluocinolone acetonide, Fluvastatin, Formestane, Fosaprepitant, Fosphenytoin, Glycerol phenylbutyrate, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Lansoprazole, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Metamizole, Methadone, Methylprednisolone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisone, Primidone, Probenecid, Progesterone, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Seratrodast, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, Acetaminophen, Acetazolamide, Acetyl sulfisoxazole, Aldesleukin, Ambroxol, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Antipyrine, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, AVE9633, Azelastine, Azithromycin, Bicalutamide, Bifonazole, Boceprevir, Bortezomib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Caffeine, Candicidin, Capsaicin, Carbomycin, Caspofungin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Cimicifuga racemosa, Ciprofloxacin, Cisapride, Clarithromycin, Clemastine, Clindamycin, Clofazimine, Clomifene, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cocaine, Colchicine, Coltuximab ravtansine, Conivaptan, Cortisone acetate, Crizotinib, Curcumin, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desogestrel, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Docetaxel, Doramectin, Doxorubicin, Doxycycline, Dronedarone, Econazole, Efavirenz, Efonidipine, Elbasvir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergonovine, Ergotamine, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fentanyl, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Glyburide, GPI-1485, Haloperidol, Histamine, Hydralazine, Hydrocortisone, Idelalisib, Ifosfamide, Imatinib, Indinavir, Indisulam, Irbesartan, Irinotecan, Isavuconazole, Isavuconazonium, Isoniazid, Itraconazole, Ivacaftor, Ivermectin, Ixabepilone, Josamycin, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lansoprazole, Lercanidipine, Letermovir, Levofloxacin, Levosalbutamol, Lidocaine, Linagliptin, Lomitapide, Lomustine, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Mefloquine, Mepartricin, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Methylprednisolone, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Mifepristone, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Mitoxantrone, Modafinil, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nisoldipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Oxetacaine, Oxybutynin, Oxymetholone, Paclitaxel, Palbociclib, Paramethasone, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Posaconazole, Pravastatin, Prednisolone, Prednisone, Primaquine, Progesterone, Propofol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Regorafenib, Repaglinide, Resveratrol, Ridaforolimus, Rilpivirine, Risperidone, Ritonavir, Rivastigmine, Rokitamycin, Rolitetracycline, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Sarilumab, Selamectin, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sitaxentan, Solithromycin, Sorafenib, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sulfinpyrazone, Sulfisoxazole, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Thiopental, Ticlopidine, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tramadol, Tranylcypromine, Trastuzumab emtansine, Troglitazone, Troleandomycin, Tylosin, Tylvalosin, Valproic Acid, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voriconazole, Zafirlukast, Ziprasidone
Interacting GroupInteracting Drugs
Lapatinib is a Cytochrome P450 2C8 substrate
1Cytochrome P450 2C8 substratesAcetaminophen, Acetylsalicylic acid, Almotriptan, Aminophenazone, Amiodarone, Amitriptyline, Amodiaquine, Amprenavir, Antipyrine, Apalutamide, Apixaban, Atorvastatin, Azelastine, Benzyl alcohol, Beraprost, Bioallethrin, Brigatinib, Brompheniramine, Buprenorphine, Bupropion, Cabazitaxel, Caffeine, Carbamazepine, Carbinoxamine, Cerivastatin, Chloroquine, Cisapride, Clozapine, Cyclophosphamide, Dabrafenib, Dapsone, Dasabuvir, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Domperidone, Elagolix, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Eszopiclone, Fluorouracil, Fluvastatin, Halofantrine, Ibuprofen, Ifosfamide, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Lansoprazole, Levomilnacipran, Licofelone, Lidocaine, Loperamide, Loratadine, Losartan, Mefenamic acid, Meloxicam, Mephenytoin, Methadone, Mirtazapine, Morphine, Muraglitazar, Mycophenolate mofetil, Naloxone, Naproxen, Nicardipine, Nicotine, Odanacatib, Olodaterol, Ombitasvir, Omeprazole, Paclitaxel, Paramethadione, Pazopanib, Pentamidine, Perospirone, Perphenazine, Phenprocoumon, Phenytoin, Pioglitazone, Piroxicam, Pitavastatin, Ponatinib, Progesterone, Propofol, Quinidine, Quinine, Repaglinide, Rifampicin, Riociguat, Rofecoxib, Rosiglitazone, Selegiline, Selexipag, Seratrodast, Simvastatin, Sitagliptin, Sorafenib, Sulfadiazine, Sulfinpyrazone, Tazarotene, Temazepam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline, Tolbutamide, Torasemide, Tretinoin, Trimethadione, Trimethoprim, Troglitazone, Velpatasvir, Verapamil, Vortioxetine, Voxilaprevir, Warfarin, Zafirlukast, Zidovudine, Zopiclone
2Cytochrome P450 2C8 inhibitorsAbiraterone, Amitriptyline, Amlodipine, Atorvastatin, Belinostat, Bezafibrate, Candesartan, Candesartan cilexetil, Celecoxib, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Clopidogrel, Clotrimazole, Cocaine, Colchicine, Crisaborole, Cyclosporine, Delavirdine, Dextropropoxyphene, Diethylstilbestrol, Efavirenz, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Ethinylestradiol, Etoposide, Felodipine, Fenofibrate, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Gemfibrozil, Idelalisib, Irbesartan, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Letermovir, Levothyroxine, Licofelone, Liotrix, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Medroxyprogesterone acetate, Mefenamic acid, Meloxicam, Metronidazole, Midostaurin, Mometasone, Montelukast, Nabilone, Nicardipine, Nifedipine, Nilotinib, Nilutamide, Nilvadipine, Opicapone, Oxybutynin, Paroxetine, Phenelzine, Pioglitazone, Piroxicam, Ponatinib, Pravastatin, Propafenone, Pyrimethamine, Quercetin, Quinine, Rabeprazole, Raloxifene, Regorafenib, Ritonavir, Rosiglitazone, Rucaparib, Rutin, Salmeterol, Saquinavir, Simvastatin, Sorafenib, Spironolactone, Sulfamethoxazole, Sulfaphenazole, Tamoxifen, Tegaserod, Terfenadine, Teriflunomide, Thioridazine, Ticlopidine, Tioconazole, Topiroxostat, Trametinib, Triazolam, Trimethoprim, Troglitazone, Troleandomycin, Valproic Acid, Vismodegib, Warfarin, Zafirlukast
3Cytochrome P450 2C8 inducersAvatrombopag, Carbamazepine, Colchicine, Cyclophosphamide, Dexamethasone, Gemfibrozil, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Ifosfamide, Isavuconazole, Ivosidenib, Lumacaftor, Midostaurin, Nilotinib, Phenobarbital, Primidone, Probenecid, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
Interacting GroupInteracting Drugs
Lapatinib is a Cytochrome P450 2C8 inhibitor
1Cytochrome P450 2C8 substratesAcetaminophen, Acetylsalicylic acid, Almotriptan, Aminophenazone, Amiodarone, Amitriptyline, Amodiaquine, Amprenavir, Antipyrine, Apalutamide, Apixaban, Atorvastatin, Azelastine, Benzyl alcohol, Beraprost, Bioallethrin, Brigatinib, Brompheniramine, Buprenorphine, Bupropion, Cabazitaxel, Caffeine, Carbamazepine, Carbinoxamine, Cerivastatin, Chloroquine, Cisapride, Clozapine, Cyclophosphamide, Dabrafenib, Dapsone, Dasabuvir, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Domperidone, Elagolix, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Eszopiclone, Fluorouracil, Fluvastatin, Halofantrine, Ibuprofen, Ifosfamide, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Lansoprazole, Levomilnacipran, Licofelone, Lidocaine, Loperamide, Loratadine, Losartan, Mefenamic acid, Meloxicam, Mephenytoin, Methadone, Mirtazapine, Morphine, Muraglitazar, Mycophenolate mofetil, Naloxone, Naproxen, Nicardipine, Nicotine, Odanacatib, Olodaterol, Ombitasvir, Omeprazole, Paclitaxel, Paramethadione, Pazopanib, Pentamidine, Perospirone, Perphenazine, Phenprocoumon, Phenytoin, Pioglitazone, Piroxicam, Pitavastatin, Ponatinib, Progesterone, Propofol, Quinidine, Quinine, Repaglinide, Rifampicin, Riociguat, Rofecoxib, Rosiglitazone, Selegiline, Selexipag, Seratrodast, Simvastatin, Sitagliptin, Sorafenib, Sulfadiazine, Sulfinpyrazone, Tazarotene, Temazepam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline, Tolbutamide, Torasemide, Tretinoin, Trimethadione, Trimethoprim, Troglitazone, Velpatasvir, Verapamil, Vortioxetine, Voxilaprevir, Warfarin, Zafirlukast, Zidovudine, Zopiclone
2Cytochrome P450 2C8 inhibitorsAbiraterone, Amitriptyline, Amlodipine, Atorvastatin, Belinostat, Bezafibrate, Candesartan, Candesartan cilexetil, Celecoxib, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Clopidogrel, Clotrimazole, Cocaine, Colchicine, Crisaborole, Cyclosporine, Delavirdine, Dextropropoxyphene, Diethylstilbestrol, Efavirenz, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Ethinylestradiol, Etoposide, Felodipine, Fenofibrate, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Gemfibrozil, Idelalisib, Irbesartan, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Letermovir, Levothyroxine, Licofelone, Liotrix, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Medroxyprogesterone acetate, Mefenamic acid, Meloxicam, Metronidazole, Midostaurin, Mometasone, Montelukast, Nabilone, Nicardipine, Nifedipine, Nilotinib, Nilutamide, Nilvadipine, Opicapone, Oxybutynin, Paroxetine, Phenelzine, Pioglitazone, Piroxicam, Ponatinib, Pravastatin, Propafenone, Pyrimethamine, Quercetin, Quinine, Rabeprazole, Raloxifene, Regorafenib, Ritonavir, Rosiglitazone, Rucaparib, Rutin, Salmeterol, Saquinavir, Simvastatin, Sorafenib, Spironolactone, Sulfamethoxazole, Sulfaphenazole, Tamoxifen, Tegaserod, Terfenadine, Teriflunomide, Thioridazine, Ticlopidine, Tioconazole, Topiroxostat, Trametinib, Triazolam, Trimethoprim, Troglitazone, Troleandomycin, Valproic Acid, Vismodegib, Warfarin, Zafirlukast
3Cytochrome P450 2C8 inducersAvatrombopag, Carbamazepine, Colchicine, Cyclophosphamide, Dexamethasone, Gemfibrozil, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Ifosfamide, Isavuconazole, Ivosidenib, Lumacaftor, Midostaurin, Nilotinib, Phenobarbital, Primidone, Probenecid, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
Interacting GroupInteracting Drugs
Lapatinib is a Cytochrome P450 3A5 substrate
1Cytochrome P450 3A5 substratesAlfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Aprepitant, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Astemizole, Asunaprevir, Atorvastatin, Axitinib, Azelastine, Benidipine, Boceprevir, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Cerivastatin, Cethromycin, Chloroquine, Chlorphenamine, Cilostazol, Cisapride, Clarithromycin, Clonidine, Clopidogrel, Cobicistat, Cocaine, Codeine, Copanlisib, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dexamethasone, Dextromethorphan, Diazepam, Diltiazem, Disulfiram, Docetaxel, Domperidone, Dutasteride, Elbasvir, Eplerenone, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Ethosuximide, Etoposide, Felodipine, Fentanyl, Finasteride, Fluoxetine, Flutamide, Fluticasone propionate, Fluvastatin, Granisetron, Halofantrine, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxyprogesterone caproate, Ibrutinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Isavuconazole, Ivacaftor, Lercanidipine, Levomethadyl acetate, Lidocaine, Losartan, Lovastatin, Methadone, Midazolam, Mifepristone, Mycophenolate mofetil, Nateglinide, Nelfinavir, Nevirapine, Nifedipine, Nimodipine, Nisoldipine, Nitrendipine, Norethisterone, Nortriptyline, Ondansetron, Oxazepam, Oxybutynin, Oxycodone, Paclitaxel, Paritaprevir, Pentamidine, Perampanel, Pimozide, Ponatinib, Pravastatin, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Sunitinib, Tacrolimus, Tadalafil, Tamoxifen, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Trastuzumab emtansine, Trazodone, Tretinoin, Triazolam, Udenafil, Valbenazine, Valproic Acid, Vardenafil, Verapamil, Vicriviroc, Vincristine, Zalcitabine, Zaleplon, Ziprasidone, Zolpidem
2Cytochrome P450 3A5 inducersArmodafinil, Beclomethasone dipropionate, Budesonide, Carbamazepine, Cyclosporine, Daunorubicin, Dexamethasone, Efavirenz, Etoposide, Midostaurin, Modafinil, Oxcarbazepine, Phenobarbital, Phenytoin, Reserpine, Rifampicin, Rifapentine, Ritonavir, Thalidomide, Troglitazone
3Cytochrome P450 3A5 inhibitorsAmiodarone, Aprepitant, Boceprevir, Chloramphenicol, Cimetidine, Ciprofloxacin, Clarithromycin, Cobicistat, Crizotinib, Delavirdine, Diltiazem, Efavirenz, Elbasvir, Enzalutamide, Erythromycin, Fluconazole, Fluticasone propionate, Fluvoxamine, Gestodene, Idelalisib, Imatinib, Indinavir, Isavuconazole, Itraconazole, Ketoconazole, Letermovir, Mibefradil, Mifepristone, Modafinil, Nefazodone, Nelfinavir, Nicardipine, Norfloxacin, Oxymetholone, Phenelzine, Ranitidine, Ritonavir, Rosuvastatin, Rucaparib, Saquinavir, Seproxetine, Telithromycin, Temsirolimus, Troglitazone, Troleandomycin, Verapamil, Voriconazole
Interacting GroupInteracting Drugs
Lapatinib is a Cytochrome P450 2C19 substrate
1Cytochrome P450 2C19 substratesAcenocoumarol, Adinazolam, Almotriptan, Ambrisentan, Aminophenazone, Amiodarone, Amitriptyline, Amoxicillin, Antipyrine, Apixaban, Aprepitant, Arformoterol, Artemether, Asunaprevir, Atomoxetine, Axitinib, Azelastine, Barbital, Benzatropine, Binimetinib, Bioallethrin, Bortezomib, Brivaracetam, Bromazepam, Brompheniramine, Bupivacaine, Cannabidiol, Carbinoxamine, Carisoprodol, Chloramphenicol, Chlorpropamide, Cilostazol, Cisapride, Citalopram, Clarithromycin, Clobazam, clomethiazole, Clomipramine, Clopidogrel, Clotiazepam, Clozapine, Cyclophosphamide, Dapsone, Desipramine, Dexlansoprazole, Dextromethorphan, Diazepam, Diclofenac, Diltiazem, Diphenhydramine, Dopamine, Doxazosin, Doxepin, Dronabinol, Eletriptan, Enasidenib, Encorafenib, Enfuvirtide, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Etizolam, Etravirine, Famotidine, Flunitrazepam, Fluoxetine, Flutamide, Formoterol, Fosphenytoin, Gliclazide, Glucosamine, Glyburide, Guanfacine, Haloperidol, Hexobarbital, Ibuprofen, Ifosfamide, Imatinib, Imipramine, Indomethacin, Ixazomib, Ketobemidone, Labetalol, Lansoprazole, Levomilnacipran, Lofexidine, Lorcaserin, Lumiracoxib, Lynestrenol, Macitentan, Medical Cannabis, Melatonin, Mephenytoin, Meprobamate, Methadone, Methohexital, Methsuximide, Methylphenobarbital, Metoprolol, Moclobemide, Nabiximols, Nelfinavir, Nicotine, Nilutamide, Nortriptyline, Omeprazole, Ospemifene, Oxiconazole, Pantoprazole, Pentamidine, Pentobarbital, Perphenazine, Pethidine, Phenacetin, Phenobarbital, Phenytoin, Piperaquine, Pipotiazine, Podofilox, Prasugrel, Praziquantel, Primidone, Progesterone, Proguanil, Promazine, Propofol, Propranolol, Quazepam, Quetiapine, Quinine, Rabeprazole, Ramelteon, Ranitidine, Romidepsin, Rosuvastatin, Rupatadine, Selegiline, Seratrodast, Sertraline, Sildenafil, Tamoxifen, Tapentadol, Temazepam, Teniposide, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiopental, Thioridazine, Ticlopidine, Timolol, Tipranavir, Tofacitinib, Tolbutamide, Tolterodine, Trabectedin, Trimethadione, Trimipramine, Troglitazone, Valproic Acid, Venlafaxine, Verapamil, Voriconazole, Vortioxetine, Warfarin, Zidovudine, Zolpidem
2Cytochrome P450 2C19 inhibitorsAbiraterone, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Aprepitant, Armodafinil, Artenimol, Atorvastatin, Azelastine, Benzbromarone, Bicalutamide, Bifonazole, Bortezomib, Buprenorphine, Carbamazepine, Cerivastatin, Chloramphenicol, Cholecalciferol, Cimetidine, Citalopram, Clarithromycin, Clevidipine, Clotrimazole, Clozapine, Cyclosporine, Delavirdine, Desipramine, Desloratadine, Dexfenfluramine, Dexlansoprazole, Diazepam, Dimethyl sulfoxide, Dosulepin, Efavirenz, Enasidenib, Eslicarbazepine acetate, Esomeprazole, Ethanol, Ethotoin, Etoricoxib, Etravirine, Felbamate, Fluconazole, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Gliclazide, Idelalisib, Imipramine, Indinavir, Indomethacin, Isavuconazole, Isoniazid, Ketoconazole, Lansoprazole, Lobeglitazone, Lopinavir, Loratadine, Losartan, Lovastatin, Luliconazole, Manidipine, Memantine, Mephenytoin, Methazolamide, Methimazole, Methsuximide, Methylphenobarbital, Miconazole, Midostaurin, Moclobemide, Modafinil, Naloxegol, Nelfinavir, Nicardipine, Nilutamide, Nilvadipine, Olanzapine, Omeprazole, Opicapone, Oxcarbazepine, Oxymetholone, Pantoprazole, Pegvisomant, Phenelzine, Phensuximide, Pimozide, Pioglitazone, Piperaquine, Probenecid, Progesterone, Quinine, Rabeprazole, Regorafenib, Rilpivirine, Ritonavir, Rosiglitazone, Rucaparib, Saquinavir, Seratrodast, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulfanilamide, Telmisartan, Thalidomide, Ticlopidine, Tioconazole, Tipranavir, Tolbutamide, Topiramate, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Troleandomycin, Valdecoxib, Valproic Acid, Vismodegib, Voriconazole, Warfarin, Zafirlukast, Zonisamide, Zucapsaicin
3Cytochrome P450 2C19 inducersAcetylsalicylic acid, Aminoglutethimide, Apalutamide, Artemether, Barbital, Carbamazepine, Dexamethasone, Enzalutamide, Hydroxyprogesterone caproate, Letermovir, Lopinavir, Loratadine, Lumacaftor, Midostaurin, Modafinil, Norethisterone, Phenobarbital, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
Interacting GroupInteracting Drugs
Lapatinib is a Multidrug resistance protein 1 inhibitor
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Apalutamide, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Amprenavir, Apixaban, Arsenic trioxide, Asunaprevir, Atazanavir, Atenolol, Avatrombopag, Axitinib, Baricitinib, Belinostat, Betamethasone, Bosutinib, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carfilzomib, Ceritinib, Cerivastatin, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxorubicin, Edoxaban, Elagolix, Elbasvir, Eletriptan, Epinastine, Erlotinib, Ertugliflozin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluciclovine (18F), Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ketazolam, Ketoconazole, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Moxidectin, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Osimertinib, Paclitaxel, Panobinostat, Paritaprevir, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Regorafenib, Reserpine, Rifampicin, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Testosterone propionate, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Trimipramine, Ubidecarenone, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Albendazole, Alectinib, Alfentanil, Amiodarone, Amitriptyline, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Atazanavir, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Concanamycin A, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Emopamil, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ketoconazole, Lansoprazole, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Mefloquine, Megestrol acetate, Methadone, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitoxantrone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrendipine, Omeprazole, ONT-093, Paclitaxel, Pantoprazole, Paroxetine, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersalpha-Tocopherol acetate, Betrixaban, Ledipasvir, Tocopherol
5Multidrug resistance protein 1 bindersTechnetium Tc-99m tetrofosmin
6Multidrug resistance protein 1 antagonistsTocofersolan
Interacting GroupInteracting Drugs
Lapatinib is a Antigen peptide transporter 1 inhibitor