Identification

Name
Ginseng
Accession Number
DB01404
Type
Small Molecule
Groups
Approved, Investigational, Nutraceutical
Description

Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens.

Synonyms
  • Aralia ginseng root
  • Asian ginseng root
  • Chinese ginseng root
  • Ginseng (panax ginseng)
  • Ginseng extract
  • Ginseng, asian
  • Hong shen root
  • Insam root
  • Korean ginseng
  • Korean ginseng root
  • Ninjin root
  • Panax ginseng
  • Panax ginseng root
  • Panax ginseng root extract
  • Panax schinseng root
  • Panax verus root
  • Red ginseng
  • Ren seng root
  • Ren shen
  • Ren shen root
  • True ginseng root
External IDs
B1673
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Siberian Ginseng ExtractumLiquid1300 mgOralClassical Remedia LtdNot applicableNot applicableCanada
Siberian Ginseng TabletTablet3000 mgOralClassical Remedia LtdNot applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ginsana Cap 100mgCapsule100 mgOralQuest Vitamins A Div Of Purity Life Health Products1995-12-312006-07-25Canada
Ginseng Energy Formula TabletsTablet100 mgOralAshbury Research CorporationNot applicableNot applicableCanada
Categories
UNII
Not Available
CAS number
50647-08-0
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UInterleukin-6
antagonist
Human
UProstaglandin G/H synthase 2
inhibitor
Human
UAryl hydrocarbon receptor
agonist
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(4R)-limoneneThe risk or severity of adverse effects can be increased when (4R)-limonene is combined with Ginseng.
16-BromoepiandrosteroneThe risk or severity of adverse effects can be increased when 16-Bromoepiandrosterone is combined with Ginseng.
19-norandrostenedioneThe risk or severity of adverse effects can be increased when 19-norandrostenedione is combined with Ginseng.
5-androstenedioneThe risk or severity of adverse effects can be increased when 5-androstenedione is combined with Ginseng.
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Ginseng.
AcemetacinThe risk or severity of adverse effects can be increased when Acemetacin is combined with Ginseng.
AlaproclateAlaproclate may increase the antiplatelet activities of Ginseng.
AlclofenacThe risk or severity of adverse effects can be increased when Alclofenac is combined with Ginseng.
AldosteroneThe risk or severity of adverse effects can be increased when Aldosterone is combined with Ginseng.
AlminoprofenThe risk or severity of adverse effects can be increased when Alminoprofen is combined with Ginseng.
Food Interactions
Not Available

References

Synthesis Reference

Iwao Hachiya, Keizo Mochizuki, Yukio Kuwada, "Method of preparing dried ginseng for drug." U.S. Patent US4446130, issued January, 1970.

US4446130
General References
  1. Lee YJ, Jin YR, Lim WC, Park WK, Cho JY, Jang S, Lee SK: Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Arch Pharm Res. 2003 Jan;26(1):58-63. [PubMed:12568360]
  2. Chan RY, Chen WF, Dong A, Guo D, Wong MS: Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab. 2002 Aug;87(8):3691-5. [PubMed:12161497]
  3. Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S: A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol. 2003 Mar;84(4):463-8. [PubMed:12732291]
  4. McElhaney JE, Gravenstein S, Cole SK, Davidson E, O'neill D, Petitjean S, Rumble B, Shan JJ: A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc. 2004 Jan;52(1):13-9. [PubMed:14687309]
  5. Lewis WH, Zenger VE, Lynch RG: No adaptogen response of mice to ginseng and Eleutherococcus infusions. J Ethnopharmacol. 1983 Aug;8(2):209-14. [PubMed:6685799]
External Links
PubChem Substance
46508934
PharmGKB
PA164781150
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Ginseng
AHFS Codes
  • 92:01.00* — Herbs and Natural Products
MSDS
Download (73.2 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceBlood Pressures / Cognition1
0Not Yet RecruitingSupportive CareCancer Survivors / Stage I Breast Cancer AJCC v7 / Stage I Colon Cancer AJCC v6 and v7 / Stage IA Breast Cancer AJCC v7 / Stage IB Breast Cancer AJCC v7 / Stage II Breast Cancer AJCC v6 and v7 / Stage II Colon Cancer AJCC v7 / Stage IIA Breast Cancer AJCC v6 and v7 / Stage IIA Colon Cancer AJCC v7 / Stage IIB Breast Cancer AJCC v6 and v7 / Stage IIB Colon Cancer AJCC v7 / Stage IIC Colon Cancer AJCC v7 / Stage III Breast Cancer AJCC V7 / Stage III Colon Cancer AJCC v7 / Stage IIIA Breast Cancer AJCC v7 / Stage IIIA Colon Cancer AJCC v7 / Stage IIIB Breast Cancer AJCC v7 / Stage IIIB Colon Cancer AJCC v7 / Stage IIIC Breast Cancer AJCC v7 / Stage IIIC Colon Cancer AJCC v71
1, 2CompletedTreatmentAlzheimer's Disease (AD) / Memory Decline1
1, 2CompletedTreatmentBMI >30 kg/m2 / Insulin Resistance / Schizoaffective Disorders / Schizophrenic Disorders / Tardive Dyskinesia1
2Active Not RecruitingTreatmentAdvanced Cancers / Tumors, Solid1
2Active Not RecruitingTreatmentCancer, Breast1
2CompletedTreatmentHealthy Volunteers1
2CompletedTreatmentTiredness1
3CompletedTreatmentPsychiatric Disorder NOS1
3Unknown StatusTreatmentPsychiatric Disorder NOS1
4CompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedSupportive CareNeoplasms, Breast / Neoplasms, Lung1
Not AvailableCompletedTreatmentDepression / Stress1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Basic Drugs Inc.
  • Contract Pharm
  • CVS Pharmacy
  • Equaline Vitamins
  • Good Neighbour Pharmacy
  • Mason Distributors
  • Mckesson Corp.
  • National Vitamin Company
  • PharmAssure
  • Pharmavite
  • Rite Aid Corp.
  • Tyler Encapsulations
Dosage forms
FormRouteStrength
CapsuleOral100 mg
TabletOral100 mg
LiquidOral1300 mg
TabletOral3000 mg
Prices
Unit descriptionCostUnit
V-r panax ginseng 300 mg capsule0.18USD capsule
Ra ginseng 100 mg softgel0.17USD softgel capsule
Eql ginseng 100 mg caplet0.15USD caplet
Eql ginseng 100 mg softgel0.15USD softgel capsule
Korean ginseng 1000 mg tablet0.14USD tablet
Siberian ginseng 250 mg capsule0.14USD capsule
CVS Pharmacy ginseng 200 mg softgel0.13USD softgel capsule
Korean ginseng 518 mg cap0.13USD capsule
Korean ginseng 350 mg capsule0.09USD capsule
Ginseng 8 gr capsule0.08USD capsule
Siberian root 1000 mg capsule0.08USD capsule
Ginseng 250 mg capsule0.07USD capsule
Ra siberian ginseng 410 mg0.05USD each
Gnp ginseng root 410 mg capsule0.04USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Interleukin-6 receptor binding
Specific Function
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Inv...
Gene Name
IL6
Uniprot ID
P05231
Uniprot Name
Interleukin-6
Molecular Weight
23717.965 Da
References
  1. Kim DH, Moon YS, Lee TH, Jung JS, Suh HW, Song DK: The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice. Neurosci Lett. 2003 Dec 15;353(1):13-6. [PubMed:14642426]
  2. Kim SJ, Jeong HJ, Yi BJ, Kang TH, An NH, Lee EH, Yang DC, Kim HM, Hong SH, Um JY: Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. Am J Chin Med. 2007;35(2):329-39. [PubMed:17436372]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Prostaglandin-endoperoxide synthase activity
Specific Function
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name
PTGS2
Uniprot ID
P35354
Uniprot Name
Prostaglandin G/H synthase 2
Molecular Weight
68995.625 Da
References
  1. Yim HW, Jong HS, Kim TY, Choi HH, Kim SG, Song SH, Kim J, Ko SG, Lee JW, Kim TY, Bang YJ: Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis. Cancer Res. 2005 Mar 1;65(5):1952-60. [PubMed:15753395]
  2. Seo JY, Lee JH, Kim NW, Her E, Chang SH, Ko NY, Yoo YH, Kim JW, Seo DW, Han JW, Kim YM, Choi WS: Effect of a fermented ginseng extract, BST204, on the expression of cyclooxygenase-2 in murine macrophages. Int Immunopharmacol. 2005 May;5(5):929-36. [PubMed:15778128]
  3. Kim SJ, Jeong HJ, Yi BJ, Kang TH, An NH, Lee EH, Yang DC, Kim HM, Hong SH, Um JY: Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. Am J Chin Med. 2007;35(2):329-39. [PubMed:17436372]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Transcription regulatory region dna binding
Specific Function
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes...
Gene Name
AHR
Uniprot ID
P35869
Uniprot Name
Aryl hydrocarbon receptor
Molecular Weight
96146.705 Da
References
  1. Wang Y, Ye X, Ma Z, Liang Q, Lu B, Tan H, Xiao C, Zhang B, Gao Y: Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells. Eur J Pharmacol. 2008 Dec 28;601(1-3):73-8. doi: 10.1016/j.ejphar.2008.10.057. Epub 2008 Nov 11. [PubMed:19022240]

Drug created on July 13, 2007 14:21 / Updated on October 16, 2018 08:36