Identification
NameGinseng
Accession NumberDB01404
TypeSmall Molecule
GroupsApproved, Nutraceutical
Description

Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens.

Structure
Thumb
Synonyms
Aralia ginseng root
Asian ginseng
Asian ginseng root
Chinese ginseng root
Ginseng (panax ginseng)
Ginseng extract
Ginseng, asian
Hong shen root
Insam root
Korean ginseng
Korean ginseng root
Ninjin root
Panax ginseng
Panax ginseng root
Panax ginseng root extract
Panax schinseng root
Panax verus root
Red ginseng
Ren seng root
Ren shen
Ren shen root
True ginseng root
External IDs B1673
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Siberian Ginseng ExtractumLiquid1300 mgOralClassical Remedia LtdNot applicableNot applicableCanada
Siberian Ginseng TabletTablet3000 mgOralClassical Remedia LtdNot applicableNot applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ginsana Cap 100mgCapsule100 mgOralQuest Vitamins A Div Of Purity Life Health Products1995-12-312006-07-25Canada
Ginseng Energy Formula TabletsTablet100 mgOralAshbury Research CorporationNot applicableNot applicableCanada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Baek Su Hee (joy 99 Year Life) (20ml)Liquid.5 g/20mLOralMercylight2015-06-26Not applicableUs
Cheong-kwan-jang Korean HongsamCapsule500 mg/500mgOralKorea Ginseng Corporation2010-11-15Not applicableUs
Cheong-kwan-jang Korean HongsamTablet500 mg/90000mgOralKorea Ginseng Corporation2011-02-24Not applicableUs
Cheong-kwan-jang Korean HongsamPowder90 g/90gOralKorea Ginseng Corporation2010-10-08Not applicableUs
Cheong-kwan-jang Sliced Korean HongsamBar, chewable75 g/75gOralKorea Ginseng Corporation2011-05-31Not applicableUs
GimLiquid24 g/100mLTopicalHalim Pharm Ltd2014-02-08Not applicableUs
Liver Care Honzo Seika Chinese Herbal Aroma OilOil46 mg/100mLTopicalPhytopia Co., Ltd.2016-04-01Not applicableUs
Liver Care Honzo Seika Chinese Herbal Aroma OilOil46 mg/100mLTopicalNic Co., Ltd.2016-04-01Not applicableUs
Qelby Healing FoodCapsule.05 g/1OralQuantum Energy Co., Ltd.2014-12-22Not applicableUs
SingisoTablet.125 g/1OralFda Trading Co.,ltd.2014-11-15Not applicableUs
SingisoTablet.125 g/.8gOralSae in Dang Co., Ltd.2015-04-01Not applicableUs
Singiso (0.8g)Tablet17.19 g/100gOralSae in Dang Co., Ltd.2016-07-06Not applicableUs
Singiso 101 (0.8g)Tablet17.19 g/100gOralSae in Dang Co., Ltd.2016-08-31Not applicableUs
Singiso 102 (0.8g)Tablet17.19 g/100gOralSae in Dang Co., Ltd.2016-08-31Not applicableUs
Soma Anti-cancergenPowder5.67 g/100gOralSoma Biotechnology Co., Ltd2013-03-06Not applicableUs
Soma HyulgihwanPowder5.67 g/100gOralSoma Biotechnology Co., Ltd2013-04-29Not applicableUs
Soma Hyulgihwan GoldPill.0567 g/gOralSoma Biotechnology Co., Ltd2013-11-14Not applicableUs
Soma Pet-circlePowder5.67 g/100gOralSoma Biotechnology Co., Ltd2013-04-29Not applicableUs
Stress Relief Honzo Seika Chinese Herbal Aroma OilOil7 mg/100mLTopicalPhytopia Co., Ltd.2016-04-01Not applicableUs
Stress Relief Honzo Seika Chinese Herbal Aroma OilOil7 mg/100mLTopicalNic Co., Ltd.2016-04-01Not applicableUs
Tamnamo Essential Hair TonicLiquid.03 mg/mLTopicalTamnamo Co., Ltd2013-08-12Not applicableUs
Tamnamo Plus Vital HairSolution.03 mg/mLTopicalTamnamo Co., Ltd2013-08-12Not applicableUs
V.S. Power / Vacsu Power (dynamic and Powerful 99 Year Life)Liquid.5 g/20mLOralMercylignt2015-01-28Not applicableUs
Wild Cultivated Ginseng Purified PharmacopunctureLiquid1 g/100mLTopicalGeolim Pharmaceutical Co., Ltd. (Busan Branch)2017-02-01Not applicableUs
International BrandsNot Available
Brand mixturesNot Available
CategoriesNot Available
UNIICUQ3A77YXI
CAS number50647-08-0
WeightNot Available
Chemical FormulaNot Available
InChI KeyNot Available
InChINot Available
IUPAC NameNot Available
SMILESNot Available
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
Interleukin-6Proteinunknown
antagonist
HumanP05231 details
Prostaglandin G/H synthase 2Proteinunknown
inhibitor
HumanP35354 details
Aryl hydrocarbon receptorProteinunknown
agonist
HumanP35869 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions Not Available
Food InteractionsNot Available
References
Synthesis Reference

Iwao Hachiya, Keizo Mochizuki, Yukio Kuwada, "Method of preparing dried ginseng for drug." U.S. Patent US4446130, issued January, 1970.

US4446130
General References
  1. Lee YJ, Jin YR, Lim WC, Park WK, Cho JY, Jang S, Lee SK: Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells. Arch Pharm Res. 2003 Jan;26(1):58-63. [PubMed:12568360 ]
  2. Chan RY, Chen WF, Dong A, Guo D, Wong MS: Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab. 2002 Aug;87(8):3691-5. [PubMed:12161497 ]
  3. Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S: A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol. 2003 Mar;84(4):463-8. [PubMed:12732291 ]
  4. McElhaney JE, Gravenstein S, Cole SK, Davidson E, O'neill D, Petitjean S, Rumble B, Shan JJ: A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc. 2004 Jan;52(1):13-9. [PubMed:14687309 ]
  5. Lewis WH, Zenger VE, Lynch RG: No adaptogen response of mice to ginseng and Eleutherococcus infusions. J Ethnopharmacol. 1983 Aug;8(2):209-14. [PubMed:6685799 ]
External Links
ATC CodesNot Available
AHFS Codes
  • 92:01.00*
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceBlood Pressures / Cognition1
1, 2CompletedTreatmentAlzheimer's Disease (AD) / Memory Decline1
1, 2CompletedTreatmentBMI >30 kg/m2 / Insulin Resistance / Schizoaffective Disorders / Schizophrenic Disorders / Tardive Dyskinesia1
2Active Not RecruitingTreatmentAdvanced Cancers / Tumors, Solid1
2Active Not RecruitingTreatmentCancer, Breast1
2CompletedTreatmentHealthy Volunteers1
2CompletedTreatmentTiredness1
3CompletedTreatmentPsychiatric Disorder NOS1
3Unknown StatusTreatmentPsychiatric Disorder NOS1
4CompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedSupportive CareNeoplasms, Breast / Neoplasms, Lung1
Not AvailableCompletedTreatmentDepressive State / Stress1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
CapsuleOral500 mg/500mg
PowderOral90 g/90g
TabletOral500 mg/90000mg
Bar, chewableOral75 g/75g
LiquidTopical24 g/100mL
CapsuleOral100 mg
TabletOral100 mg
OilTopical46 mg/100mL
CapsuleOral.05 g/1
LiquidOral1300 mg
TabletOral3000 mg
TabletOral.125 g/1
TabletOral.125 g/.8g
TabletOral17.19 g/100g
PowderOral5.67 g/100g
PillOral.0567 g/g
OilTopical7 mg/100mL
LiquidTopical.03 mg/mL
SolutionTopical.03 mg/mL
LiquidOral.5 g/20mL
LiquidTopical1 g/100mL
Prices
Unit descriptionCostUnit
V-r panax ginseng 300 mg capsule0.18USD capsule
Ra ginseng 100 mg softgel0.17USD softgel capsule
Eql ginseng 100 mg caplet0.15USD caplet
Eql ginseng 100 mg softgel0.15USD softgel capsule
Korean ginseng 1000 mg tablet0.14USD tablet
Siberian ginseng 250 mg capsule0.14USD capsule
CVS Pharmacy ginseng 200 mg softgel0.13USD softgel capsule
Korean ginseng 518 mg cap0.13USD capsule
Korean ginseng 350 mg capsule0.09USD capsule
Ginseng 8 gr capsule0.08USD capsule
Siberian root 1000 mg capsule0.08USD capsule
Ginseng 250 mg capsule0.07USD capsule
Ra siberian ginseng 410 mg0.05USD each
Gnp ginseng root 410 mg capsule0.04USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted PropertiesNot Available
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Taxonomy
ClassificationNot classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Interleukin-6 receptor binding
Specific Function:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as ...
Gene Name:
IL6
Uniprot ID:
P05231
Uniprot Name:
Interleukin-6
Molecular Weight:
23717.965 Da
References
  1. Kim DH, Moon YS, Lee TH, Jung JS, Suh HW, Song DK: The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice. Neurosci Lett. 2003 Dec 15;353(1):13-6. [PubMed:14642426 ]
  2. Kim SJ, Jeong HJ, Yi BJ, Kang TH, An NH, Lee EH, Yang DC, Kim HM, Hong SH, Um JY: Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. Am J Chin Med. 2007;35(2):329-39. [PubMed:17436372 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Uniprot Name:
Prostaglandin G/H synthase 2
Molecular Weight:
68995.625 Da
References
  1. Yim HW, Jong HS, Kim TY, Choi HH, Kim SG, Song SH, Kim J, Ko SG, Lee JW, Kim TY, Bang YJ: Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis. Cancer Res. 2005 Mar 1;65(5):1952-60. [PubMed:15753395 ]
  2. Seo JY, Lee JH, Kim NW, Her E, Chang SH, Ko NY, Yoo YH, Kim JW, Seo DW, Han JW, Kim YM, Choi WS: Effect of a fermented ginseng extract, BST204, on the expression of cyclooxygenase-2 in murine macrophages. Int Immunopharmacol. 2005 May;5(5):929-36. [PubMed:15778128 ]
  3. Kim SJ, Jeong HJ, Yi BJ, Kang TH, An NH, Lee EH, Yang DC, Kim HM, Hong SH, Um JY: Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. Am J Chin Med. 2007;35(2):329-39. [PubMed:17436372 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Transcription regulatory region dna binding
Specific Function:
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and matu...
Gene Name:
AHR
Uniprot ID:
P35869
Uniprot Name:
Aryl hydrocarbon receptor
Molecular Weight:
96146.705 Da
References
  1. Wang Y, Ye X, Ma Z, Liang Q, Lu B, Tan H, Xiao C, Zhang B, Gao Y: Induction of cytochrome P450 1A1 expression by ginsenoside Rg1 and Rb1 in HepG2 cells. Eur J Pharmacol. 2008 Dec 28;601(1-3):73-8. doi: 10.1016/j.ejphar.2008.10.057. Epub 2008 Nov 11. [PubMed:19022240 ]
Drug created on July 13, 2007 14:21 / Updated on January 27, 2017 07:50