Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam. Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal muscle relaxant properties. However, unlike other benzodiapeines camazepam is predominantly anxiolytic and is relatively weak as an anticonvulsant, hypnotic and skeletal muscle relaxant.
Camazepam also has less side effects, such as impaired cognition and reaction times, compared to other benzodiazepines. However, impairment of cognition and disrupted sleep patterns will occur at doses higher than 40mg of carazepam. Camazepam is also believed to increase attention, and is associated with skin disorders.
In the United States camazepam is regulated as a Schedule IV controlled substance.
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|Weight||Average: 371.818 |
Camazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression.
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Camazepam has been shown to bind competitively to benzodiazepine receptors in the brain with a relatively low affinity in animal models. This binding of benzodiazepine receptors by camazepam and its active metabolites is responsible for its anticonvulsant effects. Notably, only three metabolites were shown to exert anticonvulsant activity, temazepam, oxazepam, and hydroxy camazepam.
The anxiolytic properties of camazepam are also attributed to their ability to bind benzodiazepine receptors, also known as GABA receptors. When benzodiazepines bind to GABA receptors they increase the efficiency with which the inhibitory neurotransmitter GABA binds.
Almost completely absorbed into the bloodstream after oral administration. 90% bioavailability can be achieved in humans.
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Metabolized by the liver into more than 10 metabolites, some of which are also active and posses anticonvulsant properties.  One active metabolite of note is temazepam which has roughly equal in effectiveness as an anxiolytic, but is less anticonvulsant, sedating, and motor-impairing.
Camazepam undergoes enantioselective metabolism by human liver microsomes. 
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Ferrari, G. and Casagrande, C.; U.S. Patent 3,799,920; March 26,1974; assigned to Siphar SA.
|ATC Codes||N05BA15 — Camazepam|
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|Description||This compound belongs to the class of chemical entities known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.|
|Super Class||Organic compounds|
|Alternative Parents||Alpha amino acids and derivatives / Benzene and substituted derivatives / Aryl chlorides / Tertiary carboxylic acid amides / Carbamate esters / Lactams / Ketimines / Propargyl-type 1,3-dipolar organic compounds / Azacyclic compounds / Organopnictogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds|
|Substituents||1,4-benzodiazepine / Alpha-amino acid or derivatives / Aryl chloride / Aryl halide / Monocyclic benzene moiety / Benzenoid / Tertiary carboxylic acid amide / Carbamic acid ester / Carboxamide group / Ketimine/ Lactam / Carboxylic acid derivative / Azacycle / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Organohalogen compound / Organic oxygen compound / Imine / Organic nitrogen compound / Hydrocarbon derivative / Carbonyl group / Organic oxide / Organochloride / Organonitrogen compound / Organooxygen compound / Organopnictogen compound / Aromatic heteropolycyclic compound|
|Molecular Framework||Aromatic heteropolycyclic compounds|
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