Attapulgite

Identification

Name
Attapulgite
Accession Number
DB01574
Type
Small Molecule
Groups
Approved, Vet Approved
Description

Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.

Structure
Thumb
Synonyms
  • Activated attapulgite
  • Aluminium magnesium silicate (attapulgite)
  • Attapulgite (activated)
  • Attapulgite, activated
  • Attapulgite,activated
  • Attapulgus clay
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Children's Kaopectate Sus 600mg/15mlSuspension600 mgOralUpjohn1992-12-312001-07-27Canada
Extra Strength Kaopectate Tablets 750mgTablet750 mgOralJohnson & Johnson Merck Consumer Pharmaceuticals Of Canada1998-04-062005-07-14Canada
Kaopectate Chewable Tab 300mgTablet300 mgOralUpjohn1990-12-312001-07-27Canada
Kaopectate Chewable Tablets 300mgTablet300 mgOralJohnson & Johnson Merck Consumer Pharmaceuticals Of Canada1998-09-182002-07-18Canada
Kaopectate Extra Strength SusSuspension750 mgOralUpjohn1992-12-312001-07-27Canada
Kaopectate Extra Strength Tab 750mgTablet750 mgOralUpjohn1989-12-312001-07-27Canada
Kaopectate Liq 600mg/15mlLiquid600 mgOralUpjohn1989-12-312001-07-27Canada
Kaopectate Tablet - 600mgTablet600 mgOralJohnson & Johnson Merck Consumer Pharmaceuticals Of Canada1998-07-242002-07-18Canada
Kaopectate Tablets 600mgTablet600 mgOralUpjohn1989-12-311996-09-10Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Diban CapAttapulgite (300 mg) + Atropine Sulfate (9.7 mcg) + Hyoscyamine sulfate (0.0519 mg) + Opium (12 mg) + Pectin (71.4 mg) + Scopolamine (3.3 mcg)CapsuleOralAyerst Laboratories1992-12-311999-04-12Canada
Diban CapAttapulgite (300 mg) + Atropine Sulfate (9.7 mcg) + Hyoscyamine sulfate (0.0519 mg) + Opium (12 mg) + Pectin (71.4 mg) + Scopolamine (3.3 mcg)CapsuleOralWyeth Ayerst Canada Inc.1998-02-182001-01-30Canada
Donnagel-PG CapAttapulgite (300 mg) + Opium (12 mg) + Pectin (71.4 mg)CapsuleOralWyeth Ayerst Canada Inc.1994-12-312002-03-20Canada
Categories
UNII
U6V729APAM
CAS number
12174-11-7
Weight
Average: 412.684
Monoisotopic: 411.8684309
Chemical Formula
AlH9MgO15Si4
InChI Key
IXWIAFSBWGYQOE-UHFFFAOYSA-M
InChI
InChI=1S/Al.Mg.5H2O.10O.4Si/h;;5*1H2;;;;;;;;;;;;;;/q+3;+2;;;;;;10*-2;4*+4/p-1
IUPAC Name
tetrasilicon(4+) ion aluminium(3+) ion magnesium(2+) ion tetrahydrate hydroxide decaoxidandiide
SMILES
[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[Si+4].[O-][H].[H]O[H].[H]O[H].[H]O[H].[H]O[H]

Pharmacology

Indication

When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent.

Structured Indications
Not Available
Pharmacodynamics

Attapulgite is an adsorptive magnesium aluminium phyllosilicate which binds to toxins, bacteria and water.

Mechanism of action

Attapulgite adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Zaid MR, Hasan M, Khan AA: Attapulgite in the treatment of acute diarrhoea: a double-blind placebo-controlled study. J Diarrhoeal Dis Res. 1995 Mar;13(1):44-6. [PubMed:7657965]
  2. Nwachukwu CE, Okebe JU: Antimotility agents for chronic diarrhoea in people with HIV/AIDS. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD005644. doi: 10.1002/14651858.CD005644.pub2. [PubMed:18843696]
External Links
ChemSpider
32701176
PharmGKB
PA164781017
Drugs.com
Drugs.com Drug Page
Wikipedia
Attapulgite
ATC Codes
A07BC54 — Attapulgite, combinationsA07BC04 — Attapulgite

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SuspensionOral600 mg
CapsuleOral
TabletOral300 mg
SuspensionOral750 mg
TabletOral750 mg
LiquidOral600 mg
TabletOral600 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.65ChemAxon
pKa (Strongest Acidic)15.7ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area25.3 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity3.7 m3·mol-1ChemAxon
Polarizability1.51 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as post-transition metal hydroxides. These are inorganic compounds in which the largest oxoanion is hydroxide, and in which the heaviest atom not in an oxoanion is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal oxoanionic compounds
Sub Class
Post-transition metal hydroxides
Direct Parent
Post-transition metal hydroxides
Alternative Parents
Post-transition metal salts / Metalloid salts / Inorganic salts / Inorganic oxides / Inorganic hydrides
Substituents
Post-transition metal hydroxide / Inorganic post-transition metal salt / Inorganic hydride / Inorganic oxide / Inorganic salt / Inorganic metalloid salt
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on August 29, 2007 08:48 / Updated on October 02, 2017 05:00