S-adenosyl-L-homocysteine

Identification

Name
S-adenosyl-L-homocysteine
Accession Number
DB01752  (EXPT02842)
Type
Small Molecule
Groups
Experimental
Description

5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.

Structure
Thumb
Synonyms
  • 2-S-adenosyl-L-homocysteine
  • Adenosyl-L-homocysteine
  • adenosylhomocysteine
  • AdoHcy
  • S-(5'-adenosyl)-L-homocysteine
  • S-[1-(adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl]-L-homocysteine
  • S-Adenosylhomocysteine
Categories
Not Available
UNII
8K31Q2S66S
CAS number
979-92-0
Weight
Average: 384.411
Monoisotopic: 384.12158847
Chemical Formula
C14H20N6O5S
InChI Key
ZJUKTBDSGOFHSH-WFMPWKQPSA-N
InChI
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
IUPAC Name
(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid
SMILES

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UCap-specific mRNA (nucleoside-2'-O-)-methyltransferaseNot AvailableVACV
UCobalt-precorrin-4 C(11)-methyltransferaseNot AvailableBacillus megaterium
UProtein-L-isoaspartate(D-aspartate) O-methyltransferaseNot AvailableHuman
UGenome polyproteinNot AvailableDENV-2
UPhenylethanolamine N-methyltransferaseNot AvailableHuman
UCyclopropane mycolic acid synthase 2Not AvailableMycobacterium tuberculosis
UModification methylase RsrINot AvailableRhodobacter sphaeroides
UCatechol O-methyltransferase domain-containing protein 1Not AvailableHuman
UCarminomycin 4-O-methyltransferaseNot AvailableStreptomyces peucetius
UGuanidinoacetate N-methyltransferaseNot AvailableHuman
URelease factor glutamine methyltransferaseNot AvailableEscherichia coli (strain K12)
URelease factor glutamine methyltransferaseNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UProtein arginine N-methyltransferase 3Not AvailableHuman
UHistamine N-methyltransferaseNot AvailableHuman
URibosomal RNA small subunit methyltransferase HNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UrRNA adenine N-6-methyltransferaseNot AvailableBacillus subtilis
UtRNA (cytosine(38)-C(5))-methyltransferaseNot AvailableHuman
UGlycine N-methyltransferaseNot AvailableHuman
UtRNA (cytidine(34)-2'-O)-methyltransferaseNot AvailableHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
UModification methylase PvuIINot AvailableProteus hauseri
UDNA adenine methylaseNot AvailableEnterobacteria phage T4
UCyclopropane mycolic acid synthase 3Not AvailableMycobacterium tuberculosis
UProtein arginine N-methyltransferase 1Not AvailableHuman
USiroheme synthaseNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
UModification methylase HhaINot AvailableHaemophilus parahaemolyticus
UHistone-lysine N-methyltransferase SETD7Not AvailableHuman
UtRNA (guanine-N(1)-)-methyltransferaseNot AvailableHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
UCyclopropane mycolic acid synthase MmaA2Not AvailableMycobacterium tuberculosis
UDiphthine synthaseNot AvailableHuman
URdmBNot AvailableStreptomyces purpurascens
UtRNA (guanine-N(1)-)-methyltransferaseNot AvailableShigella flexneri
UUroporphyrinogen-III C-methyltransferaseNot AvailablePseudomonas denitrificans
UUncharacterized proteinNot AvailableThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
UChemotaxis protein methyltransferaseNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
UModification methylase TaqINot AvailableThermus aquaticus
UProtein-L-isoaspartate O-methyltransferaseNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

Synthesis Reference

Hideaki Yamada, Sakayu Shimizu, Shozo Shiozaki, "Process for producing S-adenosyl-L-homocysteine." U.S. Patent US4605625, issued March, 1978.

US4605625
General References
Not Available
External Links
Human Metabolome Database
HMDB00939
KEGG Compound
C00021
PubChem Compound
439155
PubChem Substance
46508993
ChemSpider
388301
BindingDB
50009672
ChEBI
16680
ChEMBL
CHEMBL418052
HET
SAH
PDB Entries
10mh / 1af7 / 1aqi / 1av6 / 1b42 / 1bc5 / 1bky / 1boo / 1cbf / 1d2h
show 777 more

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility4.08 mg/mLALOGPS
logP-2.4ALOGPS
logP-4ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)1.81ChemAxon
pKa (Strongest Basic)9.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area182.63 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity92.72 m3·mol-1ChemAxon
Polarizability38.41 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9626
Blood Brain Barrier-0.6261
Caco-2 permeable-0.8056
P-glycoprotein substrateSubstrate0.6112
P-glycoprotein inhibitor INon-inhibitor0.9437
P-glycoprotein inhibitor IINon-inhibitor0.9883
Renal organic cation transporterNon-inhibitor0.9179
CYP450 2C9 substrateNon-substrate0.8742
CYP450 2D6 substrateNon-substrate0.8034
CYP450 3A4 substrateNon-substrate0.5
CYP450 1A2 substrateNon-inhibitor0.9028
CYP450 2C9 inhibitorNon-inhibitor0.9086
CYP450 2D6 inhibitorNon-inhibitor0.9295
CYP450 2C19 inhibitorNon-inhibitor0.8862
CYP450 3A4 inhibitorNon-inhibitor0.9017
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9323
Ames testNon AMES toxic0.6549
CarcinogenicityNon-carcinogens0.9345
BiodegradationNot ready biodegradable0.9885
Rat acute toxicity2.3223 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9744
hERG inhibition (predictor II)Non-inhibitor0.7908
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0006-0943000000-80fa5c7d919e1085bc5d
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-00di-0900000000-3f143852503952daa0a8
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-03di-0900000000-23694a4b657a3478ad91
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0udr-0980000000-a8f61dcdc8693e2725f5
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-00kf-0974000000-b3f3632635b2847bf4d2
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-00di-0900000000-188a77c79aaefae8a184
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-000i-0900000000-b848c20d743785117445
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , PositiveLC-MS/MSsplash10-0udr-0980000000-64b7b303fc07300e0782
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-001i-0319020200-859d659a39a790a582f1
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-0a4i-0900000000-53acf4e10681047da062
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-001i-0910000000-5896502e31d66786e12a
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-001i-0009000000-01ea51599f8d30dec7fe
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-001i-0409000100-2de58945ab0dfa81f099
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-0a4i-1900000000-a640f1a0bafd33afdd2d
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-001i-0910000000-5f685035af9b243ccff2
LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , NegativeLC-MS/MSsplash10-001i-0009000000-8d01fd0969e47d3bcc5c
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , PositiveLC-MS/MSsplash10-000i-2901000000-6c40a4a43a8c3e142ece
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , NegativeLC-MS/MSsplash10-001i-0902000000-c6c0d5529cf011d89f7b
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0a4i-0900000000-53acf4e10681047da062
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-001i-0910000000-5896502e31d66786e12a
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-001i-0009000000-01ea51599f8d30dec7fe
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0a4i-1900000000-a640f1a0bafd33afdd2d
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-001i-0910000000-6da47cc70ea7d7eb41f1
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-001i-0009000000-8d01fd0969e47d3bcc5c
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-001i-0902000000-c6c0d5529cf011d89f7b
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0900000000-3f143852503952daa0a8
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0900000000-23694a4b657a3478ad91
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udr-0980000000-a8f61dcdc8693e2725f5
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0900000000-188a77c79aaefae8a184
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-000i-0900000000-b848c20d743785117445
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udr-0980000000-f1be2f3c6fa52d404892
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000i-2901000000-6c40a4a43a8c3e142ece
1H NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,1H] 2D NMR Spectrum2D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.
Kingdom
Organic compounds
Super Class
Nucleosides, nucleotides, and analogues
Class
5'-deoxyribonucleosides
Sub Class
5'-deoxy-5'-thionucleosides
Direct Parent
5'-deoxy-5'-thionucleosides
Alternative Parents
Glycosylamines / Pentoses / 6-aminopurines / L-alpha-amino acids / Thia fatty acids / Aminopyrimidines and derivatives / Hydroxy fatty acids / N-substituted imidazoles / Imidolactams / Tetrahydrofurans
show 15 more
Substituents
5'-deoxy-5'-thionucleoside / N-glycosyl compound / Glycosyl compound / 6-aminopurine / Alpha-amino acid / Alpha-amino acid or derivatives / Pentose monosaccharide / L-alpha-amino acid / Imidazopyrimidine / Purine
show 39 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
adenosines, organic sulfide, homocysteines (CHEBI:16680)

Targets

Kind
Protein
Organism
VACV
Pharmacological action
Unknown
General Function
Translation elongation factor activity
Specific Function
Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene p...
Gene Name
PAPS
Uniprot ID
P07617
Uniprot Name
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Molecular Weight
38887.65 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Bacillus megaterium
Pharmacological action
Unknown
General Function
Precorrin-4 c11-methyltransferase activity
Specific Function
Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A.
Gene Name
cbiF
Uniprot ID
O87696
Uniprot Name
Cobalt-precorrin-4 C(11)-methyltransferase
Molecular Weight
28452.015 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein-l-isoaspartate (d-aspartate) o-methyltransferase activity
Specific Function
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It ...
Gene Name
PCMT1
Uniprot ID
P22061
Uniprot Name
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Molecular Weight
24636.21 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
DENV-2
Pharmacological action
Unknown
General Function
Structural molecule activity
Specific Function
Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA.prM acts as a chaperone for envelope protein E during intracellular vi...
Gene Name
Not Available
Uniprot ID
P12823
Uniprot Name
Genome polyprotein
Molecular Weight
379216.195 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Phenylethanolamine n-methyltransferase activity
Specific Function
Converts noradrenaline to adrenaline.
Gene Name
PNMT
Uniprot ID
P11086
Uniprot Name
Phenylethanolamine N-methyltransferase
Molecular Weight
30854.745 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
Specific Function
Cyclopropane-fatty-acyl-phospholipid synthase activity
Gene Name
cmaA2
Uniprot ID
P9WPB5
Uniprot Name
Cyclopropane mycolic acid synthase 2
Molecular Weight
34659.795 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Rhodobacter sphaeroides
Pharmacological action
Unknown
General Function
Site-specific dna-methyltransferase (adenine-specific) activity
Specific Function
This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-? on both strands, and protects the DNA from cleavage by the RsrI endonuclease.
Gene Name
rsrIM
Uniprot ID
P14751
Uniprot Name
Modification methylase RsrI
Molecular Weight
35654.88 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
O-methyltransferase activity
Specific Function
Putative O-methyltransferase.
Gene Name
COMTD1
Uniprot ID
Q86VU5
Uniprot Name
Catechol O-methyltransferase domain-containing protein 1
Molecular Weight
28808.225 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Streptomyces peucetius
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
dnrK
Uniprot ID
Q06528
Uniprot Name
Carminomycin 4-O-methyltransferase DnrK
Molecular Weight
38781.615 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Methyltransferase activity
Specific Function
Not Available
Gene Name
GAMT
Uniprot ID
Q14353
Uniprot Name
Guanidinoacetate N-methyltransferase
Molecular Weight
26317.925 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
S-adenosylmethionine-dependent methyltransferase activity
Specific Function
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif, i.e. on 'Gln-235' in RF1 and on 'Gln-252' in RF2.
Gene Name
prmC
Uniprot ID
P0ACC1
Uniprot Name
Release factor glutamine methyltransferase
Molecular Weight
30974.67 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Protein-glutamine n-methyltransferase activity
Specific Function
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Gene Name
prmC
Uniprot ID
Q9WYV8
Uniprot Name
Release factor glutamine methyltransferase
Molecular Weight
31609.085 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein-arginine omega-n asymmetric methyltransferase activity
Specific Function
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
Gene Name
PRMT3
Uniprot ID
O60678
Uniprot Name
Protein arginine N-methyltransferase 3
Molecular Weight
59875.63 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Histamine n-methyltransferase activity
Specific Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Gene Name
HNMT
Uniprot ID
P50135
Uniprot Name
Histamine N-methyltransferase
Molecular Weight
33294.765 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Rrna (cytosine-n4-)-methyltransferase activity
Specific Function
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Gene Name
rsmH
Uniprot ID
Q9WZX6
Uniprot Name
Ribosomal RNA small subunit methyltransferase H
Molecular Weight
34892.82 Da
Kind
Protein
Organism
Bacillus subtilis
Pharmacological action
Unknown
General Function
Rrna (adenine-n6,n6-)-dimethyltransferase activity
Specific Function
This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.
Gene Name
ermC'
Uniprot ID
P13956
Uniprot Name
rRNA adenine N-6-methyltransferase
Molecular Weight
28907.235 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Trna methyltransferase activity
Specific Function
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Gene Name
TRDMT1
Uniprot ID
O14717
Uniprot Name
tRNA (cytosine(38)-C(5))-methyltransferase
Molecular Weight
44596.17 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Glycine n-methyltransferase activity
Specific Function
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial ...
Gene Name
GNMT
Uniprot ID
Q14749
Uniprot Name
Glycine N-methyltransferase
Molecular Weight
32742.0 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
Unknown
General Function
Trna methyltransferase activity
Specific Function
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the...
Gene Name
trmL
Uniprot ID
P44868
Uniprot Name
tRNA (cytidine(34)-2'-O)-methyltransferase
Molecular Weight
18401.245 Da
Kind
Protein
Organism
Proteus hauseri
Pharmacological action
Unknown
General Function
Site-specific dna-methyltransferase (cytosine-n4-specific) activity
Specific Function
This methylase recognizes the double-stranded sequence CAGCTG, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the PvuII endonuclease.
Gene Name
pvuIIM
Uniprot ID
P11409
Uniprot Name
Modification methylase PvuII
Molecular Weight
38364.585 Da
Kind
Protein
Organism
Enterobacteria phage T4
Pharmacological action
Unknown
General Function
Site-specific dna-methyltransferase (adenine-specific) activity
Specific Function
Methyltransferase that methylates adenine residues in the dsDNA sequence GATC. May prevents degradation of viral DNA by the host restriction-modification antiviral defense system.
Gene Name
DAM
Uniprot ID
P04392
Uniprot Name
DNA adenine methylase
Molecular Weight
30416.59 Da
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Involved in the phagosome maturation block (PMB). Catalyzes the conversion of a double bond to a cyclopropane ring at the proximal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. It can use cis, cis 11,14-eicosadienoic acid and linoelaidic acid as substrate. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
Specific Function
Cyclopropane-fatty-acyl-phospholipid synthase activity
Gene Name
pcaA
Uniprot ID
P9WPB3
Uniprot Name
Cyclopropane mycolic acid synthase 3
Molecular Weight
33027.5 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein-arginine omega-n asymmetric methyltransferase activity
Specific Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, H...
Gene Name
PRMT1
Uniprot ID
Q99873
Uniprot Name
Protein arginine N-methyltransferase 1
Molecular Weight
41515.2 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
Unknown
General Function
Uroporphyrin-iii c-methyltransferase activity
Specific Function
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring de...
Gene Name
cysG
Uniprot ID
P25924
Uniprot Name
Siroheme synthase
Molecular Weight
50146.22 Da
Kind
Protein
Organism
Haemophilus parahaemolyticus
Pharmacological action
Unknown
General Function
Dna (cytosine-5-)-methyltransferase activity
Specific Function
This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
Gene Name
hhaIM
Uniprot ID
P05102
Uniprot Name
Modification methylase HhaI
Molecular Weight
36996.04 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein-lysine n-methyltransferase activity
Specific Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in...
Gene Name
SETD7
Uniprot ID
Q8WTS6
Uniprot Name
Histone-lysine N-methyltransferase SETD7
Molecular Weight
40720.595 Da
Kind
Protein
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Pharmacological action
Unknown
General Function
Trna (guanine(37)-n(1))-methyltransferase activity
Specific Function
Specifically methylates guanosine-37 in various tRNAs.
Gene Name
trmD
Uniprot ID
P43912
Uniprot Name
tRNA (guanine-N(1)-)-methyltransferase
Molecular Weight
27542.435 Da
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Methyltransferase activity
Specific Function
Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also c...
Gene Name
mmaA2
Uniprot ID
Q79FX6
Uniprot Name
Cyclopropane mycolic acid synthase MmaA2
Molecular Weight
32724.06 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Diphthine synthase activity
Specific Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate call...
Gene Name
DPH5
Uniprot ID
Q9H2P9
Uniprot Name
Diphthine methyl ester synthase
Molecular Weight
31651.17 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Streptomyces purpurascens
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
rdmB
Uniprot ID
Q54527
Uniprot Name
Aclacinomycin 10-hydroxylase RdmB
Molecular Weight
39796.525 Da
Kind
Protein
Organism
Shigella flexneri
Pharmacological action
Unknown
General Function
Trna (guanine(37)-n(1))-methyltransferase activity
Specific Function
Specifically methylates guanosine-37 in various tRNAs.
Gene Name
trmD
Uniprot ID
P0A876
Uniprot Name
tRNA (guanine-N(1)-)-methyltransferase
Molecular Weight
28422.12 Da
Kind
Protein
Organism
Pseudomonas denitrificans
Pharmacological action
Unknown
General Function
Uroporphyrin-iii c-methyltransferase activity
Specific Function
Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohyd...
Gene Name
cobA
Uniprot ID
P21631
Uniprot Name
Uroporphyrinogen-III C-methyltransferase
Molecular Weight
29252.515 Da
Kind
Protein
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Pharmacological action
Unknown
General Function
Precorrin-2 dehydrogenase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q5SKH6
Uniprot Name
Uncharacterized protein
Molecular Weight
26233.475 Da
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
Unknown
General Function
Protein-glutamate o-methyltransferase activity
Specific Function
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
Gene Name
cheR
Uniprot ID
P07801
Uniprot Name
Chemotaxis protein methyltransferase
Molecular Weight
32923.325 Da
Kind
Protein
Organism
Thermus aquaticus
Pharmacological action
Unknown
General Function
Site-specific dna-methyltransferase (adenine-specific) activity
Specific Function
This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the TaqI endonuclease.
Gene Name
taqIM
Uniprot ID
P14385
Uniprot Name
Modification methylase TaqI
Molecular Weight
47861.91 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Protein-l-isoaspartate (d-aspartate) o-methyltransferase activity
Specific Function
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in...
Gene Name
pcm
Uniprot ID
Q56308
Uniprot Name
Protein-L-isoaspartate O-methyltransferase
Molecular Weight
36399.64 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Histamine n-methyltransferase activity
Specific Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Gene Name
HNMT
Uniprot ID
P50135
Uniprot Name
Histamine N-methyltransferase
Molecular Weight
33294.765 Da

Drug created on June 13, 2005 07:24 / Updated on November 09, 2017 03:04