Identification
NameD-glucose
Accession NumberDB01914  (EXPT01609, DB11280)
TypeSmall Molecule
GroupsApproved
Description

D-glucose is one of the 16 aldohexose stereoisomers and the most commonly occurring isomer of glucose in nature. It is used as fluid replenishment and caloric supply. Made during photosynthesis from water and carbon dioxide, it is the most important energy source for cellular respiration.

Structure
Thumb
Synonyms
aldehydo-D-glucose
Anhydrous dextrose
D-Glucose in linear form
D-glucose, anhydrous
D(+)-Glucose
Dextrose anhydrous
Dextrose, anhydrous
Glucose
Glucose anhydrous
Glucose, anhydrous
External IDs NSC-406891
Product Ingredients
IngredientUNIICASInChI KeyDetails
Dextrose monohydrateLX22YL083G 77938-63-7SPFMQWBKVUQXJV-BTVCFUMJSA-NDetails
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DextroseInjection, solution25 g/50mLIntravenousHospira, Inc.1990-09-30Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Accusol 35 K2Chief Medical Supplies Ltd
Accusol 35 K4Chief Medical Supplies Ltd
Haemonetics Additive Solution Formula 3 (as-3)Haemonetics Corporation
Haemonetics Anticoagulant Citrate Phosphate Double Dextrose Solution (cp2d)Haemonetics Corporation
Prismasol 2Baxter Laboratories
Prismasol 4Baxter Laboratories
Sag-mannitol SolutionLaboratorios Grifols s.a.
Selutrio 10Fresenius Medical Care Deutchland Gmbh
Selutrio 40Fresenius Medical Care Deutchland Gmbh
CategoriesNot Available
UNII5SL0G7R0OK
CAS number50-99-7
WeightAverage: 180.1559
Monoisotopic: 180.063388116
Chemical FormulaC6H12O6
InChI KeyGZCGUPFRVQAUEE-SLPGGIOYSA-N
InChI
InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6+/m0/s1
IUPAC Name
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal
SMILES
[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]([H])(O)C=O
Pharmacology
Indication

Indicated for use as a caloric suply and water replenishment in cases of hypoglycemia or water loss without electrolyte loss.

Structured Indications Not Available
Pharmacodynamics

Refer to Glucose.

Mechanism of action

Refer to Glucose.

Related Articles
Absorption

Refer to Glucose.

Volume of distribution

Refer to Glucose.

Protein binding

Refer to Glucose.

Metabolism

Refer to Glucose.

Route of elimination

Refer to Glucose.

Half life

Refer to Glucose.

Clearance

Refer to Glucose.

Toxicity

Oral LD50 that leads to toxicity is 25800 mg/kg in rats. Refer to Glucose.

Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions Not Available
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Dailymed Dextrose monohydrate injection label [Link]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB Entries
FDA labelDownload (142 KB)
MSDSDownload (47 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableRecruitingBasic ScienceBMI >30 kg/m2 / Hyperinsulinemia / Hypogonadotropic Hypogonadotropism / Infertilities1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
SolutionHemodialysis
Injection, solutionIntravenous25 g/50mL
SolutionExtracorporeal
SolutionHemodialysis; Intravenous
SolutionUnknown
SolutionIntraperitoneal
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)146 MSDS
water solubilitySolubleMSDS
Predicted Properties
PropertyValueSource
Water Solubility261.0 mg/mLALOGPS
logP-2.4ALOGPS
logP-3.6ChemAxon
logS0.16ALOGPS
pKa (Strongest Acidic)11.8ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area118.22 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity37.35 m3·mol-1ChemAxon
Polarizability16.23 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8269
Blood Brain Barrier+0.5569
Caco-2 permeable-0.8842
P-glycoprotein substrateNon-substrate0.6771
P-glycoprotein inhibitor INon-inhibitor0.9568
P-glycoprotein inhibitor IINon-inhibitor0.9378
Renal organic cation transporterNon-inhibitor0.9388
CYP450 2C9 substrateNon-substrate0.8595
CYP450 2D6 substrateNon-substrate0.8847
CYP450 3A4 substrateNon-substrate0.7206
CYP450 1A2 substrateNon-inhibitor0.8505
CYP450 2C9 inhibitorNon-inhibitor0.9411
CYP450 2D6 inhibitorNon-inhibitor0.9366
CYP450 2C19 inhibitorNon-inhibitor0.942
CYP450 3A4 inhibitorNon-inhibitor0.9065
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9652
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8077
BiodegradationReady biodegradable0.9596
Rat acute toxicity1.0110 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9883
hERG inhibition (predictor II)Non-inhibitor0.9385
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
KingdomChemical entities
Super ClassOrganic compounds
ClassOrganic oxygen compounds
Sub ClassOrganooxygen compounds
Direct ParentHexoses
Alternative ParentsMedium-chain aldehydes / Beta-hydroxy aldehydes / Alpha-hydroxyaldehydes / Secondary alcohols / Polyols / Primary alcohols / Organic oxides / Hydrocarbon derivatives
SubstituentsHexose monosaccharide / Medium-chain aldehyde / Beta-hydroxy aldehyde / Alpha-hydroxyaldehyde / Secondary alcohol / Polyol / Organic oxide / Hydrocarbon derivative / Primary alcohol / Carbonyl group
Molecular FrameworkAliphatic acyclic compounds
External Descriptorsaldehydo-glucose, D-glucose (CHEBI:42758 )

Enzymes

Kind
Protein
Organism
Streptomyces olivochromogenes
Pharmacological action
unknown
Actions
substrate
General Function:
Xylose isomerase activity
Specific Function:
Involved in D-xylose catabolism.
Gene Name:
xylA
Uniprot ID:
P15587
Uniprot Name:
Xylose isomerase
Molecular Weight:
42922.7 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Bhosale SH, Rao MB, Deshpande VV: Molecular and industrial aspects of glucose isomerase. Microbiol Rev. 1996 Jun;60(2):280-300. [PubMed:8801434 ]
Drug created on June 13, 2005 07:24 / Updated on July 18, 2017 17:04