Identification

Name
Formic Acid
Accession Number
DB01942  (EXPT01461)
Type
Small Molecule
Groups
Experimental
Description

Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed.

Structure
Thumb
Synonyms
  • Acide formique
  • Ameisensäure
  • Aminic acid
  • bilorin
  • Formate
  • Formylic acid
  • Hydrogen carboxylic acid
  • Methanoic acid
External IDs
E236 / FEMA NO. 2487
Product Ingredients
IngredientUNIICASInChI Key
Calcium formateNP3JD65NPY544-17-2CBOCVOKPQGJKKJ-UHFFFAOYSA-L
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Prenate EliteCalcium formate (155 mg/1) + 5-methyltetrahydrofolic acid (600 ug/1) + Beta carotene (2600 [iU]/1) + Biotin (330 ug/1) + Cholecalciferol (600 [iU]/1) + Cupric oxide (1.5 mg/1) + Cyanocobalamin (13 ug/1) + Ferrous asparto glycinate (20 mg/1) + Folic Acid (400 ug/1) + Magnesium oxide (25 mg/1) + Nicotinamide (21 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (21 mg/1) + Riboflavin (3.5 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin C (75 mg/1) + Vitamin E (40 [iU]/1) + Zinc oxide (15 mg/1)Tablet, coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
Prenate EssentialCalcium formate (155 mg/1) + 5-methyltetrahydrofolic acid (600 ug/1) + Biotin (280 ug/1) + Cholecalciferol (220 [iU]/1) + Cyanocobalamin (13 ug/1) + Doconexent (300 mg/1) + Ferrous asparto glycinate (18 mg/1) + Folic Acid (400 ug/1) + Icosapent (40 mg/1) + Magnesium oxide (50 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (26 mg/1) + Vitamin C (90 mg/1) + Vitamin E (10 [iU]/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-07-18Not applicableUs
Prenate StarCalcium formate (155 mg/1) + Beta carotene (3300 [iU]/1) + Biotin (330 ug/1) + Cholecalciferol (450 [iU]/1) + Cupric oxide (1.5 mg/1) + Cyanocobalamin (12 ug/1) + Ferrous asparto glycinate (20 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (21 mg/1) + Calcium pantothenate (6 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (21 mg/1) + Riboflavin (2 mg/1) + Thiamine mononitrate (1.5 mg/1) + Vitamin C (75 mg/1) + Zinc oxide (15 mg/1)Tablet, coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
Categories
UNII
0YIW783RG1
CAS number
64-18-6
Weight
Average: 46.0254
Monoisotopic: 46.005479308
Chemical Formula
CH2O2
InChI Key
BDAGIHXWWSANSR-UHFFFAOYSA-N
InChI
InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)
IUPAC Name
formic acid
SMILES
OC=O

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UPutative hydroxypyruvate isomerase YgbMNot AvailableEscherichia coli (strain K12)
UDelta-aminolevulinic acid dehydrataseNot AvailablePseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
U3-phosphoshikimate 1-carboxyvinyltransferaseNot AvailableEscherichia coli (strain K12)
USubtilisin CarlsbergNot AvailableBacillus licheniformis
UFibroblast growth factor 1Not AvailableHuman
UPeptide deformylaseNot AvailableEscherichia coli (strain K12)
UPara-aminobenzoate synthase component 1Not AvailableEscherichia coli (strain K12)
UCarbonic anhydrase 2Not AvailableHuman
UHeme oxygenase 1Not AvailableHuman
URibonuclease pancreaticNot AvailableHuman
UDihydroorotate dehydrogenase (quinone)Not AvailableEscherichia coli (strain K12)
U(S)-2-haloacid dehalogenaseNot AvailableXanthobacter autotrophicus
UBeta-lactamase OXA-2Not AvailableSalmonella typhimurium
UCatalaseNot AvailableProteus mirabilis
USignal recognition particle proteinNot AvailableThermus aquaticus
UStreptavidinNot AvailableStreptomyces avidinii
UMethylglyoxal synthaseNot AvailableShigella flexneri
UC-terminal-binding protein 1Not AvailableHuman
U6-phosphogluconolactonaseNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UCitrate lyase subunit beta-like proteinNot AvailableMycobacterium tuberculosis
UPeripheral plasma membrane protein CASKNot AvailableHuman
UGuanylate kinaseNot AvailableMycobacterium tuberculosis
UProbable butyrate kinase 2Not AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UGamma-glutamylaminecyclotransferaseNot AvailableHuman
UParvalbumin alphaNot AvailableHuman
UAcylphosphatase-2Not AvailableHuman
UUncharacterized proteinNot AvailableBacillus cereus (strain ATCC 14579 / DSM 31)
UArginine N-succinyltransferase subunit alphaNot AvailablePseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
UPutative mannose-6-phosphate isomerase YvyINot AvailableBacillus subtilis (strain 168)
UNitric oxide synthase, brainNot AvailableHuman
UABC-type transporter, periplasmic subunitNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UProbable phosphatase YcdXNot AvailableEscherichia coli (strain K12)
UPhenazine biosynthesis protein PhzDNot AvailablePseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
UOxalate decarboxylase OxdCNot AvailableBacillus subtilis (strain 168)
UPutative ketoacyl reductaseNot AvailableStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
UGephyrinNot AvailableHuman
UGlyoxalase family proteinNot AvailableBacillus cereus (strain ATCC 14579 / DSM 31)
UCytohesin-2Not AvailableHuman
UGlutaconyl-CoA decarboxylase subunit alphaNot AvailableAcidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
UTranscriptional regulator, IclR familyNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UCatalaseNot AvailableHelicobacter pylori (strain ATCC 700392 / 26695)
UPutative L-rhamnose mutarotaseNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UGlutathione S-transferaseNot AvailablePlasmodium falciparum
UHypoxanthine-guanine phosphoribosyltransferaseNot AvailableTrypanosoma cruzi
UGlutaminase 1Not AvailableBacillus subtilis (strain 168)
UGlutaminase 1Not AvailableEscherichia coli (strain K12)
UMolybdopterin synthase catalytic subunitNot AvailableEscherichia coli (strain K12)
UAminotransferase, putativeNot AvailableThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UIron binding protein FbpANot AvailablePasteurella haemolytica
UDNA gyrase subunit BNot AvailableThermus thermophilus
Absorption

Formic acid is readily metabolized and eliminated by the body.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

ORAL (LD50): Acute: 700 mg/kg [Mouse]. 1100 mg/kg [Rat]. 4000 mg/kg [Dog].

Affected organisms
Not Available
Pathways
PathwayCategory
Tryptophan MetabolismMetabolic
Alendronate Action PathwayDrug action
Zoledronate Action PathwayDrug action
Wolman diseaseDisease
Aromatase deficiencyDisease
Rosuvastatin Action PathwayDrug action
Fluvastatin Action PathwayDrug action
17-Beta Hydroxysteroid Dehydrogenase III DeficiencyDisease
CHILD SyndromeDisease
Sepiapterin reductase deficiencyDisease
Hyper-IgD syndromeDisease
Androstenedione MetabolismMetabolic
Cerivastatin Action PathwayDrug action
Pamidronate Action PathwayDrug action
Atorvastatin Action PathwayDrug action
Methotrexate Action PathwayDrug action
Hyperphenylalaninemia due to dhpr-deficiencyDisease
Cholesteryl ester storage diseaseDisease
Mevalonic aciduriaDisease
Pterine BiosynthesisMetabolic
Folate MetabolismMetabolic
Androgen and Estrogen MetabolismMetabolic
Pravastatin Action PathwayDrug action
Risedronate Action PathwayDrug action
HypercholesterolemiaDisease
Segawa syndromeDisease
Folate malabsorption, hereditaryDisease
Steroid BiosynthesisMetabolic
Ibandronate Action PathwayDrug action
Simvastatin Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

Synthesis Reference

Gunter Roscher, Helmut Schaum, Heinz Schmitz, "Process for the preparation of practically formic acid-free acetic acid." U.S. Patent US4380663, issued August, 1944.

US4380663
General References
Not Available
External Links
Human Metabolome Database
HMDB00142
KEGG Compound
C00058
PubChem Compound
284
PubChem Substance
46508355
ChemSpider
278
ChEBI
30751
ChEMBL
CHEMBL116736
PharmGKB
PA449705
HET
FMT
Wikipedia
Formic_Acid
PDB Entries
1a5n / 1a5o / 1an5 / 1aob / 1aq6 / 1aus / 1axw / 1b93 / 1bdu / 1bid
show 1000 more
MSDS
Download (78.4 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Unknown StatusNot AvailableHealthy Volunteers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Capsule, gelatin coatedOral
Tablet, coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)8.3 °CPhysProp
boiling point (°C)101 °CPhysProp
water solubility1E+006 mg/L (at 25 °C)RIDDICK,JA ET AL. (1986)
logP-0.54HANSCH,C ET AL. (1995)
pKa3.75 (at 25 °C)RIDDICK,JA ET AL. (1986)
Predicted Properties
PropertyValueSource
Water Solubility477.0 mg/mLALOGPS
logP-0.47ALOGPS
logP-0.27ChemAxon
logS1.02ALOGPS
pKa (Strongest Acidic)4.27ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity8.15 m3·mol-1ChemAxon
Polarizability3.37 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9726
Blood Brain Barrier+0.9652
Caco-2 permeable+0.6096
P-glycoprotein substrateNon-substrate0.8931
P-glycoprotein inhibitor INon-inhibitor0.9906
P-glycoprotein inhibitor IINon-inhibitor0.9913
Renal organic cation transporterNon-inhibitor0.9444
CYP450 2C9 substrateNon-substrate0.8181
CYP450 2D6 substrateNon-substrate0.9527
CYP450 3A4 substrateNon-substrate0.8338
CYP450 1A2 substrateNon-inhibitor0.9272
CYP450 2C9 inhibitorNon-inhibitor0.9723
CYP450 2D6 inhibitorNon-inhibitor0.9675
CYP450 2C19 inhibitorNon-inhibitor0.9877
CYP450 3A4 inhibitorNon-inhibitor0.9843
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9922
Ames testNon AMES toxic0.9551
CarcinogenicityCarcinogens 0.6199
BiodegradationReady biodegradable0.9383
Rat acute toxicity1.6531 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9799
hERG inhibition (predictor II)Non-inhibitor0.9886
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (7.52 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-004j-9000000000-2e63b0c1e2e417b0d747
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-092f816e62c8d2f5d56e
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-092f816e62c8d2f5d56e
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-092f816e62c8d2f5d56e
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-eb2207f7400e9144fff7
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-eb2207f7400e9144fff7
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-eb2207f7400e9144fff7
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,1H] 2D NMR Spectrum2D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as carboxylic acids. These are compounds containing a carboxylic acid group with the formula -C(=O)OH.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acids
Direct Parent
Carboxylic acids
Alternative Parents
Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Monocarboxylic acid or derivatives / Carboxylic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organooxygen compound / Carbonyl group / Aliphatic acyclic compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
monocarboxylic acid (CHEBI:30751) / Straight chain fatty acids, Saturated fatty acids (C00058)

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Hydroxypyruvate isomerase activity
Specific Function
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
Gene Name
ygbM
Uniprot ID
Q46891
Uniprot Name
Putative hydroxypyruvate isomerase YgbM
Molecular Weight
29216.725 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen...
Gene Name
hemB
Uniprot ID
Q59643
Uniprot Name
Delta-aminolevulinic acid dehydratase
Molecular Weight
37036.6 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
3-phosphoshikimate 1-carboxyvinyltransferase activity
Specific Function
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Gene Name
aroA
Uniprot ID
P0A6D3
Uniprot Name
3-phosphoshikimate 1-carboxyvinyltransferase
Molecular Weight
46095.29 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Bacillus licheniformis
Pharmacological action
Unknown
General Function
Serine-type endopeptidase activity
Specific Function
Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
Gene Name
apr
Uniprot ID
P00780
Uniprot Name
Subtilisin Carlsberg
Molecular Weight
38907.64 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
S100 protein binding
Specific Function
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Gene Name
FGF1
Uniprot ID
P05230
Uniprot Name
Fibroblast growth factor 1
Molecular Weight
17459.58 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activi...
Gene Name
def
Uniprot ID
P0A6K3
Uniprot Name
Peptide deformylase
Molecular Weight
19328.23 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Oxo-acid-lyase activity
Specific Function
Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutami...
Gene Name
pabB
Uniprot ID
P05041
Uniprot Name
Aminodeoxychorismate synthase component 1
Molecular Weight
50969.07 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion in...
Gene Name
CA2
Uniprot ID
P00918
Uniprot Name
Carbonic anhydrase 2
Molecular Weight
29245.895 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Signal transducer activity
Specific Function
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the a...
Gene Name
HMOX1
Uniprot ID
P09601
Uniprot Name
Heme oxygenase 1
Molecular Weight
32818.345 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ribonuclease a activity
Specific Function
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
Gene Name
RNASE1
Uniprot ID
P07998
Uniprot Name
Ribonuclease pancreatic
Molecular Weight
17644.125 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Fmn binding
Specific Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Gene Name
pyrD
Uniprot ID
P0A7E1
Uniprot Name
Dihydroorotate dehydrogenase (quinone)
Molecular Weight
36774.185 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Xanthobacter autotrophicus
Pharmacological action
Unknown
General Function
(s)-2-haloacid dehalogenase activity
Specific Function
Catalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isom...
Gene Name
dhlB
Uniprot ID
Q60099
Uniprot Name
(S)-2-haloacid dehalogenase
Molecular Weight
27469.15 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Salmonella typhimurium
Pharmacological action
Unknown
General Function
Penicillin binding
Specific Function
This is an oxacillin-hydrolyzing beta-lactamase.
Gene Name
bla
Uniprot ID
P0A1V8
Uniprot Name
Beta-lactamase OXA-2
Molecular Weight
31685.78 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Proteus mirabilis
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Gene Name
katA
Uniprot ID
P42321
Uniprot Name
Catalase
Molecular Weight
55614.085 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Thermus aquaticus
Pharmacological action
Unknown
General Function
Gtpase activity
Specific Function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the r...
Gene Name
ffh
Uniprot ID
O07347
Uniprot Name
Signal recognition particle protein
Molecular Weight
47355.705 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Streptomyces avidinii
Pharmacological action
Unknown
General Function
Not Available
Specific Function
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
Gene Name
Not Available
Uniprot ID
P22629
Uniprot Name
Streptavidin
Molecular Weight
18833.61 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Shigella flexneri
Pharmacological action
Unknown
General Function
Methylglyoxal synthase activity
Specific Function
Not Available
Gene Name
mgsA
Uniprot ID
P0A733
Uniprot Name
Methylglyoxal synthase
Molecular Weight
16918.435 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Transcription factor binding
Specific Function
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi...
Gene Name
CTBP1
Uniprot ID
Q13363
Uniprot Name
C-terminal-binding protein 1
Molecular Weight
47534.865 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
6-phosphogluconolactonase activity
Specific Function
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Gene Name
pgl
Uniprot ID
Q9X0N8
Uniprot Name
6-phosphogluconolactonase
Molecular Weight
25324.955 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
May play a role in fatty acid biosynthesis.
Specific Function
Lyase activity
Gene Name
citE
Uniprot ID
P9WPE1
Uniprot Name
Citrate lyase subunit beta-like protein
Molecular Weight
28885.39 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein serine/threonine kinase activity
Specific Function
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interact...
Gene Name
CASK
Uniprot ID
O14936
Uniprot Name
Peripheral plasma membrane protein CASK
Molecular Weight
105121.915 Da
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Essential for recycling GMP and indirectly, cGMP.
Specific Function
Adenylate kinase activity
Gene Name
gmk
Uniprot ID
P9WKE9
Uniprot Name
Guanylate kinase
Molecular Weight
22095.065 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Butyrate kinase activity
Specific Function
Not Available
Gene Name
buk2
Uniprot ID
Q9X278
Uniprot Name
Probable butyrate kinase 2
Molecular Weight
42022.04 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Gamma-glutamylcyclotransferase activity
Specific Function
Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by trans...
Gene Name
GGACT
Uniprot ID
Q9BVM4
Uniprot Name
Gamma-glutamylaminecyclotransferase
Molecular Weight
17328.44 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Calcium ion binding
Specific Function
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Gene Name
PVALB
Uniprot ID
P20472
Uniprot Name
Parvalbumin alpha
Molecular Weight
12058.635 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Acylphosphatase activity
Specific Function
Its physiological role is not yet clear.
Gene Name
ACYP2
Uniprot ID
P14621
Uniprot Name
Acylphosphatase-2
Molecular Weight
11139.52 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q81C15
Uniprot Name
Uncharacterized protein
Molecular Weight
12777.45 Da
Kind
Protein
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pharmacological action
Unknown
General Function
Arginine n-succinyltransferase activity
Specific Function
Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.
Gene Name
astA
Uniprot ID
P80357
Uniprot Name
Arginine N-succinyltransferase subunit alpha
Molecular Weight
36930.335 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Not Available
Gene Name
yvyI
Uniprot ID
P39841
Uniprot Name
Putative mannose-6-phosphate isomerase YvyI
Molecular Weight
35427.725 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Tetrahydrobiopterin binding
Specific Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. P...
Gene Name
NOS1
Uniprot ID
P29475
Uniprot Name
Nitric oxide synthase, brain
Molecular Weight
160969.095 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9X0V0
Uniprot Name
Mannoside ABC transport system, sugar-binding protein
Molecular Weight
64077.82 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Hydrolyzes p-nitrophenyl phosphate (pNPP) in vitro. Involved in the swarming motility process.
Gene Name
ycdX
Uniprot ID
P75914
Uniprot Name
Probable phosphatase YcdX
Molecular Weight
26890.25 Da
Kind
Protein
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pharmacological action
Unknown
General Function
Isochorismatase activity
Specific Function
Not Available
Gene Name
phzD1
Uniprot ID
Q7DC80
Uniprot Name
Phenazine biosynthesis protein PhzD
Molecular Weight
23195.32 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Oxalate decarboxylase activity
Specific Function
Converts oxalate to formate and CO(2) in an O(2)-dependent reaction. Can also catalyze minor side reactions: oxalate oxidation to produce H(2)O(2), and oxalate-dependent, H(2)O(2)-independent dye o...
Gene Name
oxdC
Uniprot ID
O34714
Uniprot Name
Oxalate decarboxylase OxdC
Molecular Weight
43565.77 Da
Kind
Protein
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Not Available
Gene Name
actIII
Uniprot ID
P16544
Uniprot Name
Putative ketoacyl reductase
Molecular Weight
27264.88 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Molybdopterin molybdotransferase activity
Specific Function
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Ca...
Gene Name
GPHN
Uniprot ID
Q9NQX3
Uniprot Name
Gephyrin
Molecular Weight
79747.635 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31)
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q81F54
Uniprot Name
Glyoxalase family protein
Molecular Weight
16581.885 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Lipid binding
Specific Function
Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell...
Gene Name
CYTH2
Uniprot ID
Q99418
Uniprot Name
Cytohesin-2
Molecular Weight
46545.725 Da
Kind
Protein
Organism
Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
Pharmacological action
Unknown
General Function
Ligase activity
Specific Function
Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
Gene Name
gcdA
Uniprot ID
Q06700
Uniprot Name
Glutaconyl-CoA decarboxylase subunit alpha
Molecular Weight
64346.32 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Dna binding
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9WXS0
Uniprot Name
Transcriptional regulator, IclR family
Molecular Weight
28118.475 Da
Kind
Protein
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Gene Name
katA
Uniprot ID
P77872
Uniprot Name
Catalase
Molecular Weight
58628.85 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9X0F9
Uniprot Name
Putative L-rhamnose mutarotase
Molecular Weight
13061.115 Da
Kind
Protein
Organism
Plasmodium falciparum
Pharmacological action
Unknown
General Function
Glutathione transferase activity
Specific Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin I...
Gene Name
GST
Uniprot ID
Q8MU52
Uniprot Name
Glutathione S-transferase
Molecular Weight
24788.9 Da
Kind
Protein
Organism
Trypanosoma cruzi
Pharmacological action
Unknown
General Function
Hypoxanthine phosphoribosyltransferase activity
Specific Function
Not Available
Gene Name
HGPRTase
Uniprot ID
Q27796
Uniprot Name
Hypoxanthine-guanine phosphoribosyltransferase
Molecular Weight
25529.02 Da
Kind
Protein
Organism
Bacillus subtilis (strain 168)
Pharmacological action
Unknown
General Function
Glutaminase activity
Specific Function
Not Available
Gene Name
glsA1
Uniprot ID
O31465
Uniprot Name
Glutaminase 1
Molecular Weight
36186.3 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Glutaminase activity
Specific Function
Not Available
Gene Name
glsA1
Uniprot ID
P77454
Uniprot Name
Glutaminase 1
Molecular Weight
32903.075 Da
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Molybdopterin synthase activity
Specific Function
Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD.
Gene Name
moaE
Uniprot ID
P30749
Uniprot Name
Molybdopterin synthase catalytic subunit
Molecular Weight
16980.955 Da
Kind
Protein
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action
Unknown
General Function
Transaminase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9X0L5
Uniprot Name
Aminotransferase, putative
Molecular Weight
47135.19 Da
Kind
Protein
Organism
Pasteurella haemolytica
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
fbpA
Uniprot ID
Q9Z4N6
Uniprot Name
Iron ABC transporter substrate-binding protein
Molecular Weight
38023.085 Da
Kind
Protein
Organism
Thermus thermophilus
Pharmacological action
Unknown
General Function
Dna topoisomerase type ii (atp-hydrolyzing) activity
Specific Function
Not Available
Gene Name
gyrB
Uniprot ID
Q5SHZ4
Uniprot Name
DNA gyrase subunit B
Molecular Weight
70536.815 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Symporter activity
Specific Function
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine...
Gene Name
SLC16A3
Uniprot ID
O15427
Uniprot Name
Monocarboxylate transporter 4
Molecular Weight
49468.9 Da
References
  1. Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. [PubMed:11101640]

Drug created on June 13, 2005 07:24 / Updated on October 02, 2017 05:04