An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.

Structure

Similar Structures

Synonyms

2-Propanol
Alcohol isopropílico
Isopropanol
Isopropyl alcohol

External IDs

FEMA NO. 2929 / NSC-135801

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Unlock Additional Data
4072First Aid Kit	Kit	0.7 mL/1mL	Topical	Honeywell Safety Products USA, Inc	2018-11-06	Not applicable
4183 First Aid Kit	Kit	0.7 mL/1mL	Topical	Honeywell Safety Products USA, Inc	2018-11-24	Not applicable
50 percent Isopropyl alcohol	Liquid	50 mL/100mL	Topical	Whole Foods Market	2017-05-31	Not applicable
50% Isopropyl Alcohol	Solution	500 mg/1mL	Topical	Wal-Mart Stores, Inc.	2019-03-08	Not applicable
50% Isopropyl Rubbing Alcohol	Liquid	50 mL/100mL	Topical	Amerincan Health Packaging	2017-07-15	Not applicable
50% Isopropyl Rubbing Alcohol with Wintergreen	Liquid	50 mL/100mL	Topical	Amerincan Health Packaging	2017-07-15	Not applicable
50% Rubbing	Liquid	500 mg/1mL	Topical	Family Dollar Services, Inc	2016-06-14	Not applicable
50% Rubbing	Liquid	500 mg/1mL	Topical	Greenbrier International, Inc.	2014-10-08	Not applicable
50% Rubbing	Liquid	500 mg/1mL	Topical	Geiss, Destin & Dunn, Inc	2010-05-21	Not applicable
50% Rubbing	Liquid	500 mg/1mL	Topical	DOLGENCORP,LLC	2014-10-08	Not applicable

Additional Data Available

Application Number

A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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Product Code

A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
25 Person ANSI	Isopropyl alcohol (70 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ethanol (62 g/100g) + Ibuprofen (200 mg/1) + Lidocaine (0.5 g/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Topical	Genuine First Aid	2010-04-25	Not applicable
3M DuraPrep Surgical	Isopropyl alcohol (636.4 mg/1mL) + Iodine povacrylex (6.02 mg/1mL)	Solution	Topical	3 M Pharmaceuticals	2006-09-29	Not applicable
3M SoluPrep	Isopropyl alcohol (0.7 mL/1mL) + Chlorhexidine gluconate (20 mg/1mL)	Solution	Topical	3M Company	2018-10-08	Not applicable
3M SoluPrep	Isopropyl alcohol (0.7 mL/1mL) + Chlorhexidine gluconate (20 mg/1mL)	Solution	Topical	3M Company	2018-10-08	Not applicable
3m Soluprep Sponge	Isopropyl alcohol (70 %) + Chlorhexidine gluconate (2 %)	Sponge	Topical	3 M Pharmaceuticals	2013-09-11	Not applicable
4047 Fist Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-24	Not applicable
4048 Fist Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-24	Not applicable
4051 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4052 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4078 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Povidone-iodine (10 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
4047 Fist Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-24	Not applicable
4048 Fist Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-24	Not applicable
4051 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4052 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (0.5 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-21	Not applicable
4072First Aid Kit	Isopropyl alcohol (0.7 mL/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-11-06	Not applicable
4078 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Povidone-iodine (10 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4079 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Povidone-iodine (10 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4125 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Levomenthol (0.33 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4129 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Ammonia (0.045 g/0.3mL) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzocaine (20 g/100g) + Ethanol (0.5 mL/1mL) + Hydrocortisone acetate (1 g/100g) + Lidocaine hydrochloride (20 mg/1mL) + Povidone-iodine (10 mg/1mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4133 First Aid Kit	Isopropyl alcohol (0.7 mL/1mL) + Ammonia (0.045 g/0.3mL) + Ethanol (0.5 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Lidocaine hydrochloride (2 g/100g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit	Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

International/Other Brands

Isopro

Categories

UNII

ND2M416302

CAS number

67-63-0

Weight

Average: 60.095
Monoisotopic: 60.057514878

Chemical Formula

C₃H₈O

InChI Key

KFZMGEQAYNKOFK-UHFFFAOYSA-N

InChI

InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3

IUPAC Name

propan-2-ol

SMILES

CC(C)O

Pharmacology

Indication

Not Available

Associated Conditions

Infection NOS

Associated Therapies

Prophylaxis of bacterial skin infections

Pharmacodynamics

Not Available

Mechanism of action

Target	Actions	Organism
UmRNA-capping enzyme	Not Available	Humans
UFMN-dependent NADH-azoreductase	Not Available	Escherichia coli (strain K12)
UTranscription termination/antitermination protein NusG	Not Available	Aquifex aeolicus (strain VF5)
U1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	Not Available	Humans
UGTP cyclohydrolase 1	Not Available	Humans
UGrowth/differentiation factor 5	Not Available	Humans
USubtilisin BPN'	Not Available	Bacillus amyloliquefaciens
UIg kappa chain V-IV region Len	Not Available	Humans
URibonuclease pancreatic	Not Available	Humans
UPectate lyase	Not Available	Azospirillum irakense
UTrypsin-2	Not Available	Humans
UGag polyprotein	Not Available	SIV-mac
UAldehyde oxidoreductase	Not Available	Desulfovibrio gigas
UPhospholipase A2, membrane associated	Not Available	Humans
UGanglioside GM2 activator	Not Available	Humans
UThermolysin	Not Available	Geobacillus stearothermophilus
UScaffolding dockerin binding protein A	Not Available	Clostridium thermocellum
UChitotriosidase-1	Not Available	Humans
UAlr1529 protein	Not Available	Nostoc sp. (strain PCC 7120 / UTEX 2576)
UL-xylulose reductase	Not Available	Humans
UPeroxiredoxin-6	Not Available	Humans
UHydrolase, TatD family	Not Available	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
UTumor necrosis factor	Not Available	Humans
UTartrate-resistant acid phosphatase type 5	Not Available	Humans
UAdenosylhomocysteinase	Not Available	Humans
USpliceosome RNA helicase DDX39B	Not Available	Humans
UDNA mismatch repair protein MutL	Not Available	Escherichia coli (strain K12)
UGag-Pro-Pol polyprotein	Not Available	RSV-SRA
ULysozyme	Not Available	Enterobacteria phage lambda
UGlucarate dehydratase	Not Available	Escherichia coli (strain K12)

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Additional Data Available

Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available

Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available

Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: Not Available

References

Synthesis Reference

http://en.wikipedia.org/wiki/Alcohol#Laboratory_synthesis

General References

Not Available

External Links

Human Metabolome Database: HMDB0000863
KEGG Drug: D00137
KEGG Compound: C01845
PubChem Compound: 3776
PubChem Substance: 46508136
ChemSpider: 3644
ChEBI: 17824
ChEMBL: CHEMBL582
PharmGKB: PA450117
HET: IPA
Wikipedia: Isopropyl_alcohol

ATC Codes

D08AX05 — Isopropanol

AHFS Codes

84:04.92 — Miscellaneous Local Anti-infectives

PDB Entries

1ak9 / 1am7 / 1aqn / 1asw / 1au9 / 1bnd / 1bw9 / 1c1d / 1c1x / 1ci8 …

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MSDS

Download (51.8 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Recruiting	Basic Science	Cleaning Product Causing Toxic Effect	1
1	Completed	Not Available	Surgical Site Infections	2
1	Recruiting	Treatment	Allogeneic Hematopoietic Stem Cell Transplant Recipient / Allogeneic Hematopoietic Stem Cell Transplantation Recipient / Blasts Under 5 Percent of Bone Marrow Nucleated Cells / IDH2 Gene Mutation / Leukemia Acute Myeloid Leukemia (AML) / Myeloid leukaemia in remission	1
1, 2	Completed	Not Available	Topical Antisepsis	1
2	Completed	Not Available	Surgical Site Infections	1
2	Completed	Prevention	Bacterial Recovery of Skin Flora Post-Product Application	1
2	Completed	Prevention	Preoperative Skin Preparation	1
2	Completed	Treatment	Ankylosing Spondylitis (AS)	1
2	Completed	Treatment	Psoriasis	1
2	Completed	Treatment	Psoriatic Arthritis	2
2	Not Yet Recruiting	Prevention	Cesarean Section / Surgical Site Infections	1
2	Not Yet Recruiting	Treatment	Acute, recurrent Myeloid Leukemia / Blasts 5 Percent or More of Bone Marrow Nucleated Cells / IDH2 Gene Mutation	1
2	Recruiting	Supportive Care	Breast Cancer	1
2	Recruiting	Treatment	Acute Bilineal Leukemia / Acute Biphenotypic Leukemia (ABL) / Acute, recurrent Myeloid Leukemia / Chronic Myelomonocytic Leukemia / IDH2 Gene Mutation / Myelodysplastic Syndrome / Refractory Acute Myeloid Leukemia	1
2	Terminated	Not Available	Surgical Site Infections	1
3	Active Not Recruiting	Prevention	Surgical Skin Preparation	1
3	Completed	Not Available	Healthy Volunteers	1
3	Completed	Not Available	Topical Antisepsis	1
3	Completed	Other	Surgical Site Infections	1
3	Completed	Prevention	Bacteria Microflora Reduction	1
3	Completed	Prevention	Bacterial Microflora Reduction	1
3	Completed	Prevention	Bacterial Reduction Post-product Application	1
3	Completed	Prevention	Bacterial Reduction on Skin Flora Post-product Application	1
3	Completed	Prevention	Infectious Diseases	2
3	Completed	Prevention	Postoperative Wound Infection	1
3	Completed	Prevention	Surgical Skin Preparation	2
3	Completed	Treatment	Psoriasis	5
3	Enrolling by Invitation	Treatment	Psoriasis	1
3	Recruiting	Other	Antimicrobial Effect	1
3	Recruiting	Prevention	General Surgery / Postoperative Wound Infection / Surgery--Complications / Surgical Site Infections	1
3	Recruiting	Treatment	Psoriasis Vulgaris (Plaque Psoriasis)	1
3	Terminated	Prevention	Skin Flora Bacterial Reduction Post-product Application	1
3	Terminated	Treatment	Leukemia Acute Myeloid Leukemia (AML) / Leukemias / Myeloid Leukemias	1
4	Active Not Recruiting	Prevention	Arrhythmia / Heart Failure	1
4	Completed	Not Available	Antimicrobial Effectiveness	2
4	Completed	Not Available	Arthroplasty, Replacement, Hip	1
4	Completed	Not Available	Healthy Volunteers	1
4	Completed	Prevention	Bacteremia	1
4	Completed	Prevention	Bacteremia / Bacterial Infections / Catheter-Associated Infections / Central Venous Catheterization	1
4	Completed	Treatment	Gastritis Acute / Gastritis Chronic	1
4	Completed	Treatment	Nausea	1
4	Enrolling by Invitation	Treatment	Closed Lower Extremity Fracture / Fracture of Pelvis / Fractures, Open / Lower Extremity Fractures / Open Appendicular Fracture / Pelvis; Fracture / Surgical Site Infections / Unplanned Fracture-Related Reoperation	1
4	Not Yet Recruiting	Prevention	Central Venous Catheter Related Bacteremia / Sepsis Affecting Skin	1
4	Recruiting	Prevention	Cardiac Surgery in Adult Patient	1
4	Recruiting	Prevention	Neoplasms, Breast / Wound Infections	1
4	Recruiting	Prevention	Surgical Site Infections	1
4	Terminated	Prevention	Arthroplasty, Knee Replacement / Knee Replacement Surgery	1
4	Unknown Status	Prevention	Bacterial Colonization / Lower Extremity Surgery / Surgical Antiseptic / Surgical Site Infections	1
Not Available	Active Not Recruiting	Treatment	Nausea	1
Not Available	Completed	Not Available	Drying Time	1
Not Available	Completed	Prevention	Bacteremia / Catheter-related Bloodstream Infection (CRBSI) NOS	1
Not Available	Completed	Prevention	Colonization / Line Insertion Site	1
Not Available	Completed	Prevention	Surgery, Colorectal	1
Not Available	Completed	Prevention	Surgical Site Infections	1
Not Available	Completed	Treatment	Arthroplasties, Hip Replacement / Postoperative Wound Infection	1
Not Available	Completed	Treatment	Contraception	1
Not Available	Completed	Treatment	Stings	1
Not Available	Completed	Treatment	Surgical Site Infections	1
Not Available	Enrolling by Invitation	Prevention	Propionibacterium infection	1
Not Available	Not Yet Recruiting	Supportive Care	Neoplasms, Malignant	1
Not Available	Unknown Status	Prevention	Central Line-associated Bloodstream Infection (CLABSI) / Line Insertion Site	1
Not Available	Unknown Status	Treatment	Anti-infecting Agents, Local	1
Not Available	Withdrawn	Prevention	Infection NOS	1
Not Available	Withdrawn	Prevention	Surgical Site Infections	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

B. Braun Melsungen AG
Derm Buro Inc.
Medical Components Inc.
Medical Techniques LLC
Smiths Medical ASD Inc.

Dosage forms

Form	Route	Strength
Sponge	Topical
Kit	Respiratory (inhalation)
Kit	Irrigation
Solution	Topical	500 mg/1mL
Spray	Topical	700 mg/1mL
Solution	Topical	0.7 mg/1mL
Cream	Topical
Liquid	Topical	62.0 %
Gel	Topical	62 mL/100mL
Liquid	Topical	0.99 mL/1mL
Patch	Topical	700 mg/1g
Solution	Topical	70 mL/100mL
Swab	Topical	.70 g/1g
Swab	Topical	7 mL/10mL
Swab	Topical	700 mg/1g
Gel	Topical	700 mL/1000mL
Swab	Topical	0.7 1/1
Swab	Topical	0.70 mL/1
Cloth	Topical	0.7 mL/0.7mL
Cloth	Topical	700 mg/1mL
Swab	Topical	70 1/1
Liquid	Topical	70 mL/100mL
Sponge	Topical	7 mL/10mL
Swab	Topical	.70 mg/1mg
Swab	Topical	0.28 mL/0.4mL
Swab	Topical	0.56 mL/0.8mL
Swab	Topical	0.7 mL/1mL
Swab	Topical	0.7 mL/1
Swab	Topical	0.70 mL/1mL
Swab	Topical	700 mg/1
Swab	Topical
Cloth	Topical	70 mg/1
Liquid	Topical	70 g/100g
Liquid	Topical
Swab	Topical	1.4 mL/1
Swab	Topical	.70 mL/1
Swab	Topical	0.70 g/1mL
Gel	Topical
Lotion	Topical
Liquid	Topical	76 mL/100mL
Liquid	Topical	760 g/1000mL
Jelly	Topical
Liquid	Topical	0.56118 g/1mL
Liquid	Topical	715 mL/1L
Gel	Topical	70 mL/100mL
Solution / drops	Auricular (otic)
Kit	Topical	70 mL/100mL
Kit	Oral
Patch	Topical	.70 mL/1mL
Liquid	Auricular (otic)	95 mL/100mL
Liquid	Topical	30 mg/30mL
Liquid	Topical	63 mL/100mL
Liquid	Topical	70 mg/100mg
Liquid	Topical	91 mL/100mL
Liquid	Auricular (otic)	950 mg/1mL
Cloth	Topical	0.7 g/1g
Swab	Topical	70 g/100g
Liquid	Topical	50 mL/100mL
Liquid	Auricular (otic)	0.76 g/1mL
Swab	Topical	0.7 g/1mL
Cloth	Topical
Liquid	Auricular (otic)	94.998 1/100mL
Liquid	Auricular (otic)
Liquid	Auricular (otic)	95 g/100mL
Liquid	Auricular (otic)	94.998 g/100mL
Solution	Topical	75 mL/100mL
Liquid	Auricular (otic)	0.95 g/100g
Liquid	Topical	610 mg/1mL
Kit	Ophthalmic
Liquid	Topical	13 g/100g
Aerosol, foam	Topical
Solution	Topical	0.14 g/0.2mL
Solution	Topical	1.4 g/2mL
Patch	Topical	70 g/100g
Patch	Topical
Solution	Topical	700 g/1000g
Liquid	Topical	500 mg/1mL
Swab	Topical	0.07 mL/1mL
Spray	Topical	75 kg/100kg
Solution	Topical	0.57 1/1
Liquid	Topical; Vaginal
Solution / drops	Topical	0.95 g/100mL
Spray	Topical	70 mL/100mL
Liquid	Topical	924 mg/1mL
Liquid	Topical	.70 L/100L
Liquid	Topical	.91 mg/1mL
Liquid	Topical	.91 L/100L
Liquid	Topical	0.70 mg/1mL
Liquid	Topical	0.91 mg/1mL
Liquid	Topical	613 mg/1mL
Liquid	Topical	700 mL/1L
Liquid	Topical	91 mg/1mL
Liquid	Topical	91 kg/100L
Solution	Topical	0.105 mL/0.15mL
Solution	Topical	30 mg/1mL
Solution	Topical	462 mg/1mL
Solution	Topical	91 mL/100mL
Spray	Topical	550.2 g/1L
Spray	Topical	700 mL/1L
Swab	Topical	.7 mL/1
Swab	Topical	0.238 mL/1
Swab	Topical	0.75 g/1
Solution	Topical	50 mL/100mL
Liquid	Topical	99 %
Liquid	Topical	990 mg/1mL
Solution	Topical	.70 mL/1mL
Sponge	Topical	0.07 mL/1mL
Liquid	Topical	0.7 mL/1mL
Liquid	Topical	.7 mL/1mL
Liquid	Cutaneous	350 mL/500mL
Solution	Topical	0.7 L/1L
Solution	Topical	700 mg/1mL
Liquid	Topical	30 mg/1mL
Liquid	Topical	70 %
Solution	Topical	90 mL/100mL
Liquid	Topical	99 mL/100mL
Swab	Topical	70 mL/100mL
Spray	Topical	15 g/100g
Kit	Topical
Cloth	Topical	70 mL/100mL
Cloth	Topical	0.7 mL/1
Cloth	Topical	0.7 g/1
Liquid	Topical
Liquid	Topical	630 mg/1g
Aerosol, spray	Topical
Solution	Auricular (otic)	0.95 g/1mL
Stick	Topical
Kit	Epidural; Intracaudal; Perineural
Kit	Intra-articular; Intramuscular
Liquid	Topical	1 mL/1
Kit	Infiltration; Intramuscular
Swab	Topical	700 mg/1mL
Gel	Topical
Kit	Topical	12 mg/0.6mL
Kit	Topical	0.7 mL/1mL
Liquid	Topical	0.45 mg/1g
Solution	Topical	1.75 mL/25mL
Soap	Topical
Gel	Topical	700 g/1kg
Cloth	Topical	0.7 mL/1mL
Solution; sponge	Topical
Cloth	Topical
Patch	Topical	0.7 mL/1mL
Liquid	Topical	0.8 g/1mL
Solution	Topical
Liquid	Topical	700 mg/1mL
Liquid	Topical	910 mg/1mL
Liquid	Topical	70 L/100L
Stick	Topical	70 1/1001
Solution	Auricular (otic)	950 mg/1mL
Liquid	Topical	70.14 g/100mL
Solution	Topical	0.13 g/1mL
Liquid	Topical	0.7 mL/0.7mL
Cloth	Topical	70 g/100g
Liquid	Topical	90 mL/100mL
Kit

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
Unlock Additional Data
US6036976	No	2000-03-14	2016-12-13
US7422388	No	2008-09-09	2027-04-25
US6536975	No	2003-03-25	2020-11-10
US6729786	No	2004-05-04	2023-03-14
US7241065	No	2007-07-10	2023-03-14
US5690958	No	1997-11-25	2016-09-30
US6991394	No	2006-01-31	2024-01-31
US7182536	No	2007-02-27	2023-12-30
US5538353	No	1996-07-23	2015-08-25
US5772346	No	1998-06-30	2017-04-22
USD468424	No	2003-01-07	2017-01-07
US9295657	No	2016-03-29	2035-03-13
US9119876	No	2015-09-01	2035-03-13
US8623935	No	2014-01-07	2029-07-26

Additional Data Available

Filed On

The date on which a patent was filed with the relevant government.

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Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	-89.5 °C	PhysProp
boiling point (°C)	82.3 °C	PhysProp
water solubility	1E+006 mg/L (at 25 °C)	RIDDICK,JA ET AL. (1986)
logP	0.05	HANSCH,C ET AL. (1995)
pKa	17.1	SERJEANT,EP & DEMPSEY,B (1979)

Predicted Properties

Property	Value	Source
Water Solubility	378.0 mg/mL	ALOGPS
logP	0.04	ALOGPS
logP	0.25	ChemAxon
logS	0.8	ALOGPS
pKa (Strongest Acidic)	17.26	ChemAxon
pKa (Strongest Basic)	-1.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	17.43 m³·mol^-1	ChemAxon
Polarizability	7.14 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9905
Blood Brain Barrier	+	0.9694
Caco-2 permeable	+	0.7135
P-glycoprotein substrate	Non-substrate	0.8146
P-glycoprotein inhibitor I	Non-inhibitor	0.9609
P-glycoprotein inhibitor II	Non-inhibitor	0.9785
Renal organic cation transporter	Non-inhibitor	0.932
CYP450 2C9 substrate	Non-substrate	0.8061
CYP450 2D6 substrate	Non-substrate	0.8916
CYP450 3A4 substrate	Non-substrate	0.7103
CYP450 1A2 substrate	Non-inhibitor	0.8634
CYP450 2C9 inhibitor	Non-inhibitor	0.9466
CYP450 2D6 inhibitor	Non-inhibitor	0.9581
CYP450 2C19 inhibitor	Non-inhibitor	0.9267
CYP450 3A4 inhibitor	Non-inhibitor	0.9764
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.949
Ames test	Non AMES toxic	0.9246
Carcinogenicity	Carcinogens	0.7397
Biodegradation	Ready biodegradable	0.7608
Rat acute toxicity	1.3372 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9583
hERG inhibition (predictor II)	Non-inhibitor	0.9457

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Download (3.84 KB)

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	Not Available
GC-MS Spectrum - EI-B	GC-MS	splash10-0002-9000000000-b56f808ef55c854e8324
GC-MS Spectrum - EI-B	GC-MS	splash10-0002-9000000000-f68d78a99d0ee77081c8
GC-MS Spectrum - EI-B	GC-MS	splash10-0002-9000000000-a1c27780d39325f67c84
GC-MS Spectrum - EI-B	GC-MS	splash10-0002-9000000000-40a45591af6378500aeb
GC-MS Spectrum - EI-B	GC-MS	splash10-0002-9000000000-2261ea7d03d835d46644
GC-MS Spectrum - EI-B	GC-MS	splash10-0002-9000000000-3c81c56ab53eb5aaa2ec
GC-MS Spectrum - EI-B	GC-MS	splash10-0002-9000000000-7936ed4d93d5699b0366
Mass Spectrum (Electron Ionization)	MS	splash10-0002-9000000000-8f0393a68e54e5668638
MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	LC-MS/MS	splash10-03di-9000000000-958007b112253f530fa1
MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	LC-MS/MS	splash10-03dl-9000000000-eec0fd84c38e3cc2fb7d
MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	LC-MS/MS	splash10-03di-9000000000-e524005ac3e29f5e6e60
MS/MS Spectrum - EI-B (HITACHI RMU-6M) , Positive	LC-MS/MS	splash10-0002-9000000000-b56f808ef55c854e8324
MS/MS Spectrum - EI-B (JEOL JMS-D-3000) , Positive	LC-MS/MS	splash10-0002-9000000000-2261ea7d03d835d46644
MS/MS Spectrum - EI-B (HITACHI M-80B) , Positive	LC-MS/MS	splash10-0002-9000000000-3c81c56ab53eb5aaa2ec
MS/MS Spectrum - EI-B (HITACHI RMU-7M) , Positive	LC-MS/MS	splash10-0002-9000000000-7936ed4d93d5699b0366
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-03di-9000000000-52e1a906e58615d920fd
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-03di-9000000000-e66cba449fc3e39cabcb
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0006-9000000000-34d2b3ce7e4949d6207e
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0a4i-9000000000-06d1878fb0f08269b040
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0a4i-9000000000-a3c0cec1f0523a5089d6
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0a4i-9000000000-b7cef7808f5c6bfd85c9
1H NMR Spectrum	1D NMR	Not Applicable
1H NMR Spectrum	1D NMR	Not Applicable
13C NMR Spectrum	1D NMR	Not Applicable
[1H,13C] 2D NMR Spectrum	2D NMR	Not Applicable

Taxonomy

Description: This compound belongs to the class of organic compounds known as secondary alcohols. These are compounds containing a secondary alcohol functional group, with the general structure HOC(R)(R') (R,R'=alkyl, aryl).
Kingdom: Organic compounds
Super Class: Organic oxygen compounds
Class: Organooxygen compounds
Sub Class: Alcohols and polyols
Direct Parent: Secondary alcohols
Alternative Parents: Hydrocarbon derivatives
Substituents: Secondary alcohol / Hydrocarbon derivative / Aliphatic acyclic compound
Molecular Framework: Aliphatic acyclic compounds
External Descriptors: secondary alcohol (CHEBI:17824) / a small molecule (ISO-PROPANOL)

Targets

Details1. mRNA-capping enzyme

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Triphosphatase activity
Specific Function: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap ...
Gene Name: RNGTT
Uniprot ID: O60942
Uniprot Name: mRNA-capping enzyme
Molecular Weight: 68556.21 Da

References

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details2. FMN-dependent NADH-azoreductase

Kind: Protein
Organism: Escherichia coli (strain K12)
Pharmacological action: Unknown

General Function: Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
Specific Function: Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl ...
Gene Name: azoR
Uniprot ID: P41407
Uniprot Name: FMN-dependent NADH-azoreductase
Molecular Weight: 21657.47 Da

Details3. Transcription termination/antitermination protein NusG

Kind: Protein
Organism: Aquifex aeolicus (strain VF5)
Pharmacological action: Unknown

General Function: Not Available
Specific Function: Participates in transcription elongation, termination and antitermination.
Gene Name: nusG
Uniprot ID: O67757
Uniprot Name: Transcription termination/antitermination protein NusG
Molecular Weight: 27998.575 Da

Details4. 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Oxidoreductase activity
Specific Function: Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary...
Gene Name: ADI1
Uniprot ID: Q9BV57
Uniprot Name: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Molecular Weight: 21498.23 Da

References

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details5. GTP cyclohydrolase 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Zinc ion binding
Specific Function: Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the fu...
Gene Name: GCH1
Uniprot ID: P30793
Uniprot Name: GTP cyclohydrolase 1
Molecular Weight: 27902.855 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details6. Growth/differentiation factor 5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Transforming growth factor beta receptor binding
Specific Function: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentia...
Gene Name: GDF5
Uniprot ID: P43026
Uniprot Name: Growth/differentiation factor 5
Molecular Weight: 55410.15 Da

Details7. Subtilisin BPN'

Kind: Protein
Organism: Bacillus amyloliquefaciens
Pharmacological action: Unknown

General Function: Serine-type endopeptidase activity
Specific Function: Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin.
Gene Name: apr
Uniprot ID: P00782
Uniprot Name: Subtilisin BPN'
Molecular Weight: 39180.935 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details8. Ig kappa chain V-IV region Len

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Antigen binding
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: P06312
Uniprot Name: Ig kappa chain V-IV region Len
Molecular Weight: 12639.965 Da

Details9. Ribonuclease pancreatic

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Ribonuclease a activity
Specific Function: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
Gene Name: RNASE1
Uniprot ID: P07998
Uniprot Name: Ribonuclease pancreatic
Molecular Weight: 17644.125 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details10. Pectate lyase

Kind: Protein
Organism: Azospirillum irakense
Pharmacological action: Unknown

General Function: Lyase activity
Specific Function: Not Available
Gene Name: pelA
Uniprot ID: Q9X592
Uniprot Name: Pectate lyase
Molecular Weight: 47006.465 Da

Details11. Trypsin-2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Serine-type endopeptidase activity
Specific Function: In the ileum, may be involved in defensin processing, including DEFA5.
Gene Name: PRSS2
Uniprot ID: P07478
Uniprot Name: Trypsin-2
Molecular Weight: 26487.55 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details12. Gag polyprotein

Kind: Protein
Organism: SIV-mac
Pharmacological action: Unknown

General Function: Zinc ion binding
Specific Function: Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localiza...
Gene Name: gag
Uniprot ID: P05893
Uniprot Name: Gag polyprotein
Molecular Weight: 56725.035 Da

Details13. Aldehyde oxidoreductase

Kind: Protein
Organism: Desulfovibrio gigas
Pharmacological action: Unknown

General Function: Metal ion binding
Specific Function: Not Available
Gene Name: mop
Uniprot ID: Q46509
Uniprot Name: Aldehyde oxidoreductase
Molecular Weight: 97033.97 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details14. Phospholipase A2, membrane associated

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Phospholipid binding
Specific Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-ph...
Gene Name: PLA2G2A
Uniprot ID: P14555
Uniprot Name: Phospholipase A2, membrane associated
Molecular Weight: 16082.525 Da

References

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details15. Ganglioside GM2 activator

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Phospholipase activator activity
Specific Function: The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides a...
Gene Name: GM2A
Uniprot ID: P17900
Uniprot Name: Ganglioside GM2 activator
Molecular Weight: 20838.1 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details16. Thermolysin

Kind: Protein
Organism: Geobacillus stearothermophilus
Pharmacological action: Unknown

General Function: Metalloendopeptidase activity
Specific Function: Extracellular zinc metalloprotease.
Gene Name: nprS
Uniprot ID: P43133
Uniprot Name: Thermolysin
Molecular Weight: 60616.22 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details17. Scaffolding dockerin binding protein A

Kind: Protein
Organism: Clostridium thermocellum
Pharmacological action: Unknown

General Function: Carbohydrate binding
Specific Function: Not Available
Gene Name: sdbA
Uniprot ID: P71143
Uniprot Name: Scaffolding dockerin binding protein A
Molecular Weight: 68618.73 Da

Details18. Chitotriosidase-1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Endochitinase activity
Specific Function: Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Gene Name: CHIT1
Uniprot ID: Q13231
Uniprot Name: Chitotriosidase-1
Molecular Weight: 51680.985 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details19. Alr1529 protein

Kind: Protein
Organism: Nostoc sp. (strain PCC 7120 / UTEX 2576)
Pharmacological action: Unknown

General Function: Not Available
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q8YWS4
Uniprot Name: Alr1529 protein
Molecular Weight: 23595.705 Da

Details20. L-xylulose reductase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
Specific Function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role i...
Gene Name: DCXR
Uniprot ID: Q7Z4W1
Uniprot Name: L-xylulose reductase
Molecular Weight: 25912.875 Da

References

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details21. Peroxiredoxin-6

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Ubiquitin protein ligase binding
Specific Function: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as wel...
Gene Name: PRDX6
Uniprot ID: P30041
Uniprot Name: Peroxiredoxin-6
Molecular Weight: 25034.715 Da

References

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details22. Hydrolase, TatD family

Kind: Protein
Organism: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Pharmacological action: Unknown

General Function: Endodeoxyribonuclease activity, producing 5'-phosphomonoesters
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q9WZD5
Uniprot Name: Putative deoxyribonuclease YcfH
Molecular Weight: 29180.945 Da

Details23. Tumor necrosis factor

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Tumor necrosis factor receptor binding
Specific Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct ac...
Gene Name: TNF
Uniprot ID: P01375
Uniprot Name: Tumor necrosis factor
Molecular Weight: 25644.15 Da

References

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details24. Tartrate-resistant acid phosphatase type 5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Ferrous iron binding
Specific Function: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and th...
Gene Name: ACP5
Uniprot ID: P13686
Uniprot Name: Tartrate-resistant acid phosphatase type 5
Molecular Weight: 36598.47 Da

References

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details25. Adenosylhomocysteinase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Nad binding
Specific Function: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylation...
Gene Name: AHCY
Uniprot ID: P23526
Uniprot Name: Adenosylhomocysteinase
Molecular Weight: 47715.715 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details26. Spliceosome RNA helicase DDX39B

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: U6 snrna binding
Specific Function: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically ass...
Gene Name: DDX39B
Uniprot ID: Q13838
Uniprot Name: Spliceosome RNA helicase DDX39B
Molecular Weight: 48990.945 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Details27. DNA mismatch repair protein MutL

Kind: Protein
Organism: Escherichia coli (strain K12)
Pharmacological action: Unknown

General Function: Mismatched dna binding
Specific Function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the f...
Gene Name: mutL
Uniprot ID: P23367
Uniprot Name: DNA mismatch repair protein MutL
Molecular Weight: 67923.04 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details28. Gag-Pro-Pol polyprotein

Kind: Protein
Organism: RSV-SRA
Pharmacological action: Unknown

General Function: Zinc ion binding
Specific Function: Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins ...
Gene Name: gag-pro-pol
Uniprot ID: Q04095
Uniprot Name: Gag-Pro-Pol polyprotein
Molecular Weight: 173931.55 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details29. Lysozyme

Kind: Protein
Organism: Enterobacteria phage lambda
Pharmacological action: Unknown

General Function: Lysozyme activity
Specific Function: Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis ...
Gene Name: R
Uniprot ID: P03706
Uniprot Name: Endolysin
Molecular Weight: 17825.045 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Details30. Glucarate dehydratase

Kind: Protein
Organism: Escherichia coli (strain K12)
Pharmacological action: Unknown

General Function: Magnesium ion binding
Specific Function: Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate.
Gene Name: gudD
Uniprot ID: P0AES2
Uniprot Name: Glucarate dehydratase
Molecular Weight: 49140.715 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Drug created on June 13, 2005 07:24 / Updated on December 09, 2019 19:26

Isopropyl alcohol

Identification

Structure for Isopropyl alcohol (DB02325)

Pharmacology

Interactions

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Taxonomy

Targets

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