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IdentificationPharmacologyInteractionsReferencesTrialsEconomicsPropertiesSpectraTaxonomyIsopropyl Alcohol
Identification
- Name
- Isopropyl Alcohol
- Accession Number
- DB02325 (EXPT01912, DB04402)
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Description
An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic. [PubChem]
- Structure
Structure for Isopropyl Alcohol (DB02325)
- Synonyms
- Isopropanol
- External IDs
- FEMA NO. 2929 / NSC-135801
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Alpet E-3 Liquid 70 % Topical Best Sanitizers, Inc Not applicable Not applicable Canada 
Viraguard! With Virahol (gel) Gel 65 % Topical Veridien Corporation Not applicable Not applicable Canada - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End 50 percent Isopropyl alcohol Liquid 50 mL/100mL Topical Whole Foods Market 2017-05-31 Not applicable US 
50% Isopropyl Rubbing Alcohol Liquid 50 mL/100mL Topical Amerincan Health Packaging 2017-07-15 Not applicable US 50% Isopropyl Rubbing Alcohol with Wintergreen Liquid 50 mL/100mL Topical Amerincan Health Packaging 2017-07-15 Not applicable US 50% Rubbing Liquid 500 mg/1mL Topical Vi-Jon 1989-07-15 Not applicable US 50% Rubbing Liquid 500 mg/1mL Topical Greenbrier International, Inc. 2014-10-08 Not applicable US 50% Rubbing Liquid 500 mg/1mL Topical Topco Associates 2017-04-03 Not applicable US 50% Rubbing Liquid 500 mg/1mL Topical Family Dollar Services 2016-06-14 Not applicable US 50% Rubbing Liquid 500 mg/1mL Topical Dolgencorp 2014-10-08 Not applicable US 50% Rubbing Liquid 500 mg/1mL Topical Sound Body 2014-10-08 Not applicable US 50% Rubbing Liquid 500 mg/1mL Topical Geiss, Destin, & Dunn 2010-05-21 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End 25 Person ANSI Isopropyl Alcohol (70 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ethanol (62 g/100g) + Ibuprofen (200 mg/1) + Lidocaine (0.5 g/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B Sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL) Kit Genuine First Aid 2010-04-25 Not applicable US 3M DuraPrep Surgical Isopropyl Alcohol (636.4 mg/1mL) + Iodine povacrylex (6.02 mg/1mL) Solution Topical 3 M Pharmaceuticals 2006-09-29 Not applicable US 3m Soluprep Sponge Isopropyl Alcohol (70 %) + Chlorhexidine gluconate (2 %) Sponge Topical 3 M Pharmaceuticals 2013-09-11 Not applicable Canada 50 Person ANSI Isopropyl Alcohol (70 mL/100mL) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Ethanol (62 g/100g) + Ibuprofen (200 mg/1) + Lidocaine (0.5 g/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B Sulfate (5000 [iU]/1g) + Water (98.16 mL/100mL) Kit Genuine First Aid 2010-06-02 Not applicable US ACME FIRST AID Contains 404 PIECES Isopropyl Alcohol (70 mL/100mL) + Acetylsalicylic acid (81 mg/1) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Benzalkonium chloride (0.40 mL/100mL) + Benzocaine (6 mL/100mL) + Ethanol (60 mL/100mL) + Lidocaine (0.5 g/100g) + Neomycin sulfate (5 mg/1g) + Polymyxin B Sulfate (5000 [iU]/1g) + Water (98.16 mL/100mL) Kit Acme United Corporation 2010-04-27 Not applicable US Acme Home/Office/Auto Kit Isopropyl Alcohol (0.70 mL/1mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (0.13 g/100g) + Lidocaine hydrochloride (0.5 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B Sulfate (5000 [iU]/1g) Kit Dukal Corporation 2010-05-01 Not applicable US Acnomel Skin Tone Cream Isopropyl Alcohol (11 %) + Octasulfur (8 %) + Resorcinol (2 %) Cream Topical Numark Laboratories, Inc. 1992-12-31 2004-07-30 Canada Acunistat-30 Isopropyl Alcohol (0.7 mL/1mL) + Ketorolac tromethamine (30 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) Kit It3 Medical Llc 2017-03-01 Not applicable US Acunistat-60 Isopropyl Alcohol (0.7 mL/1mL) + Ketorolac tromethamine (30 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) Kit It3 Medical Llc 2017-03-01 Not applicable US Acunivive 90 Isopropyl Alcohol (0.7 mL/1mL) + Ketorolac tromethamine (30 mg/1mL) + Ketorolac tromethamine (30 mg/1mL) Kit It3 Medical Llc 2017-03-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Adyphren Amp II Kit Isopropyl Alcohol (70 mL/100mL) + Epinephrine (1 mg/1mL) Kit Intramuscular; Subcutaneous; Topical Asclemed Usa, Inc. 2016-10-27 Not applicable US Adyphren Amp Kit Isopropyl Alcohol (70 mL/100mL) + Epinephrine (1 mg/1mL) Kit Intramuscular; Subcutaneous; Topical Asclemed Usa, Inc. 2016-10-27 Not applicable US Adyphren II Kit Isopropyl Alcohol (70 mL/100mL) + Epinephrine (1 mg/1mL) Kit Intramuscular; Intraocular; Subcutaneous Asclemed Usa, Inc. 2016-10-04 Not applicable US Adyphren Kit Isopropyl Alcohol (70 mL/100mL) + Epinephrine (1 mg/1mL) Kit Intramuscular; Intraocular; Subcutaneous Asclemed Usa, Inc. 2016-10-04 Not applicable US Betalido Kit Isopropyl Alcohol (70 mL/100mL) + Betamethasone sodium phosphate (3 mg/1mL) + Betamethasone acetate (3 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL) Kit Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical Asclemed Usa, Inc. 2014-06-13 Not applicable US Dexlido Kit Isopropyl Alcohol (70 mL/100mL) + Dexamethasone sodium phosphate (10 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL) Kit Infiltration; Intramuscular; Intravenous; Topical Asclemed Usa, Inc. 2014-07-25 Not applicable US Dexlido-M Kit Isopropyl Alcohol (70 mL/100mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Dexamethasone sodium phosphate (10 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL) Kit Epidural; Infiltration; Intramuscular; Intravenous; Topical Asclemed Usa, Inc. 2014-07-25 Not applicable US DoubleDex Kit Isopropyl Alcohol (70 mL/100mL) + Dexamethasone sodium phosphate (10 mg/1mL) + Povidone-iodine (10 mg/1mL) Kit Intramuscular; Intravenous; Topical Asclemed Usa, Inc. 2014-07-25 Not applicable US Dyural 40 Kit Isopropyl Alcohol (70 mL/100mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) + Methylprednisolone acetate (40 mg/1mL) + Povidone-iodine (10 mg/1mL) Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical Asclemed Usa, Inc. 2014-07-25 Not applicable US Dyural 80 Kit Isopropyl Alcohol (70 mL/100mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) + Methylprednisolone acetate (80 mg/1mL) + Povidone-iodine (10 mg/1mL) Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical Asclemed Usa, Inc. 2014-08-01 Not applicable US - Categories
- UNII
- ND2M416302
- CAS number
- 67-63-0
- Weight
- Average: 60.095
Monoisotopic: 60.057514878 - Chemical Formula
- C3H8O
- InChI Key
- KFZMGEQAYNKOFK-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3
- IUPAC Name
- propan-2-ol
- SMILES
- CC(C)O
Pharmacology
- Indication
- Not Available
- Associated Conditions
- Associated Therapies
- Pharmacodynamics
- Not Available
- Mechanism of action
Target Actions Organism UmRNA-capping enzyme Not Available Human UFMN-dependent NADH-azoreductase Not Available Escherichia coli (strain K12) UTranscription termination/antitermination protein NusG Not Available Aquifex aeolicus (strain VF5) U1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase Not Available Human UGTP cyclohydrolase 1 Not Available Human UGrowth/differentiation factor 5 Not Available Human USubtilisin BPN' Not Available Bacillus amyloliquefaciens UIg kappa chain V-IV region Len Not Available Human URibonuclease pancreatic Not Available Human UPectate lyase Not Available Azospirillum irakense UTrypsin-2 Not Available Human UGag polyprotein Not Available SIV-mac UAldehyde oxidoreductase Not Available Desulfovibrio gigas UPhospholipase A2, membrane associated Not Available Human UGanglioside GM2 activator Not Available Human UThermolysin Not Available Geobacillus stearothermophilus UScaffolding dockerin binding protein A Not Available Clostridium thermocellum UChitotriosidase-1 Not Available Human UAlr1529 protein Not Available Nostoc sp. (strain PCC 7120 / UTEX 2576) UL-xylulose reductase Not Available Human UPeroxiredoxin-6 Not Available Human UHydrolase, TatD family Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UTumor necrosis factor Not Available Human UTartrate-resistant acid phosphatase type 5 Not Available Human UAdenosylhomocysteinase Not Available Human USpliceosome RNA helicase DDX39B Not Available Human UDNA mismatch repair protein MutL Not Available Escherichia coli (strain K12) UGag-Pro-Pol polyprotein Not Available RSV-SRA ULysozyme Not Available Enterobacteria phage lambda UGlucarate dehydratase Not Available Escherichia coli (strain K12) - Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half life
- Not Available
- Clearance
- Not Available
- Toxicity
- Not Available
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
References
- Synthesis Reference
http://en.wikipedia.org/wiki/Alcohol#Laboratory_synthesis
- General References
- Not Available
- External Links
- ATC Codes
- D08AX05 — Isopropanol
- AHFS Codes
- 84:04.92 — Miscellaneous Local Anti-infectives
- PDB Entries
- 1ak9 / 1am7 / 1aqn / 1asw / 1au9 / 1bnd / 1bw9 / 1c1d / 1c1x / 1ci8 … show 558 more
- MSDS
- Download (51.8 KB)
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- B. Braun Melsungen AG
- Derm Buro Inc.
- Medical Components Inc.
- Medical Techniques LLC
- Smiths Medical ASD Inc.
- Dosage forms
Form Route Strength Sponge Topical Spray Topical 700 mg/1mL Solution Topical 0.7 mg/1mL Liquid Topical 500 mg/1mL Cream Topical Kit Oral; Topical Kit Intramuscular; Subcutaneous; Topical Liquid Topical 62.0 % Gel Topical 62 mL/100mL Liquid Topical 0.99 mL/1mL Patch Topical 700 mg/1g Solution Topical 70 mL/100mL Swab Topical .70 g/1g Swab Topical 7 mL/10mL Swab Topical 700 mg/1g Gel Topical 700 mL/1000mL Swab Topical 0.7 1/1 Swab Topical 0.70 mL/1 Cloth Topical 0.7 mL/0.7mL Swab Topical 70 1/1 Liquid Topical 70 mL/100mL Sponge Topical 7 mL/10mL Swab Topical .70 mg/1mg Swab Topical 0.28 mL/0.4mL Swab Topical 0.56 mL/0.8mL Swab Topical 0.7 mL/1mL Swab Topical 0.7 mL/1 Swab Topical 0.70 mL/1mL Swab Topical 700 mg/1 Cloth Topical 70 mg/1 Liquid Topical 70 g/100g Liquid Topical 70 % Swab Topical 1.4 mL/1 Swab Topical .70 mL/1 Swab Topical 0.70 g/1mL Gel Topical 70 % Lotion Topical 70 % Liquid Topical 21 ml Liquid Topical 760 g/1000mL Jelly Topical 50 % Liquid Topical 0.56118 g/1mL Liquid Topical 715 mL/1L Gel Topical 70 mL/100mL Solution / drops Auricular (otic) Kit 70 mL/100mL Patch Topical .70 mL/1mL Liquid Auricular (otic) 95 mL/100mL Kit Intramuscular Liquid Topical 30 mg/30mL Kit Infiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical Liquid Topical 60 % Liquid Topical 63 % Liquid Topical 63 mL/100mL Liquid Topical 70 mg/100mg Liquid Auricular (otic) 950 mg/1mL Cloth Topical 0.7 g/1g Liquid Topical Liquid Topical 50 mL/100mL Kit Intramuscular; Intravenous; Topical Liquid Auricular (otic) 0.76 g/1mL Swab Topical 0.7 g/1mL Cloth Topical 70 % Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical Kit Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical Liquid Auricular (otic) 94.998 1/100mL Liquid Auricular (otic) Liquid Auricular (otic) 95 g/100mL Liquid Auricular (otic) 94.998 g/100mL Solution Topical 75 mL/100mL Liquid Auricular (otic) 0.95 g/100g Kit Intramuscular; Intraocular; Subcutaneous Liquid Topical .70 L/100L Liquid Topical 13 g/100g Aerosol, foam Topical Solution Topical 0.14 g/0.2mL Solution Topical 1.4 g/2mL Patch Topical 70 g/100g Patch Topical Gel Topical Solution Topical 700 g/1000g Swab Topical 70 g/100g Swab Topical 70 mL/100mL Spray Topical 75 kg/100kg Liquid Topical 700 mg/1mL Solution Topical 0.57 1/1 Liquid Topical; Vaginal Solution / drops Topical 0.95 g/100mL Spray Topical 70 mL/100mL Liquid Topical 924 mg/1mL Solution Topical 462 mg/1mL Liquid Topical .91 L/100L Liquid Topical .91 mg/1mL Liquid Topical 0.70 mg/1mL Liquid Topical 613 mg/1mL Liquid Topical 700 mL/1L Liquid Topical 91 kg/100L Liquid Topical 91 mg/1mL Solution Topical 0.105 mL/0.15mL Solution Topical 91 mL/100mL Spray Topical 550.2 g/1L Spray Topical 700 mL/1L Swab Topical .7 mL/1 Swab Topical 0.238 mL/1 Swab Topical 0.75 g/1 Liquid Topical 91 mL/100mL Liquid Topical 99 % Solution Topical .70 mL/1mL Sponge Topical 0.07 mL/1mL Liquid Topical 0.7 mL/1mL Liquid Topical .7 mL/1mL Liquid Cutaneous 350 mL/500mL Solution Topical 0.7 L/1L Solution Topical 700 mg/1mL Liquid Topical 30 mg/1mL Solution Topical 90 mL/100mL Liquid Topical 99 mL/100mL Kit Infiltration; Intramuscular; Intravenous; Topical Kit Epidural; Infiltration; Intramuscular; Intravenous; Topical Spray Topical 15 g/100g Kit Kit Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical Kit Epidural; Infiltration; Topical Kit Intramuscular; Topical Cloth Topical 0.7 mL/1 Cloth Topical 0.7 g/1 Liquid Topical 630 mg/1g Liquid Topical 97.79 % Aerosol, spray Topical Solution Auricular (otic) 0.95 g/1mL Stick Topical 70 % Liquid Topical 1 mL/1 Kit Infiltration; Soft tissue; Topical Kit Epidural; Infiltration; Intracaudal; Perineural Kit Epidural; Infiltration; Intracaudal Swab Topical 700 mg/1mL Gel Topical 49 % Kit 12 mg/0.6mL Kit Topical 0.7 mL/1mL Liquid Topical 0.45 mg/1g Solution Topical 1.75 mL/25mL Soap Topical Gel Topical 700 g/1kg Cloth Topical 0.7 mL/1mL Solution; sponge Topical Swab Topical Cloth Topical Solution Topical Patch Topical 0.7 mL/1mL Liquid Topical 0.8 g/1mL Liquid Topical 910 mg/1mL Liquid Topical 70 L/100L Liquid Topical 95 ml Stick Topical 70 1/1001 Solution Auricular (otic) 950 mg/1mL Liquid Topical 70.14 g/100mL Solution Topical 0.13 g/1mL Liquid Topical 0.7 mL/0.7mL Cloth Topical 70 g/100g Liquid Topical 90 mL/100mL Gel Topical 65 % Kit Topical - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) US7422388 No 2007-04-25 2027-04-25 US US6536975 No 2000-11-10 2020-11-10 US US6729786 No 2003-03-14 2023-03-14 US US7241065 No 2003-03-14 2023-03-14 US US5690958 No 1996-09-30 2016-09-30 US US6991394 No 2004-01-31 2024-01-31 US US7182536 No 2003-12-30 2023-12-30 US US5538353 No 1995-08-25 2015-08-25 US US5772346 No 1997-04-22 2017-04-22 US USD468424 No 1997-01-07 2017-01-07 US US9295657 No 2015-03-13 2035-03-13 US US9119876 No 2015-03-13 2035-03-13 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) -89.5 °C PhysProp boiling point (°C) 82.3 °C PhysProp water solubility 1E+006 mg/L (at 25 °C) RIDDICK,JA ET AL. (1986) logP 0.05 HANSCH,C ET AL. (1995) pKa 17.1 SERJEANT,EP & DEMPSEY,B (1979) - Predicted Properties
Property Value Source Water Solubility 378.0 mg/mL ALOGPS logP 0.04 ALOGPS logP 0.25 ChemAxon logS 0.8 ALOGPS pKa (Strongest Acidic) 17.26 ChemAxon pKa (Strongest Basic) -1.8 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 1 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 20.23 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 17.43 m3·mol-1 ChemAxon Polarizability 7.14 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.9905 Blood Brain Barrier + 0.9694 Caco-2 permeable + 0.7135 P-glycoprotein substrate Non-substrate 0.8146 P-glycoprotein inhibitor I Non-inhibitor 0.9609 P-glycoprotein inhibitor II Non-inhibitor 0.9785 Renal organic cation transporter Non-inhibitor 0.932 CYP450 2C9 substrate Non-substrate 0.8061 CYP450 2D6 substrate Non-substrate 0.8916 CYP450 3A4 substrate Non-substrate 0.7103 CYP450 1A2 substrate Non-inhibitor 0.8634 CYP450 2C9 inhibitor Non-inhibitor 0.9466 CYP450 2D6 inhibitor Non-inhibitor 0.9581 CYP450 2C19 inhibitor Non-inhibitor 0.9267 CYP450 3A4 inhibitor Non-inhibitor 0.9764 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.949 Ames test Non AMES toxic 0.9246 Carcinogenicity Carcinogens 0.7397 Biodegradation Ready biodegradable 0.7608 Rat acute toxicity 1.3372 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9583 hERG inhibition (predictor II) Non-inhibitor 0.9457
Spectra
- Mass Spec (NIST)
- Download (3.84 KB)
- Spectra
Taxonomy
- Description
- This compound belongs to the class of organic compounds known as secondary alcohols. These are compounds containing a secondary alcohol functional group, with the general structure HOC(R)(R') (R,R'=alkyl, aryl).
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Alcohols and polyols
- Direct Parent
- Secondary alcohols
- Alternative Parents
- Hydrocarbon derivatives
- Substituents
- Secondary alcohol / Hydrocarbon derivative / Aliphatic acyclic compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- secondary alcohol (CHEBI:17824) / a small molecule (ISO-PROPANOL)
Targets
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Triphosphatase activity
- Specific Function
- Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap ...
- Gene Name
- RNGTT
- Uniprot ID
- O60942
- Uniprot Name
- mRNA-capping enzyme
- Molecular Weight
- 68556.21 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
- Specific Function
- Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl ...
- Gene Name
- azoR
- Uniprot ID
- P41407
- Uniprot Name
- FMN-dependent NADH-azoreductase
- Molecular Weight
- 21657.47 Da
- Kind
- Protein
- Organism
- Aquifex aeolicus (strain VF5)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Participates in transcription elongation, termination and antitermination.
- Gene Name
- nusG
- Uniprot ID
- O67757
- Uniprot Name
- Transcription termination/antitermination protein NusG
- Molecular Weight
- 27998.575 Da
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary...
- Gene Name
- ADI1
- Uniprot ID
- Q9BV57
- Uniprot Name
- 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
- Molecular Weight
- 21498.23 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the fu...
- Gene Name
- GCH1
- Uniprot ID
- P30793
- Uniprot Name
- GTP cyclohydrolase 1
- Molecular Weight
- 27902.855 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Transforming growth factor beta receptor binding
- Specific Function
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentia...
- Gene Name
- GDF5
- Uniprot ID
- P43026
- Uniprot Name
- Growth/differentiation factor 5
- Molecular Weight
- 55410.15 Da
- Kind
- Protein
- Organism
- Bacillus amyloliquefaciens
- Pharmacological action
- Unknown
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Has a high substrate specificity to fibrin.
- Gene Name
- apr
- Uniprot ID
- P00782
- Uniprot Name
- Subtilisin BPN'
- Molecular Weight
- 39180.935 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Antigen binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P06312
- Uniprot Name
- Ig kappa chain V-IV region Len
- Molecular Weight
- 12639.965 Da
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Ribonuclease a activity
- Specific Function
- Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
- Gene Name
- RNASE1
- Uniprot ID
- P07998
- Uniprot Name
- Ribonuclease pancreatic
- Molecular Weight
- 17644.125 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Azospirillum irakense
- Pharmacological action
- Unknown
- General Function
- Lyase activity
- Specific Function
- Not Available
- Gene Name
- pelA
- Uniprot ID
- Q9X592
- Uniprot Name
- Pectate lyase
- Molecular Weight
- 47006.465 Da
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Serine-type endopeptidase activity
- Specific Function
- In the ileum, may be involved in defensin processing, including DEFA5.
- Gene Name
- PRSS2
- Uniprot ID
- P07478
- Uniprot Name
- Trypsin-2
- Molecular Weight
- 26487.55 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- SIV-mac
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localiza...
- Gene Name
- gag
- Uniprot ID
- P05893
- Uniprot Name
- Gag polyprotein
- Molecular Weight
- 56725.035 Da
- Kind
- Protein
- Organism
- Desulfovibrio gigas
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- mop
- Uniprot ID
- Q46509
- Uniprot Name
- Aldehyde oxidoreductase
- Molecular Weight
- 97033.97 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Phospholipid binding
- Specific Function
- Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-ph...
- Gene Name
- PLA2G2A
- Uniprot ID
- P14555
- Uniprot Name
- Phospholipase A2, membrane associated
- Molecular Weight
- 16082.525 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Phospholipase activator activity
- Specific Function
- The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides a...
- Gene Name
- GM2A
- Uniprot ID
- P17900
- Uniprot Name
- Ganglioside GM2 activator
- Molecular Weight
- 20838.1 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Geobacillus stearothermophilus
- Pharmacological action
- Unknown
- General Function
- Metalloendopeptidase activity
- Specific Function
- Extracellular zinc metalloprotease.
- Gene Name
- nprS
- Uniprot ID
- P43133
- Uniprot Name
- Thermolysin
- Molecular Weight
- 60616.22 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Clostridium thermocellum
- Pharmacological action
- Unknown
- General Function
- Carbohydrate binding
- Specific Function
- Not Available
- Gene Name
- sdbA
- Uniprot ID
- P71143
- Uniprot Name
- Scaffolding dockerin binding protein A
- Molecular Weight
- 68618.73 Da
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Endochitinase activity
- Specific Function
- Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
- Gene Name
- CHIT1
- Uniprot ID
- Q13231
- Uniprot Name
- Chitotriosidase-1
- Molecular Weight
- 51680.985 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Nostoc sp. (strain PCC 7120 / UTEX 2576)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q8YWS4
- Uniprot Name
- Alr1529 protein
- Molecular Weight
- 23595.705 Da
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
- Specific Function
- Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role i...
- Gene Name
- DCXR
- Uniprot ID
- Q7Z4W1
- Uniprot Name
- L-xylulose reductase
- Molecular Weight
- 25912.875 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Ubiquitin protein ligase binding
- Specific Function
- Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as wel...
- Gene Name
- PRDX6
- Uniprot ID
- P30041
- Uniprot Name
- Peroxiredoxin-6
- Molecular Weight
- 25034.715 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Endodeoxyribonuclease activity, producing 5'-phosphomonoesters
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9WZD5
- Uniprot Name
- Putative deoxyribonuclease YcfH
- Molecular Weight
- 29180.945 Da
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Tumor necrosis factor receptor binding
- Specific Function
- Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct ac...
- Gene Name
- TNF
- Uniprot ID
- P01375
- Uniprot Name
- Tumor necrosis factor
- Molecular Weight
- 25644.15 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Ferrous iron binding
- Specific Function
- Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and th...
- Gene Name
- ACP5
- Uniprot ID
- P13686
- Uniprot Name
- Tartrate-resistant acid phosphatase type 5
- Molecular Weight
- 36598.47 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- Nad binding
- Specific Function
- Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylation...
- Gene Name
- AHCY
- Uniprot ID
- P23526
- Uniprot Name
- Adenosylhomocysteinase
- Molecular Weight
- 47715.715 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Human
- Pharmacological action
- Unknown
- General Function
- U6 snrna binding
- Specific Function
- Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically ass...
- Gene Name
- DDX39B
- Uniprot ID
- Q13838
- Uniprot Name
- Spliceosome RNA helicase DDX39B
- Molecular Weight
- 48990.945 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Mismatched dna binding
- Specific Function
- This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the f...
- Gene Name
- mutL
- Uniprot ID
- P23367
- Uniprot Name
- DNA mismatch repair protein MutL
- Molecular Weight
- 67923.04 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- RSV-SRA
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins ...
- Gene Name
- gag-pro-pol
- Uniprot ID
- Q04095
- Uniprot Name
- Gag-Pro-Pol polyprotein
- Molecular Weight
- 173931.55 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Enterobacteria phage lambda
- Pharmacological action
- Unknown
- General Function
- Lysozyme activity
- Specific Function
- Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis ...
- Gene Name
- R
- Uniprot ID
- P03706
- Uniprot Name
- Endolysin
- Molecular Weight
- 17825.045 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Magnesium ion binding
- Specific Function
- Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate.
- Gene Name
- gudD
- Uniprot ID
- P0AES2
- Uniprot Name
- Glucarate dehydratase
- Molecular Weight
- 49140.715 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Drug created on June 13, 2005 07:24 / Updated on October 16, 2018 08:37