Vorinostat Completed Phase 1 Trials for Stage IV Adult Diffuse Large Cell Lymphoma / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Stage III Grade 2 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Stage IV Adult Lymphoblastic Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Acute Myeloid Leukemia / Stage III Adult Diffuse Large Cell Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Recurrent Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Burkitt Lymphoma / Untreated Adult Acute Myeloid Leukemia / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Splenic Marginal Zone Lymphoma / Stage IV Marginal Zone Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Untreated Adult Acute Lymphoblastic Leukemia / Recurrent Marginal Zone Lymphoma / Recurrent Adult Acute Lymphoblastic Leukemia / Stage III Grade 3 Follicular Lymphoma / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Stage IV Grade 2 Follicular Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage IV Adult Burkitt Lymphoma / Recurrent Adult Burkitt Lymphoma / Recurrent Small Lymphocytic Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Recurrent Grade 3 Follicular Lymphoma / Stage III Marginal Zone Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage III Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage III Small Lymphocytic Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage IV Small Lymphocytic Lymphoma / Blastic Phase Chronic Myelogenous Leukemia / Nodal marginal zone B-cell lymphomas / Stage IV Mantle Cell Lymphoma / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma Treatment

IndicationsStatusPurposePhase
CompletedTreatment1
clinicaltrials.gov IdentifierTitleDrugs
NCT00275080Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia
NCT00121277Vorinostat and Capecitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
NCT00227513Vorinostat and Bortezomib in Treating Patients With Metastatic or Unresectable Solid Tumors
NCT00243100Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
NCT00287937Vorinostat, Paclitaxel, and Carboplatin in Treating Patients With Advanced or Refractory Solid Tumors
NCT00331955Vorinostat and Doxorubicin in Treating Patients With Metastatic or Locally Advanced Solid Tumors
NCT00324480Vorinostat and Alvocidib in Treating Patients With Advanced Solid Tumors