Vorinostat Completed Phase 1 Trials for Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Recurrent Adult Acute Lymphoblastic Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Stage III Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Stage III Small Lymphocytic Lymphoma / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Stage IV Grade 3 Follicular Lymphoma / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Splenic Marginal Zone Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Stage III Adult Diffuse Large Cell Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Stage III Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Untreated Adult Acute Myeloid Leukemia / Stage III Grade 1 Follicular Lymphoma / Recurrent Small Lymphocytic Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Recurrent Adult Acute Myeloid Leukemia / Recurrent Marginal Zone Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Stage III Marginal Zone Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Mantle Cell Lymphoma / Stage III Adult Burkitt Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Untreated Adult Acute Lymphoblastic Leukemia / Stage IV Marginal Zone Lymphoma / Stage III Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage III Grade 3 Follicular Lymphoma / Nodal marginal zone B-cell lymphomas / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Recurrent Grade 2 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Small Lymphocytic Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage III Adult Lymphoblastic Lymphoma Treatment

IndicationsStatusPurposePhase
CompletedTreatment1
clinicaltrials.gov IdentifierTitleDrugs
NCT00227513Vorinostat and Bortezomib in Treating Patients With Metastatic or Unresectable Solid Tumors
NCT00324480Vorinostat and Alvocidib in Treating Patients With Advanced Solid Tumors
NCT00275080Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia
NCT00287937Vorinostat, Paclitaxel, and Carboplatin in Treating Patients With Advanced or Refractory Solid Tumors
NCT00243100Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
NCT00331955Vorinostat and Doxorubicin in Treating Patients With Metastatic or Locally Advanced Solid Tumors
NCT00121277Vorinostat and Capecitabine in Treating Patients With Metastatic or Unresectable Solid Tumors