Showing BioInteractions for Phencyclidine (DB03575)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Phencyclidine is a Glutamate receptor ionotropic, NMDA 3A antagonist
1Glutamate receptor ionotropic, NMDA 3A antagonistsAmantadine, Dextromethorphan, Ethanol, Halothane, Ketamine, Orphenadrine, Procaine, Profenamine, Tenocyclidine
2Glutamate receptor ionotropic, NMDA 3A activatorsAcetylcysteine
Interacting GroupInteracting Drugs
Phencyclidine is a Cytochrome P450 2B6 inhibitor
1Cytochrome P450 2B6 substratesAmitriptyline, Amlodipine, Antipyrine, Apomorphine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Norgestimate, Osilodrostat, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2Cytochrome P450 2B6 inducersArmodafinil, Artemether, Artemisinin, Atorvastatin, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dabrafenib, Dexamethasone, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Pexidartinib, Phenobarbital, Phenytoin, Pitolisant, Prednisolone phosphate, Prednisone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Vemurafenib, Zanubrutinib
3Cytochrome P450 2B6 inhibitorsAbemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Desipramine, Doxorubicin, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Methimazole, Methylene blue, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Pexidartinib, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Safinamide, Selegiline, Sertraline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Triclabendazole, Voriconazole
4Cytochrome P450 2B6 activatorsVerapamil