Showing BioInteractions for Deoxycholic acid (DB03619)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Transporter Mediated Interactions 5

	Interacting Group	Interacting Drugs
	Deoxycholic acid is a Bile salt export pump inducer
1	Bile salt export pump inhibitors	Amiodarone, Bosentan, Celecoxib, Chlorpromazine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Erythromycin, Ethinylestradiol, Fusidic acid, Glyburide, Glycochenodeoxycholic Acid, Ketoconazole, Lenvatinib, Letermovir, Lopinavir, Nifedipine, Obeticholic acid, Olmesartan, Paclitaxel, Pralsetinib, Progesterone, Quinidine, Remdesivir, Reserpine, Rifampicin, Ritonavir, Simeprevir, Sulfamethoxazole, Tamoxifen, Tipranavir, Troglitazone, Ursodeoxycholic acid, Valinomycin, Vinblastine
2	Bile salt export pump substrates	Amiodarone, Astemizole, Atazanavir, Atenolol, Atorvastatin, Atropine, Belantamab mafodotin, Benzbromarone, Budesonide, Cefaclor, Cerivastatin, Cholic Acid, Clarithromycin, Clotrimazole, Cyclosporine, Daunorubicin, Diclofenac, Diethylstilbestrol, Digoxin, Dihydroergocristine, Dipyridamole, Disulfiram, Doxorubicin, Efavirenz, Erythromycin, Ezetimibe, Felodipine, Fenofibrate, Flucloxacillin, Fluorescein, Fluvoxamine, Glimepiride, Glipizide, Glyburide, Glycochenodeoxycholic Acid, Glycyrrhizic acid, Imatinib, Indinavir, Indocyanine green acid form, Indomethacin, Isradipine, Loratadine, Losartan, Lovastatin, Mifepristone, Naproxen, Nefazodone, Nelfinavir, Nicardipine, Nitrendipine, Nitrofurantoin, Ofloxacin, Paclitaxel, Pilsicainide, Pitavastatin, Prasterone sulfate, Pravastatin, Ranolazine, Repaglinide, Rosiglitazone, Rosuvastatin, Saquinavir, Simvastatin, Spironolactone, Sulfinpyrazone, Taurocholic acid, Telmisartan, Terfenadine, Tinidazole, Tipranavir, Ursodeoxycholic acid, Vinblastine, Vincristine
3	Bile salt export pump inducers	Cholic Acid, Dexamethasone, Dexamethasone acetate, Obeticholic acid, Phenobarbital, Taurocholic acid, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Deoxycholic acid is a Solute carrier organic anion transporter family member 1A2 substrate
1	Solute carrier organic anion transporter family member 1A2 substrates	Aminohippuric acid, Atorvastatin, Bilastine, Budesonide, Bumetanide, Cholic Acid, Conjugated estrogens, Digoxin, Dinoprostone, Enalapril, Erythromycin, Fexofenadine, Glycochenodeoxycholic Acid, Indomethacin, Levofloxacin, Levothyroxine, Lifitegrast, Liothyronine, Liotrix, Medrysone, Methotrexate, Mirabegron, Ouabain, Prasterone, Pravastatin, Rocuronium, Taurocholic acid, Ursodeoxycholic acid
2	Solute carrier organic anion transporter family member 1A2 inhibitors	Aldosterone, Betamethasone phosphate, Cholic Acid, Conjugated estrogens, Cortisone acetate, Dexamethasone, Dexamethasone acetate, Digitoxin, Erythromycin, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Everolimus, Glyburide, Glycochenodeoxycholic Acid, Hydrocortisone, Hydroxychloroquine, Ibuprofen, Indinavir, Indomethacin, Ketoprofen, Lovastatin, Methyltestosterone, Naloxone, Naproxen, Nelfinavir, Ouabain, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Probenecid, Quinidine, Quinine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Simvastatin, Spironolactone, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tolbutamide, Ursodeoxycholic acid, Verapamil
3	Solute carrier organic anion transporter family member 1A2 inducers	Cholic Acid, Methyltestosterone, Sumatriptan, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Deoxycholic acid is a Solute carrier organic anion transporter family member 1A2 inhibitor
1	Solute carrier organic anion transporter family member 1A2 substrates	Aminohippuric acid, Atorvastatin, Bilastine, Budesonide, Bumetanide, Cholic Acid, Conjugated estrogens, Digoxin, Dinoprostone, Enalapril, Erythromycin, Fexofenadine, Glycochenodeoxycholic Acid, Indomethacin, Levofloxacin, Levothyroxine, Lifitegrast, Liothyronine, Liotrix, Medrysone, Methotrexate, Mirabegron, Ouabain, Prasterone, Pravastatin, Rocuronium, Taurocholic acid, Ursodeoxycholic acid
2	Solute carrier organic anion transporter family member 1A2 inhibitors	Aldosterone, Betamethasone phosphate, Cholic Acid, Conjugated estrogens, Cortisone acetate, Dexamethasone, Dexamethasone acetate, Digitoxin, Erythromycin, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Everolimus, Glyburide, Glycochenodeoxycholic Acid, Hydrocortisone, Hydroxychloroquine, Ibuprofen, Indinavir, Indomethacin, Ketoprofen, Lovastatin, Methyltestosterone, Naloxone, Naproxen, Nelfinavir, Ouabain, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Probenecid, Quinidine, Quinine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Simvastatin, Spironolactone, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tolbutamide, Ursodeoxycholic acid, Verapamil
3	Solute carrier organic anion transporter family member 1A2 inducers	Cholic Acid, Methyltestosterone, Sumatriptan, Taurocholic acid, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid

	Interacting Group	Interacting Drugs
	Deoxycholic acid is a Ileal sodium/bile acid cotransporter inhibitor
1	Ileal sodium/bile acid cotransporter substrates	Acyclovir, Cholic Acid, Glycochenodeoxycholic Acid, Taurocholic acid, Valaciclovir
2	Ileal sodium/bile acid cotransporter inducers	Cholic Acid, Taurocholic acid
3	Ileal sodium/bile acid cotransporter inhibitors	Cholic Acid, Cyclosporine, Levamlodipine, Ursodeoxycholic acid, Volixibat

	Interacting Group	Interacting Drugs
	Deoxycholic acid is a Sodium/bile acid cotransporter substrate
1	Sodium/bile acid cotransporter inhibitors	Bulevirtide, Bumetanide, Cholic Acid, Conjugated estrogens, Cyclosporine, Ethinylestradiol, Probenecid, Progesterone, Remdesivir, Simeprevir, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Ursodeoxycholic acid
2	Sodium/bile acid cotransporter substrates	Bumetanide, Cholic Acid, Glycochenodeoxycholic Acid, Indomethacin, Liothyronine, Liotrix, Pitavastatin, Taurocholic acid, Thyroid, porcine, Ursodeoxycholic acid