Identification Name D-Arginine Accession Number DB04027 (EXPT01113) Type Small Molecule Groups Experimental Description
A D-α-amino acid that is the D-isomer of arginine (only the L-form is physiologically active).
(2R)-2-amino-5-(carbamimidamido)pentanoic acid (2R)-2-amino-5-guanidinopentanoic acid (R)-2-amino-5-guanidinopentanoic acid D-2-Amino-5-guanidinovaleric acid D-Arginin External IDs Not Available Product Ingredients Not Available Approved Prescription Products Not Available Approved Generic Prescription Products Not Available Approved Over the Counter Products Not Available Unapproved/Other Products Not Available International Brands Not Available Brand mixtures Not Available Categories Not Available UNII R54Z304Z7C CAS number 157-06-2 Weight Average: 174.201 Monoisotopic: 174.111675712 Chemical Formula C 6H 14N 4O 2 InChI Key ODKSFYDXXFIFQN-SCSAIBSYSA-N InChI
Pharmacology Indication Not Available Structured Indications Not Available Pharmacodynamics Not Available Mechanism of action
Target Kind Pharmacological action Actions Organism UniProt ID Creatine kinase M-type Protein unknown Not Available Human P06732 details Related Articles Absorption Not Available Volume of distribution Not Available Protein binding Not Available Metabolism Not Available Route of elimination Not Available Half life Not Available Clearance Not Available Toxicity Not Available Affected organisms Not Available Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Interactions Drug Interactions Not Available Food Interactions Not Available References Synthesis Reference
Kyriakos Makryaleas, Karlheinz Drauz, Andreas Bommarius, "Method for the preparation of D-arginine and L-ornithine." U.S. Patent US5591613, issued April, 1995.
US5591613 General References Not Available External Links ATC Codes Not Available AHFS Codes Not Available PDB Entries FDA label Not Available MSDS Not Available Clinical Trials Clinical Trials Not Available Pharmacoeconomics Manufacturers Not Available Packagers Not Available Dosage forms Not Available Prices Not Available Patents Not Available Properties State Solid Experimental Properties Not Available Predicted Properties Predicted ADMET features
Property Value Probability Human Intestinal Absorption - 0.7047 Blood Brain Barrier + 0.6875 Caco-2 permeable - 0.7139 P-glycoprotein substrate Non-substrate 0.5629 P-glycoprotein inhibitor I Non-inhibitor 0.988 P-glycoprotein inhibitor II Non-inhibitor 0.8802 Renal organic cation transporter Non-inhibitor 0.7663 CYP450 2C9 substrate Non-substrate 0.7822 CYP450 2D6 substrate Non-substrate 0.6948 CYP450 3A4 substrate Non-substrate 0.8044 CYP450 1A2 substrate Non-inhibitor 0.8491 CYP450 2C9 inhibitor Non-inhibitor 0.8966 CYP450 2D6 inhibitor Non-inhibitor 0.9172 CYP450 2C19 inhibitor Non-inhibitor 0.7693 CYP450 3A4 inhibitor Non-inhibitor 0.9192 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9951 Ames test AMES toxic 0.7057 Carcinogenicity Non-carcinogens 0.9254 Biodegradation Ready biodegradable 0.9466 Rat acute toxicity 1.6259 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9446 hERG inhibition (predictor II) Non-inhibitor 0.9652
ADMET data is predicted using
, a free tool for evaluating chemical ADMET properties. (
Spectra Mass Spec (NIST) Not Available Spectra Taxonomy Description This compound belongs to the class of chemical entities known as d-alpha-amino acids. These are alpha amino acids which have the D-configuration of the alpha-carbon atom. Kingdom Chemical entities Super Class Organic compounds Class Organic acids and derivatives Sub Class Carboxylic acids and derivatives Direct Parent D-alpha-amino acids Alternative Parents Fatty acids and conjugates / Guanidines / Amino acids / Propargyl-type 1,3-dipolar organic compounds / Monocarboxylic acids and derivatives / Carboxylic acids / Carboximidamides / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds show 2 more Substituents D-alpha-amino acid / Fatty acid / Guanidine / Amino acid / Carboxylic acid / Monocarboxylic acid or derivatives / Carboximidamide / Propargyl-type 1,3-dipolar organic compound / Organic 1,3-dipolar compound / Amine / Hydrocarbon derivative / Organic oxide / Primary amine / Organooxygen compound / Organonitrogen compound / Organopnictogen compound / Primary aliphatic amine / Organic oxygen compound / Organic nitrogen compound / Carbonyl group / Aliphatic acyclic compound show 11 more Molecular Framework Aliphatic acyclic compounds External Descriptors D-alpha-amino acid, arginine ( CHEBI:15816 ) / Other amino acids ( C00792 )