Fructose

Identification

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Name
Fructose
Accession Number
DB04173  (EXPT01495)
Type
Small Molecule
Groups
Approved, Experimental
Description
Not Available
Structure
Thumb
Synonyms
Not Available
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Anti NauseaFructose (1.87 g/5mL) + D-glucose monohydrate (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralMedicine Shoppe International2008-02-062013-06-09Us
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralRite Aid1996-06-122017-11-04Us
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralSafeway2007-07-30Not applicableUs
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralKroger2000-10-042017-11-01Us
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralH.E.B.1995-11-222017-09-08Us
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralMeijer Distribution1996-08-212017-11-01Us
Anti Nausea LiquidFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)SolutionOralTopco Associates2018-05-14Not applicableUs
Anti Nausea Liquid Cherry FlavorFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)SolutionOralQUALITY CHOICE (Chain Drug Marketing Association)2019-04-16Not applicableUs
Best Choice Anti Nausea Cherry FlavorFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralBest Choice (Valu Merchandisers Company)2019-04-16Not applicableUs
Discount Drug Mart nausea control Cherry FlavorFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)SolutionOralDiscount Drug Mart2019-03-28Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralH.E.B.1995-11-222017-09-08Us
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralMeijer Distribution1996-08-212017-11-01Us
Anti NauseaFructose (1.87 g/5mL) + D-glucose monohydrate (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralMedicine Shoppe International2008-02-062013-06-09Us
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralRite Aid1996-06-122017-11-04Us
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralSafeway2007-07-30Not applicableUs
Anti NauseaFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralKroger2000-10-042017-11-01Us
Anti Nausea LiquidFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)SolutionOralTopco Associates2018-05-14Not applicableUs
Anti Nausea Liquid Cherry FlavorFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)SolutionOralQUALITY CHOICE (Chain Drug Marketing Association)2019-04-16Not applicableUs
Best Choice Anti Nausea Cherry FlavorFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralBest Choice (Valu Merchandisers Company)2019-04-16Not applicableUs
Discount Drug Mart nausea control Cherry FlavorFructose (1.87 g/5mL) + Dextrose, unspecified form (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)SolutionOralDiscount Drug Mart2019-03-28Not applicableUs
International/Other Brands
Fructosteril (Fresenius) / Levugen (Baxter) / lnulon
Categories
UNII
WR469VI1J3
CAS number
Not Available
Weight
Average: 180.1559
Monoisotopic: 180.063388116
Chemical Formula
C6H12O6
InChI Key
RFSUNEUAIZKAJO-AZGQCCRYSA-N
InChI
InChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m0/s1
IUPAC Name
(2S,3R,4R,5S)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol
SMILES
OC[C@@H]1O[C@@](O)(CO)[C@H](O)[C@H]1O

Pharmacology

Indication
Not Available
Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UMaltoporinNot AvailableEscherichia coli (strain K12)
UBis(5'-adenosyl)-triphosphataseNot AvailableHumans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

Synthesis Reference

Larry W. Peckous, "Integrated process for producing crystalline fructose and a high-fructose, liquid phase sweetener." U.S. Patent US5656094, issued 0000.

US5656094
General References
Not Available
External Links
PubChem Compound
439553
PubChem Substance
46504785
ChemSpider
388644
ChEBI
43703
PharmGKB
PA449716
HET
LFR
Wikipedia
Fructose
ATC Codes
V06DC02 — Fructose
PDB Entries
1zx5 / 2cgj / 2cgl

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableCompletedTreatmentSickle Cell Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionOral
LiquidOral
SolutionOral750 mg/1
SyrupOral
Tablet, chewableOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1110.0 mg/mLALOGPS
logP-2.4ALOGPS
logP-2.8ChemAxon
logS0.79ALOGPS
pKa (Strongest Acidic)10.28ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area110.38 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity36.36 m3·mol-1ChemAxon
Polarizability16.29 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.6923
Blood Brain Barrier+0.7551
Caco-2 permeable-0.8511
P-glycoprotein substrateNon-substrate0.6415
P-glycoprotein inhibitor INon-inhibitor0.9343
P-glycoprotein inhibitor IINon-inhibitor0.9704
Renal organic cation transporterNon-inhibitor0.8814
CYP450 2C9 substrateNon-substrate0.8519
CYP450 2D6 substrateNon-substrate0.8504
CYP450 3A4 substrateNon-substrate0.6607
CYP450 1A2 substrateNon-inhibitor0.9365
CYP450 2C9 inhibitorNon-inhibitor0.9507
CYP450 2D6 inhibitorNon-inhibitor0.9575
CYP450 2C19 inhibitorNon-inhibitor0.9252
CYP450 3A4 inhibitorNon-inhibitor0.9846
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9767
Ames testNon AMES toxic0.9391
CarcinogenicityNon-carcinogens0.9398
BiodegradationReady biodegradable0.6874
Rat acute toxicity1.0362 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9772
hERG inhibition (predictor II)Non-inhibitor0.9115
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as c-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a C-glycosidic bond.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
C-glycosyl compounds
Alternative Parents
Pentoses / Tetrahydrofurans / Secondary alcohols / Hemiacetals / Polyols / Oxacyclic compounds / Primary alcohols / Hydrocarbon derivatives
Substituents
C-glycosyl compound / Pentose monosaccharide / Monosaccharide / Tetrahydrofuran / Secondary alcohol / Hemiacetal / Oxacycle / Organoheterocyclic compound / Polyol / Hydrocarbon derivative
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
L-fructofuranose (CHEBI:43703)

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Virus receptor activity
Specific Function
Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic res...
Gene Name
lamB
Uniprot ID
P02943
Uniprot Name
Maltoporin
Molecular Weight
49912.005 Da
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Ubiquitin protein ligase binding
Specific Function
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates ...
Gene Name
FHIT
Uniprot ID
P49789
Uniprot Name
Bis(5'-adenosyl)-triphosphatase
Molecular Weight
16858.11 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Drug created on June 13, 2005 07:24 / Updated on June 04, 2019 06:02