Fructose

Identification

Name
Fructose
Accession Number
DB04173  (EXPT01495)
Type
Small Molecule
Groups
Approved, Experimental
Description
Not Available
Structure
Thumb
Synonyms
Not Available
International/Other Brands
Fructosteril (Fresenius) / Levugen (Baxter) / lnulon
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralRite Aid1996-06-12Not applicableUs
Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralMeijer Distribution1996-08-21Not applicableUs
Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralKroger2000-10-04Not applicableUs
Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralMedicine Shoppe International2008-02-062018-01-06Us
Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralH.E.B.1995-11-22Not applicableUs
Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralSafeway2007-07-30Not applicableUs
Emetrol CherryFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)SolutionOralWell Spring Pharmaceutical Corporation2009-06-24Not applicableUs
Equate Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralWalmart Stores1995-03-222017-11-07Us
Good Neighbor Pharmacy Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralAmerisource Bergen1994-04-01Not applicableUs
Good Sense Anti NauseaFructose (1.87 g/5mL) + Glucose (1.87 g/5mL) + Phosphoric acid (21.5 mg/5mL)LiquidOralL. Perrigo Company1994-02-212017-11-10Us
Categories
UNII
6YSS42VSEV
CAS number
Not Available
Weight
Average: 180.1559
Monoisotopic: 180.063388116
Chemical Formula
C6H12O6
InChI Key
RFSUNEUAIZKAJO-AZGQCCRYSA-N
InChI
InChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m0/s1
IUPAC Name
(2S,3R,4R,5S)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol
SMILES

Pharmacology

Indication
Not Available
Structured Indications
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UBis(5'-adenosyl)-triphosphataseNot AvailableHuman
UMaltoporinNot AvailableEscherichia coli (strain K12)
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

Synthesis Reference

Larry W. Peckous, "Integrated process for producing crystalline fructose and a high-fructose, liquid phase sweetener." U.S. Patent US5656094, issued 0000.

US5656094
General References
Not Available
External Links
PubChem Compound
439553
PubChem Substance
46504785
ChemSpider
388644
ChEBI
43703
PharmGKB
PA449716
HET
LFR
ATC Codes
V06DC02 — Fructose
PDB Entries
1zx5 / 2cgj / 2cgl

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableCompletedTreatmentSickle Cell Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionOral
LiquidOral
SyrupOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1110.0 mg/mLALOGPS
logP-2.4ALOGPS
logP-2.8ChemAxon
logS0.79ALOGPS
pKa (Strongest Acidic)10.28ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area110.38 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity36.36 m3·mol-1ChemAxon
Polarizability16.29 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.6923
Blood Brain Barrier+0.7551
Caco-2 permeable-0.8511
P-glycoprotein substrateNon-substrate0.6415
P-glycoprotein inhibitor INon-inhibitor0.9343
P-glycoprotein inhibitor IINon-inhibitor0.9704
Renal organic cation transporterNon-inhibitor0.8814
CYP450 2C9 substrateNon-substrate0.8519
CYP450 2D6 substrateNon-substrate0.8504
CYP450 3A4 substrateNon-substrate0.6607
CYP450 1A2 substrateNon-inhibitor0.9365
CYP450 2C9 inhibitorNon-inhibitor0.9507
CYP450 2D6 inhibitorNon-inhibitor0.9575
CYP450 2C19 inhibitorNon-inhibitor0.9252
CYP450 3A4 inhibitorNon-inhibitor0.9846
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9767
Ames testNon AMES toxic0.9391
CarcinogenicityNon-carcinogens0.9398
BiodegradationReady biodegradable0.6874
Rat acute toxicity1.0362 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9772
hERG inhibition (predictor II)Non-inhibitor0.9115
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as c-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a C-glycosidic bond.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
C-glycosyl compounds
Alternative Parents
Pentoses / Tetrahydrofurans / Secondary alcohols / Hemiacetals / Polyols / Oxacyclic compounds / Primary alcohols / Hydrocarbon derivatives
Substituents
C-glycosyl compound / Pentose monosaccharide / Monosaccharide / Tetrahydrofuran / Secondary alcohol / Hemiacetal / Oxacycle / Organoheterocyclic compound / Polyol / Hydrocarbon derivative
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
L-fructofuranose (CHEBI:43703)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquitin protein ligase binding
Specific Function
Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates ...
Gene Name
FHIT
Uniprot ID
P49789
Uniprot Name
Bis(5'-adenosyl)-triphosphatase
Molecular Weight
16858.11 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Virus receptor activity
Specific Function
Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic res...
Gene Name
lamB
Uniprot ID
P02943
Uniprot Name
Maltoporin
Molecular Weight
49912.005 Da

Drug created on June 13, 2005 07:24 / Updated on December 01, 2017 15:24