Identification

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Name
Lactic acid
Accession Number
DB04398  (EXPT01996, DB09294)
Type
Small Molecule
Groups
Approved, Vet approved
Description

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as corn or beets, and then, by neutralizing the resulting lactic acid to create a compound having the formula NaC3H5O3.

Structure
Thumb
Synonyms
  • (±)-2-hydroxypropanoic acid
  • 2-Hydroxypropanoic acid
  • 2-Hydroxypropionic acid
  • ácido láctico
  • Acidum lacticum
  • DL- lactic acid
  • DL-Lactic Acid
  • DL-Milchsäure
  • Lacticum acidum
  • Milchsäure
  • Milk acid
  • rac-lactic acid
  • α-hydroxypropanoic acid
  • α-hydroxypropionic acid
External IDs
BRN 5238667 / CCRIS 2951 / E270 / NSC 367919 / SY-83
Product Ingredients
IngredientUNIICASInChI Key
Sodium lactateTU7HW0W0QT72-17-3NGSFWBMYFKHRBD-UHFFFAOYSA-M
Active Moieties
NameKindUNIICASInChI Key
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lactic AcidLotion1 g/10mLTopicalStratus Pharmaceuticals2009-01-082017-05-03Us
Lactic AcidLotion.1 mL/1mLTopicalRiver's Edge Pharmaceuticals, LLC2006-06-012010-02-28Us
Lactic AcidCream11.34 g/113.4gTopicalStratus Pharmaceuticals2009-01-162017-05-03Us
Lactic AcidCream100 mg/1gTopicalRiver's Edge Pharmaceuticals, LLC2006-06-012011-11-30Us
LactinolLotion35.484 mL/354.84mLTopicalPedinol Pharmacal, Inc.1992-02-012009-10-26Us
Lactinol-ECream11.34 g/113.4gTopicalPedinol Pharmacal, Inc.1991-02-012009-11-10Us
Sodium LactateInjection, solution1.87 g/100mLIntravenousBaxter Laboratories1971-03-222012-10-31Us
Sodium LactateInjection, solution, concentrate5.6 g/10mLIntravenousHospira, Inc.2006-06-28Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cheongin HaejanghwanPellet0.001 g/1gOralEntechbio Co., Ltd2011-02-18Not applicableUs
Cheongin HaewoohwanPellet0.001 g/1gOralEntechbio Co., Ltd2011-02-18Not applicableUs
Cheongin SamrakhwanPellet0.001 g/1gOralEntechbio Co., Ltd2011-02-17Not applicableUs
Cluederm Aqua Solution Peel PlusLiquid45 mg/500mLTopicalClassys Inc.2018-07-19Not applicableUs
Fresh Morning Bifidus bifidusPowder0.0316 mg/1mgOralSaimdang Cosmetics Co., Ltd2010-08-21Not applicableUs
Herbal Stemcell Aha PeelLiquid0.01 mg/1mLTopicalAmi Cosmetic Co.,Ltd.2013-08-01Not applicableUs
Keri Fast Absorbing - Aha - Lot 5%LotionTopicalBristol Myers Squibb1996-06-272001-07-30Canada
Keri Original - Aha - Lotion 5%LotionTopicalBristol Myers Squibb1996-06-272002-07-04Canada
Lactimol - Crm 10%CreamTopicalUcb Inc1996-12-061998-04-21Canada
Penederm LotionLotionTopicalPenederm Inc.1995-12-312001-08-17Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USPSodium lactate (310 mg) + Calcium Chloride (20 mg) + Potassium chloride (328 mg) + Sodium chloride (600 mg)SolutionIntravenousBaxter Laboratories2002-12-112016-07-15Canada
5% Dextrose In Lactated Ringer's InjectionSodium lactate (310 mg) + Calcium Chloride (20 mg) + Dextrose, unspecified form (5 g) + Potassium chloride (30 mg) + Sodium chloride (600 mg)SolutionIntravenousB. Braun Medical Inc.1993-12-312012-04-10Canada
Balance 1.5% Glucose, 1.25mmol/l CalciumSodium lactate (3.925 g) + Calcium Chloride (0.1838 g) + Dextrose, unspecified form (16.5 g) + Magnesium chloride (0.1017 g) + Sodium chloride (5.640 g)SolutionHemodialysisFresenius Medical Care Deutchland Gmbh2006-07-25Not applicableCanada
Balance 1.5% Glucose, 1.75mmol/l CalciumSodium lactate (3.925 g) + Calcium Chloride (0.2573 g) + Dextrose, unspecified form (16.5 g) + Magnesium chloride (0.1017 g) + Sodium chloride (5.640 g)SolutionHemodialysisFresenius Medical Care Deutchland GmbhNot applicableNot applicableCanada
Balance 2.3% Glucose, 1.25mmol/l CalciumSodium lactate (3.925 g) + Calcium Chloride (0.1838 g) + Dextrose, unspecified form (25.0 g) + Magnesium chloride (0.1017 g) + Sodium chloride (5.640 g)SolutionHemodialysisFresenius Medical Care Deutchland Gmbh2006-01-03Not applicableCanada
Balance 2.3% Glucose, 1.75mmol/l CalciumSodium lactate (3.925 g) + Calcium Chloride (0.2573 g) + Dextrose, unspecified form (25.0 g) + Magnesium chloride (0.1017 g) + Sodium chloride (5.640 g)SolutionHemodialysisFresenius Medical Care Deutchland GmbhNot applicableNot applicableCanada
Balance 4.25% Glucose, 1.25mmol/l CalciumSodium lactate (3.925 g) + Calcium Chloride (0.1838 g) + Dextrose, unspecified form (46.75 g) + Magnesium chloride (0.1017 g) + Sodium chloride (5.640 g)SolutionHemodialysisFresenius Medical Care Deutchland Gmbh2006-01-03Not applicableCanada
Balance 4.25% Glucose, 1.75mmol/l CalciumSodium lactate (3.925 g) + Calcium Chloride (0.2573 g) + Dextrose, unspecified form (46.75 g) + Magnesium chloride (0.1017 g) + Sodium chloride (5.640 g)SolutionHemodialysisFresenius Medical Care Deutchland GmbhNot applicableNot applicableCanada
Caneal Peritoneal Dialysis SolutionSodium lactate (448 mg) + Calcium Chloride (18.3 mg) + Dextrose, unspecified form (1.5 g) + Magnesium chloride (5.08 mg) + Sodium chloride (538 mg)SolutionHemodialysisChief Medical Supplies LtdNot applicableNot applicableCanada
Caneal Peritoneal Dialysis SolutionSodium lactate (392 mg) + Calcium Chloride (25.7 mg) + Dextrose, unspecified form (4.25 g) + Magnesium chloride (15.2 mg) + Sodium chloride (567 mg)SolutionHemodialysisChief Medical Supplies LtdNot applicableNot applicableCanada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Cheongin HaejanghwanLactic acid (0.001 g/1g)PelletOralEntechbio Co., Ltd2011-02-18Not applicableUs
Cheongin HaewoohwanLactic acid (0.001 g/1g)PelletOralEntechbio Co., Ltd2011-02-18Not applicableUs
Cheongin SamrakhwanLactic acid (0.001 g/1g)PelletOralEntechbio Co., Ltd2011-02-17Not applicableUs
Cluederm Aqua Solution Peel PlusLactic acid (45 mg/500mL)LiquidTopicalClassys Inc.2018-07-19Not applicableUs
Dianeal for Peritoneal DialysisSodium lactate (4.48 g/1000mL) + Calcium chloride dihydrate (0.184 g/1000mL) + D-glucose (38.6 g/1000mL) + Magnesium chloride hexahydrate (0.051 g/1000mL) + Sodium chloride (5.38 g/1000mL)Injection, solutionIntraperitonealBaxter Healthcare Corporation2014-10-27Not applicableUs
Dianeal for Peritoneal DialysisSodium lactate (4.48 g/1000mL) + Calcium chloride dihydrate (0.184 g/1000mL) + D-glucose (22.7 g/1000mL) + Magnesium chloride hexahydrate (0.051 g/1000mL) + Sodium chloride (5.38 g/1000mL)Injection, solutionIntraperitonealBaxter Healthcare Corporation2014-10-27Not applicableUs
Dianeal for Peritoneal DialysisSodium lactate (4.48 g/1000mL) + Calcium chloride dihydrate (0.184 g/1000mL) + D-glucose (13.6 g/1000mL) + Magnesium chloride hexahydrate (0.051 g/1000mL) + Sodium chloride (5.38 g/1000mL)Injection, solutionIntraperitonealBaxter Healthcare Corporation2014-10-27Not applicableUs
Fresh Morning Bifidus bifidusLactic acid (0.0316 mg/1mg)PowderOralSaimdang Cosmetics Co., Ltd2010-08-21Not applicableUs
Glysol-500Sodium lactate (1.60 g/100mL) + Glycerin (57.10 g/100mL) + Potassium chloride (0.03 g/100mL)SolutionExtracorporealBiomet Biologics2010-01-012010-09-06Us
Herbal Stemcell Aha PeelLactic acid (0.01 mg/1mL)LiquidTopicalAmi Cosmetic Co.,Ltd.2013-08-01Not applicableUs
Categories
UNII
3B8D35Y7S4
CAS number
50-21-5
Weight
Average: 90.0779
Monoisotopic: 90.031694058
Chemical Formula
C3H6O3
InChI Key
JVTAAEKCZFNVCJ-UHFFFAOYSA-N
InChI
InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)
IUPAC Name
2-hydroxypropanoic acid
SMILES
CC(O)C(O)=O

Pharmacology

Indication

For use as an alkalinizing agent.

Associated Conditions
Pharmacodynamics

Lactic acid produces a metabolic alkalinizing effect.

Mechanism of action

Lactate ions are metabolized ultimately to carbon dioxide and water, which requires the consumption of hydrogen cations.

TargetActionsOrganism
UBifunctional protein PutANot AvailableEscherichia coli (strain K12)
UNimA-related proteinNot AvailableDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

Synthesis Reference

Yoshihide Hagiwara, Miyauchi Tetsuji, Yuki Morimasa, "Process for preparing food products containing a lactic acid bacteria-fermented product of a cereal germ." U.S. Patent US4056637, issued February, 1933.

US4056637
General References
Not Available
External Links
Human Metabolome Database
HMDB0144295
KEGG Drug
D00111
KEGG Compound
C01432
PubChem Compound
612
PubChem Substance
46505582
ChemSpider
592
BindingDB
23233
ChEBI
78320
ChEMBL
CHEMBL1200559
Guide to Pharmacology
GtP Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Lactic_acid
ATC Codes
G01AD01 — Lactic acid
AHFS Codes
  • 84:24.12 — Basic Ointments and Protectants
  • 84:04.92 — Miscellaneous Local Anti-infectives

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentStriae Distensae1
1, 2CompletedTreatmentRecurrent Tonsillitis in Children1
1, 2Not Yet RecruitingTreatmentBrain Injuries,Traumatic1
2CompletedSupportive CareHygiene1
2CompletedTreatmentAcute Heart Failure (AHF)1
2Not Yet RecruitingTreatmentEnd Stage Renal Disease (ESRD)1
2TerminatedTreatmentCongestive Heart Failure (CHF)1
2, 3CompletedPreventionHead Trauma1
2, 3CompletedPreventionPost-ERCP Acute Pancreatitis1
2, 3Not Yet RecruitingTreatmentShock, Septic1
2, 3TerminatedTreatmentIntracranial Pressure Increase / Severe Trauma Brain Injury1
3CompletedPreventionHygiene4
3CompletedSupportive CareCancer, Breast / Drug/Agent Toxicity by Tissue/Organ / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedSupportive CareHealthy Volunteers7
3CompletedSupportive CareHygiene26
3CompletedTreatmentContinuous ambulatory peritoneal dialysis therapy / Diabetes Mellitus (DM) / End Stage Renal Disease (ESRD)1
3CompletedTreatmentDiabetes Mellitus (DM) / ESRD1
3CompletedTreatmentHygiene10
3CompletedTreatmentShock, Hemorrhagic1
3TerminatedTreatmentCongestive Heart Failure (CHF)1
3Unknown StatusTreatmentDengue Shock Syndrome1
4CompletedSupportive CareHygiene3
4CompletedTreatmentAPD / Continuous ambulatory peritoneal dialysis therapy / Diabetes Mellitus (DM) / ESRD1
4CompletedTreatmentChronic Kidney Disease (CKD) / Peritoneal dialysis therapy1
4CompletedTreatmentCoronary Heart Disease (CHD)1
4CompletedTreatmentHygiene1
4RecruitingTreatmentImpaired Renal Function1
4TerminatedTreatmentHypertriglyceridemias / Peritoneal dialysis therapy1
4Unknown StatusNot AvailableAtopic Dermatitis (AD)1
Not AvailableCompletedBasic ScienceType 1 Diabetes Mellitus With Hypoglycemia1
Not AvailableCompletedDiagnosticPost Cardiac Surgery1
Not AvailableCompletedTreatmentEnd Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentTraumatic Brain Injury (TBI)1
Not AvailableNot Yet RecruitingScreeningActual Impaired Fluid Volume1
Not AvailableNot Yet RecruitingTreatmentLactate / Severe Sepsis With Septic Shock1
Not AvailableRecruitingTreatmentShock / Shock, Septic1
Not AvailableUnknown StatusNot AvailablePatients Undergoing Open Resection of Colorectal Tumours1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Contract Pharm
  • Groupe Parima Inc.
  • Paddock Labs
  • PEDiNOL
  • Philipp Thomas Usa LLC
  • Rising Pharmaceuticals
  • River's Edge Pharmaceuticals
  • Sheffield Laboratories Div Faria Limited LLC
  • Sonar Products Inc.
  • Stratus Pharmaceuticals Inc.
  • Synthera Dr Friedrichs Gmgh Co. KG
Dosage forms
FormRouteStrength
PelletOral0.001 g/1g
LiquidTopical45 mg/500mL
SolutionIntraperitoneal
InjectionIntravenous
Injection, solutionIntravenous
Injection, solutionIntraperitoneal
LiquidHemodialysis
SolutionHemodialysis
PowderOral0.0316 mg/1mg
SolutionUnknown
SolutionExtracorporeal
LiquidTopical0.01 mg/1mL
LiquidIntraperitoneal
SolutionHemodialysis; Intraperitoneal
GelTopical
Tablet, chewableOral
LiquidIrrigation
IrrigantIrrigation
Solution, for slushIrrigation
SolutionIrrigation
CreamTopical100 mg/1g
LotionTopical.1 mL/1mL
LotionTopical1 g/10mL
CreamTopical
CreamTopical
LotionTopical35.484 mL/354.84mL
CreamTopical11.34 g/113.4g
LotionTopical
LiquidIntravenous
Capsule, gelatin coatedOral
KitHemodialysis
SolutionIntravenous
SolutionHemodialysis; Intravenous
Injection, solutionIntravenous1.87 g/100mL
Injection, solution, concentrateIntravenous5.6 g/10mL
LotionTopical
SolutionTopical
LiquidTopical
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6077836No2000-06-202017-06-20Us
US6248726No2001-06-192018-06-19Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

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Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)16.8 °CPhysProp
boiling point (°C)122 °C at 1.50E+01 mm HgPhysProp
water solubility1E+006 mg/LMERCK INDEX (1996)
logP-0.72HANSCH,C ET AL. (1995)
pKa3.86 (at 20 °C)KORTUM,G ET AL (1961)
Predicted Properties
PropertyValueSource
Water Solubility562.0 mg/mLALOGPS
logP-0.79ALOGPS
logP-0.47ChemAxon
logS0.79ALOGPS
pKa (Strongest Acidic)3.78ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity18.84 m3·mol-1ChemAxon
Polarizability8.05 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (2 TMS)GC-MSsplash10-014i-1900000000-e4b0458c1830f2273dbf
GC-MS Spectrum - EI-BGC-MSsplash10-00kb-9000000000-e9462d6d6eeac598b73b
GC-MS Spectrum - GC-EI-TOFGC-MSsplash10-00kb-0900000000-31df199e59f138c8cc73
Mass Spectrum (Electron Ionization)MSsplash10-0002-9000000000-6b805941ef8da414e517
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dl-9000000000-02a1cd4a8992ca170923
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dj-9000000000-aea7835dfa5a89c7ad72
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-05dj-9000000000-853c8ae85554cbf4f3aa
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dl-9000000000-02a1cd4a8992ca170923
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dj-9000000000-aea7835dfa5a89c7ad72
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-05dj-9000000000-853c8ae85554cbf4f3aa
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dl-9000000000-02a1cd4a8992ca170923
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dj-9000000000-aea7835dfa5a89c7ad72
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-05dj-9000000000-853c8ae85554cbf4f3aa
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dl-9000000000-02a1cd4a8992ca170923
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dj-9000000000-aea7835dfa5a89c7ad72
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-05dj-9000000000-853c8ae85554cbf4f3aa
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dl-9000000000-02a1cd4a8992ca170923
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00dj-9000000000-aea7835dfa5a89c7ad72
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-05dj-9000000000-853c8ae85554cbf4f3aa
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-9000000000-b6d22eee857dbd8c67c1
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0079-9000000000-79419ab380c5c954afa8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-9000000000-1ab6a665296f80ee0127
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-9000000000-b6d22eee857dbd8c67c1
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0079-9000000000-79419ab380c5c954afa8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-9000000000-1ab6a665296f80ee0127
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-9000000000-b6d22eee857dbd8c67c1
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0079-9000000000-79419ab380c5c954afa8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-9000000000-1ab6a665296f80ee0127
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-9000000000-b6d22eee857dbd8c67c1
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0079-9000000000-79419ab380c5c954afa8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-9000000000-1ab6a665296f80ee0127
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-9000000000-b6d22eee857dbd8c67c1
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0079-9000000000-79419ab380c5c954afa8
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-9000000000-1ab6a665296f80ee0127
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-000i-9000000000-32a7c59ca2c276cf73a6
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as alpha hydroxy acids and derivatives. These are organic compounds containing a carboxylic acid substituted with a hydroxyl group on the adjacent carbon.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Hydroxy acids and derivatives
Sub Class
Alpha hydroxy acids and derivatives
Direct Parent
Alpha hydroxy acids and derivatives
Alternative Parents
Secondary alcohols / Monocarboxylic acids and derivatives / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Alpha-hydroxy acid / Secondary alcohol / Monocarboxylic acid or derivatives / Carboxylic acid / Carboxylic acid derivative / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organooxygen compound / Carbonyl group
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
2-hydroxy monocarboxylic acid (CHEBI:78320)

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Transcriptional repressor activity, bacterial-type rna polymerase core promoter proximal region sequence-specific binding
Specific Function
Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon.
Gene Name
putA
Uniprot ID
P09546
Uniprot Name
Bifunctional protein PutA
Molecular Weight
143813.665 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Pharmacological action
Unknown
General Function
Oxidoreductase activity
Specific Function
Not Available
Gene Name
Not Available
Uniprot ID
Q9RW27
Uniprot Name
NimA-related protein
Molecular Weight
21890.23 Da

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Symporter activity
Specific Function
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucin...
Gene Name
SLC16A7
Uniprot ID
O60669
Uniprot Name
Monocarboxylate transporter 2
Molecular Weight
52199.745 Da
References
  1. Lin RY, Vera JC, Chaganti RS, Golde DW: Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. [PubMed:9786900]
  2. Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. [PubMed:10417314]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name
SLCO2B1
Uniprot ID
O94956
Uniprot Name
Solute carrier organic anion transporter family member 2B1
Molecular Weight
76709.98 Da
References
  1. Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. [PubMed:12724351]
  2. Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. [PubMed:14610227]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Symporter activity
Specific Function
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucin...
Gene Name
SLC16A1
Uniprot ID
P53985
Uniprot Name
Monocarboxylate transporter 1
Molecular Weight
53943.685 Da
References
  1. Lin RY, Vera JC, Chaganti RS, Golde DW: Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. [PubMed:9786900]
  2. Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW: Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J. 1998 Jul 1;333 ( Pt 1):167-74. [PubMed:9639576]
  3. Broer S, Rahman B, Pellegri G, Pellerin L, Martin JL, Verleysdonk S, Hamprecht B, Magistretti PJ: Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J Biol Chem. 1997 Nov 28;272(48):30096-102. [PubMed:9374487]
  4. Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. [PubMed:10579682]
  5. Takanaga H, Tamai I, Inaba S, Sai Y, Higashida H, Yamamoto H, Tsuji A: cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem Biophys Res Commun. 1995 Dec 5;217(1):370-7. [PubMed:8526936]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Transporter activity
Specific Function
Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).
Gene Name
SLC16A10
Uniprot ID
Q8TF71
Uniprot Name
Monocarboxylate transporter 10
Molecular Weight
55492.07 Da
References
  1. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. [PubMed:11278508]
  2. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. [PubMed:11827462]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, a...
Gene Name
SLCO2A1
Uniprot ID
Q92959
Uniprot Name
Solute carrier organic anion transporter family member 2A1
Molecular Weight
70043.33 Da
References
  1. Chan BS, Endo S, Kanai N, Schuster VL: Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. Am J Physiol Renal Physiol. 2002 Jun;282(6):F1097-102. [PubMed:11997326]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Symporter activity
Specific Function
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine...
Gene Name
SLC16A3
Uniprot ID
O15427
Uniprot Name
Monocarboxylate transporter 4
Molecular Weight
49468.9 Da
References
  1. Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. [PubMed:11101640]

Drug created on June 13, 2005 07:24 / Updated on September 23, 2019 04:11