Identification
- Summary
Hemoglobin is an iron-containing protein found in all red blood cells (RBCs) for proper binding of oxygen and transport throughout the body, included in blood transfusions in severe hemorrhage.
- Generic Name
- Hemoglobin
- DrugBank Accession Number
- DB04945
- Background
The respiratory protein of the red blood cells. It consists primarily of globin and heme.
- Type
- Biotech
- Groups
- Approved, Experimental, Investigational
- Biologic Classification
- Protein Based Therapies
Blood factors - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Deoxyhemoglobin
- Haemoglobin
- Human hemoglobin
Pharmacology
- Indication
Investigated for use/treatment in blood (blood forming organ disorders, unspecified) and hemorrhage.
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Not Available
- Mechanism of action
A heme group is made up of iron (Fe) ion (charged atom) located in a heterocyclic ring, which is also called a porphyrin ring. The site of oxygen binding, the iron ion, binds with the nitrogens located in the center of the porphyrin ring. The iron ion binds with high affinity to the globular protein through the imidazole ring of the F8 residue on histidine which is found below the porphyrin ring. A sixth position can bind reversibly to oxygen, completing the formation of the octahedral group. One oxygen atom binds Fe and the other is found to protrude at an angle. When oxygen is not bound to Fe, a water molecule (weakly bound) fills the site, producing a distorted shape, often described as an octahedron.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
This means that the oxygen binding curve for fetal hemoglobin is left-shifted (i.e., a higher percentage of hemoglobin has oxygen bound to it at lower oxygen tension), in comparison to that of adult hemoglobin
- Metabolism
There is a group of genetic disorders, known as the porphyrias that are characterized by errors in metabolic pathways of heme synthesis
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Deschiens Sirop Liquid 8.3 g / 100 mL Oral Rodeca Inc., Division Of Technilab Inc. 1951-12-31 1999-09-17 Canada 
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- VSU9IB86SP
- CAS number
- 9008-02-0
References
- General References
- Not Available
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Acute Coronary Syndrome (ACS) / Occlusion, Coronary 1 2 Completed Treatment Angina Pectoris / Myocardial Infarction / Unstable Angina Pectoris 1 2 Completed Treatment Lactic Acidosis / Shock, Hemorrhagic / Traumatic Shock 1 2 Unknown Status Treatment Coronary Artery Disease (CAD) 1 2 Unknown Status Treatment Wounds and Injuries 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Liquid Oral 8.3 g / 100 mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Drug created at October 21, 2007 22:23 / Updated at June 12, 2020 16:52