Showing BioInteractions for Ezogabine (DB04953)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Enzyme Mediated Interactions 5

	Interacting Group	Interacting Drugs
	Ezogabine is a UDP-glucuronosyltransferase 1-1 substrate
1	UDP-glucuronosyltransferase 1-1 substrates	Abacavir, Acetaminophen, Alvocidib, Atorvastatin, Axitinib, Belinostat, Bictegravir, Binimetinib, Cabotegravir, Carvedilol, Cerivastatin, Deferasirox, Delafloxacin, Dexibuprofen, Dolutegravir, Eltrombopag, Elvitegravir, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Febuxostat, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Fusidic acid, Gavestinel, Gemfibrozil, Glipizide, Indacaterol, Indomethacin, Irinotecan, Ketoprofen, Labetalol, Letermovir, Levothyroxine, Liothyronine, Losartan, Lovastatin, Metronidazole, Migalastat, Minoxidil, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Nintedanib, Norgestimate, Phenytoin, Propacetamol, Propofol, Raloxifene, Raltegravir, Sacituzumab govitecan, Selumetinib, Simvastatin, Suprofen, Tecovirimat, Tiagabine, Tramadol, Troglitazone, Valproic acid, Vericiguat, Zidovudine, Zonisamide
2	UDP-glucuronosyltransferase 1-1 inhibitors	Adenine, Atazanavir, Dacomitinib, Dasabuvir, Deferasirox, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Indomethacin, Ketoconazole, Nilotinib, Ombitasvir, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Probenecid, Propofol, Regorafenib, Rucaparib, Silibinin, Sodium aurothiomalate, Sorafenib, Ubrogepant, Valproic acid
3	UDP-glucuronosyltransferase 1-1 inducers	Carbamazepine, Desogestrel, Efavirenz, Ethinylestradiol, Nelfinavir, Phenobarbital, Phenytoin, Rifampicin, Testosterone propionate, Tipranavir, Zidovudine

	Interacting Group	Interacting Drugs
	Ezogabine is a UDP-glucuronosyltransferase 1-3 substrate
1	UDP-glucuronosyltransferase 1-3 substrates	Ambrisentan, Anastrozole, Atorvastatin, Baloxavir marboxil, Candesartan, Candesartan cilexetil, Cyproheptadine, Delafloxacin, Dexibuprofen, Diclofenac, Dolutegravir, Eltrombopag, Empagliflozin, Enasidenib, Etodolac, Ezetimibe, Febuxostat, Flurbiprofen, Fluvastatin, Gavestinel, Gemfibrozil, Hydromorphone, Ibuprofen, Irbesartan, Ketotifen, Letermovir, Licofelone, Lorlatinib, Losartan, Lovastatin, Mitiglinide, Morphine, Muraglitazar, Naldemedine, Nalmefene, Naproxen, Pitavastatin, Simvastatin, Telmisartan, Troglitazone, Valproic acid
2	UDP-glucuronosyltransferase 1-3 inhibitors	Deferasirox, Dovitinib, Flunitrazepam, Gemfibrozil

	Interacting Group	Interacting Drugs
	Ezogabine is a UDP-glucuronosyltransferase 1-4 substrate
1	UDP-glucuronosyltransferase 1-4 substrates	Amitriptyline, Anastrozole, Asenapine, Clozapine, Cyclobenzaprine, Enasidenib, Ethinylestradiol, Idelalisib, Imidafenacin, Ketotifen, Midazolam, Olanzapine, Osilodrostat, Paricalcitol, Pexidartinib, Phenytoin, Tecovirimat, Trifluoperazine, Troglitazone, Valproic acid
2	UDP-glucuronosyltransferase 1-4 inhibitors	Ertugliflozin, Idelalisib, Methylene blue

	Interacting Group	Interacting Drugs
	Ezogabine is a UDP-glucuronosyltransferase 1-9 substrate
1	UDP-glucuronosyltransferase 1-9 substrates	Acetaminophen, Ambrisentan, Artenimol, Artesunate, Ataluren, Cabotegravir, Canagliflozin, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Diclofenac, Dolutegravir, Empagliflozin, Enasidenib, Entacapone, Ertugliflozin, Ethinylestradiol, Etodolac, Febuxostat, Fenofibrate, Flurbiprofen, Formoterol, Fostamatinib, Gavestinel, Gemfibrozil, Glasdegib, Haloperidol, Ibuprofen, Indomethacin, Irinotecan, Ketobemidone, Labetalol, Lumiracoxib, Mycophenolate mofetil, Mycophenolic acid, Naproxen, Nateglinide, Oxazepam, Oxymetazoline, Phenytoin, Propacetamol, Propofol, Regorafenib, Seratrodast, Sorafenib, Tapentadol, Topiroxostat, Troglitazone, Umifenovir, Vadimezan, Valdecoxib, Valproic acid, Vericiguat, Zileuton
2	UDP-glucuronosyltransferase 1-9 inhibitors	Deferasirox, Diflunisal, Eltrombopag, Fosphenytoin, Isavuconazole, Mefenamic acid, Methylene blue, Morniflumate, Niflumic acid, Phenytoin, Regorafenib, Rifampicin, Sorafenib, Umifenovir

	Interacting Group	Interacting Drugs
	Ezogabine is a Arylamine N-acetyltransferase 2 substrate
1	Arylamine N-acetyltransferase 2 substrates	Acetylsalicylic acid, Amifampridine, Clonazepam, Dapsone, Isoniazid, Ozanimod, Sulfamethoxazole
2	Arylamine N-acetyltransferase 2 inhibitors	Acetaminophen, Propacetamol