keyhole limpet hemocyanin

Identification

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Name
keyhole limpet hemocyanin
Accession Number
DB05299
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Description

keyhole limpet hemocyanin is an immune modulators, given as a vaccine to help the body respond to cancer. A natural protein isolated from the marine mollusc keyhole limpet. Keyhole limpet hemocyanin is an immunogenic carrier protein that, in vivo, increases antigenic immune responses to haptens and other weak antigens such as idiotype proteins.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
Not Available
Categories
UNII
FV4Y0JO2CX
CAS number
Not Available

Pharmacology

Indication

Investigated for use/treatment in bladder cancer and solid tumors.

Pharmacodynamics
Not Available
Mechanism of action

Keyhole Limpet Hemocyanin (KLH) is generally a very efficient coupling agent. It is the most common carrier protein used in the preparation of hapten conjugates. KLH is composed of five subunits. It is lysine rich with a large number of available primary amines to facilitate conjugation, antibody production and promote peptide attachment after dissociation.

TargetActionsOrganism
UInterleukin-2Not AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. McFadden DW, Riggs DR, Jackson BJ, Ng A, Cunningham C: Keyhole limpet hemocyanin potentiates standard immunotherapy for melanoma. Am J Surg. 2007 Feb;193(2):284-7. [PubMed:17236863]
External Links
PubChem Substance
347910062
Wikipedia
Keyhole_limpet_hemocyanin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0TerminatedTreatmentAutoimmune Disorders1
1CompletedTreatmentMelanoma (Skin)1
1CompletedTreatmentProstate Cancer1
1RecruitingTreatmentHealthy Volunteers1
1TerminatedBasic ScienceHealthy Adult Volunteers1
1TerminatedTreatmentGerm Cell Tumors / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm1
1, 2CompletedTreatmentLeukemia, Acute Lymphocytic (ALL) / Leukemia, Acute Myelogenous (AML) / Leukemia, Chronic Myelogenous (CML) / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentGlioblastomas / Gliomas1
2CompletedTreatmentLung Cancers1
2CompletedTreatmentMalignant Lymphomas2
2CompletedTreatmentRefractory Plasma Cell Neoplasm / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2CompletedTreatmentRheumatoid Arthritis1
2TerminatedTreatmentMalignant Lymphomas1
2Unknown StatusTreatmentRenal Cancers1
3CompletedTreatmentBladder Cancers1
3CompletedTreatmentCancer, Breast1
3Unknown StatusTreatmentMalignant Lymphomas1
4CompletedNot AvailableDisseminated Sclerosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Kinase activator activity
Specific Function
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimu...
Gene Name
IL2
Uniprot ID
P60568
Uniprot Name
Interleukin-2
Molecular Weight
17627.52 Da

Drug created on November 18, 2007 11:23 / Updated on June 04, 2019 06:15