Ragweed pollen extract

Identification

Summary

Ragweed pollen extract is an extract from Ragweed pollen extract used in allergy testing.

Generic Name
Ragweed pollen extract
DrugBank Accession Number
DB05368
Background

Ragweed pollen extract has been developed by Curalogic. The company has initiated a phase III trial with its product for oral immunotherapy of ragweed allergy. While traditional disease-modifying immunotherapeutics are administered by subcutaneous injection, Curalogic has developed a more convenient orally administered drug.

Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Allergenics
Allergen Extract
Synonyms
Not Available

Pharmacology

Indication

Investigated for use/treatment in allergic reaction.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

Ragweed pollen extract is the oral immunotherapy delivered via microencapsulated beads put into a capsule, which "enables the antigen to be delivered more efficiently to the Peyer's patches in the jejunum and duodenum, where the antigen can be presented and processed and not destroyed by stomach acid.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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International/Other Brands
Ragwitek (Merck Sharp & Dohme)

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Litwin A, Flanagan M, Entis G, Gottschlich G, Esch R, Gartside P, Michael JG: Immunologic effects of encapsulated short ragweed extract: a potent new agent for oral immunotherapy. Ann Allergy Asthma Immunol. 1996 Aug;77(2):132-8. [Article]
  2. Andre C, Perrin-Fayolle M, Grosclaude M, Couturier P, Basset D, Cornillon J, Piperno D, Girodet B, Sanchez R, Vallon C, Bellier P, Nasr M: A double-blind placebo-controlled evaluation of sublingual immunotherapy with a standardized ragweed extract in patients with seasonal rhinitis. Evidence for a dose-response relationship. Int Arch Allergy Immunol. 2003 Jun;131(2):111-8. [Article]
PubChem Substance
347910104

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Drug created at November 18, 2007 18:24 / Updated at June 12, 2020 16:52