Identification

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Name
Corticorelin
Accession Number
DB05394
Type
Small Molecule
Groups
Investigational
Description

Corticotropin-releasing factor is studied in the treatment of brain cancer. It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory. Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling) of the brain. It is a type of neurohormone, also called hCRF.

Synonyms
  • Corticoliberin human
  • Corticorelin (human)
  • Corticotropin releasing hormone human
  • Corticotropin-releasing factor
  • Corticotropin-releasing factor (human)
  • Corticotropin-releasing hormone
  • CRF
  • hCRF
  • Human corticoliberin
  • Human corticotropin-releasing factor
External IDs
NEU-3002
Categories
UNII
305OE8862Y
CAS number
86784-80-7

Pharmacology

Indication

Investigated for use/treatment in brain cancer and neurologic disorders.

Pharmacodynamics
Not Available
Mechanism of action

Corticotropin-releasing factor is produced by neuroendocrine cells in the paraventricular nucleus of the hypothalamus and is released from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system. The portal system carries the Corticotropin-releasing hormone(CRH) to the anterior lobe of the pituitary where it stimulates the secretion of corticotropin (ACTH) and other biologically active substances.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. Hoare SR, Sullivan SK, Ling N, Crowe PD, Grigoriadis DE: Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists. Mol Pharmacol. 2003 Mar;63(3):751-65. [PubMed:12606786]
  2. Lowery EG, Sparrow AM, Breese GR, Knapp DJ, Thiele TE: The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice. Alcohol Clin Exp Res. 2008 Feb;32(2):240-8. Epub 2007 Dec 21. [PubMed:18162074]
External Links
PubChem Substance
347910116
Wikipedia
Corticotropin-releasing_hormone
ATC Codes
V04CD04 — Corticorelin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingBasic ScienceSleep Restriction1
1CompletedBasic ScienceStress1
1CompletedTreatmentEdema1
1RecruitingBasic ScienceSleep Restriction1
1, 2TerminatedTreatmentBrain Swelling / Neoplasms, Brain1
3CompletedTreatmentBrain Swelling / Neoplasms, Brain2
3CompletedTreatmentDisseminated Neuroblastoma / Localized Resectable Neuroblastoma / Localized Unresectable Neuroblastoma / Regional Neuroblastoma / Stage 4S Neuroblastoma1
3WithdrawnTreatmentBrain Swelling / Neoplasms, Brain1
4CompletedBasic ScienceHealthy Volunteers1
Not AvailableCompletedNot AvailableAdrenal Gland Hyperfunction / Adrenal Gland Hypofunction / Cushing's Syndrome / Healthy Volunteers1
Not AvailableCompletedNot AvailableCocaine-Related Disorders / Dependence, Cocaine / Substance-Related Disorders1
Not AvailableWithdrawnBasic ScienceFunctional Dyspepsia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
L-ascorbic acid binding
Specific Function
Conversion of dopamine to noradrenaline.
Gene Name
DBH
Uniprot ID
P09172
Uniprot Name
Dopamine beta-hydroxylase
Molecular Weight
69064.45 Da
References
  1. Lima L, Sourkes TL: Effect of corticotropin-releasing factor on adrenal DBH and PNMT activity. Peptides. 1987 May-Jun;8(3):437-41. [PubMed:3498935]

Drug created on November 18, 2007 11:24 / Updated on November 02, 2019 01:50