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Identification
NameTelaprevir
Accession NumberDB05521
TypeSmall Molecule
GroupsApproved
DescriptionTelaprevir (VX-950) is a highly selective and potent inhibitor of the HCV NS3-4A serine protease. It is a member of a class of antiviral drugs known as protease inhibitors and is the first hepatitis C drug that has demonstrated activity in patients who have failed prior therapy. On April 28, 2011, the FDA Antiviral Drugs Advisory Committee voted 18-0 to recommend approval telaprevir for people with genotype 1 chronic hepatitis C and was approved in the U.S. in May, 2011.
Structure
Thumb
Synonyms
(1S,3AR,6as)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide
Incivek
MP-424
VX 950
VX-950
External Identifiers
  • AIDS-213006
  • AIDS213006
  • LY-570310
  • VRT111950
  • VX-950
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IncivekTablet375 mgOralVertex Pharmaceuticals (Canada) Incorporated2011-10-032015-04-21Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IncivoTablet, film coated375 mgOralJanssen Cilag International N.V.2011-09-19Not applicableEu
IncivoTablet, film coated375 mgOralJanssen Cilag International N.V.2011-09-19Not applicableEu
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII655M5O3W0U
CAS number402957-28-2
WeightAverage: 679.8493
Monoisotopic: 679.405732463
Chemical FormulaC36H53N7O6
InChI KeyBBAWEDCPNXPBQM-GDEBMMAJSA-N
InChI
InChI=1S/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25-,27-,28-,30+/m0/s1
IUPAC Name
(3S)-3-{[(1S,3aR,6aS)-2-[(2S)-2-[(2S)-2-cyclohexyl-2-(pyrazin-2-ylformamido)acetamido]-3,3-dimethylbutanoyl]-octahydrocyclopenta[c]pyrrol-1-yl]formamido}-N-cyclopropyl-2-oxohexanamide
SMILES
[H][C@@]12CCC[C@]1([H])[[email protected]](N(C2)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C1=NC=CN=C1)C1CCCCC1)C(C)(C)C)C(=O)N[C@@H](CCC)C(=O)C(=O)NC1CC1
Pharmacology
IndicationTreating chronic hepatitis C virus (genotype 1) infection in patients with compensated liver (due to liver diseases like cirrhosis) that are treatment naive or have failed therapy with interferons (either null or partial responders and treatment relapsers).
Structured Indications Not Available
PharmacodynamicsTelaprevir is a direct-acting antiviral agent (DAA) against the hepatitis C virus. In a biochemical assay, telaprevir inhibited the proteolytic activity of the recombinant HCV NS3 protease domain with an IC50 value of 10 nM.
Mechanism of actionTelaprevir is an inhibitor of the HCV NS3/4A serine protease, necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS4A, NS4B, NS5A and NS5B proteins and essential for viral replication. It belongs to the chemical class of alpha-ketoamids and binds to NS3/4A in a covalent but reversible manner.
TargetKindPharmacological actionActionsOrganismUniProt ID
Genome polyproteinProteinyes
inhibitor
Hepatitis C virusB0B3C9 details
Related Articles
AbsorptionTelaprevir is orally available, most likely absorbed in the small intestine, with no evidence for absorption in the colon. Maximum plasma concentrations after a single dose of telaprevir are generally achieved after 4 to 5 hours. In vitro studies performed with human Caco-2 cells indicated that telaprevir is a substrate of P-glycoprotein (P-gp). Exposure to telaprevir is higher during co-administration of peginterferon alfa and ribavirin than after administration of telaprevir alone. Dissolution of telaprevir is not dependent by pH.
Volume of distribution

Apparent volume of distribution (Vd/F) = 252 L. This large volume of distribution suggests extensive penetration into tissues.

Protein binding59% to 76% and binds to alpha 1-acid glycoprotein and albumin in a concentration dependent manner.
Metabolism

Telaprevir is extensively metabolized in the liver, involving hydrolysis, oxidation, and reduction. Multiple metabolites were detected in feces, plasma, and urine. After repeated-oral administration, the R-diastereomer of telaprevir (30-fold less active), pyrazinoic acid, and a metabolite that underwent reduction at the α-ketoamide bond of telaprevir (not active) were found to be the predominant metabolites of telaprevir. In vitro studies using recombinant human cytochrome P450 (CYP) isoforms indicated that CYP3A4 was the major CYP isoform responsible for telaprevir metabolism. However, non-CYP mediated metabolism likely plays a role after multiple dosing of telaprevir.

SubstrateEnzymesProduct
Telaprevir
Not Available
Pyrazinoic acidDetails
Route of eliminationFollowing administration of a single oral dose of 750 mg 14C-telaprevir in healthy subjects, 90% of total radioactivity was recovered in feces, urine and expired air within 96 hours post-dose. The median recovery of the administered radioactive dose was approximately 82% in the feces, 9% in exhaled air and 1% in urine. The contribution of unchanged 14C-telaprevir and the R-diastereomer of telaprevir towards total radioactivity recovered in feces was 31.9% and 18.8%, respectively.
Half lifeThe mean elimination half-life after single-dose oral administration of telaprevir 750 mg typically ranged from about 4.0 to 4.7 hours. At steady state, the effective half-life is about 9 to 11 hours.
Clearance

After oral administration, the apparent total clearance (Cl/F) was estimated to be 32.4 L/h with an inter-individual variability of 27.2%.

ToxicityThe highest documented dose administered is 1875 mg every 8 hours for 4 days in healthy subjects with telaprevir alone. In that study, the following common adverse events were reported more frequently with the 1875 mg q8h regimen compared to the 750 mg q8h regimen: nausea, headache, diarrhea, decreased appetite, dysgeusia, and vomiting. The two most common adverse events that caused the discontinuation of treatment are anemia and rash.
Affected organisms
  • Hepatitis C virus, RSV and other RNA/DNA viruses
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of Telaprevir can be decreased when it is combined with 16-Bromoepiandrosterone.Investigational
19-norandrostenedioneThe serum concentration of Telaprevir can be decreased when it is combined with 19-norandrostenedione.Experimental, Illicit
4-AndrostenedioneThe serum concentration of Telaprevir can be decreased when it is combined with 4-Androstenedione.Experimental, Illicit
5-androstenedioneThe serum concentration of Telaprevir can be decreased when it is combined with 5-androstenedione.Experimental, Illicit
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Telaprevir.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Telaprevir.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Telaprevir.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Telaprevir.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Telaprevir.Approved
AfatinibThe serum concentration of Telaprevir can be increased when it is combined with Afatinib.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Telaprevir.Approved, Vet Approved
AlclometasoneThe serum concentration of Telaprevir can be decreased when it is combined with Alclometasone.Approved
AldosteroneThe serum concentration of Telaprevir can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Telaprevir can be increased when it is combined with Alectinib.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Telaprevir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Telaprevir.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Telaprevir.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Telaprevir.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Telaprevir.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Telaprevir.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Telaprevir.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Telaprevir.Approved, Illicit, Investigational
AmantadineThe serum concentration of Telaprevir can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Telaprevir.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Telaprevir.Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Telaprevir.Experimental
AmcinonideThe serum concentration of Telaprevir can be decreased when it is combined with Amcinonide.Approved
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Telaprevir.Illicit, Withdrawn
Aminohippuric acidThe serum concentration of Telaprevir can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Telaprevir.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Telaprevir.Approved
AmiodaroneThe risk or severity of adverse effects can be increased when Telaprevir is combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Telaprevir.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Telaprevir.Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Telaprevir.Approved
AmsacrineThe serum concentration of Telaprevir can be increased when it is combined with Amsacrine.Approved
AnecortaveThe serum concentration of Telaprevir can be decreased when it is combined with Anecortave.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Telaprevir.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Telaprevir.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Telaprevir.Approved, Investigational
AprepitantThe serum concentration of Telaprevir can be increased when it is combined with Aprepitant.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Telaprevir.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Telaprevir.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Telaprevir.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Telaprevir.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Telaprevir.Approved, Withdrawn
AtazanavirThe serum concentration of Telaprevir can be decreased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Telaprevir can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Telaprevir can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Telaprevir.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Telaprevir.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Telaprevir.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Telaprevir.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Telaprevir.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Telaprevir.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Telaprevir.Approved
BeclomethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Beclomethasone.Investigational
Beclomethasone dipropionateThe serum concentration of Telaprevir can be decreased when it is combined with Beclomethasone dipropionate.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Telaprevir.Approved
BenzocaineThe serum concentration of Telaprevir can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Telaprevir.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Telaprevir.Approved
BepridilThe risk or severity of adverse effects can be increased when Telaprevir is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Betamethasone.Approved, Vet Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Telaprevir.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Telaprevir.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Telaprevir.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Telaprevir.Approved
BiperidenThe serum concentration of Telaprevir can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Telaprevir.Approved
BoceprevirThe serum concentration of Telaprevir can be decreased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Telaprevir.Approved, Investigational
BosentanThe serum concentration of Telaprevir can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Telaprevir.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Telaprevir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Telaprevir.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Telaprevir.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Telaprevir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Telaprevir.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Telaprevir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Telaprevir.Approved
BudesonideThe serum concentration of Telaprevir can be decreased when it is combined with Budesonide.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Telaprevir.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Telaprevir.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Telaprevir.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Telaprevir.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Telaprevir.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Telaprevir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Telaprevir.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Telaprevir.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Telaprevir.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Telaprevir.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Telaprevir.Approved
CandesartanThe serum concentration of Telaprevir can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Telaprevir can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Telaprevir.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Telaprevir.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Telaprevir.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Telaprevir.Approved, Investigational
CaspofunginThe serum concentration of Telaprevir can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Telaprevir.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Telaprevir.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Telaprevir.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Telaprevir.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Telaprevir.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Telaprevir.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Telaprevir.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Telaprevir.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Telaprevir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Telaprevir.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Telaprevir.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Telaprevir.Approved, Vet Approved
ChlorpropamideThe serum concentration of Telaprevir can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Telaprevir can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Telaprevir.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Telaprevir.Approved, Nutraceutical
CholesterolThe serum concentration of Telaprevir can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Telaprevir can be decreased when it is combined with Cholic Acid.Approved
CiclesonideThe serum concentration of Telaprevir can be decreased when it is combined with Ciclesonide.Approved, Investigational
CilazaprilThe serum concentration of Telaprevir can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Telaprevir.Approved
CimetidineThe serum concentration of Telaprevir can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Telaprevir.Approved
CiprofloxacinThe serum concentration of Telaprevir can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Telaprevir.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Telaprevir.Approved
ClarithromycinThe serum concentration of Telaprevir can be increased when it is combined with Clarithromycin.Approved
ClemastineThe metabolism of Telaprevir can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Telaprevir.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Telaprevir.Approved, Illicit
ClobetasolThe serum concentration of Telaprevir can be decreased when it is combined with Clobetasol.Investigational
Clobetasol propionateThe serum concentration of Telaprevir can be decreased when it is combined with Clobetasol propionate.Approved
ClocortoloneThe serum concentration of Telaprevir can be decreased when it is combined with Clocortolone.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Telaprevir.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Telaprevir.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Telaprevir.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Telaprevir.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Telaprevir.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Telaprevir.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Telaprevir.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Telaprevir.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Telaprevir.Approved, Illicit
ClotrimazoleThe metabolism of Telaprevir can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Telaprevir.Approved
CobicistatThe serum concentration of Telaprevir can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Telaprevir.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Telaprevir.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Telaprevir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Telaprevir.Approved
ColforsinThe serum concentration of Telaprevir can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Telaprevir.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Telaprevir.Approved
Cortisone acetateThe serum concentration of Telaprevir can be decreased when it is combined with Cortisone acetate.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Telaprevir.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Telaprevir.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Telaprevir is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Telaprevir.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Telaprevir.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Telaprevir.Approved, Investigational
DabrafenibThe serum concentration of Telaprevir can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Telaprevir.Approved
DactinomycinThe serum concentration of Telaprevir can be increased when it is combined with Dactinomycin.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Telaprevir.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Telaprevir.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Telaprevir.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Telaprevir.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Telaprevir.Approved, Investigational
DarunavirThe serum concentration of Telaprevir can be decreased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Telaprevir.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Telaprevir.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Telaprevir.Approved
DeferasiroxThe serum concentration of Telaprevir can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of Telaprevir can be decreased when it is combined with dehydroepiandrosterone sulfate.Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Telaprevir.Approved
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Telaprevir.Approved
DesloratadineThe serum concentration of Telaprevir can be increased when it is combined with Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Telaprevir.Approved
DesoximetasoneThe serum concentration of Telaprevir can be decreased when it is combined with Desoximetasone.Approved
Desoxycorticosterone acetateThe serum concentration of Telaprevir can be decreased when it is combined with Desoxycorticosterone acetate.Approved
Desoxycorticosterone PivalateThe serum concentration of Telaprevir can be decreased when it is combined with Desoxycorticosterone Pivalate.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Telaprevir.Approved
DexamethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Telaprevir can be decreased when it is combined with Dexamethasone isonicotinate.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Telaprevir.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Telaprevir.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Telaprevir.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Telaprevir.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Telaprevir.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Telaprevir.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Telaprevir.Approved
DiflorasoneThe serum concentration of Telaprevir can be decreased when it is combined with Diflorasone.Approved
DifluocortoloneThe serum concentration of Telaprevir can be decreased when it is combined with Difluocortolone.Approved
DifluprednateThe serum concentration of Telaprevir can be decreased when it is combined with Difluprednate.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Telaprevir.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Telaprevir.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Telaprevir.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Telaprevir.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Telaprevir.Approved
DipyridamoleThe serum concentration of Telaprevir can be increased when it is combined with Dipyridamole.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Telaprevir.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Telaprevir.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Telaprevir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Telaprevir.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Telaprevir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Telaprevir.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Telaprevir.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Telaprevir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Telaprevir.Approved
DoxazosinThe serum concentration of Telaprevir can be increased when it is combined with Doxazosin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Telaprevir.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Telaprevir.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Telaprevir.Approved, Investigational
DoxycyclineThe metabolism of Telaprevir can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Telaprevir.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Telaprevir.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Telaprevir.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Telaprevir.Approved, Investigational
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Telaprevir.Approved
EfavirenzThe serum concentration of Telaprevir can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Telaprevir can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Telaprevir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Telaprevir.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Telaprevir.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Telaprevir.Approved, Vet Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Telaprevir.Approved, Investigational
EnzalutamideThe serum concentration of Telaprevir can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Telaprevir.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Telaprevir.Approved
EquileninThe serum concentration of Telaprevir can be decreased when it is combined with Equilenin.Experimental
EquilinThe serum concentration of Telaprevir can be decreased when it is combined with Equilin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Telaprevir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Telaprevir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Telaprevir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Telaprevir.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Telaprevir.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Telaprevir.Approved, Vet Approved
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Telaprevir.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Telaprevir.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Telaprevir can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Telaprevir.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Telaprevir.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Telaprevir.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Telaprevir.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Telaprevir.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Telaprevir.Approved
EstriolThe serum concentration of Telaprevir can be decreased when it is combined with Estriol.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Telaprevir.Approved
EstroneThe serum concentration of Telaprevir can be decreased when it is combined with Estrone.Approved
Estrone sulfateThe serum concentration of Telaprevir can be decreased when it is combined with Estrone sulfate.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Telaprevir.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Telaprevir.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Telaprevir.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Telaprevir.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Telaprevir.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Telaprevir.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Telaprevir.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Telaprevir.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Telaprevir.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Telaprevir.Approved, Investigational
EtravirineThe serum concentration of Telaprevir can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Telaprevir.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Telaprevir.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Telaprevir.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Telaprevir.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Telaprevir.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Telaprevir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Telaprevir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Telaprevir.Approved
FexofenadineThe serum concentration of Telaprevir can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Telaprevir can be increased when it is combined with Fidaxomicin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Telaprevir.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Telaprevir.Approved, Investigational
FlecainideThe risk or severity of adverse effects can be increased when Telaprevir is combined with Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Telaprevir.Approved
fluasteroneThe serum concentration of Telaprevir can be decreased when it is combined with fluasterone.Investigational
FluconazoleThe metabolism of Telaprevir can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Telaprevir can be decreased when it is combined with Fludrocortisone.Approved
FlumethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Flumethasone.Approved, Vet Approved
FlunisolideThe serum concentration of Telaprevir can be decreased when it is combined with Flunisolide.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Telaprevir.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Telaprevir can be decreased when it is combined with Fluocinolone Acetonide.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Telaprevir can be decreased when it is combined with Fluocinonide.Approved, Investigational
FluocortoloneThe serum concentration of Telaprevir can be decreased when it is combined with Fluocortolone.Approved, Withdrawn
FluorometholoneThe serum concentration of Telaprevir can be decreased when it is combined with Fluorometholone.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Telaprevir.Approved, Vet Approved
FlupentixolThe serum concentration of Telaprevir can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Telaprevir can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe serum concentration of Telaprevir can be decreased when it is combined with Fluprednidene.Approved, Withdrawn
FluprednisoloneThe serum concentration of Telaprevir can be decreased when it is combined with Fluprednisolone.Approved
FlurandrenolideThe serum concentration of Telaprevir can be decreased when it is combined with Flurandrenolide.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Telaprevir.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Telaprevir.Approved
Fluticasone furoateThe serum concentration of Telaprevir can be decreased when it is combined with Fluticasone furoate.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Telaprevir.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Telaprevir.Approved
FluvoxamineThe metabolism of Telaprevir can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Telaprevir can be decreased when it is combined with Formestane.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Telaprevir can be decreased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Telaprevir can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Telaprevir.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Telaprevir.Approved, Investigational
Fusidic AcidThe serum concentration of Telaprevir can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Telaprevir.Approved
GarlicThe serum concentration of Telaprevir can be decreased when it is combined with Garlic.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Telaprevir.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Telaprevir.Approved
GenisteinThe serum concentration of Telaprevir can be increased when it is combined with Genistein.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Telaprevir.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Telaprevir.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Telaprevir.Approved
GlycerolThe serum concentration of Telaprevir can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Telaprevir can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Telaprevir.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Telaprevir.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Telaprevir.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Telaprevir.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Telaprevir.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Telaprevir.Approved, Vet Approved
HE3286The serum concentration of Telaprevir can be decreased when it is combined with HE3286.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Telaprevir.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Telaprevir.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Telaprevir.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Telaprevir.Approved, Illicit
HydrocortisoneThe serum concentration of Telaprevir can be decreased when it is combined with Hydrocortisone.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Telaprevir.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Telaprevir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Telaprevir.Approved
IdelalisibThe serum concentration of Telaprevir can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Telaprevir resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Telaprevir.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Telaprevir.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Telaprevir.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Telaprevir.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Telaprevir.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Telaprevir.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Telaprevir.Approved
IndinavirThe metabolism of Telaprevir can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Telaprevir can be increased when it is combined with Indomethacin.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Telaprevir.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Telaprevir.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Telaprevir.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Telaprevir.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Telaprevir.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Telaprevir.Approved
IstaroximeThe serum concentration of Telaprevir can be decreased when it is combined with Istaroxime.Investigational
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Telaprevir.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Telaprevir.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Telaprevir.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Telaprevir.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Telaprevir.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Telaprevir.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Telaprevir.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Telaprevir.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Telaprevir.Approved
KetoconazoleThe serum concentration of Telaprevir can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoconazoleThe metabolism of Telaprevir can be decreased when combined with Ketoconazole.Approved, Investigational
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Telaprevir.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Telaprevir.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Telaprevir.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Telaprevir.Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Telaprevir.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Telaprevir.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Telaprevir.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Telaprevir.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Telaprevir.Approved
LevofloxacinThe serum concentration of Telaprevir can be increased when it is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Telaprevir.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Telaprevir.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Telaprevir.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Telaprevir.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Telaprevir.Approved, Vet Approved
LidocaineThe risk or severity of adverse effects can be increased when Telaprevir is combined with Lidocaine.Approved, Vet Approved
LiothyronineThe serum concentration of Telaprevir can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Telaprevir can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Telaprevir can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Telaprevir.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Telaprevir.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Telaprevir.Approved
LopinavirThe serum concentration of Telaprevir can be decreased when it is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Telaprevir.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Telaprevir.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Telaprevir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Telaprevir.Approved, Investigational
LuliconazoleThe serum concentration of Telaprevir can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Telaprevir can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Telaprevir.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Telaprevir.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Telaprevir.Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Telaprevir.Approved
MaprotilineThe serum concentration of Telaprevir can be increased when it is combined with Maprotiline.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Telaprevir.Approved, Investigational
ME-609The serum concentration of Telaprevir can be decreased when it is combined with ME-609.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Telaprevir.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Telaprevir.Approved, Investigational
MedrysoneThe serum concentration of Telaprevir can be decreased when it is combined with Medrysone.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Telaprevir.Approved
Megestrol acetateThe serum concentration of Telaprevir can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelengestrolThe serum concentration of Telaprevir can be decreased when it is combined with Melengestrol.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Telaprevir.Approved, Vet Approved
MeprobamateThe serum concentration of Telaprevir can be increased when it is combined with Meprobamate.Approved, Illicit
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Telaprevir.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Telaprevir.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Telaprevir.Experimental
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Telaprevir.Illicit, Withdrawn
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Telaprevir.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Telaprevir.Approved, Vet Approved
MethylergometrineThe serum concentration of Methylergometrine can be increased when it is combined with Telaprevir.Approved
MethylprednisoloneThe serum concentration of Telaprevir can be decreased when it is combined with Methylprednisolone.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Telaprevir.Approved
MetoprololThe serum concentration of Telaprevir can be increased when it is combined with Metoprolol.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Telaprevir.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Telaprevir.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Telaprevir.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Telaprevir.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Telaprevir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Telaprevir.Approved, Illicit
MifepristoneThe serum concentration of Telaprevir can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Telaprevir.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Telaprevir.Approved
MitomycinThe serum concentration of Telaprevir can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Telaprevir can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Telaprevir can be decreased when it is combined with Mitoxantrone.Approved, Investigational
ModafinilThe metabolism of Modafinil can be decreased when combined with Telaprevir.Approved, Investigational
MometasoneThe serum concentration of Telaprevir can be decreased when it is combined with Mometasone.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Telaprevir.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Telaprevir.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Telaprevir.Approved, Investigational
NafcillinThe serum concentration of Telaprevir can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Telaprevir.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Telaprevir.Approved, Vet Approved
NaltrexoneThe serum concentration of Telaprevir can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Telaprevir can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Telaprevir.Approved, Investigational
NCX 1022The serum concentration of Telaprevir can be decreased when it is combined with NCX 1022.Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Telaprevir.Approved, Withdrawn
NelfinavirThe metabolism of Telaprevir can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Telaprevir can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Telaprevir can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Telaprevir can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Telaprevir.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Telaprevir.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Telaprevir.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Telaprevir.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Telaprevir.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Telaprevir.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Telaprevir.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Telaprevir.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Telaprevir.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Telaprevir.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Telaprevir.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Telaprevir.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Telaprevir.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Telaprevir.Approved
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Telaprevir.Approved
Oleoyl estroneThe serum concentration of Telaprevir can be decreased when it is combined with Oleoyl estrone.Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Telaprevir.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Telaprevir.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Telaprevir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Telaprevir.Investigational
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Telaprevir.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Telaprevir.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Telaprevir.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Telaprevir.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Telaprevir.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Telaprevir is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Telaprevir.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Telaprevir can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Telaprevir.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Telaprevir.Approved
Palmitic AcidThe serum concentration of Telaprevir can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Telaprevir.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Telaprevir.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Telaprevir.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Telaprevir.Approved
ParamethasoneThe serum concentration of Telaprevir can be decreased when it is combined with Paramethasone.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Telaprevir.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Telaprevir.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Telaprevir.Approved
ParoxetineThe serum concentration of Telaprevir can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Telaprevir.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Telaprevir.Approved
PentobarbitalThe serum concentration of Telaprevir can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Telaprevir.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Telaprevir.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Telaprevir.Approved
PerindoprilThe serum concentration of Telaprevir can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Telaprevir.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Telaprevir.Approved
PethidineThe risk or severity of adverse effects can be increased when Telaprevir is combined with Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Telaprevir.Withdrawn
PhenobarbitalThe serum concentration of Telaprevir can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Telaprevir.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Telaprevir.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Telaprevir.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Telaprevir.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Telaprevir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Telaprevir.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Telaprevir.Withdrawn
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Telaprevir.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Telaprevir.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Telaprevir.Approved
Platelet Activating FactorThe serum concentration of Telaprevir can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Telaprevir.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Telaprevir.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Telaprevir.Approved
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Telaprevir.Approved, Investigational, Vet Approved
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Telaprevir.Approved
PrasteroneThe serum concentration of Telaprevir can be decreased when it is combined with Prasterone.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Telaprevir resulting in a loss in efficacy.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Telaprevir.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Telaprevir.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Telaprevir.Approved, Vet Approved
PrazosinThe serum concentration of Telaprevir can be increased when it is combined with Prazosin.Approved
PrednicarbateThe serum concentration of Telaprevir can be decreased when it is combined with Prednicarbate.Approved
PrednisoloneThe serum concentration of Telaprevir can be decreased when it is combined with Prednisolone.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Telaprevir.Approved, Vet Approved
PrednisoneThe serum concentration of Telaprevir can be decreased when it is combined with Prednisone.Approved, Vet Approved
PregnenoloneThe serum concentration of Telaprevir can be decreased when it is combined with Pregnenolone.Experimental
PrimaquineThe metabolism of Primaquine can be decreased when combined with Telaprevir.Approved
PrimidoneThe serum concentration of Telaprevir can be decreased when it is combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Telaprevir can be increased when it is combined with Probenecid.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Telaprevir.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Telaprevir.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Telaprevir.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Telaprevir.Approved, Vet Approved
PromethazineThe serum concentration of Telaprevir can be increased when it is combined with Promethazine.Approved
PropafenoneThe risk or severity of adverse effects can be increased when Telaprevir is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Telaprevir.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Telaprevir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Telaprevir.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Telaprevir.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Telaprevir.Approved, Illicit
QuercetinThe serum concentration of Telaprevir can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Telaprevir.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Telaprevir.Approved
QuinidineThe risk or severity of adverse effects can be increased when Telaprevir is combined with Quinidine.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Telaprevir.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Telaprevir.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Telaprevir.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Telaprevir.Approved, Investigational
RanitidineThe serum concentration of Telaprevir can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Telaprevir.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Telaprevir.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Telaprevir.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Telaprevir.Approved, Investigational
ReserpineThe serum concentration of Telaprevir can be decreased when it is combined with Reserpine.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Telaprevir.Approved
RifabutinThe serum concentration of Telaprevir can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Telaprevir can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Telaprevir can be decreased when it is combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Telaprevir.Approved
RimexoloneThe serum concentration of Telaprevir can be decreased when it is combined with Rimexolone.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Telaprevir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Telaprevir.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Telaprevir.Approved, Investigational
RitonavirThe serum concentration of Telaprevir can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Telaprevir.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Telaprevir.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Telaprevir.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Telaprevir.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Telaprevir.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Telaprevir.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Telaprevir.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Telaprevir.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Telaprevir.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Telaprevir.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Telaprevir.Approved
SaquinavirThe metabolism of Telaprevir can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Telaprevir.Approved
ScopolamineThe serum concentration of Telaprevir can be increased when it is combined with Scopolamine.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Telaprevir.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Telaprevir.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Telaprevir.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Telaprevir.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Telaprevir.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Telaprevir.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Telaprevir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Telaprevir.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Telaprevir.Approved
SiltuximabThe serum concentration of Telaprevir can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Telaprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Telaprevir.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Telaprevir.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Telaprevir.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Telaprevir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Telaprevir.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Telaprevir.Approved, Investigational
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Telaprevir.Approved
SpironolactoneThe serum concentration of Telaprevir can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Telaprevir can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Telaprevir can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Telaprevir can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Telaprevir can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Telaprevir.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Telaprevir.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Telaprevir.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Telaprevir.Approved
SulfisoxazoleThe metabolism of Telaprevir can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Telaprevir can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Telaprevir.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Telaprevir.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Telaprevir.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Telaprevir.Approved
TacrineThe serum concentration of Telaprevir can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Telaprevir.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Telaprevir.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Telaprevir.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Telaprevir.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Telaprevir.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Telaprevir.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Telaprevir.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Telaprevir.Experimental
Taurocholic AcidThe serum concentration of Telaprevir can be increased when it is combined with Taurocholic Acid.Experimental
TelithromycinThe serum concentration of Telaprevir can be increased when it is combined with Telithromycin.Approved
TelmisartanThe serum concentration of Telaprevir can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Telaprevir.Approved
TemsirolimusThe risk or severity of adverse effects can be increased when Telaprevir is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Telaprevir.Approved
TenofovirThe serum concentration of Tenofovir can be increased when it is combined with Telaprevir.Approved, Investigational
TerazosinThe serum concentration of Telaprevir can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Telaprevir.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Telaprevir.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Telaprevir.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Telaprevir.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Telaprevir.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Telaprevir.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Telaprevir.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Telaprevir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Telaprevir.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Telaprevir resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Telaprevir.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Telaprevir.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Telaprevir.Approved
TipranavirThe serum concentration of Telaprevir can be decreased when it is combined with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Telaprevir can be decreased when it is combined with Tixocortol.Approved
TocilizumabThe serum concentration of Telaprevir can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Telaprevir.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Telaprevir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Telaprevir.Approved
ToremifeneThe risk or severity of adverse effects can be increased when Telaprevir is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Telaprevir.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Telaprevir.Approved, Investigational
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Telaprevir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Telaprevir.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Telaprevir.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Telaprevir can be decreased when it is combined with Triamcinolone.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Telaprevir.Approved
TrifluoperazineThe serum concentration of Telaprevir can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Telaprevir can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Telaprevir.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Telaprevir.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Telaprevir.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Telaprevir.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Telaprevir.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Telaprevir.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Telaprevir.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Telaprevir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Telaprevir.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Telaprevir.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Telaprevir.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Telaprevir.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Telaprevir.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Telaprevir.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Telaprevir.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Telaprevir.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Telaprevir.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Telaprevir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Telaprevir.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Telaprevir.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Telaprevir.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Telaprevir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Telaprevir.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Telaprevir.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Telaprevir.Approved
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Telaprevir.Approved
VoriconazoleThe serum concentration of Telaprevir can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Telaprevir.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Telaprevir.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Telaprevir.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Telaprevir.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Telaprevir.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Telaprevir.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Telaprevir.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Telaprevir.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Telaprevir can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Telaprevir.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Telaprevir.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Telaprevir.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Telaprevir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Telaprevir.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Telaprevir.Approved, Investigational
Food Interactions
  • St. John's wort is a CYP3A4 inducer which will decrease levels of telaprevir.
References
Synthesis Reference

Znabet A, Polak MM, Janssen E, de Kanter FJ, Turner NJ, Orru RV, Ruijter E. A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions. Chem Commun (Camb). 2010 Nov 14;46(42):7918-20. Epub 2010 Sep 20.

General References
  1. Kim JJ, Culley CM, Mohammad RA: Telaprevir: an oral protease inhibitor for hepatitis C virus infection. Am J Health Syst Pharm. 2012 Jan 1;69(1):19-33. doi: 10.2146/ajhp110123. [PubMed:22180548 ]
  2. Liu-Young G, Kozal MJ: Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008 Jun;22(6):449-57. doi: 10.1089/apc.2007.0199. [PubMed:18479202 ]
  3. Forestier N, Zeuzem S: Telaprevir for the treatment of hepatitis C. Expert Opin Pharmacother. 2012 Mar;13(4):593-606. doi: 10.1517/14656566.2012.660524. Epub 2012 Feb 15. [PubMed:22332992 ]
  4. Garg V, Kauffman RS, Beaumont M, van Heeswijk RP: Telaprevir: pharmacokinetics and drug interactions. Antivir Ther. 2012;17(7):1211-21. doi: 10.3851/IMP2356. Epub 2012 Sep 7. [PubMed:22954756 ]
External Links
ATC CodesJ05AE11
AHFS Codes
  • 8:18.40
PDB EntriesNot Available
FDA labelDownload (508 KB)
MSDSDownload (88.2 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9547
Blood Brain Barrier-0.9659
Caco-2 permeable-0.7982
P-glycoprotein substrateSubstrate0.8567
P-glycoprotein inhibitor IInhibitor0.9355
P-glycoprotein inhibitor IIInhibitor0.8879
Renal organic cation transporterNon-inhibitor0.8919
CYP450 2C9 substrateNon-substrate0.8245
CYP450 2D6 substrateNon-substrate0.6612
CYP450 3A4 substrateSubstrate0.7632
CYP450 1A2 substrateNon-inhibitor0.6961
CYP450 2C9 inhibitorInhibitor0.5969
CYP450 2D6 inhibitorNon-inhibitor0.7431
CYP450 2C19 inhibitorInhibitor0.5866
CYP450 3A4 inhibitorInhibitor0.8926
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8476
Ames testNon AMES toxic0.7536
CarcinogenicityNon-carcinogens0.8622
BiodegradationNot ready biodegradable0.9954
Rat acute toxicity2.6980 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9894
hERG inhibition (predictor II)Inhibitor0.6931
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral375 mg
Tablet, film coatedOral375 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7820671 No2005-02-252025-02-25Us
US8431615 No2008-05-302028-05-30Us
US8529882 No2001-08-312021-08-31Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility0.0047 mg/mLFDA Label
Predicted Properties
PropertyValueSource
Water Solubility0.0355 mg/mLALOGPS
logP2.56ALOGPS
logP2.58ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)11.86ChemAxon
pKa (Strongest Basic)-0.69ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area179.56 Å2ChemAxon
Rotatable Bond Count14ChemAxon
Refractivity180.04 m3·mol-1ChemAxon
Polarizability74.37 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentHybrid peptides
Alternative Parents
Substituents
  • Hybrid peptide
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • N-substituted-alpha-amino acid
  • Pyrazinecarboxamide
  • Pyrazine carboxylic acid or derivatives
  • Pyrrolidine-2-carboxamide
  • Pyrrolidine carboxylic acid or derivatives
  • N-acylpyrrolidine
  • Fatty acyl
  • Pyrazine
  • N-acyl-amine
  • Fatty amide
  • Heteroaromatic compound
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Cyclic alcohol
  • Alpha-aminoketone
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Ketone
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Hepatitis C virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type peptidase activity
Specific Function:
Not Available
Gene Name:
NS3/4A
Uniprot ID:
B0B3C9
Molecular Weight:
72789.28 Da
References
  1. Liu-Young G, Kozal MJ: Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008 Jun;22(6):449-57. doi: 10.1089/apc.2007.0199. [PubMed:18479202 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Kim JJ, Culley CM, Mohammad RA: Telaprevir: an oral protease inhibitor for hepatitis C virus infection. Am J Health Syst Pharm. 2012 Jan 1;69(1):19-33. doi: 10.2146/ajhp110123. [PubMed:22180548 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Garg V, Kauffman RS, Beaumont M, van Heeswijk RP: Telaprevir: pharmacokinetics and drug interactions. Antivir Ther. 2012;17(7):1211-21. doi: 10.3851/IMP2356. Epub 2012 Sep 7. [PubMed:22954756 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Garg V, Kauffman RS, Beaumont M, van Heeswijk RP: Telaprevir: pharmacokinetics and drug interactions. Antivir Ther. 2012;17(7):1211-21. doi: 10.3851/IMP2356. Epub 2012 Sep 7. [PubMed:22954756 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kiang TK, Wilby KJ, Ensom MH: Telaprevir: clinical pharmacokinetics, pharmacodynamics, and drug-drug interactions. Clin Pharmacokinet. 2013 Jul;52(7):487-510. doi: 10.1007/s40262-013-0053-x. [PubMed:23553423 ]
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Drug created on November 18, 2007 11:25 / Updated on December 04, 2016 02:45