Sivifene

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Sivifene
Accession Number
DB05686
Type
Small Molecule
Groups
Investigational
Description
Not Available
Structure
Thumb
Synonyms
Not Available
External IDs
A-007
Categories
UNII
XAV05295I5
CAS number
2675-35-6
Weight
Average: 394.343
Monoisotopic: 394.091334187
Chemical Formula
C19H14N4O6
InChI Key
YOQPCWIXYUNEET-UHFFFAOYSA-N
InChI
InChI=1S/C19H14N4O6/c24-15-6-1-12(2-7-15)19(13-3-8-16(25)9-4-13)21-20-17-10-5-14(22(26)27)11-18(17)23(28)29/h1-11,20,24-25H
IUPAC Name
4-{[2-(2,4-dinitrophenyl)hydrazin-1-ylidene](4-hydroxyphenyl)methyl}phenol
SMILES
OC1=CC=C(C=C1)C(=NNC1=CC=C(C=C1[N+]([O-])=O)[N+]([O-])=O)C1=CC=C(O)C=C1

Pharmacology

Indication

Investigated for use/treatment in cervical dysplasia/cancer, genital warts, and skin cancer.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
10632319
ChEMBL
CHEMBL307697
Wikipedia
Sivifene

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Kaposi s Sarcoma (KS) / Lymphoproliferative Disorders1
2CompletedTreatmentCervical Intraepithelial Neoplasia (CIN) / Uterine Cervical Dysplasia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00461 mg/mLALOGPS
logP4.79ALOGPS
logP5.47ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)8.77ChemAxon
pKa (Strongest Basic)3.94ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area151.13 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity104.97 m3·mol-1ChemAxon
Polarizability38.11 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 18, 2007 11:26 / Updated on August 02, 2019 07:46