NAV

Sivifene

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Sivifene
DrugBank Accession Number
DB05686
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 394.343
Monoisotopic: 394.091334187
Chemical Formula
C19H14N4O6
Synonyms
  • Sivifene
External IDs
  • A-007
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Pharmacology

Indication

Investigated for use/treatment in cervical dysplasia/cancer, genital warts, and skin cancer.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
XAV05295I5
CAS number
2675-35-6
InChI Key
YOQPCWIXYUNEET-UHFFFAOYSA-N
InChI
InChI=1S/C19H14N4O6/c24-15-6-1-12(2-7-15)19(13-3-8-16(25)9-4-13)21-20-17-10-5-14(22(26)27)11-18(17)23(28)29/h1-11,20,24-25H
IUPAC Name
4-{[2-(2,4-dinitrophenyl)hydrazin-1-ylidene](4-hydroxyphenyl)methyl}phenol
SMILES
OC1=CC=C(C=C1)C(=NNC1=CC=C(C=C1[N+]([O-])=O)[N+]([O-])=O)C1=CC=C(O)C=C1

References

General References
Not Available
ChemSpider
10632319
ChEMBL
CHEMBL307697
ZINC
ZINC000003914981
Wikipedia
Sivifene

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentCervical Dysplasia, Uterine / Cervical Intraepithelial Neoplasia (CIN)2
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Kaposi's Sarcoma / Lymphoproliferative Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00461 mg/mLALOGPS
logP4.79ALOGPS
logP5.47Chemaxon
logS-4.9ALOGPS
pKa (Strongest Acidic)8.77Chemaxon
pKa (Strongest Basic)3.94Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count8Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area151.13 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity104.97 m3·mol-1Chemaxon
Polarizability38.11 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at November 18, 2007 18:26 / Updated at February 21, 2021 18:51