AZD-9684

Identification

Generic Name
AZD-9684
DrugBank Accession Number
DB05712
Background

AZD-9684 is the first member of a new anti-thrombotic class (CPU inhibitors). It is being developed by AstraZeneca.

Type
Small Molecule
Groups
Investigational
Synonyms
Not Available
External IDs
  • AZD9684

Pharmacology

Indication

Investigated for use/treatment in thrombosis.

Reduce drug development failure rates
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Contraindications & Blackbox Warnings
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Pharmacodynamics

AZD-9684 enhances endogenous fibrinolysis.

Mechanism of action

AZD-9684 is a Carboxypeptidase U inhibitor (CPUi).

TargetActionsOrganism
UCarboxypeptidase B2Not AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
84KQ4M4N8B
CAS number
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
Not Available
PubChem Substance
347910195

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis...
Gene Name
CPB2
Uniprot ID
Q96IY4
Uniprot Name
Carboxypeptidase B2
Molecular Weight
48423.85 Da

Drug created at November 18, 2007 18:27 / Updated at June 12, 2020 16:52