Mesenchymal Stem Cells


Mesenchymal Stem Cells
Accession Number
Biologic Classification
Protein Based Therapies
Other protein based therapies

Mesenchymal stem cells (MSCs) from healthy donors improve cardiac function in experimental acute myocardial infarction (AMI) models. Osiris' stem cells are derived from human bone marrow. The source marrow is voluntarily donated by healthy adults between the ages of 18 and 30 years. Blood samples from the donor are screened prior to donation for transmissible diseases, including HIV and hepatitis, and the medical and social history of each donor is obtained to ascertain whether signs, symptoms or behaviors consistent with high risk for carrying a disease are present.

Protein chemical formula
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Protein average weight
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International/Other Brands
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CAS number
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Investigated for use/treatment in heart disease and myocardial infarction.

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Mechanism of action

Mesenchymal stem cells have a large capacity for self-renewal while maintaining their multipotency.

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Volume of distribution
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Protein binding
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Route of elimination
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Half life
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Affected organisms
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Pharmacogenomic Effects/ADRs
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Drug Interactions
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Food Interactions
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General References
  1. Grauss RW, Winter EM, van Tuyn J, Pijnappels DA, Steijn RV, Hogers B, van der Geest RJ, de Vries AA, Steendijk P, van der Laarse A, Gittenberger-de Groot AC, Schalij MJ, Atsma DE: Mesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2438-47. Epub 2007 Jul 20. [PubMed:17644573]
External Links
PubChem Substance

Clinical Trials

Clinical Trials
0Not Yet RecruitingTreatmentPsoriasis1
1Active Not RecruitingBasic ScienceKidney Transplant Rejection1
1Active Not RecruitingTreatmentDuchenne's Muscular Dystrophy (DMD)1
1Active Not RecruitingTreatmentOsteogenesis Imperfecta1
1Active Not RecruitingTreatmentRotator Cuff Syndrome1
1Active Not RecruitingTreatmentSystem; Lupus Erythematosus1
1CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
1CompletedTreatmentLung Transplant Reject / Obliterative Bronchiolitis1
1CompletedTreatmentMyocardial Infarction1
1CompletedTreatmentSpinal Cord Injuries (SCI)1
1Not Yet RecruitingTreatmentHematopoietic Stem Cell Transplant (HSCT)1
1RecruitingOtherBrain Death1
1RecruitingTreatmentAplastic Anaemia (AA)1
1RecruitingTreatmentCystic Fibrosis (CF)1
1RecruitingTreatmentDiabetic Foot / Lower Limb Ischemia1
1RecruitingTreatmentDiabetic Foot / Peripheral Vascular Disease (PVD) / Transient ischemia attacks1
1RecruitingTreatmentParkinson's Disease (PD)1
1RecruitingTreatmentPediatric Liver Transplantation1
1Unknown StatusTreatmentAcute Respiratory Distress Syndrome (ARDS)1
1Unknown StatusTreatmentChronic Lung Disease of Prematurity / Infant, Extremely Premature / No Severe Congenital Anomalies / No Severe IVH Neither Cystic PVL / Severe BPD That Conventional Therapies Has Failed1
1Unknown StatusTreatmentHypoxic Ischemic Encephalopathy (HIE)1
1Unknown StatusTreatmentIschaemic Cardiomyopathy1
1Unknown StatusTreatmentType 2 Diabetes Mellitus1
1WithdrawnTreatmentCerebral Adrenoleukodystrophy1
1, 2CompletedTreatmentBack Pain Lower Back / Intervertebral Disc Degeneration / Intervertebral Disc Disease1
1, 2CompletedTreatmentCerebellar Ataxia1
1, 2CompletedTreatmentCritical Limb Ischemia (CLI)1
1, 2CompletedTreatmentDisseminated Sclerosis2
1, 2CompletedTreatmentGraft Versus Host Disease (GVHD)2
1, 2CompletedTreatmentIncontinence, Fecal1
1, 2CompletedTreatmentRecovery Following Partial Medial Meniscectomy1
1, 2CompletedTreatmentThe Sequelae Caused by Severe Brain Injury1
1, 2Not Yet RecruitingTreatmentHematopoietic Stem Cell Transplant (HSCT) / Lupus Erythematosus1
1, 2Not Yet RecruitingTreatmentHuman Immunodeficiency Virus (HIV)1
1, 2Not Yet RecruitingTreatmentNeonatal Stroke / Perinatal Arterial Ischemic Stroke1
1, 2RecruitingPreventionTransplantation, Liver1
1, 2RecruitingTreatmentCritical Limb Ischemia (CLI)1
1, 2RecruitingTreatmentCrohn's Disease (CD)1
1, 2RecruitingTreatmentLiver Cirrhosis1
1, 2TerminatedTreatmentDisseminated Sclerosis1
1, 2Unknown StatusTreatmentAplastic Anaemia (AA)1
1, 2Unknown StatusTreatmentCongestive Cardiomyopathy1
1, 2Unknown StatusTreatmentCritical Limb Ischemia (CLI) / Diabetic Foot / Mesenchymal Stem Cells / Umbilical Cord1
1, 2Unknown StatusTreatmentDiabetes Mellitus (DM) / Diabetes, Diabetes Mellitus Type 1 / Mesenchymal Stem Cells / Umbilical Cord1
1, 2Unknown StatusTreatmentHepatic Failure / Renal Failure1
1, 2Unknown StatusTreatmentLiver Cirrhosis1
1, 2Unknown StatusTreatmentLiver Cirrhosis / Mesenchymal Stem Cells / Radiology / Umbilical Cord1
1, 2Unknown StatusTreatmentMesenchymal Stem Cells / Ulcerative Colitis (UC) / Umbilical Cord1
1, 2Unknown StatusTreatmentParkinson's Disease (PD)1
1, 2Unknown StatusTreatmentSpinal Cord Injuries (SCI)1
1, 2WithdrawnTreatmentPulmonary Emphysema1
1, 2WithdrawnTreatmentStroke, Ischemic1
2Active Not RecruitingTreatmentCerebral Palsy, Spastic1
2Active Not RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
2Active Not RecruitingTreatmentDisseminated Sclerosis1
2Active Not RecruitingTreatmentGlomerulonephritis minimal lesion / Renal Insufficiency,Chronic1
2Active Not RecruitingTreatmentIschaemic Cardiomyopathy1
2CompletedTreatmentChronic Ischemic Heart Disease1
2Enrolling by InvitationTreatmentSevere Aplastic Anemia (SAA)1
2Not Yet RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
2Not Yet RecruitingTreatmentNonunion Fractures1
2RecruitingTreatmentAchilles Degeneration / Achilles Tendinitis / Achilles Tendinitis, Left Leg / Achilles Tendinitis, Right Leg / Achilles Tendon Thickening / Tendinopathy1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Hodgkins Disease (HD) / Leukemia Acute Myeloid Leukemia (AML) / Leukemia, Myelocytic, Chronic / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Myeloproliferative Disorders / Non-Hodgkin's Lymphoma (NHL)1
2RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS) / Blood And Marrow Transplantation1
2RecruitingTreatmentChronic Myocardial Ischemia1
2RecruitingTreatmentCritical Limb Ischemia (CLI)1
2RecruitingTreatmentDisseminated Sclerosis1
2RecruitingTreatmentGraft Versus Host Disease (GVHD)1
2RecruitingTreatmentGraft Versus Host Disease (GVHD) / Low Donor T-cell Chimerism / Poor Graft Function1
2RecruitingTreatmentGraft Versus Host Disease, Acute1
2RecruitingTreatmentSystemic Lupus Erythematosus (SLE)1
2Unknown StatusPreventionGraft Versus Host Disease (GVHD) / Relapses1
2Unknown StatusTreatmentAcute Graft-Versus-Host Disease1
2Unknown StatusTreatmentChronic Graft Versus Host Disease1
2Unknown StatusTreatmentDisease, Chronic1
2Unknown StatusTreatmentGraft Failure / Hematological Diseases / Hematopoietic Stem Cell Transplantation (HSCT) / Mesenchymal Stem Cells / Umbilical Cord Blood1
2Unknown StatusTreatmentHematological Diseases / Mesenchymal Stem Cells / Poor Graft Function / Stem Cell Transplantation, Hematopoietic1
2, 3Unknown StatusTreatmentEvidence of Liver Transplantation1
3CompletedTreatmentGraft Versus Host Disease (GVHD)1
3CompletedTreatmentHematopoietic Stem Cell Transplantation (HSCT)1
4Unknown StatusTreatmentComplications of Organ Transplant Stem Cells Umbilical Cord1
Not AvailableCompletedPreventionDiabetes, Diabetes Mellitus Type 11
Not AvailableCompletedTreatmentCalcaneocuboid Arthrodesis / Double Arthrodesis (i.e. Calcaneocuboid and Talonavicular) / Subtalar Arthrodesis / Talonavicular Arthrodesis / Tibiotalar Arthrodesis / Triple Arthrodesis (i.e. Subtalar, Calcaneocuboid, and Talonavicular)1
Not AvailableNot Yet RecruitingTreatmentKnee Osteoarthritis (Knee OA) / Umbilical Cord Bleeding2
Not AvailableNot Yet RecruitingTreatmentShock, Septic1


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Dosage forms
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Experimental Properties
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Organic Compounds
Super Class
Organic Acids
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Alternative Parents
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Molecular Framework
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External Descriptors
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Drug created on November 18, 2007 11:28 / Updated on November 02, 2018 06:13