Mesenchymal Stem Cells

Identification

Name
Mesenchymal Stem Cells
Accession Number
DB05914
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Description

Mesenchymal stem cells (MSCs) from healthy donors improve cardiac function in experimental acute myocardial infarction (AMI) models. Osiris' stem cells are derived from human bone marrow. The source marrow is voluntarily donated by healthy adults between the ages of 18 and 30 years. Blood samples from the donor are screened prior to donation for transmissible diseases, including HIV and hepatitis, and the medical and social history of each donor is obtained to ascertain whether signs, symptoms or behaviors consistent with high risk for carrying a disease are present.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
Not Available
International/Other Brands
Provacel
Categories
Not Available
UNII
Not Available
CAS number
Not Available

Pharmacology

Indication

Investigated for use/treatment in heart disease and myocardial infarction.

Pharmacodynamics
Not Available
Mechanism of action

Mesenchymal stem cells have a large capacity for self-renewal while maintaining their multipotency.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Grauss RW, Winter EM, van Tuyn J, Pijnappels DA, Steijn RV, Hogers B, van der Geest RJ, de Vries AA, Steendijk P, van der Laarse A, Gittenberger-de Groot AC, Schalij MJ, Atsma DE: Mesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2438-47. Epub 2007 Jul 20. [PubMed:17644573]
External Links
PubChem Substance
347910310
Wikipedia
Mesenchymal_stem_cell

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingBasic ScienceKidney Transplant Rejection1
1Active Not RecruitingTreatmentDuchenne's Muscular Dystrophy (DMD)1
1Active Not RecruitingTreatmentOsteogenesis Imperfecta1
1Active Not RecruitingTreatmentRotator Cuff Syndrome1
1Active Not RecruitingTreatmentSystem; Lupus Erythematosus1
1CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
1CompletedTreatmentLung Transplant Reject / Obliterative Bronchiolitis1
1CompletedTreatmentMyocardial Infarction1
1CompletedTreatmentSpinal Cord Injuries (SCI)1
1Not Yet RecruitingTreatmentHematopoietic Stem Cell Transplant (HSCT)1
1RecruitingOtherBrain Death1
1RecruitingTreatmentAplastic Anaemia (AA)1
1RecruitingTreatmentCystic Fibrosis (CF)1
1RecruitingTreatmentDiabetic Foot / Lower Limb Ischemia1
1RecruitingTreatmentDiabetic Foot / Peripheral Vascular Disease (PVD) / Transient ischemia attacks1
1RecruitingTreatmentParkinson's Disease (PD)1
1RecruitingTreatmentPediatric Liver Transplantation1
1Unknown StatusTreatmentAcute Respiratory Distress Syndrome (ARDS)1
1Unknown StatusTreatmentChronic Lung Disease of Prematurity / Infant, Extremely Premature / No Severe Congenital Anomalies / No Severe IVH Neither Cystic PVL / Severe BPD That Conventional Therapies Has Failed1
1Unknown StatusTreatmentHypoxic Ischemic Encephalopathy (HIE)1
1Unknown StatusTreatmentIschaemic Cardiomyopathy1
1Unknown StatusTreatmentType 2 Diabetes Mellitus1
1WithdrawnTreatmentCerebral Adrenoleukodystrophy1
1, 2CompletedTreatmentBack Pain Lower Back / Intervertebral Disc Degeneration / Intervertebral Disc Disease1
1, 2CompletedTreatmentCerebellar Ataxia1
1, 2CompletedTreatmentCritical Limb Ischemia (CLI)1
1, 2CompletedTreatmentDisseminated Sclerosis2
1, 2CompletedTreatmentGraft Versus Host Disease (GVHD)2
1, 2CompletedTreatmentIncontinence, Fecal1
1, 2CompletedTreatmentRecovery Following Partial Medial Meniscectomy1
1, 2CompletedTreatmentThe Sequelae Caused by Severe Brain Injury1
1, 2Not Yet RecruitingTreatmentHematopoietic Stem Cell Transplant (HSCT) / Lupus Erythematosus1
1, 2Not Yet RecruitingTreatmentHuman Immunodeficiency Virus (HIV)1
1, 2Not Yet RecruitingTreatmentNeonatal Stroke / Perinatal Arterial Ischemic Stroke1
1, 2RecruitingPreventionTransplantation, Liver1
1, 2RecruitingTreatmentCritical Limb Ischemia (CLI)1
1, 2RecruitingTreatmentCrohn's Disease (CD)1
1, 2RecruitingTreatmentDisseminated Sclerosis1
1, 2RecruitingTreatmentLiver Cirrhosis1
1, 2Unknown StatusTreatmentAplastic Anaemia (AA)1
1, 2Unknown StatusTreatmentCongestive Cardiomyopathy1
1, 2Unknown StatusTreatmentCritical Limb Ischemia (CLI) / Diabetic Foot / Mesenchymal Stem Cells / Umbilical Cord1
1, 2Unknown StatusTreatmentDiabetes Mellitus (DM) / Diabetes, Diabetes Mellitus Type 1 / Mesenchymal Stem Cells / Umbilical Cord1
1, 2Unknown StatusTreatmentHepatic Failure / Renal Failure1
1, 2Unknown StatusTreatmentLiver Cirrhosis1
1, 2Unknown StatusTreatmentLiver Cirrhosis / Mesenchymal Stem Cells / Radiology / Umbilical Cord1
1, 2Unknown StatusTreatmentMesenchymal Stem Cells / Ulcerative Colitis (UC) / Umbilical Cord1
1, 2Unknown StatusTreatmentParkinson's Disease (PD)1
1, 2Unknown StatusTreatmentSpinal Cord Injuries (SCI)1
1, 2WithdrawnTreatmentPulmonary Emphysema1
1, 2WithdrawnTreatmentStroke, Ischemic1
2Active Not RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
2Active Not RecruitingTreatmentGlomerulonephritis minimal lesion / Renal Insufficiency,Chronic1
2CompletedTreatmentChronic Ischemic Heart Disease1
2Enrolling by InvitationTreatmentSevere Aplastic Anemia (SAA)1
2Not Yet RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
2Not Yet RecruitingTreatmentNonunion Fractures1
2RecruitingTreatmentAchilles Degeneration / Achilles Tendinitis / Achilles Tendinitis, Left Leg / Achilles Tendinitis, Right Leg / Achilles Tendon Thickening / Tendinopathy1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Chronic Lymphocytic Leukaemia (CLL) / Hodgkins Disease (HD) / Leukemia Acute Myeloid Leukemia (AML) / Leukemia, Myelocytic, Chronic / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Myeloproliferative Disorders / Non-Hodgkin's Lymphoma (NHL)1
2RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS) / Blood And Marrow Transplantation1
2RecruitingTreatmentChronic Myocardial Ischemia1
2RecruitingTreatmentCritical Limb Ischemia (CLI)1
2RecruitingTreatmentDisseminated Sclerosis2
2RecruitingTreatmentGraft Versus Host Disease (GVHD)1
2RecruitingTreatmentGraft Versus Host Disease (GVHD) / Low Donor T-cell Chimerism / Poor Graft Function1
2RecruitingTreatmentGraft Versus Host Disease, Acute1
2RecruitingTreatmentSystemic Lupus Erythematosus (SLE)1
2SuspendedTreatmentIschaemic Cardiomyopathy1
2Unknown StatusPreventionGraft Versus Host Disease (GVHD) / Relapses1
2Unknown StatusTreatmentAcute Graft-Versus-Host Disease1
2Unknown StatusTreatmentChronic Graft Versus Host Disease1
2Unknown StatusTreatmentDisease, Chronic1
2Unknown StatusTreatmentGraft Failure / Hematological Diseases / Hematopoietic Stem Cell Transplantation (HSCT) / Mesenchymal Stem Cells / Umbilical Cord Blood1
2Unknown StatusTreatmentHematological Diseases / Mesenchymal Stem Cells / Poor Graft Function / Stem Cell Transplantation, Hematopoietic1
2, 3Unknown StatusTreatmentEvidence of Liver Transplantation1
3CompletedTreatmentGraft Versus Host Disease (GVHD)1
3CompletedTreatmentHematopoietic Stem Cell Transplantation (HSCT)1
4Unknown StatusTreatmentComplications of Organ Transplant Stem Cells Umbilical Cord1
Not AvailableCompletedPreventionDiabetes, Diabetes Mellitus Type 11
Not AvailableCompletedTreatmentCalcaneocuboid Arthrodesis / Double Arthrodesis (i.e. Calcaneocuboid and Talonavicular) / Subtalar Arthrodesis / Talonavicular Arthrodesis / Tibiotalar Arthrodesis / Triple Arthrodesis (i.e. Subtalar, Calcaneocuboid, and Talonavicular)1
Not AvailableNot Yet RecruitingTreatmentKnee Osteoarthritis (Knee OA) / Umbilical Cord Bleeding2
Not AvailableNot Yet RecruitingTreatmentShock, Septic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on November 18, 2007 11:28 / Updated on November 02, 2018 06:13