This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Aldoxorubicin
Accession Number
DB06013
Type
Small Molecule
Groups
Investigational
Description

Aldoxorubicin, an antineoplastic agents, is an albumin-binding prodrug of doxorubicin.

Structure
Thumb
Synonyms
Not Available
External IDs
INNO-206
Product Ingredients
IngredientUNIICASInChI Key
Aldoxorubicin hydrochlorideS098K6HGD91361563-03-2NGKHWQPYPXRQTM-UKFSEGPMSA-N
Categories
UNII
C28MV4IM0B
CAS number
1361644-26-9
Weight
Average: 750.758
Monoisotopic: 750.274837428
Chemical Formula
C37H42N4O13
InChI Key
OBMJQRLIQQTJLR-USGQOSEYSA-N
InChI
InChI=1S/C37H42N4O13/c1-17-32(46)20(38)13-27(53-17)54-22-15-37(51,23(16-42)39-40-24(43)9-4-3-5-12-41-25(44)10-11-26(41)45)14-19-29(22)36(50)31-30(34(19)48)33(47)18-7-6-8-21(52-2)28(18)35(31)49/h6-8,10-11,17,20,22,27,32,42,46,48,50-51H,3-5,9,12-16,38H2,1-2H3,(H,40,43)/b39-23+/t17-,20-,22-,27-,32+,37-/m0/s1
IUPAC Name
N'-[(1E)-1-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide
SMILES
COC1=C2C(=O)C3=C(O)C4=C(C[[email protected]](O)(C[[email protected]@H]4O[[email protected]]4C[[email protected]](N)[[email protected]](O)[[email protected]](C)O4)C(\CO)=N\NC(=O)CCCCCN4C(=O)C=CC4=O)C(O)=C3C(=O)C2=CC=C1

Pharmacology

Indication

Investigated for use/treatment in solid tumors.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action

INNO-206 is the (6-Maleimidocaproyl) hydrazone of doxorubicin. INNO-206 is a prodrug of doxorubicin that binds endogenous albumin after administration. The bound doxorubicin is released in the acidic environment of the tumor cell through cleavage of an acid sensitive linker. In preclinical models, INNO-206 was superior to doxorubicin with regard to antitumor efficacy and toxicity.

TargetActionsOrganism
ADNA topoisomerase 2-alpha
inhibitor
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
AceclofenacAceclofenac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
AcemetacinAcemetacin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Experimental, Investigational
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be decreased when it is combined with Aldoxorubicin.Approved
AcetyldigoxinThe serum concentration of Acetyldigoxin can be decreased when it is combined with Aldoxorubicin.Experimental
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved
AdapaleneAdapalene may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
AlclofenacAlclofenac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Withdrawn
AlcuroniumAldoxorubicin may increase the respiratory depressant activities of Alcuronium.Experimental
Alendronic acidAldoxorubicin may increase the hypocalcemic activities of Alendronic acid.Approved
AlminoprofenAlminoprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
AmdinocillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Amdinocillin.Investigational, Withdrawn
AmoxicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Amoxicillin.Approved, Vet Approved
Amphotericin BAmphotericin B may increase the nephrotoxic activities of Aldoxorubicin.Approved, Investigational
AmpicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Ampicillin.Approved, Vet Approved
AndrographolideAndrographolide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
AnisodamineAnisodamine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
AntipyrineAntipyrine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
ApocyninApocynin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
ApremilastApremilast may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
AspoxicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Aspoxicillin.Experimental
AtracuriumAldoxorubicin may increase the respiratory depressant activities of Atracurium.Approved, Experimental, Investigational
Atracurium besylateAldoxorubicin may increase the respiratory depressant activities of Atracurium besylate.Approved
AzapropazoneAzapropazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Withdrawn
AzelastineAzelastine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
AzidocillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Azidocillin.Approved
AzlocillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Azlocillin.Approved
AzosemideThe serum concentration of Aldoxorubicin can be increased when it is combined with Azosemide.Investigational
BacampicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Bacampicillin.Approved, Investigational
BalsalazideBalsalazide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
BendazacBendazac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
BenorilateBenorilate may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
BenoxaprofenBenoxaprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Withdrawn
Benzathine benzylpenicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Benzathine benzylpenicillin.Approved, Vet Approved
BenzydamineBenzydamine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
BenzylpenicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Benzylpenicillin.Approved, Vet Approved
Benzylpenicilloyl PolylysineThe serum concentration of Aldoxorubicin can be decreased when it is combined with Benzylpenicilloyl Polylysine.Approved
BevoniumBevonium may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
Botulinum Toxin Type AAldoxorubicin may increase the neuromuscular blocking activities of Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BAldoxorubicin may increase the neuromuscular blocking activities of Botulinum Toxin Type B.Approved, Investigational
BromfenacBromfenac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
BucillamineBucillamine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
BufexamacBufexamac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Experimental
BumadizoneBumadizone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
BumetanideThe serum concentration of Aldoxorubicin can be increased when it is combined with Bumetanide.Approved
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Aldoxorubicin.Approved
Carbaspirin calciumCarbaspirin calcium may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental, Investigational
CarbenicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Carbenicillin.Approved, Investigational
Carbenicillin indanylThe serum concentration of Aldoxorubicin can be decreased when it is combined with Carbenicillin indanyl.Approved, Investigational
CarboplatinAldoxorubicin may increase the ototoxic activities of Carboplatin.Approved
CarfecillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Carfecillin.Experimental
CarprofenCarprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
CelecoxibCelecoxib may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
ChloroquineChloroquine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Vet Approved
Choline magnesium trisalicylateCholine magnesium trisalicylate may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
CisatracuriumAldoxorubicin may increase the respiratory depressant activities of Cisatracurium.Approved, Experimental
Cisatracurium besylateAldoxorubicin may increase the respiratory depressant activities of Cisatracurium besylate.Approved
CisplatinCisplatin may increase the nephrotoxic activities of Aldoxorubicin.Approved
Clodronic AcidAldoxorubicin may increase the hypocalcemic activities of Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinClonixin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
CloxacillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Cloxacillin.Approved, Investigational, Vet Approved
ColistimethateAldoxorubicin may increase the nephrotoxic activities of Colistimethate.Approved, Vet Approved
CurcuminCurcumin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
CyclacillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Cyclacillin.Approved
CyclosporineAldoxorubicin may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CymarinThe serum concentration of Cymarin can be decreased when it is combined with Aldoxorubicin.Experimental
DecamethoniumAldoxorubicin may increase the respiratory depressant activities of Decamethonium.Approved
DeslanosideThe serum concentration of Deslanoside can be decreased when it is combined with Aldoxorubicin.Approved
DiclofenacDiclofenac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved
DicloxacillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Dicloxacillin.Approved, Investigational, Vet Approved
DifenpiramideDifenpiramide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
DiflunisalDiflunisal may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Aldoxorubicin.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Aldoxorubicin.Approved
Digoxin Immune Fab (Ovine)The serum concentration of Digoxin Immune Fab (Ovine) can be decreased when it is combined with Aldoxorubicin.Approved
Domoic AcidAldoxorubicin may increase the respiratory depressant activities of Domoic Acid.Experimental
Doxacurium chlorideAldoxorubicin may increase the respiratory depressant activities of Doxacurium chloride.Approved
DroxicamDroxicam may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Withdrawn
DuvelisibDuvelisib may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
E-6201E-6201 may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
EpicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Epicillin.Experimental
EpirizoleEpirizole may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
Etacrynic acidThe serum concentration of Aldoxorubicin can be increased when it is combined with Etacrynic acid.Approved, Investigational
EtanerceptEtanercept may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
EthenzamideEthenzamide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
Etidronic acidAldoxorubicin may increase the hypocalcemic activities of Etidronic acid.Approved
EtodolacEtodolac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
EtoricoxibEtoricoxib may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
Evening primrose oilEvening primrose oil may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
ExisulindExisulind may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
FelbinacFelbinac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
FenbufenFenbufen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
FenoprofenFenoprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
FentiazacFentiazac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
FeprazoneFeprazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
Ferulic acidFerulic acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
FloctafenineFloctafenine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Withdrawn
FlucloxacillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Flucloxacillin.Approved, Investigational
FlunixinFlunixin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Vet Approved
FlunoxaprofenFlunoxaprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
FlurbiprofenFlurbiprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
FoscarnetFoscarnet may increase the nephrotoxic activities of Aldoxorubicin.Approved
FurosemideThe serum concentration of Aldoxorubicin can be increased when it is combined with Furosemide.Approved, Vet Approved
GallamineAldoxorubicin may increase the respiratory depressant activities of Gallamine.Experimental
Gallamine TriethiodideAldoxorubicin may increase the respiratory depressant activities of Gallamine Triethiodide.Approved
GitoformateThe serum concentration of Gitoformate can be decreased when it is combined with Aldoxorubicin.Experimental
GuacetisalGuacetisal may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
HigenamineHigenamine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
IbandronateAldoxorubicin may increase the hypocalcemic activities of Ibandronate.Approved, Investigational
IbuprofenIbuprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
IbuproxamIbuproxam may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Withdrawn
IcatibantIcatibant may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
Imidazole salicylateImidazole salicylate may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
IndobufenIndobufen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
IndomethacinIndomethacin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
IndoprofenIndoprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Withdrawn
IsoxicamIsoxicam may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Withdrawn
KebuzoneKebuzone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
KetoprofenKetoprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved
KetorolacKetorolac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
Lanatoside CThe serum concentration of Lanatoside C can be decreased when it is combined with Aldoxorubicin.Experimental
LeflunomideLeflunomide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
LisofyllineLisofylline may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
LonazolacLonazolac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
LornoxicamLornoxicam may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
LoxoprofenLoxoprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
LumiracoxibLumiracoxib may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
Magnesium salicylateMagnesium salicylate may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
MannitolMannitol may increase the nephrotoxic activities of Aldoxorubicin.Approved, Investigational
MasoprocolMasoprocol may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
MecamylamineAldoxorubicin may increase the neuromuscular blocking activities of Mecamylamine.Approved, Investigational
Meclofenamic acidMeclofenamic acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved
Mefenamic acidMefenamic acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
MeloxicamMeloxicam may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved
MesalazineMesalazine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
MetamizoleMetamizole may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Withdrawn
MetampicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Metampicillin.Experimental
MeticillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Meticillin.Approved, Investigational
MetildigoxinThe serum concentration of Metildigoxin can be decreased when it is combined with Aldoxorubicin.Experimental
MetocurineAldoxorubicin may increase the respiratory depressant activities of Metocurine.Approved
Metocurine IodideAldoxorubicin may increase the respiratory depressant activities of Metocurine Iodide.Approved, Withdrawn
MezlocillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Mezlocillin.Approved, Investigational
MivacuriumAldoxorubicin may increase the respiratory depressant activities of Mivacurium.Approved
MizoribineMizoribine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
MofebutazoneMofebutazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
Mycophenolate mofetilMycophenolate mofetil may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
Mycophenolic acidMycophenolic acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
NabumetoneNabumetone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
NafamostatNafamostat may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
NafcillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Nafcillin.Approved, Investigational
NaftifineNaftifine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
NaproxenNaproxen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved
NeosaxitoxinAldoxorubicin may increase the respiratory depressant activities of Neosaxitoxin.Investigational
NepafenacNepafenac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
NifenazoneNifenazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
Niflumic AcidNiflumic Acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
NimesulideNimesulide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Withdrawn
NitroaspirinNitroaspirin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
OleandrinThe serum concentration of Oleandrin can be decreased when it is combined with Aldoxorubicin.Experimental, Investigational
OlopatadineOlopatadine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
OlsalazineOlsalazine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
OrgoteinOrgotein may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Vet Approved
OuabainThe serum concentration of Ouabain can be decreased when it is combined with Aldoxorubicin.Approved
OxacillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Oxacillin.Approved, Investigational
OxaprozinOxaprozin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
OxyphenbutazoneOxyphenbutazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Withdrawn
PamidronateAldoxorubicin may increase the hypocalcemic activities of Pamidronate.Approved
PancuroniumAldoxorubicin may increase the respiratory depressant activities of Pancuronium.Approved
ParecoxibParecoxib may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
ParthenolideParthenolide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
PenamecillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Penamecillin.Experimental
PenimepicyclineThe serum concentration of Aldoxorubicin can be decreased when it is combined with Penimepicycline.Experimental
PeruvosideThe serum concentration of Peruvoside can be decreased when it is combined with Aldoxorubicin.Experimental
PhenoxymethylpenicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Phenoxymethylpenicillin.Approved, Vet Approved
PhenylbutazonePhenylbutazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Vet Approved
PimecrolimusPimecrolimus may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
PipecuroniumAldoxorubicin may increase the respiratory depressant activities of Pipecuronium.Approved
PiperacillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Piperacillin.Approved
PiretanideThe serum concentration of Aldoxorubicin can be increased when it is combined with Piretanide.Approved
PirfenidonePirfenidone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
PiroxicamPiroxicam may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
PirprofenPirprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
PivampicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Pivampicillin.Approved
PivmecillinamThe serum concentration of Aldoxorubicin can be decreased when it is combined with Pivmecillinam.Approved
PranoprofenPranoprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental, Investigational
Procaine benzylpenicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Procaine benzylpenicillin.Approved, Vet Approved
ProglumetacinProglumetacin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
PropacetamolPropacetamol may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
PropicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Propicillin.Experimental
PropyphenazonePropyphenazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
ProquazoneProquazone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
ProscillaridinThe serum concentration of Proscillaridin can be decreased when it is combined with Aldoxorubicin.Experimental
PTC299PTC299 may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
PyrantelAldoxorubicin may increase the respiratory depressant activities of Pyrantel.Approved, Vet Approved
RapacuroniumAldoxorubicin may increase the respiratory depressant activities of Rapacuronium.Withdrawn
ResveratrolResveratrol may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Experimental, Investigational
RisedronateAldoxorubicin may increase the hypocalcemic activities of Risedronate.Approved, Investigational
RocuroniumAldoxorubicin may increase the respiratory depressant activities of Rocuronium.Approved
RofecoxibRofecoxib may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Withdrawn
SalicylamideSalicylamide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
Salicylic acidSalicylic acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Vet Approved
SalsalateSalsalate may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
SemapimodSemapimod may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
SeratrodastSeratrodast may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
SerrapeptaseSerrapeptase may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
SRT501SRT501 may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
SuccinylcholineAldoxorubicin may increase the respiratory depressant activities of Succinylcholine.Approved
SulbactamThe serum concentration of Aldoxorubicin can be decreased when it is combined with Sulbactam.Approved
SulbenicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Sulbenicillin.Experimental
SulfasalazineSulfasalazine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
SulindacSulindac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
SultamicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Sultamicillin.Approved, Investigational
SuprofenSuprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Withdrawn
SuxibuzoneSuxibuzone may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
TalampicillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Talampicillin.Experimental
TarenflurbilTarenflurbil may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
TazobactamThe serum concentration of Aldoxorubicin can be decreased when it is combined with Tazobactam.Approved
Technetium Tc-99m etidronateAldoxorubicin may increase the hypocalcemic activities of Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateAldoxorubicin may increase the hypocalcemic activities of Technetium Tc-99m medronate.Approved
TenidapTenidap may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
Tenofovir disoproxilThe serum concentration of Aldoxorubicin can be increased when it is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamTenoxicam may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
TepoxalinTepoxalin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Vet Approved
TeriflunomideTeriflunomide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
Tiaprofenic acidTiaprofenic acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
TicarcillinThe serum concentration of Aldoxorubicin can be decreased when it is combined with Ticarcillin.Approved, Investigational, Vet Approved
Tiludronic acidAldoxorubicin may increase the hypocalcemic activities of Tiludronic acid.Approved, Investigational, Vet Approved
TinoridineTinoridine may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
Tolfenamic AcidTolfenamic Acid may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
TolmetinTolmetin may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved
TorasemideThe serum concentration of Aldoxorubicin can be increased when it is combined with Torasemide.Approved
TranilastTranilast may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
TribenosideTribenoside may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Experimental
TriptolideTriptolide may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Investigational
TubocurarineAldoxorubicin may increase the respiratory depressant activities of Tubocurarine.Approved
ValdecoxibValdecoxib may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Withdrawn
VancomycinVancomycin may increase the nephrotoxic activities of Aldoxorubicin.Approved
VecuroniumAldoxorubicin may increase the respiratory depressant activities of Vecuronium.Approved
ZaltoprofenZaltoprofen may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational
ZileutonZileuton may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Approved, Investigational, Withdrawn
Zoledronic acidAldoxorubicin may increase the hypocalcemic activities of Zoledronic acid.Approved
ZomepiracZomepirac may decrease the excretion rate of Aldoxorubicin which could result in a higher serum level.Withdrawn
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Drug
D10383
ChemSpider
7986464
ChEMBL
CHEMBL2107818
Wikipedia
Aldoxorubicin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentAdvanced Solid Tumors2
1CompletedTreatmentMalignant Solid Tumours1
1CompletedTreatmentMetastatic Solid Tumors1
1, 2Not Yet RecruitingTreatmentSquamous Cell Carcinoma (SCC)1
1, 2Not Yet RecruitingTreatmentTriple Negative Breast Cancer (TNBC)1
1, 2RecruitingTreatmentMalignant Neoplasm of Pancreas1
1, 2RecruitingTreatmentMetastatic, Locally Advanced, or Unresectable Soft Tissue Sarcoma1
2CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / HIV positve / Hiv-positive / Kaposi s Sarcoma (KS)1
2CompletedTreatmentGlioblastomas1
2CompletedTreatmentPancreatic Ductal Adenocarcinoma1
2RecruitingTreatmentMetastatic Small Cell Lung Cancer1
2Unknown StatusTreatmentLocally Advanced Soft Tissue Sarcoma / Metastatic Soft Tissue Sarcoma / Unresectable Soft Tissue Sarcoma1
2WithdrawnTreatmentLung Cancer Small Cell Lung Cancer (SCLC)1
3CompletedTreatmentMetastatic, Locally Advanced or Unresectable Soft Tissue Sarcoma1
Not AvailableNo Longer AvailableNot AvailableSarcomas1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.151 mg/mLALOGPS
logP1.26ALOGPS
logP0.71ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)8.2ChemAxon
pKa (Strongest Basic)9.39ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count15ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area267.84 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity189.86 m3·mol-1ChemAxon
Polarizability75.89 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Ubiquitin binding
Specific Function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segr...
Gene Name
TOP2A
Uniprot ID
P11388
Uniprot Name
DNA topoisomerase 2-alpha
Molecular Weight
174383.88 Da
References
  1. Chawla SP, Chua VS, Hendifar AF, Quon DV, Soman N, Sankhala KK, Wieland DS, Levitt DJ: A phase 1B/2 study of aldoxorubicin in patients with soft tissue sarcoma. Cancer. 2015 Feb 15;121(4):570-9. doi: 10.1002/cncr.29081. Epub 2014 Oct 13. [PubMed:25312684]

Drug created on November 18, 2007 11:29 / Updated on February 06, 2018 19:25