Trofinetide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Trofinetide
Accession Number
DB06045
Type
Small Molecule
Groups
Investigational
Description

Trofinetide (NNZ-2566), a neuroprotective analogue of glypromate, is a novel molecule that has a profile suitable for both intravenous infusion and chronic oral delivery. It is currently in development to treat traumatic brain injury.

Structure
Thumb
Synonyms
  • Trofinetide
External IDs
NNZ 2566 / NNZ-2566
Categories
UNII
Z2ME8F52QL
CAS number
853400-76-7
Weight
Average: 315.326
Monoisotopic: 315.143035408
Chemical Formula
C13H21N3O6
InChI Key
BUSXWGRAOZQTEY-SDBXPKJASA-N
InChI
InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
IUPAC Name
(2S)-2-{[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidin-2-yl]formamido}pentanedioic acid
SMILES
C[C@]1(CCCN1C(=O)CN)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Pharmacology

Indication

Investigated for use/treatment in traumatic brain injuries.

Pharmacodynamics

NNZ-2566 is shown to have multi-faceted action to significantly reduce both inflammation and apoptosis (cell death), protecting the neurons and their surrounding infrastructure.

Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
9493869
ChEMBL
CHEMBL197084
Wikipedia
Trofinetide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentBrain Injuries,Traumatic2
2CompletedSupportive CareBrain Injury1
2CompletedTreatmentBrain Injury1
2CompletedTreatmentFragile X Syndrome (FXS)1
2CompletedTreatmentRett's Syndrome2
2TerminatedTreatmentConcussions1
3RecruitingTreatmentRett's Syndrome1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility10.4 mg/mLALOGPS
logP-3ALOGPS
logP-4.5ChemAxon
logS-1.5ALOGPS
pKa (Strongest Acidic)3.27ChemAxon
pKa (Strongest Basic)7.83ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area150.03 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity73.79 m3·mol-1ChemAxon
Polarizability30.95 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on November 18, 2007 11:29 / Updated on December 02, 2019 07:17