Lumiliximab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Lumiliximab
Accession Number
DB06162
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description

Lumiliximab is a chimeric monoclonal antibody which is used as an immunosuppressive drug. It is a primatized anti-CD23 macaque/human chimeric antibody that inhibits the production of the IgE antibody, for the potential treatment of allergic conditions. Lumiliximab was developed by IDEC Pharmaceuticals, which was acquired by Biogen. Clinical trials for CLL were terminated in 2010, and for allergic asthma in 2007. Results published from the CLL clinical trial failed to meet primary endpoints.

Protein structure
Db06162
Protein chemical formula
C2115H3252N556O673S16
Protein average weight
47750.0 Da
Sequences
Not Available
Synonyms
  • Gomiliximab
External IDs
IDEC-152 / ST-152
Categories
UNII
8Z13S29R5A
CAS number
357613-86-6

Pharmacology

Indication

Investigated for use/treatment in asthma and leukemia (lymphoid).

Pharmacodynamics
Not Available
Mechanism of action

Lumiliximab is a chimeric macaque-human monoclonal antibody to CD23, a protein expressed on virtually all chronic lymphocytic leukemia (CLL) cells. CD23, also known as Fc epsilon RII, or FcεRII, is the "low affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells and platelets.

TargetActionsOrganism
ULow affinity immunoglobulin epsilon Fc receptorNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Lumiliximab.
AbituzumabThe risk or severity of adverse effects can be increased when Lumiliximab is combined with Abituzumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Lumiliximab.
AdecatumumabThe risk or severity of adverse effects can be increased when Adecatumumab is combined with Lumiliximab.
AducanumabThe risk or severity of adverse effects can be increased when Lumiliximab is combined with Aducanumab.
AfelimomabThe risk or severity of adverse effects can be increased when Afelimomab is combined with Lumiliximab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Lumiliximab.
AlirocumabThe risk or severity of adverse effects can be increased when Lumiliximab is combined with Alirocumab.
AmatuximabThe risk or severity of adverse effects can be increased when Lumiliximab is combined with Amatuximab.
AMG 108The risk or severity of adverse effects can be increased when AMG 108 is combined with Lumiliximab.
Food Interactions
Not Available

References

General References
Not Available
External Links
Wikipedia
Lumiliximab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableChronic Lymphocytic Leukaemia (CLL)1
1CompletedTreatmentLeukemias / Malignant Lymphomas1
2TerminatedTreatmentChronic Lymphocytic Leukaemia (CLL)2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Metal ion binding
Specific Function
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Gene Name
FCER2
Uniprot ID
P06734
Uniprot Name
Low affinity immunoglobulin epsilon Fc receptor
Molecular Weight
36468.49 Da
References
  1. Pathan NI, Chu P, Hariharan K, Cheney C, Molina A, Byrd J: Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines. Blood. 2008 Feb 1;111(3):1594-602. Epub 2007 Nov 21. [PubMed:18032710]

Drug created on March 19, 2008 10:15 / Updated on November 02, 2018 06:14