Showing BioInteractions for Nalmefene (DB06230)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 3
Enzyme Mediated Interactions 3

	Interacting Group	Interacting Drugs
	Nalmefene is a Mu-type opioid receptor antagonist
1	Mu-type opioid receptor agonists	3-Methylfentanyl, 3-Methylthiofentanyl, Alfentanil, Anileridine, Butyrfentanyl, Carfentanil, Codeine, Dextromethorphan, Dextropropoxyphene, Dezocine, Diamorphine, Dihydromorphine, Dimethylthiambutene, Diphenoxylate, Eluxadoline, Ethylmorphine, Etorphine, Fentanyl, Hydrocodone, Hydromorphone, Ketobemidone, Levacetylmethadol, Levorphanol, Loperamide, Loxicodegol, Meperidine, Metenkefalin, Methadone, Methadyl acetate, Morphine, Oliceridine, Opium, Oxycodone, Oxymorphone, Remifentanil, Sufentanil, Tapentadol, Tianeptine, Tramadol, Trimebutine
2	Mu-type opioid receptor partial agonists	Buprenorphine, Levallorphan
3	Mu-type opioid receptor antagonists	Alvimopan, Diprenorphine, Methylnaltrexone, Nalbuphine, Naldemedine, Naloxegol, Naloxone, Naltrexone, Pentazocine, Pentoxyverine, Pholcodine
4	Mu-type opioid receptor partial antagonists	Butorphanol
5	Mu-type opioid receptor binders	Amitriptyline, Ketamine
6	Mu-type opioid receptor ligands	Aripiprazole

	Interacting Group	Interacting Drugs
	Nalmefene is a Kappa-type opioid receptor partial agonist
1	Kappa-type opioid receptor agonists	3-Methylfentanyl, 3-Methylthiofentanyl, Amitriptyline, Butorphanol, Butyrfentanyl, Carfentanil, Codeine, Dextromethorphan, Diamorphine, Dihydromorphine, Eluxadoline, Etorphine, Fentanyl, Hydromorphone, Ketamine, Ketobemidone, Levomenthol, Levorphanol, Loperamide, Loxicodegol, Mianserin, Mirtazapine, Morphine, Nalbuphine, Opium, Oxycodone, Pentazocine, Pentoxyverine, Remifentanil, Tramadol
2	Kappa-type opioid receptor antagonists	Alvimopan, Buprenorphine, Dextropropoxyphene, Dezocine, Diprenorphine, Methylnaltrexone, Naldemedine, Naloxone, Naltrexone, Pholcodine
3	Kappa-type opioid receptor activators	Progesterone
4	Kappa-type opioid receptor potentiators	Progesterone
5	Kappa-type opioid receptor partial agonists	Atomoxetine
6	Kappa-type opioid receptor inhibitors	Lamotrigine
7	Kappa-type opioid receptor ligands	Aripiprazole

	Interacting Group	Interacting Drugs
	Nalmefene is a Delta-type opioid receptor antagonist
1	Delta-type opioid receptor agonists	3-Methylfentanyl, 3-Methylthiofentanyl, Amitriptyline, Butorphanol, Butyrfentanyl, Carfentanil, Codeine, Dextromethorphan, Dextropropoxyphene, Diamorphine, Dihydromorphine, Dimethylthiambutene, Diphenoxylate, Etorphine, Fentanyl, Hydrocodone, Ketobemidone, Levorphanol, Loperamide, Loxicodegol, Metenkefalin, Methadone, Morphine, Opium, Oxycodone, Remifentanil, Sufentanil, Tramadol
2	Delta-type opioid receptor partial agonists	Hydromorphone
3	Delta-type opioid receptor antagonists	Alvimopan, Buprenorphine, Diprenorphine, Eluxadoline, Nalbuphine, Naldemedine, Naloxone, Naltrexone, Oxymorphone, Pholcodine
4	Delta-type opioid receptor binders	Ketamine
5	Delta-type opioid receptor ligands	Aripiprazole

	Interacting Group	Interacting Drugs
	Nalmefene is a UDP-glucuronosyltransferase 2B7 substrate
1	UDP-glucuronosyltransferase 2B7 substrates	Acemetacin, Ambrisentan, Anastrozole, Artenimol, Artesunate, Bempedoic acid, Carbamazepine, Carvedilol, Cenobamate, Codeine, Dabigatran etexilate, Dapagliflozin, Dexibuprofen, Dextromethorphan, Diclofenac, Empagliflozin, Enasidenib, Epirubicin, Ertugliflozin, Ethinylestradiol, Etodolac, Ezetimibe, Febuxostat, Flurbiprofen, Fluvastatin, Formoterol, Gemfibrozil, Hydromorphone, Ibuprofen, Indomethacin, Ketorolac, Labetalol, Letrozole, Losartan, Lovastatin, Loxoprofen, Mitiglinide, Morphine, Mycophenolate mofetil, Mycophenolic acid, Naproxen, Osilodrostat, Oxazepam, Pitavastatin, Silodosin, Simvastatin, Suprofen, Tamoxifen, Tapentadol, Troglitazone, Vadimezan, Valproic acid, Zaltoprofen, Zidovudine
2	UDP-glucuronosyltransferase 2B7 inhibitors	Chenodeoxycholic acid, Dovitinib, Flunitrazepam, Indomethacin, Ketoconazole, Mefenamic acid, Umifenovir
3	UDP-glucuronosyltransferase 2B7 inducers	Phenobarbital

	Interacting Group	Interacting Drugs
	Nalmefene is a UDP-glucuronosyltransferase 1-3 substrate
1	UDP-glucuronosyltransferase 1-3 substrates	Ambrisentan, Anastrozole, Atorvastatin, Baloxavir marboxil, Candesartan, Candesartan cilexetil, Cyproheptadine, Delafloxacin, Dexibuprofen, Diclofenac, Dolutegravir, Eltrombopag, Empagliflozin, Enasidenib, Etodolac, Ezetimibe, Ezogabine, Febuxostat, Flurbiprofen, Fluvastatin, Gavestinel, Gemfibrozil, Hydromorphone, Ibuprofen, Irbesartan, Ketotifen, Letermovir, Licofelone, Lorlatinib, Losartan, Lovastatin, Mitiglinide, Morphine, Muraglitazar, Naldemedine, Naproxen, Pitavastatin, Simvastatin, Telmisartan, Troglitazone, Valproic acid
2	UDP-glucuronosyltransferase 1-3 inhibitors	Deferasirox, Dovitinib, Flunitrazepam, Gemfibrozil

	Interacting Group	Interacting Drugs
	Nalmefene is a UDP-glucuronosyltransferase 1-8 substrate
1	UDP-glucuronosyltransferase 1-8 substrates	Bazedoxifene, Diflunisal, Empagliflozin, Formoterol, Morphine, Mycophenolate mofetil, Naproxen, Nintedanib, Propofol, Raloxifene, Troglitazone, Valproic acid
2	UDP-glucuronosyltransferase 1-8 inhibitors	Isavuconazole