rPSGL-Ig

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
rPSGL-Ig
Accession Number
DB06256
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Fusion proteins
Description

Recombinant P-selectin glycoprotein ligand IgG fusion protein (rPSGL-Ig) is a fusion protein of human P-selectin ligand and IgG1-Fc.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • rPSGL-Ig
  • YSPSL
Categories
Not Available
UNII
Not Available
CAS number
Not Available

Pharmacology

Indication

Investigated for use/treatment in myocardial infarction, red blood cell disorders, anemia, kidney transplant surgery, transplant (rejection), liver transplant surgery, and ischemic reperfusion injury.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Gaber AO, Mulgaonkar S, Kahan BD, Woodle ES, Alloway R, Bajjoka I, Jensik S, Klintmalm GB, Patton PR, Wiseman A, Lipshutz G, Kupiec-Weglinski J, Gaber LW, Katz E, Irish W, Squiers EC, Hemmerich S: YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study. Clin Transplant. 2011 Jul-Aug;25(4):523-33. doi: 10.1111/j.1399-0012.2010.01295.x. Epub 2010 Jun 22. [PubMed:20573162]
External Links
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentPancreatic Cancer Stage III / Pancreatic Cancer Stage IV1
1CompletedTreatmentAdvanced Solid Tumors1
1CompletedTreatmentBiliary Tract Cancer1
1CompletedTreatmentHepatocellular,Carcinoma1
1CompletedTreatmentMalignant Neoplasm of Stomach1
1CompletedTreatmentNeoplasms, Gastrointestinal1
1, 2Active Not RecruitingTreatmentMalignant Neoplasm of Stomach1
1, 2CompletedNot AvailableDelayed Graft Function1
1, 2CompletedPreventionKidney Diseases1
1, 2CompletedTreatmentNeoplasms, Colorectal1
1, 2SuspendedTreatmentMalignant Neoplasm of Stomach1
1, 2Unknown StatusTreatmentAdvanced Non-Small Cell Lung Cancer1
2Active Not RecruitingTreatmentAdvanced Biliary Tract Cancer(BTC)1
2Active Not RecruitingTreatmentBiliary Tract Neoplasms1
2CompletedTreatmentBiliary Tract Cancer1
2CompletedTreatmentBiliary Tract Neoplasms1
2CompletedTreatmentHead and Neck Carcinoma1
2CompletedTreatmentMalignant Neoplasm of Pancreas2
2CompletedTreatmentMalignant Neoplasm of Stomach2
2CompletedTreatmentNeoplasms Metastasis / Neoplasms, Pancreatic1
2CompletedTreatmentNeoplasms, Breast2
2CompletedTreatmentNeoplasms, Colorectal1
2CompletedTreatmentPancreas Neoplasms1
2CompletedTreatmentStomach Neoplasms4
2Not Yet RecruitingTreatmentPancreatic Ductal Adenocarcinoma1
2RecruitingPreventionMalignant Neoplasm of Stomach1
2RecruitingTreatmentCancer treatment / Chemoradiotherapy / Neoadjuvant Therapy / Stomach Neoplasms1
2RecruitingTreatmentGastric Adenocarcinoma1
2RecruitingTreatmentMalignant Neoplasm of Stomach2
2RecruitingTreatmentNeoplasms, Colorectal1
2RecruitingTreatmentNeoplasms, Esophageal1
2RecruitingTreatmentOverall Survival1
2TerminatedTreatmentBiliary Tract Cancer1
2TerminatedTreatmentLocally Advanced Biliary Tract Cancer / Metastatic Biliary Tract Cancer1
2TerminatedTreatmentMalignant Neoplasm of Pancreas1
2TerminatedTreatmentMalignant Neoplasm of Stomach1
2Unknown StatusPreventionLiver Diseases1
2Unknown StatusTreatmentCancer, Breast1
2Unknown StatusTreatmentCarcinoma NOS / Hepatocellular,Carcinoma / Liver Diseases1
2Unknown StatusTreatmentColorectal Cancers1
2Unknown StatusTreatmentElderly / First-Line / Malignant Neoplasm of Stomach / Oxaliplatin / S-11
2Unknown StatusTreatmentGastroesophageal Junction Cancer / Malignant Neoplasm of Stomach1
2Unknown StatusTreatmentMalignant Neoplasm of Stomach1
2, 3CompletedTreatmentColorectal Cancers1
2, 3CompletedTreatmentMalignant Neoplasm of Stomach1
3Active Not RecruitingTreatmentMalignant Neoplasm of Stomach1
3CompletedTreatmentAdvanced Gastric Cancer1
3CompletedTreatmentColorectal Cancers1
3CompletedTreatmentMalignant Neoplasm of Pancreas1
3CompletedTreatmentMalignant Neoplasm of Stomach6
3SuspendedTreatmentMetastatic Colorectal Cancers1
3Unknown StatusTreatmentMalignant Neoplasm of Stomach1
Not AvailableCompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on March 19, 2008 10:19 / Updated on June 04, 2019 06:22