This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Coltuximab ravtansine
Accession Number
DB06342
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description

Coltuximab ravtansine (SAR3419) targets CD19 and is being investigated for the treatment of acute lymphoblastic leukemia (ALL).

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • Anti-CD19 humanized monoclonal antibody conjugated to DM4
External IDs
SAR-3419 / SAR3419
Categories
UNII
MRS84YT9L2
CAS number
1269764-99-9

Pharmacology

Indication

Investigated for use/treatment in lymphoma (non-hodgkin's).

Pharmacodynamics
Not Available
Mechanism of action

SAR3419 is an anti-CD19-DM4 immunoconjugate consisting of an anti-CD19 monoclonal antibody conjugated to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. SAR3419 targets the cell surface antigen CD19, found on a number of B-cell-derived cancers. Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CD19-expressing tumor cells. [National Cancer Institute Drug Dictionary]

TargetActionsOrganism
UB-lymphocyte antigen CD19Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe serum concentration of (R)-warfarin can be increased when it is combined with Coltuximab ravtansine.
(S)-WarfarinThe serum concentration of (S)-Warfarin can be increased when it is combined with Coltuximab ravtansine.
3-isobutyl-1-methyl-7H-xanthineThe metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Coltuximab ravtansine.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Coltuximab ravtansine.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Coltuximab ravtansine.
5-androstenedioneThe metabolism of 5-androstenedione can be decreased when combined with Coltuximab ravtansine.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Coltuximab ravtansine.
7-DeazaguanineThe metabolism of 7-Deazaguanine can be decreased when combined with Coltuximab ravtansine.
7,9-DimethylguanineThe metabolism of 7,9-Dimethylguanine can be decreased when combined with Coltuximab ravtansine.
8-azaguanineThe metabolism of 8-azaguanine can be decreased when combined with Coltuximab ravtansine.
Food Interactions
Not Available

References

General References
  1. Link [Link]
External Links
Wikipedia
Coltuximab_ravtansine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentMalignant Lymphomas / Non-Hodgkins2
2CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)2
2TerminatedTreatmentAcute Lymphocytic Leukemia (ALL)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Receptor signaling protein activity
Specific Function
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Gene Name
CD19
Uniprot ID
P15391
Uniprot Name
B-lymphocyte antigen CD19
Molecular Weight
61127.985 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Kuper JI, D'Aprile M: Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. Clin Pharmacokinet. 2000 Sep;39(3):203-14. [PubMed:11020135]

Drug created on March 19, 2008 10:25 / Updated on November 02, 2018 06:16