Calcitonin gene-related peptide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Calcitonin gene-related peptide
Accession Number
DB06379  (DB05621)
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Peptides
Description

A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.

As a potential drug, it has demonstrated in preclinical studies a profile that could make it an ideal anti-asthmatic drug candidate with bronchodilatory, bronchoprotecting and anti-inflammatory properties.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • Calcitonin gene related peptide
  • Calcitonin-gene-related peptide
  • CGRP
  • LAB CGRP
Categories
UNII
JHB2QIZ69Z
CAS number
83652-28-2

Pharmacology

Indication

Investigated for use/treatment in myocardial infarction, heart disease, and asthma.

Pharmacodynamics
Not Available
Mechanism of action

While current drugs for treating HF and MI have a single mechanism of action, CGRP appears to work on several levels: for example, it (1) increases local blood flow enhancing hemodynamic proficiency; (2) protects heart muscle cells from the damage due to lack of oxygen (ischemia); and, (3) modulates the immune system by boosting anti-inflammatory cytokine expression while suppressing pro-inflammatory cytokines, which reduces the inflammatory response to provide a cardioprotective effect. All these actions are meant to minimize heart muscle damage and subsequent scar tissue formation, while promoting the healing process.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
Patent BlueThe therapeutic efficacy of Calcitonin gene-related peptide can be decreased when used in combination with Patent Blue.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

References

General References
Not Available
External Links
Wikipedia
Calcitonin_gene-related_peptide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableActive Not RecruitingBasic ScienceCluster Headache1
Not AvailableActive Not RecruitingBasic ScienceMigraine With Aura1
Not AvailableCompletedNot AvailableMigraine Without Aura1
Not AvailableCompletedBasic ScienceFamilial Hemiplegic Migraine / Healthy Volunteers / Migraine With Aura1
Not AvailableCompletedEducational/Counseling/TrainingFamilial Hemiplegic Migraine1
Not AvailableCompletedTreatmentMigraine1
Not AvailableCompletedTreatmentMigraine Without Aura1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on March 19, 2008 10:28 / Updated on June 04, 2019 06:23