Eprodisate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Name
Eprodisate
Accession Number
DB06405
Type
Small Molecule
Groups
Investigational
Description

Eprodisate slows the decline of renal function in AA amyloidosis.

Structure
Thumb
Synonyms
  • 1,3-propanedisulfonic acid
  • Propane-1,3-disulfonate
  • Propane-1,3-disulfonic acid
  • Propane-1,3-disulphonate
External IDs
NC-503
International/Other Brands
Kiacta
Categories
UNII
6QFP76V7S7
CAS number
21668-77-9
Weight
Average: 204.21
Monoisotopic: 203.976230326
Chemical Formula
C3H8O6S2
InChI Key
MGNVWUDMMXZUDI-UHFFFAOYSA-N
InChI
InChI=1S/C3H8O6S2/c4-10(5,6)2-1-3-11(7,8)9/h1-3H2,(H,4,5,6)(H,7,8,9)
IUPAC Name
propane-1,3-disulfonic acid
SMILES
OS(=O)(=O)CCCS(O)(=O)=O

Pharmacology

Indication

Investigated for use/treatment in amyloidosis.

Pharmacodynamics
Not Available
Mechanism of action

Decline in renal function associated with Amyloid A (AA) amyloidosis can be slowed by eprodisate (Kiacta), a drug that inhibits the deposit of the complex protein in tissues. AA amyloidosis is a serious, frequently fatal disorder involving deposits of amyloid fibrils in various organs and tissues. It is a complication of many chronic inflammatory disorders, but little is known about its etiology or natural history. Eprodisate delays the progression of AA amyloidosis-associated renal disease.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
379112
ChEMBL
CHEMBL2111092
Wikipedia
1,3-Propanedisulfonic_acid

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentMetabolic Syndromes / Type 2 Diabetes Mellitus1
2, 3CompletedTreatmentFamilial Mediterranean Syndrome / Gastrointestinal Diseases / Glomerulonephritis minimal lesion / Kidney Diseases / Rheumatoid Arthritis / Secondary (AA) Amyloidosis1
3CompletedPreventionAmyloidosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility14.2 mg/mLALOGPS
logP-2.6ALOGPS
logP-1.7ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)-2ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area108.74 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity36.21 m3·mol-1ChemAxon
Polarizability16.64 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on March 19, 2008 10:29 / Updated on September 02, 2019 18:20