Eprodisate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Eprodisate
DrugBank Accession Number
DB06405
Background

Eprodisate slows the decline of renal function in AA amyloidosis.

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 204.21
Monoisotopic: 203.976230326
Chemical Formula
C3H8O6S2
Synonyms
  • 1,3-propanedisulfonic acid
  • Eprodisate
  • Propane-1,3-disulfonate
  • Propane-1,3-disulfonic acid
  • Propane-1,3-disulphonate
External IDs
  • NC-503

Pharmacology

Indication

Investigated for use/treatment in amyloidosis.

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Pharmacodynamics

Not Available

Mechanism of action

Decline in renal function associated with Amyloid A (AA) amyloidosis can be slowed by eprodisate (Kiacta), a drug that inhibits the deposit of the complex protein in tissues. AA amyloidosis is a serious, frequently fatal disorder involving deposits of amyloid fibrils in various organs and tissues. It is a complication of many chronic inflammatory disorders, but little is known about its etiology or natural history. Eprodisate delays the progression of AA amyloidosis-associated renal disease.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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International/Other Brands
Kiacta

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
6QFP76V7S7
CAS number
21668-77-9
InChI Key
MGNVWUDMMXZUDI-UHFFFAOYSA-N
InChI
InChI=1S/C3H8O6S2/c4-10(5,6)2-1-3-11(7,8)9/h1-3H2,(H,4,5,6)(H,7,8,9)
IUPAC Name
propane-1,3-disulfonic acid
SMILES
OS(=O)(=O)CCCS(O)(=O)=O

References

General References
Not Available
ChemSpider
379112
ChEMBL
CHEMBL2111092
ZINC
ZINC000005225211
Wikipedia
1,3-Propanedisulfonic_acid

Clinical Trials

Clinical Trials

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility14.2 mg/mLALOGPS
logP-2.6ALOGPS
logP-1.7Chemaxon
logS-1.2ALOGPS
pKa (Strongest Acidic)-2Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area108.74 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity36.21 m3·mol-1Chemaxon
Polarizability16.64 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0290000000-a881bdcaa79204d74055
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-347f0598ed48c2aac773
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00ec-8910000000-b3e6eb27ed3827404088
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-3090000000-02ec8c685655f0c9eb36
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-9200000000-1802d1893372ec917e13
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-a9072c477dd6ccde98e2
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-142.8268418
predicted
DarkChem Lite v0.1.0

Drug created at March 19, 2008 16:29 / Updated at February 21, 2021 18:52