Etilevodopa

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Etilevodopa
Accession Number
DB06535
Type
Small Molecule
Groups
Investigational
Description
Not Available
Structure
Thumb
Synonyms
Not Available
External IDs
TV-1203
Categories
UNII
895X917GYE
CAS number
37178-37-3
Weight
Average: 225.244
Monoisotopic: 225.100107967
Chemical Formula
C11H15NO4
InChI Key
NULMGOSOSZBEQL-QMMMGPOBSA-N
InChI
InChI=1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1
IUPAC Name
ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
SMILES
CCOC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1

Pharmacology

Indication

Investigated for use/treatment in parkinson's disease.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AmisulprideThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Amisulpride.
AripiprazoleThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Aripiprazole.
AsenapineThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Asenapine.
AzaperoneThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Azaperone.
BifeprunoxThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Bifeprunox.
BlonanserinThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Blonanserin.
BrexpiprazoleThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Brexpiprazole.
BupropionThe risk or severity of adverse effects can be increased when Bupropion is combined with Etilevodopa.
CariprazineThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Cariprazine.
ChlorpromazineThe therapeutic efficacy of Etilevodopa can be decreased when used in combination with Chlorpromazine.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
148944
ChEBI
135971
ChEMBL
CHEMBL1823681
Wikipedia
Etilevodopa
ATC Codes
N04BA06 — Etilevodopa and decarboxylase inhibitor

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.78 mg/mLALOGPS
logP0.22ALOGPS
logP0.97ChemAxon
logS-2.1ALOGPS
pKa (Strongest Acidic)9.29ChemAxon
pKa (Strongest Basic)6.97ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.78 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity58.6 m3·mol-1ChemAxon
Polarizability23.27 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as tyrosine and derivatives. These are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Tyrosine and derivatives
Alternative Parents
Phenylalanine and derivatives / Alpha amino acid esters / Amphetamines and derivatives / Catechols / Fatty acid esters / Aralkylamines / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Carboxylic acid esters / Monocarboxylic acids and derivatives
show 5 more
Substituents
Tyrosine or derivatives / Phenylalanine or derivatives / Alpha-amino acid ester / Amphetamine or derivatives / Catechol / 1-hydroxy-4-unsubstituted benzenoid / 1-hydroxy-2-unsubstituted benzenoid / Fatty acid ester / Phenol / Aralkylamine
show 17 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on March 19, 2008 10:36 / Updated on September 02, 2019 18:21