Ammonium lactate

Identification

Name
Ammonium lactate
Accession Number
DB06768
Type
Small Molecule
Groups
Approved
Description

Ammonium lactate is the ammonium salt of lactic acid.

Structure
Thumb
Synonyms
  • Ammonium (+-)-lactate
  • Ammonium lactate
  • Lactic acid ammonium salt
External IDs
E328
Active Moieties
NameKindUNIICASInChI Key
Lactic Acidunknown3B8D35Y7S450-21-5JVTAAEKCZFNVCJ-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lac Hydrin CreamCream120 mg/1gTopicalRanbaxy Inc.2009-03-16Not applicableUs
Lac-HydrinLotion120 mg/1gTopicalRanbaxy, Inc2008-01-28Not applicableUs
Lac-HydrinLotion120 mg/1gTopicalPhysicians Total Care, Inc.2008-08-152012-06-30Us
Lac-HydrinLotion120 mg/1gTopicalSun Pharmaceutical Industries Limited2008-08-152008-08-15Us
Lac-HydrinCream120 mg/1gTopicalBristol Myers Squibb Pharma Company2009-06-012012-10-15Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ammonium LactateCream120 mg/1gTopicalGoldline Laboratories, Inc.2009-02-282009-03-01Us
Ammonium LactateCream12 g/100gTopicalPerrigo New York Inc2006-08-16Not applicableUs
Ammonium LactateLotion12 g/100gTopicalPhysicians Total Care, Inc.2002-02-14Not applicableUs
Ammonium LactateLotion120 mg/1gTopicalTaro Pharmaceuticals U.S.A., Inc.2004-05-28Not applicableUs
Ammonium LactateCream120 mg/1gTopicalPaddock Laboratories, Inc.2006-02-072012-03-31Us
Ammonium LactateLotion12 g/100gTopicalWatson Pharmaceuticals2012-06-05Not applicableUs
Ammonium LactateLotion12 g/100gTopicalPerrigo New York Inc2006-06-20Not applicableUs
Ammonium LactateCream12 g/100gTopicalWatson Pharmaceuticals2012-06-05Not applicableUs
Ammonium LactateCream120 mg/1gTopicalTaro Pharmaceuticals U.S.A., Inc.2003-04-10Not applicableUs
LAClotionLotion120 mg/1gTopicalPaddock Laboratories, Inc.2002-06-112012-09-30Us
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ammonium LactateCream17 g/1gTopicalNnodum Pharmaceuticals2007-12-30Not applicableUs
Ammonium LactateLotion17 g/1gTopicalNnodum Pharmaceuticals2007-12-30Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Ultravate XAmmonium lactate (100 mg/1g) + Ulobetasol propionate (0.50 mg/1g)KitRanbaxy Inc.2012-07-01Not applicableUs
Ultravate XAmmonium lactate (100 mg/1g) + Ulobetasol propionate (0.5 mg/1g)KitRanbaxy Inc.2012-07-09Not applicableUs
International/Other Brands
Amlactin / Lac-hydrin
Categories
UNII
67M901L9NQ
CAS number
515-98-0
Weight
Average: 107.1085
Monoisotopic: 107.058243159
Chemical Formula
C3H9NO3
InChI Key
RZOBLYBZQXQGFY-UHFFFAOYSA-N
InChI
InChI=1S/C3H6O3.H3N/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);1H3
IUPAC Name
ammonium 2-hydroxypropanoate
SMILES
[NH4+].CC(O)C([O-])=O

Pharmacology

Indication

For the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.

Associated Conditions
Pharmacodynamics

Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion.

Mechanism of action

Unknown.

Absorption

In vitro study of percutaneous absorption of ammonium lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

The oral administration of Lac-Hydrin to rats and mice showed this drug to be practically non-toxic (LD50 > 15 mL/kg).

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0015671
KEGG Drug
D02920
PubChem Compound
62358
PubChem Substance
175427089
ChemSpider
56149
ChEMBL
CHEMBL1200747
PharmGKB
PA165958400
Wikipedia
Ammonium_lactate
FDA label
Download (14.2 KB)
MSDS
Download (46.8 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical12 g/100g
CreamTopical17 g/1g
LotionTopical12 g/100g
LotionTopical17 g/1g
CreamTopical120 mg/1g
LotionTopical120 mg/1g
Kit
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility866.0 mg/mLALOGPS
logP-0.51ALOGPS
logP-0.47ChemAxon
logS0.91ALOGPS
pKa (Strongest Acidic)3.78ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity29.68 m3·mol-1ChemAxon
Polarizability7.65 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7873
Blood Brain Barrier+0.7656
Caco-2 permeable-0.7876
P-glycoprotein substrateNon-substrate0.7911
P-glycoprotein inhibitor INon-inhibitor0.9869
P-glycoprotein inhibitor IINon-inhibitor0.9581
Renal organic cation transporterNon-inhibitor0.952
CYP450 2C9 substrateNon-substrate0.8121
CYP450 2D6 substrateNon-substrate0.9016
CYP450 3A4 substrateNon-substrate0.7749
CYP450 1A2 substrateNon-inhibitor0.9606
CYP450 2C9 inhibitorNon-inhibitor0.9147
CYP450 2D6 inhibitorNon-inhibitor0.9687
CYP450 2C19 inhibitorNon-inhibitor0.9614
CYP450 3A4 inhibitorNon-inhibitor0.9755
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9734
Ames testNon AMES toxic0.9357
CarcinogenicityNon-carcinogens0.5528
BiodegradationReady biodegradable0.9862
Rat acute toxicity1.5255 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.986
hERG inhibition (predictor II)Non-inhibitor0.9698
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Carboxylic acid salts
Alternative Parents
Secondary alcohols / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic salts / Organic oxides / Organic nitrogen compounds / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Secondary alcohol / Carboxylic acid salt / Monocarboxylic acid or derivatives / Carboxylic acid / Organic nitrogen compound / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic salt / Organic zwitterion
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available

Drug created on September 14, 2010 10:21 / Updated on December 14, 2018 16:58