Povidone-iodine

Identification

Name
Povidone-iodine
Accession Number
DB06812
Type
Small Molecule
Groups
Approved
Description

Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered in 1955 at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. They carried out tests in vitro to demonstrate anti-bacterial activity, and found that the complex was less toxic in mice than tincture of iodine. Human clinical trials showed the product to be superior to other iodine formulations. Povidone-iodine was immediately marketed, and has since become the universally preferred iodine antiseptic.

Synonyms
  • Iodopovidone
  • Povidone iodine
  • PVP-I
Active Moieties
NameKindUNIICASInChI Key
Iodineunknown9679TC07X47553-56-2PNDPGZBMCMUPRI-UHFFFAOYSA-N
PovidoneunknownFZ989GH94E9003-39-8Not applicable
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BetadineSolution5 mg/1mLOphthalmicRebel Distributors2000-04-01Not applicableUs
BetadineSolution5 mg/1mLOphthalmicAlcon, Inc.2000-04-01Not applicableUs
Douche Tray 1%Kit1 %TopicalAllegiance Healthcare Corporation1993-12-311999-07-08Canada
E-Z Scrub 245Sponge6.5 %TopicalBecton DickinsonNot applicableNot applicableCanada
Irrigation Tray 10% KitLiquid10 %TopicalBaxter Laboratories1991-12-311999-08-10Canada
Irrigation Tray W Pvp-I Prep Pad 1%Liquid1 %TopicalBaxter Laboratories1992-12-311999-08-10Canada
Urethral Cath Tray W Iodphor Pvp Pad 1%Liquid1 %TopicalBaxter Laboratories1992-12-311999-08-10Canada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
3-in-1 First Aid Povidone-Iodine SwabLiquid10 mg/1mLTopicalSwabplus Inc.2003-03-012013-01-30Us
3M Skin and Nasal AntisepticSolution5 mg/1mLTopical3M Health Care2009-07-01Not applicableUs
Acu Dyne OintmentOintment10 %TopicalAcme United Corporation1977-12-311997-05-30Canada
Acu Dyne Prep Soln LiqLiquid10 %TopicalAcme United Corporation1977-12-311997-05-30Canada
Acu Dyne Skin CleanserLiquid7.5 %TopicalAcme United Corporation1976-12-311997-05-30Canada
Acu Dyne Swab StickStick10 %TopicalAcme United Corporation1977-12-311997-05-30Canada
Acudyne Prep SolutionSolution1 %TopicalAcme United Corporation1976-12-311997-05-30Canada
Acudyne Prep Swab F420Swab1 %TopicalAcme United Corporation1973-12-311997-05-30Canada
Alphadine ScrubSolution7.5 mg/100mLTopicalEcolab Inc.1997-06-192018-02-19Us
Alphadine Solution 10%Solution10 %TopicalEcolab Inc.1992-12-312004-03-01Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
3-Step First Aid KitPovidone-iodine (100 mg/10mL) + Benzalkonium chloride (11 mg/10mL) + Lidocaine hydrochloride (100 mg/10mL)KitTopicalSwabplus Inc.2003-03-01Not applicableUs
Aplicare ExCel APPovidone-iodine (7.5 mg/1mL) + Isopropyl Alcohol (720 mg/1mL)SolutionTopicalAplicare Products, Llc.2004-06-01Not applicableUs
Aplicare Total Joint PrepPovidone-iodine (9.8 g/96.4mL) + Povidone-iodine (9.8 g/96.4mL)KitTopicalAplicare2011-12-01Not applicableUs
Aplicare Total Joint PrepPovidone-iodine (9.8 g/96.4mL) + Povidone-iodine (9.8 g/96.4mL)KitTopicalAplicare2011-12-01Not applicableUs
Arrow Central Venous Catheterization KitPovidone-iodine (10 %) + Povidone-iodine (10 %) + Lidocaine hydrochloride (1 %)LiquidIntravenousArrow International1991-12-311999-07-02Canada
Arrow Central Venous Catheterization KitPovidone-iodine (10 %) + Povidone-iodine (10 %) + Lidocaine hydrochloride (1 %)LiquidIntravenousArrow International1991-12-311999-07-02Canada
Arrow Multi-lumen Central Venous Catheter KitPovidone-iodine (10 %) + Lidocaine hydrochloride (1 %)LiquidIntravenousArrow International1990-12-311999-07-02Canada
Arrow Pneumothorax KitPovidone-iodine (10 %) + Lidocaine hydrochloride (1 %)Kit; LiquidIntravenousArrow International1991-12-311999-07-02Canada
Arrow Two-lumen Central Venous Cathetar KitPovidone-iodine (10 %) + Lidocaine hydrochloride (1 %)LiquidIntravenousArrow International1990-12-311999-07-02Canada
Arrow Two-lumen Jugular Catheterization KitPovidone-iodine (10 %) + Povidone-iodine (10 %) + Lidocaine hydrochloride (1 %)LiquidIntravenousArrow International1991-12-311999-07-02Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Betalido KitPovidone-iodine (10 mg/1mL) + Betamethasone sodium phosphate (3 mg/1mL) + Betamethasone acetate (3 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL)KitInfiltration; Intra-articular; Intralesional; Intramuscular; Perineural; TopicalAsclemed Usa, Inc.2014-06-13Not applicableUs
Bupivilog KitPovidone-iodine (10 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Triamcinolone acetonide (40 mg/1mL)KitEpidural; Intra-articular; Intramuscular; TopicalAsclemed Usa, Inc.2014-02-04Not applicableUs
Dexlido KitPovidone-iodine (10 mg/1mL) + Dexamethasone sodium phosphate (10 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL)KitInfiltration; Intramuscular; Intravenous; TopicalAsclemed Usa, Inc.2014-07-25Not applicableUs
Dexlido-M KitPovidone-iodine (10 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Dexamethasone sodium phosphate (10 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL)KitEpidural; Infiltration; Intramuscular; Intravenous; TopicalAsclemed Usa, Inc.2014-07-25Not applicableUs
Disposable Convenience Kit (Single Shot Epidural)Povidone-iodine (0.1 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL) + Sodium Chloride (9 mg/1mL)KitTrue Fit Rx Llc2016-02-04Not applicableUs
DoubleDex KitPovidone-iodine (10 mg/1mL) + Dexamethasone sodium phosphate (10 mg/1mL) + Isopropyl Alcohol (70 mL/100mL)KitIntramuscular; Intravenous; TopicalAsclemed Usa, Inc.2014-07-25Not applicableUs
Dyural 40 KitPovidone-iodine (10 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Methylprednisolone acetate (40 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; TopicalAsclemed Usa, Inc.2014-07-25Not applicableUs
Dyural 80 KitPovidone-iodine (10 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Methylprednisolone acetate (80 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; TopicalAsclemed Usa, Inc.2014-08-01Not applicableUs
Dyural L KitPovidone-iodine (10 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Methylprednisolone acetate (40 mg/1mL)KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; TopicalAsclemed Usa, Inc.2014-08-15Not applicableUs
Dyural LM KitPovidone-iodine (10 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Methylprednisolone acetate (40 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; TopicalAsclemed Usa, Inc.2014-08-21Not applicableUs
International/Other Brands
Betadine
Categories
UNII
85H0HZU99M
CAS number
25655-41-8
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

For topical application in the treatment and prevention of infection in wounds.

Associated Conditions
Associated Therapies
Pharmacodynamics

Povidone iodine is a kind of iodine disinfectant which directly cause in vivo protein denaturation, precipitation of bacteria, and further resulting in the death of pathogenic microorganisms. Therefore, it is effective in disinfection and sterilization. It can kill viruses, bacteria, spores, fungi, and protozoa with low toxicity to human. Povidone-iodine aqueous solution has strong pharmacological activity against Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, syphilis, hepatitis B virus, HIV, and Trichomonas vaginalis. Povidone iodine gel is a gynecological topical semi-mobile colloidal agent made by povidone iodine and hydrophilic matrix. It is a system for maintaining its sustained release. Owing to the continuous release of free iodine, it can enable the skin and mucous membranes to maintain a certain effective concentration of iodine for killing bacteria. It is mainly used for gynecological vaginal infection. It exerted its effect through being miscible with vaginal secretions and further killing the inside pathogenic microorganisms, and thus blocking the spread of sexually transmitted diseases and invasion, as well as treating other infected vaginal diseases caused by other kinds of bacteria.

Published reports on the in vitro antimicrobial efficacy of iodophors demonstrate that iodophors are bactericidal, mycobactericidal, and virucidal but can require prolonged contact times to kill certain fungi and bacterial spores. Three brands of povidone-iodine solution have demonstrated more rapid kill (seconds to minutes) of S. aureus and M. chelonae at a 1:100 dilution than did the stock solution. The virucidal activity of 75–150 ppm available iodine was demonstrated against seven viruses. Other investigators have questioned the efficacy of iodophors against poliovirus in the presence of organic matter and rotavirus in distilled or tapwater. Manufacturers' data demonstrate that commercial iodophors are not sporicidal, but they are tuberculocidal, fungicidal, virucidal, and bactericidal at their recommended use-dilution.

Mechanism of action

Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine (I2) penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes [1]. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated [1]. In vitro evidence suggests that iodine also counteracts inflammation elicited by both pathogens and the host response via multifactorial effects. In hosts, povidone-iodine was demonstrated to modulate the redox potential, inhibit the release of inflammatory mediators such as TNF-α and β-galactosidase, inhibit metalloproteinase production, and potentiate the healing signals from pro-inflammatory cytokines by activation of monocytes, T-lymphocytes, and macrophages, in vitro [1].

Absorption

Povidone-Iodine is intended for topical application and is not absorbed.

Volume of distribution

Povidone-Iodine is intended for topical application and has no volume of distribution.

Protein binding

To be used topical. No plasma protein binding reported.

Metabolism

Povidone-Iodine is not absorbed or metabolized.

Route of elimination

Povidone-Iodine is intended for topical application and is not eliminated.

Half life

Povidone-Iodine is intended for topical application and is not eliminated.

Clearance

Povidone-Iodine is intended for topical application and is not eliminated.

Toxicity

ORAL (LD50): Acute: 8000 mg/kg [Rat]. 8100 mg/kg [Mouse]

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA: Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017 Aug;44:260-268. doi: 10.1016/j.ijsu.2017.06.073. Epub 2017 Jun 23. [PubMed:28648795]
  2. The efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection: an evidence-based review [Link]
  3. Iodophore activity, CDC [Link]
External Links
KEGG Drug
D00863
KEGG Compound
C08043
PubChem Substance
347910372
ChEBI
8347
ChEMBL
CHEMBL1201724
Wikipedia
Povidone-iodine
ATC Codes
R02AA15 — Povidone-iodineD08AG02 — Povidone-iodineD11AC06 — Povidone-iodineG01AX11 — Povidone-iodineD09AA09 — Povidone-iodineS01AX18 — Povidone-iodine
AHFS Codes
  • 40:36.00 — Irrigating Solutions
  • 84:04.92 — Miscellaneous Local Anti-infectives
MSDS
Download (47.9 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Not Yet RecruitingBasic ScienceCleaning Product Causing Toxic Effect1
0RecruitingPreventionAge-Related Macular Degeneration (ARMD) / Diabetic Vascular Diseases / Proliferative Retinopathy / Retina Vein Occlusion1
2CompletedPreventionPostoperative Infections1
2CompletedTreatmentBacterial Keratitis / Childhood Blindness / Infected Corneal Ulcers / Ulcerative keratitis1
2Not Yet RecruitingSupportive CareCancer, Breast1
2RecruitingPreventionSurgical Site Infections1
2RecruitingTreatmentAcanthamoeba Keratitis1
2TerminatedPreventionSurgical Site Infections1
2Unknown StatusPreventionSurgical Site Infections1
2, 3RecruitingBasic ScienceCesarean Section; Infection / Surgical Site Infections1
2, 3RecruitingTreatmentClostridium Difficile1
3CompletedNot AvailableHealthy Volunteers1
3CompletedPreventionCariostatic Agents / Dental Decay1
3CompletedPreventionInfection NOS1
3CompletedPreventionInfection, Postoperative Wound1
3CompletedPreventionInfectious Diseases1
3CompletedPreventionPostoperative Infections1
3CompletedPreventionSurgical Site Infections1
3CompletedPreventionWound Infections1
3CompletedTreatmentDental Plaque1
3Not Yet RecruitingTreatmentStroke, Acute / Transient Ischaemic Attack (TIA)1
3RecruitingTreatmentAdenoviral Conjunctivitis1
3RecruitingTreatmentAdenoviral Conjunctivitis / Conjunctivitis, Bacterial1
3RecruitingTreatmentMalignant Pleural Effusions1
3TerminatedPreventionVentilator-associated Bacterial Pneumonia1
3TerminatedTreatmentFungal Keratitis1
3TerminatedTreatmentRecurrences / Varicosities of the great saphenous vein / Wound Infections1
4Active Not RecruitingPreventionSurgical Site Infections1
4CompletedOtherSurgical Preparation of the Vagina1
4CompletedPreventionBacteremia1
4CompletedPreventionPostpartum Endometritis1
4CompletedPreventionSkin Health1
4CompletedPreventionSurgical Site Infections1
4CompletedTreatmentConjunctivitis, Viral1
4CompletedTreatmentSkin Diseases, Infectious / Soft Tissues Infections1
4Enrolling by InvitationPreventionCatheter Bacteraemia / Catheter-Related Infections / Catheter; Infection (Indwelling Catheter) / Infection due to indwelling catheter / Urinary Tract Infections (UTIs)1
4Enrolling by InvitationTreatmentGranuloma / Tracheostomy care1
4Not Yet RecruitingTreatmentMalignant Pleural Effusions / Pleural Effusion Due to Congestive Heart Failure / Pleural Effusion in Conditions Classified Elsewhere / Pleural Effusions / Pleural Effusions, Chronic / Pleurodesis1
4RecruitingOtherVaginal Surgeries1
4RecruitingPreventionHospitalization / Infection NOS1
4RecruitingPreventionInfection; Cesarean Section1
4RecruitingPreventionNeoplasms, Breast / Wound Infections1
4RecruitingTreatmentBacterial Infections1
4TerminatedNot AvailableSurgical Site Infections1
4TerminatedPreventionArthroplasty, Knee Replacement / Knee Replacement Surgery1
4Unknown StatusPreventionBacteriuria / Hospital Acquired Infections / Urinary Tract Infections (UTIs)1
4Unknown StatusPreventionInfection NOS / Misadventure During Aspirating Needle Biopsy / Prostatic Diseases1
4Unknown StatusTreatmentAmputation Wound / Wound Infections1
Not AvailableActive Not RecruitingScreeningMRSA/ MSSA Colonization of the Nares1
Not AvailableCompletedPreventionBacteremia1
Not AvailableCompletedPreventionColonization / Line Insertion Site1
Not AvailableCompletedPreventionInfective Complications Post-transrectal Prostate Biopsy1
Not AvailableCompletedPreventionSurgical Site Infections1
Not AvailableCompletedPreventionSuture Strabismus Surgery1
Not AvailableCompletedTreatmentContraception1
Not AvailableCompletedTreatmentSurgical Site Infections1
Not AvailableNot Yet RecruitingNot AvailableCardiovascular Disease, Colorectal Cancer1
Not AvailableNot Yet RecruitingPreventionWound Infections1
Not AvailableRecruitingDiagnosticInfective pericarditis1
Not AvailableRecruitingPreventionMotility Disorders / Staphylococcus Aureus1
Not AvailableRecruitingPreventionNeoplasms, Esophageal1
Not AvailableRecruitingTreatmentAdenoviral Conjunctivitis / Conjunctivitis1
Not AvailableRecruitingTreatmentPeriodontitis, Adult1
Not AvailableTerminatedNot AvailableBacterial blepharitis1
Not AvailableUnknown StatusDiagnosticDiabetic Macular Edema (DME) / Retinopathy, Diabetic1
Not AvailableUnknown StatusPreventionCentral Line-associated Bloodstream Infection (CLABSI) / Line Insertion Site1
Not AvailableUnknown StatusTreatmentHidradenitis Suppurativa (HS)1
Not AvailableUnknown StatusTreatmentSkin Burns1
Not AvailableWithdrawnPreventionInfection NOS1
Not AvailableWithdrawnPreventionSurgical Site Infections1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionTopical5 mg/1mL
OintmentTopical10 %
StickTopical10 %
SolutionTopical1 %
SolutionTopical7.5 mg/100mL
SolutionTopical10 %
SwabTopical0.1 mg/1mL
DoucheVaginal10 g/100g
OintmentTopical10 mg/1g
LiquidTopical10 1/100g
SolutionTopical8.1 g/100g
KitTopical
EmulsionTopical75 mg/1mL
Kit; liquidIntravenous
LiquidIntravenous
SolutionTopical50 mg/1mL
Kit0.3 g/100mL
SolutionOphthalmic5 mg/1mL
SprayTopical.05 mL/1mL
SprayTopical.5 mg/1mL
AerosolTopical5 g
SwabTopical450 mg
ShampooTopical7.5 %
LiquidTopical4 g
LiquidTopical7.5 g
DressingTopical1 mg
SwabTopical.01 mL/1
DoucheVaginal10 %
GelVaginal10 %
SuppositoryVaginal200 mg
KitInfiltration; Intra-articular; Intralesional; Intramuscular; Perineural; Topical
KitEpidural; Intra-articular; Intramuscular; Topical
LiquidSubcutaneous
Liquid; ointmentIntravenous; Topical
Kit; liquid; ointmentInfiltration; Parenteral; Subcutaneous; Topical
PatchTopical100 mg/1
SwabTopical1 %
GelTopical9.7 g/1mL
SolutionTopical9.5 g/1mL
SolutionTopical7.86 g/1mL
KitIntramuscular; Intravenous; Topical
KitTopical1 %
SwabTopical7.5 g/100g
GelTopical1.20 mL/100mL
LiquidTopical100 mg/7.5mL
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical
KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
SpongeTopical13 %
SpongeTopical10 %
SpongeTopical6.5 %
LiquidTopical6.5 %
SolutionTopical7.5 mL/100mL
KitEpidural; Infiltration
Kit; ointment; solutionInfiltration; Intravenous; Topical
LiquidTopical100 mg/1mL
LiquidTopical7.5 mg/100mL
SolutionTopical0.01 g/1mL
SolutionTopical1 g/100mL
SwabTopical0.2 g/1
PatchTopical10 g/100g
KitIntra-amniotic
Kit
SwabTopical10 g/100g
SpongeTopical10 mL/100mL
SpongeTopical7.5 mL/100mL
SolutionTopical7500 mg/100mL
Liquid; ointmentEpidural; Topical
SoapTopical3.9 g/100g
LiquidTopical10 %
LiquidTopical10 g/100g
GelTopical10 g/100g
SpongeTopical2 g/20g
KitInfiltration; Intramuscular; Intravenous; Topical
KitEpidural; Infiltration; Intramuscular; Intravenous; Topical
SolutionTopical1 g/100g
SolutionTopical1.18 g/118mL
LiquidTopical1 g/100mL
OintmentTopical100 mg/1g
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical
KitEpidural; Infiltration; Topical
LiquidTopical1 mg/10mL
SolutionTopical0.1 g/1
SolutionTopical0.10 g/1
OintmentTopical10 g/100g
PatchTopical100 mg/1g
GelTopical10 mg/1mL
LiquidTopical10 mg/1mL
KitEpidural; Infiltration; Intra-articular; Intramuscular; Topical
SpongeTopical10 mg/1mL
SpongeTopical5 mg/1mL
SolutionTopical.25 mL/5mL
Liquid; ointmentSubcutaneous; Topical
IrrigantTopical10 mg/1mL
LiquidInfiltration; Subcutaneous; Topical
LiquidEpidural; Intravenous
Kit; ointment; solutionInfiltration; Subcutaneous; Topical
LiquidTopical
KitInfiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical
KitEpidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical
KitInfiltration; Soft tissue; Topical
KitEpidural; Infiltration; Intracaudal; Perineural
KitEpidural; Infiltration; Intracaudal
SolutionTopical10 mL/100mL
SolutionTopical7.5 mg/1mL
SwabTopical10 mg/1mL
OintmentTopical1 g/10g
SolutionTopical.10 mg/1mL
SolutionTopical0.10 mg/1mL
SwabTopical1 mL/10mL
SwabTopical10 mL/100mL
SwabTopical100 mg/1mL
SpongeTopical0.1 mg/1mL
SpongeTopical7.5 mg/1mL
GelTopical0.10 g/1mL
OintmentTopical.10 g/1g
SolutionTopical.10 g/1mL
SwabTopical1 g/100mL
SolutionEpidural; Percutaneous; Topical.10 g/1
SwabTopical10 mg/100mL
ClothTopical10 g/1mL
SwabTopical0.75 mg/1mL
SwabTopical7.5 mg/1mL
SolutionTopical10.34 mg/1mL
SpongeTopical100 mg/1mL
SpongeTopical50 mg/1mL
SpongeTopical90 mg/1mL
LiquidTopical1 %
Aerosol, sprayTopical0.1 g/1g
OintmentTopical1 g/100g
SolutionTopical10 mg/1mL
SolutionTopical9.8 g/100g
SwabPercutaneous0.1 mL/1
SwabTopical0.05 g/1
SolutionTopical0.75 mg/1mL
StickTopical10 mg/1mL
SwabTopical9.43 g/100g
SolutionTopical0.1 g/1mL
SwabTopical1 mL/100mL
SwabTopical10 mg/1g
SwabPercutaneous10 mg/1
SwabPercutaneous10 mL/1
SwabTopical0.1 mL/1mL
SwabTopical0.10 g/1
SwabTopical100 mg/1
ClothTopical10 mg/1mL
SwabTopical100 mg/1g
SolutionEpidural; Percutaneous; Topical.10 mg/1mL
SolutionEpidural; Percutaneous; Topical0.10 mg/1mL
SpongeTopical100 mg/1g
SolutionTopical7.5 %
SwabTopical0.07 g/1
SpongeTopical75 mg/1g
SwabTopical75 mg/1g
SolutionTopical.075 mg/1mL
SolutionPercutaneous0.01 mg/1g
SolutionTopical1 mg/100mL
SolutionTopical1.1 mg/100mL
SolutionTopical100 mg/1mL
GelTopical
KitEpidural; Infiltration; Intra-articular; Intramuscular
SolutionTopical10 g/100g
SolutionTopical7.5 g/100g
AerosolTopical.5 %
LiquidTopical7.5 %
LiquidVaginal10 %
OintmentTopical10 mg
SuppositoryVaginal25 mg
EmulsionTopical7.5 mg/1mL
SwabTopical.10 g/1g
SolutionTopical0.006 g/0.6mL
SolutionTopical0.1 g/100mL
SolutionTopical0.75 g/100mL
SolutionTopical8 mL/100mL
SolutionTopical7.5 mg/1
SwabTopical0.9 g/100mL
SwabTopical0.9 mg/100mL
DoucheVaginal0.30 mL/100mL
Kit.3 g/100mL
SwabTopical10 %
LiquidTopical5 mg/1mL
SolutionTopical9 mg/1mL
SolutionTopical15 mg/1mL
SolutionTopical0.75 mg/100mL
SolutionTopical0.15 g/100mL
SolutionTopical0.9 g/100mL
LiquidTopical8.64 g/100mL
LiquidTopical.75 %
SolutionTopical
KitInfiltration; Topical
LiquidParenteral; Topical
KitTopical10 mg/1mL
DoucheVaginal4 g/133mL
SolutionTopical75 mg/1mL
LiquidTopical10.5 g/100mL
SwabTopical10 mg/1
SwabTopical10 mg/100mg
SolutionEpidural; Percutaneous; Topical.075 L/1L
SolutionEpidural; Percutaneous; Topical.075 mL/1mL
SolutionTopical.075 mL/1mL
SolutionTopical.10 L/1L
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7066916No2006-06-272024-02-17Us
US7595021No2009-09-292023-05-12Us
US7717889No2010-05-182025-02-27Us
US7935093No2011-05-032027-10-02Us
US7427574No2008-09-232026-04-25Us

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on September 14, 2010 10:21 / Updated on November 17, 2018 04:48