Showing BioInteractions for Pralatrexate (DB06813)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Pralatrexate is a Dihydrofolate reductase inhibitor
1	Dihydrofolate reductase inhibitors	Aminopterin, Lamotrigine, Methotrexate, Pemetrexed, Proguanil, Pyrimethamine, Trimetrexate
2	Dihydrofolate reductase substrates	Folic acid, Methotrexate, Trimetrexate

	Interacting Group	Interacting Drugs
	Pralatrexate is a Thymidylate synthase inhibitor
1	Thymidylate synthase inhibitors	Capecitabine, Gemcitabine, Methotrexate, Pemetrexed, Raltitrexed, Tegafur, Trifluridine
2	Thymidylate synthase substrates	Fluorouracil, Methotrexate
3	Thymidylate synthase antagonists	Tegafur-uracil

	Interacting Group	Interacting Drugs
	Pralatrexate is a Folylpolyglutamate synthase, mitochondrial substrate
1	Folylpolyglutamate synthase, mitochondrial antagonists	Raltitrexed
2	Folylpolyglutamate synthase, mitochondrial substrates	Methotrexate

	Interacting Group	Interacting Drugs
	Pralatrexate is a Folate transporter 1 substrate
1	Folate transporter 1 substrates	Levomefolic acid, Methotrexate, Trimetrexate

	Interacting Group	Interacting Drugs
	Pralatrexate is a Canalicular multispecific organic anion transporter 1 substrate
1	Canalicular multispecific organic anion transporter 1 inhibitors	5-methyltetrahydrofolic acid, Aminohippuric acid, Azithromycin, Cyclosporine, Daunorubicin, Ethinylestradiol, Etoposide, Furosemide, Fusidic acid, Glutathione, Glyburide, Grepafloxacin, Indomethacin, Ivermectin, Letermovir, Lomefloxacin, Lonafarnib, Methotrexate, Norgestimate, Octreotide, Ofloxacin, Pranlukast, Probenecid, Quinidine, Reserpine, Simeprevir, Sorafenib, Sparfloxacin, Sulfinpyrazone, Sunitinib, Telmisartan, Tetrahydrofolic acid, Tricarbonyl(1,10-phenanthroline)rhenium(1+), Vinblastine, Vincristine
2	Canalicular multispecific organic anion transporter 1 substrates	Aminohippuric acid, Atorvastatin, Avibactam, Azithromycin, Belantamab mafodotin, Canagliflozin, Carbamazepine, Carboplatin, Cerivastatin, Conjugated estrogens, Docetaxel, Doxorubicin, Eluxadoline, Erythromycin, Etoposide, Ezetimibe, Fexofenadine, Fluvastatin, Gadoxetic acid, Glutathione, Indinavir, Indomethacin, Irinotecan, Lovastatin, Methotrexate, Octreotide, Olmesartan, Oxaliplatin, Paclitaxel, Phenytoin, Pitavastatin, Pravastatin, Probenecid, Raloxifene, Ritonavir, Rosuvastatin, Saquinavir, Simeprevir, Simvastatin, Sulfasalazine, Sulfinpyrazone, Talinolol, Tamoxifen, Tenofovir disoproxil, Valsartan, Vasopressin, Vinblastine, Vincristine
3	Canalicular multispecific organic anion transporter 1 inducers	Arsenic trioxide, Cholic Acid, Cisplatin, Dexamethasone, Dexamethasone acetate, Eprosartan, Ethinylestradiol, Hyperforin, Nifedipine, Olmesartan, Phenobarbital, Quercetin, Rifampicin, Spironolactone, Taurocholic acid, Ursodeoxycholic acid, Vinblastine
4	Canalicular multispecific organic anion transporter 1 transporters	Indocyanine green acid form

	Interacting Group	Interacting Drugs
	Pralatrexate is a ATP-binding cassette sub-family G member 2 substrate
1	ATP-binding cassette sub-family G member 2 substrates	Abemaciclib, Afatinib, Allopurinol, Alpelisib, Alvocidib, Apixaban, Artesunate, Baricitinib, Berotralstat, Brigatinib, Camptothecin, Carboplatin, Celecoxib, Cerivastatin, Cisplatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dacomitinib, Dactinomycin, Darolutamide, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Dolutegravir, Donepezil, Doxorubicin, Duvelisib, Empagliflozin, Enasidenib, Ertugliflozin, Etoposide, Ezetimibe, Fimasartan, Fluorouracil, Folic acid, Fostemsavir, Gefitinib, Glasdegib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Larotrectinib, Leflunomide, Lenvatinib, Lusutrombopag, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nifurtimox, Nilotinib, Nitrofurantoin, Ombitasvir, Osimertinib, Oxaliplatin, Ozanimod, Palbociclib, Pantoprazole, Pazopanib, Pemigatinib, Pibrentasvir, Pitavastatin, Ponatinib, Pralsetinib, Prasterone, Pravastatin, Prazosin, Raloxifene, Revefenacin, Riluzole, Rimegepant, Riociguat, Ripretinib, Risdiplam, Rivaroxaban, Rosuvastatin, Rucaparib, Selpercatinib, Selumetinib, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sumatriptan, Talazoparib, Tamoxifen, Tazemetostat, Tegaserod, Teniposide, Tenofovir alafenamide, Teriflunomide, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Topotecan, Trastuzumab deruxtecan, Tucatinib, Ubrogepant, Upadacitinib, Velpatasvir, Vemurafenib, Vincristine, Voxilaprevir, Zidovudine
2	ATP-binding cassette sub-family G member 2 inhibitors	Abemaciclib, Afatinib, Alectinib, Avatrombopag, Baricitinib, Beclomethasone dipropionate, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Cannabidiol, Capmatinib, Clofazimine, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Dacomitinib, Daidzin, Darolutamide, Dasabuvir, Dasatinib, Dexamethasone, Dexamethasone acetate, Diethylstilbestrol, Dovitinib, Dronabinol, Elacridar, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Fedratinib, Fostamatinib, Fostemsavir, Fusidic acid, Gefitinib, Genistein, Gilteritinib, Glasdegib, Glecaprevir, Hesperetin, Imatinib, Isavuconazole, Istradefylline, Lansoprazole, Lasmiditan, Letermovir, Lonafarnib, Medical Cannabis, Nabiximols, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Olaparib, Omeprazole, Palbociclib, Pantoprazole, Paritaprevir, Pibrentasvir, Ponatinib, Pralsetinib, Progesterone, Quercetin, Rabeprazole, Regorafenib, Relugolix, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Safinamide, Saquinavir, Selpercatinib, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Tafamidis, Taurocholic acid, Telmisartan, Teriflunomide, Topiroxostat, Upadacitinib, Vandetanib, Velpatasvir, Vemurafenib, Venetoclax, Vismodegib, Voxilaprevir
3	ATP-binding cassette sub-family G member 2 inducers	Apalutamide, Cholesterol, Dovitinib, Progesterone, Venlafaxine
4	ATP-binding cassette sub-family G member 2 antagonists	Zafirlukast
5	ATP-binding cassette sub-family G member 2 weak inhibitors	Cobimetinib
6	ATP-binding cassette sub-family G member 2 transporters	Ledipasvir
7	ATP-binding cassette sub-family G member 2 modulators	Avapritinib