This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Protokylol
Accession Number
DB06814
Type
Small Molecule
Groups
Approved, Vet approved
Description

Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.

Structure
Thumb
Synonyms
  • Protokylolum
  • Protoquilol
External IDs
AN 1031 / JB 251
Product Ingredients
IngredientUNIICASInChI Key
Protokylol hydrochloride7U7O8Q48IO136-69-6LOVXREQUMZKFCM-UHFFFAOYSA-N
International/Other Brands
Asmetil / Caytine / Palison / Ventaire
Categories
UNII
8Y5Y4EEO2V
CAS number
136-70-9
Weight
Average: 331.368
Monoisotopic: 331.14197278
Chemical Formula
C18H21NO5
InChI Key
LUMAEVHDZXIGEP-UHFFFAOYSA-N
InChI
InChI=1S/C18H21NO5/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3
IUPAC Name
4-(2-{[1-(2H-1,3-benzodioxol-5-yl)propan-2-yl]amino}-1-hydroxyethyl)benzene-1,2-diol
SMILES
CC(CC1=CC=C2OCOC2=C1)NCC(O)C1=CC=C(O)C(O)=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
ABeta-2 adrenergic receptor
agonist
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Protokylol.
AcebutololThe therapeutic efficacy of Protokylol can be decreased when used in combination with Acebutolol.
AcepromazineAcepromazine may decrease the vasoconstricting activities of Protokylol.
AlclometasoneThe risk or severity of hypokalemia can be increased when Alclometasone is combined with Protokylol.
AlfuzosinAlfuzosin may decrease the vasoconstricting activities of Protokylol.
AlprenololAlprenolol may decrease the bronchodilatory activities of Protokylol.
AmcinonideThe risk or severity of hypokalemia can be increased when Amcinonide is combined with Protokylol.
AmineptineThe risk or severity of adverse effects can be increased when Amineptine is combined with Protokylol.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Protokylol.
AmitriptylinoxideThe risk or severity of adverse effects can be increased when Amitriptylinoxide is combined with Protokylol.
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
4798
ChEBI
135413
ChEMBL
CHEMBL1201273
Wikipedia
Protokylol

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.236 mg/mLALOGPS
logP1.29ALOGPS
logP1.48ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)9.86ChemAxon
pKa (Strongest Basic)8.98ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area91.18 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity88.78 m3·mol-1ChemAxon
Polarizability35.44 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately ...
Gene Name
ADRB2
Uniprot ID
P07550
Uniprot Name
Beta-2 adrenergic receptor
Molecular Weight
46458.32 Da
References
  1. Aggerbeck M, Guellaen G, Hanoune J: N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. Br J Pharmacol. 1979 Jan;65(1):155-9. [PubMed:216448]

Drug created on September 14, 2010 10:21 / Updated on August 02, 2018 07:54