Protokylol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Protokylol
Accession Number
DB06814
Type
Small Molecule
Groups
Approved, Vet approved
Description

Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.

Structure
Thumb
Synonyms
  • Protokylolum
  • Protoquilol
External IDs
AN 1031 / JB 251
Product Ingredients
IngredientUNIICASInChI Key
Protokylol hydrochloride7U7O8Q48IO136-69-6LOVXREQUMZKFCM-UHFFFAOYSA-N
International/Other Brands
Asmetil / Caytine / Palison / Ventaire
Categories
UNII
8Y5Y4EEO2V
CAS number
136-70-9
Weight
Average: 331.368
Monoisotopic: 331.14197278
Chemical Formula
C18H21NO5
InChI Key
LUMAEVHDZXIGEP-UHFFFAOYSA-N
InChI
InChI=1S/C18H21NO5/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3
IUPAC Name
4-(2-{[1-(2H-1,3-benzodioxol-5-yl)propan-2-yl]amino}-1-hydroxyethyl)benzene-1,2-diol
SMILES
CC(CC1=CC=C2OCOC2=C1)NCC(O)C1=CC=C(O)C(O)=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
ABeta-2 adrenergic receptor
agonist
Humans
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
1-benzylimidazole1-benzylimidazole may decrease the hypertensive activities of Protokylol.
2,5-Dimethoxy-4-ethylamphetamineThe therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be increased when used in combination with Protokylol.
2,5-Dimethoxy-4-ethylthioamphetamineThe therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when used in combination with Protokylol.
4-Bromo-2,5-dimethoxyamphetamineThe therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be increased when used in combination with Protokylol.
4-MethoxyamphetamineThe risk or severity of Tachycardia can be increased when 4-Methoxyamphetamine is combined with Protokylol.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Protokylol.
AbediterolThe risk or severity of adverse effects can be increased when Protokylol is combined with Abediterol.
AcebutololThe therapeutic efficacy of Protokylol can be decreased when used in combination with Acebutolol.
AcepromazineThe therapeutic efficacy of Protokylol can be decreased when used in combination with Acepromazine.
AcetazolamideThe risk or severity of Cardiac Arrhythmia can be increased when Protokylol is combined with Acetazolamide.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Evidence Level

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
4798
ChEBI
135413
ChEMBL
CHEMBL1201273
Wikipedia
Protokylol

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.236 mg/mLALOGPS
logP1.29ALOGPS
logP1.48ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)9.86ChemAxon
pKa (Strongest Basic)8.98ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area91.18 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity88.78 m3·mol-1ChemAxon
Polarizability35.44 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately ...
Gene Name
ADRB2
Uniprot ID
P07550
Uniprot Name
Beta-2 adrenergic receptor
Molecular Weight
46458.32 Da
References
  1. Aggerbeck M, Guellaen G, Hanoune J: N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. Br J Pharmacol. 1979 Jan;65(1):155-9. [PubMed:216448]

Drug created on September 14, 2010 10:21 / Updated on November 02, 2018 08:52