Pyrithione

Identification

Name
Pyrithione
Accession Number
DB06815
Type
Small Molecule
Groups
Approved
Description

Pyrithione zinc, or zinc pyrithione or zinc pyridinethione, is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. In the crystalline state, it exists as a centrosymmetric dimer. Due to its dynamic fungistatic and bacteriostatic properties, pyrithione zinc is used to treat dandruff and seborrheic dermatitis. Dandruff is a common scalp disease affecting >40% of the world's adult population, and may be caused by fungi such as Malassezia globosa and M. restricta [3].

Pyrithione zinc is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos. It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth [1]. Due to low solubility, pyrithione zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces [2]. Other uses of pyrithione zinc include additive in antifouling outdoor paints and algaecide. While its use has been approved in the early 1960's by the FDA [4], safety and effectiveness of pyrithione zinc has been reported for decades. It is not shown to have any significant estrogenic activity according to the in vivo and in vitro assays [4].

Structure
Thumb
Synonyms
  • 2-pyridinethiol 1-oxide
  • Omadine
  • Pyridinethiol N-oxide
External IDs
NSC-290409
Product Ingredients
IngredientUNIICASInChI Key
Pyrithione sodium6L3991491R3811-73-2WNGMMIYXPIAYOB-UHFFFAOYSA-M
Pyrithione zincR953O2RHZ513463-41-7OTPSWLRZXRHDNX-UHFFFAOYSA-L
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dermazinc CreamCream2.5 mgTopicalDermalogix Partners, Inc.Not applicableNot applicableCanada
Dermazinc ShampooShampoo20 mgTopicalDermalogix Partners, Inc.Not applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2 In 1Shampoo10.4 mg/1mLTopicalTarget Corporation.2013-05-16Not applicableUs
2 In 1Shampoo10.3 mg/1mLTopicalTarget Corporation.2013-05-06Not applicableUs
2 In 1Shampoo10.3 mg/1mLTopicalWalmart Stores2012-07-12Not applicableUs
2 In 1 Anti-dandruff Shampoo and ConditionerLotion1 %TopicalAvon Products, Inc.2003-10-092010-07-30Canada
2 in 1 AntidandruffShampoo10 mg/1mLTopicalApollo Health and Beauty Care Inc.2017-03-29Not applicableUs
2 In 1 Conditioning Dandruff ShampooShampoo1 %TopicalScott Chemical Canada2000-01-012005-09-16Canada
2 In 1 Conditioning Dandruff Treatment ShampooShampoo1 %TopicalAPOLLO HEALTH AND BEAUTY CARE2002-10-302011-07-07Canada
2 in 1 DandruffShampoo1 g/1mLTopicalWakfern Food Corporation2014-07-16Not applicableUs
2 in 1 DandruffShampoo1 g/1mLTopicalDza Brands,2015-03-20Not applicableUs
2 in 1 DandruffShampoo1 g/1mLTopicalDolgencorp2016-01-18Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
ActiprepPyrithione zinc (1 %) + Ethanol (83 %)LiquidTopicalHealthpoint2002-09-122004-07-13Canada
D-COL Personal Hygiene Convenience kitPyrithione zinc (10 mg/1mL) + Chloroxylenol (2.4 mg/1mL)KitD-COL Inc2018-05-30Not applicableUs
Head and Shoulders Dual Sachets Classic CleanPyrithione zinc (1 g/100mL) + Pyrithione zinc (0.5 g/100mL)KitProcter And Gamble2013-09-27Not applicableUs
Head and Shoulders Dual Sachets Classic CleanPyrithione zinc (1 g/100mL) + Pyrithione zinc (0.5 g/100mL)KitProcter And Gamble2013-09-27Not applicableUs
Head and Shoulders Dual Sachets Full and StrongPyrithione zinc (1 g/100mL) + Pyrithione zinc (5 mg/1mL)KitProcter And Gamble2014-01-272018-03-01Us
Head and Shoulders Dual Sachets Full and StrongPyrithione zinc (1 g/100mL) + Pyrithione zinc (5 mg/1mL)KitProcter And Gamble2014-01-272018-03-01Us
Head and Shoulders Dual Sachets Green ApplePyrithione zinc (1 g/100mL) + Pyrithione zinc (5 mg/1mL)KitProcter And Gamble2014-01-272018-03-01Us
Head and Shoulders Dual Sachets Green ApplePyrithione zinc (1 g/100mL) + Pyrithione zinc (5 mg/1mL)KitProcter And Gamble2014-01-272018-03-01Us
Head and Shoulders Dual Sachets Instant ReliefPyrithione zinc (1 g/100mL) + Pyrithione zinc (0.5 g/100mL)KitProcter And Gamble2016-01-10Not applicableUs
Head and Shoulders Dual Sachets Instant ReliefPyrithione zinc (1 g/100mL) + Pyrithione zinc (0.5 g/100mL)KitProcter And Gamble2016-01-10Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Add More HairPyrithione zinc (0.28 g/100mL) + Panthenol (0.5 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2018-06-09Not applicableUs
Add More HairPyrithione zinc (0.29 g/100mL) + Panthenol (0.5 g/100mL) + Salicylic acid (0.2 g/100mL)ShampooTopicalCoretree Co.,Ltd2017-03-01Not applicableUs
Anti Hair LossPyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g)SoapTopicalGolden B America, Llc.2018-03-13Not applicableUs
Bonnoir Hair MediPyrithione zinc (7.35 mL/350mL) + Biotin (0.21 mL/350mL) + Nicotinamide (1.05 mL/350mL) + Panthenol (1.75 mL/350mL)ShampooTopicalCellinbio Co Ltd2011-07-27Not applicableUs
Bonogen hair care shampooPyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.5 g/100g)ShampooTopicalBonogen Co., Ltd2010-03-01Not applicableUs
Bonogen Plus hair care shampooPyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.6 g/100g)ShampooTopicalBonogen Co., Ltd2010-04-09Not applicableUs
Born HairPyrithione zinc (2.1 g/100g) + Biotin (0.06 g/100g) + Nadide (0.3 g/100g) + Panthenol (0.6 g/100g)ShampooTopicalBonogen Co., Ltd2010-04-09Not applicableUs
Carione RgPyrithione zinc (2.1 g/100mL) + Biotin (0.06 g/100mL) + Nicotinamide (0.3 g/100mL) + Panthenol (0.5 g/100mL)ShampooTopicalCell Activation Research Institute Co., Ltd2016-07-31Not applicableUs
Doll LashPyrithione zinc (2 mL/100mL) + Biotin (0.06 mL/100mL) + Nicotinamide (0.3 mL/100mL) + Panthenol (0.5 mL/100mL)LiquidTopicalHanbit Korea2010-11-06Not applicableUs
Dong Sung Anti-Hair LossPyrithione zinc (2.1 g/100mL) + Biotin (0.06 g/100mL) + Nicotinamide (0.3 g/100mL) + Panthenol (0.5 g/100mL)ShampooTopicalDaolcosmetic Co.,ltd2016-03-302016-04-01Us
Categories
UNII
6GK82EC25D
CAS number
1121-31-9
Weight
Average: 127.16
Monoisotopic: 127.009184959
Chemical Formula
C5H5NOS
InChI Key
FGVVTMRZYROCTH-UHFFFAOYSA-N
InChI
InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H
IUPAC Name
2-sulfanylpyridin-1-ium-1-olate
SMILES
[O-][N+]1=C(S)C=CC=C1

Pharmacology

Indication

Indicated for the treatment of dandruff and seborrheic dermatitis [2].

Associated Conditions
Pharmacodynamics

Pyrithione zinc has a broad antimicrobial spectrum of activity, including fungi, gram-positive and gram-negative bacteria [2]. Pyrithione zinc is effective against Malassezia and all other fungi, especially the Malassezia species found on scalp [5]. In patients with dandruff, treatment with pyrithione zinc reduced the amount of fungus on the scalp, which reduces the amount of free fatty acids, thereby reducing scalp flaking and itch [5].

Mechanism of action

Inhibition of fungal growth by pyrithione zinc is linked to increased copper uptake and cellular levels of copper, which is demonstrated by decreased CTR1-lacZ expression and slightly increased CUP1-lacZ expression in affected microorganisms [3]. The coordination complex of pyrithione zinc dissociates, and pyrithione ligand forms a CuPT complex from available extracellular copper in the target organism. Pyrithione acts as an ionophore, interacting nonspecifically with the plasma membrane to shuttle copper into the cell, and facilitates copper transport across intracellular membranes [3]. Copper may be shuttled into the mitochondria. Copper inactivates iron-sulfur (Fe-S) cluster-containing proteins via a mechanism similar to that described for copper-induced growth inhibition in bacteria [3]. Decreased activity of Fe-S proteins leads to inhibition of fungal metabolism and fungal growth. Pyrithione zinc has been shown to slightly increase the levels of zinc [3].

Absorption

Following oral ingestion, only the pyrithione moiety is absorbed. Less than 1% of administered zinc pyrithione is absorbed from the skin [6]. Radioabeled Zn pyrithione administered to rats, rabbits and monkeys, either orally or via intraperitoneal injection were absorbed into circulatin to extent of 80-90% [6].

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

After oral administration in rabbits, rats, monkeys, and dogs, pyrithione zinc is biotransformed into 2-pyridinethiol 1-oxide S-glucuronide and 2-pyridinethiol S-glucuronide [6].

Route of elimination

The major route of elimination from the body after oral administration in rat was urine, with S-glucuronides of 2-mercaptopyridine-N-oxide being the major metabolites and 2-mercaptopyridine-N-oxide as the minor metabolite. Following oral administration, the majority of zinc is eliminated in the feces [6]. Upon dermal administration, >90% of recovery was obtained from washings of the application site of pigs. Urinary excretion was 3% in animals with intact skin [6].

Half life
Not Available
Clearance
Not Available
Toxicity

Acute oral LD50 value is 177 mg/kg in rat and 160 mg/kg in mouse. Acute dermal LD50 was 100 mg/kg in rabbit [MSDS].

Affected organisms
  • Yeast and other fungi
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcetaminophenAcetaminophen may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
AlprazolamAlprazolam may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Illicit, Investigational
AmilorideAmiloride may increase the excretion rate of Pyrithione which could result in a lower serum level and potentially a reduction in efficacy.Approved
AmlodipineAmlodipine may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
AmoxicillinAmoxicillin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
AmphetamineAmphetamine may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Illicit, Investigational
AmpicillinAmpicillin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
AuranofinAuranofin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
BaclofenBaclofen may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
BudesonideBudesonide may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
BumetanideBumetanide may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
CevimelineCevimeline may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
ChlorpromazineChlorpromazine may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational, Vet Approved
ChlorzoxazoneChlorzoxazone may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
ClonazepamPyrithione may decrease the excretion rate of Clonazepam which could result in a higher serum level.Approved, Illicit
ClorazepateClorazepate may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Illicit
CyanocobalaminCyanocobalamin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Nutraceutical
DaptomycinDaptomycin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
DiazepamDiazepam may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Illicit, Investigational, Vet Approved
DiclofenacDiclofenac may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
DiflunisalDiflunisal may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
DoxycyclineDoxycycline may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational, Vet Approved
EthambutolEthambutol may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
FluconazoleFluconazole may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
FlurbiprofenFlurbiprofen may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
Folic AcidFolic Acid may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Nutraceutical, Vet Approved
GentamicinGentamicin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
HaloperidolHaloperidol may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
HydralazineHydralazine may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
HydroxocobalaminHydroxocobalamin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
IbuprofenIbuprofen may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
IcosapentIcosapent may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Nutraceutical
ImipraminePyrithione may decrease the excretion rate of Imipramine which could result in a higher serum level.Approved
IndomethacinIndomethacin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
IopromidePyrithione may decrease the excretion rate of Iopromide which could result in a higher serum level.Approved
IoversolPyrithione may decrease the excretion rate of Ioversol which could result in a higher serum level.Approved
KetamineKetamine may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
KetoprofenKetoprofen may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
KetorolacKetorolac may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
LeuprolideLeuprolide may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
LisinoprilLisinopril may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
LorazepamLorazepam may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
MannitolMannitol may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
Medroxyprogesterone acetateMedroxyprogesterone acetate may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
MetforminMetformin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
MethylphenidateMethylphenidate may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
MetolazoneMetolazone may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
NaproxenNaproxen may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
NeomycinNeomycin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
OseltamivirOseltamivir may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
ParoxetineParoxetine may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
PindololPindolol may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
Potassium ChloridePotassium Chloride may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Withdrawn
PropranololPropranolol may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
PyridoxinePyridoxine may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational, Nutraceutical, Vet Approved
SalbutamolSalbutamol may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
Salmon CalcitoninSalmon Calcitonin may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Investigational
Sodium aurothiomalatePyrithione may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.Approved, Investigational
SpironolactoneSpironolactone may increase the excretion rate of Pyrithione which could result in a lower serum level and potentially a reduction in efficacy.Approved
SucralfateSucralfate may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
TerbutalineTerbutaline may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
Testosterone cypionatePyrithione may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.Approved
Testosterone enanthatePyrithione may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.Approved
TimololTimolol may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
TrimebutinePyrithione may decrease the excretion rate of Trimebutine which could result in a higher serum level.Approved
TrimethoprimTrimethoprim may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved, Vet Approved
VerapamilVerapamil may decrease the excretion rate of Pyrithione which could result in a higher serum level.Approved
WarfarinPyrithione may decrease the excretion rate of Warfarin which could result in a higher serum level.Approved
Food Interactions
Not Available

References

Synthesis Reference

Schwartz JR: Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics. J Drugs Dermatol. 2016 Feb;15(2):140-4.

General References
  1. Reeder NL, Xu J, Youngquist RS, Schwartz JR, Rust RC, Saunders CW: The antifungal mechanism of action of zinc pyrithione. Br J Dermatol. 2011 Oct;165 Suppl 2:9-12. doi: 10.1111/j.1365-2133.2011.10571.x. [PubMed:21919897]
  2. Schwartz JR: Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics. J Drugs Dermatol. 2016 Feb;15(2):140-4. [PubMed:26885780]
  3. Reeder NL, Kaplan J, Xu J, Youngquist RS, Wallace J, Hu P, Juhlin KD, Schwartz JR, Grant RA, Fieno A, Nemeth S, Reichling T, Tiesman JP, Mills T, Steinke M, Wang SL, Saunders CW: Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins. Antimicrob Agents Chemother. 2011 Dec;55(12):5753-60. doi: 10.1128/AAC.00724-11. Epub 2011 Sep 26. [PubMed:21947398]
  4. Yoon KS, Youn N, Gu H, Kwack SJ: Estrogenic activity of zinc pyrithione: an in vivo and in vitro study. Environ Health Toxicol. 2017 Feb 9;32:e2017004. doi: 10.5620/eht.e2017004. eCollection 2017. [PubMed:28183164]
  5. DeAngelis YM, Gemmer CM, Kaczvinsky JR, Kenneally DC, Schwartz JR, Dawson TL Jr: Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity. J Investig Dermatol Symp Proc. 2005 Dec;10(3):295-7. doi: 10.1111/j.1087-0024.2005.10119.x. [PubMed:16382685]
  6. Pyrithione zinc - National Library of Medicine HSDB Database - Toxnet [Link]
External Links
PubChem Compound
26041
PubChem Substance
347827800
ChemSpider
10446934
BindingDB
50366038
ChEBI
36584
ChEMBL
CHEMBL1356238
Wikipedia
Pyrithione_zinc
ATC Codes
D11AX12 — Pyrithione zinc
AHFS Codes
  • 84:28.00 — Keratolytic Agents
  • 84:04.92 — Miscellaneous Local Anti-infectives
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedBasic ScienceHealthy Volunteers3
1CompletedTreatmentDisseminated Sclerosis1
1, 2CompletedTreatmentAnterior Cruciate Ligament Injury / Osteoarthritis (OA)1
2CompletedTreatmentHigh Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
3RecruitingTreatmentAcute Urticaria1
3TerminatedSupportive CareCancer, Breast / Lung Cancers / Pain1
4CompletedSupportive CareOral Lichen Planus1
4CompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
Not AvailableCompletedNot AvailablePoisoning caused by organophosphorus pesticides1
Not AvailableCompletedNot AvailablePulmonary Embolism (PE) / Sinus Thrombosis, Intracranial / Thrombosis, Venous1
Not AvailableCompletedTreatmentOral Contraceptives (OC)1
Not AvailableRecruitingTreatmentAtopic Dermatitis (AD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
ShampooTopical10.3 mg/1mL
ShampooTopical1 g/1mL
ShampooTopical1.2 %
LotionTopical1 %
LotionTopical0.1 %
LotionTopical0.15 mL/150mL
ShampooTopical0.15 g/1mL
SoapTopical2 g/1000g
LotionTopical10 mg/1g
ShampooCutaneous0.01 mg/1mL
ShampooTopical1 mg/1mL
ShampooCutaneous10 mg/1mL
SoapTopical
ShampooTopical0.05 g/100g
ShampooTopical2.0 %
ShampooTopical10 mg/1000mg
ShampooTopical20 mg/1mL
EmulsionTopical10 mg/1g
LotionTopical2.14 mg/1mL
ShampooTopical2.14 mg/1mL
ShampooTopical10.32 mg/1mL
CreamTopical2.14 mg/1mL
LiquidTopical0.2 %
ShampooTopical10.2 mg/1mL
LiquidTopical10.2 mg/1mL
LiquidTopical4.9 mg/1mL
CreamTopical0.2 g/100g
Liquid; shampooTopical1 %
ShampooTopical2.3 g/230g
ShampooTopical1.05 g/100mL
Lotion / shampooTopical.1 g/10g
Lotion / shampooTopical.5 g/10g
Lotion / shampooTopical1 g/10g
ShampooTopical4.5 mL/300mL
SprayTopical0.19 mg/1mL
CreamTopical0.2 mg/1mL
ShampooTopical
CreamTopical.1 %
ShampooTopical1 g/100g
ShampooTopical5.7 g/285mL
ShampooTopical5.8 mg/290mL
GelTopical0.1 %
SuspensionTopical0.5 g/100mL
ShampooTopical1.0 g/100mL
LotionTopical0.0036 mg/1mL
LiquidTopical15 g/300mL
ShampooCutaneous3 g/300g
ShampooTopical2 %
Lotion / shampooTopical1 kg/100kg
Lotion / shampooTopical1 g/100mL
ShampooTopical1 kg/100L
ShampooTopical1.9 g/100mL
ShampooTopical10.4 mg/1mL
ShampooTopical100 g/1mL
ShampooTopical9.5 mg/100mL
Shampoo, suspensionTopical958 mg/1mL
Lotion / shampooTopical1.0000 mL/100mL
SuspensionTopical0.5 %
Lotion / shampooTopical0.500 mL/100mL
CreamTopical1 %
ShampooTopical1.45 %
Lotion / shampooTopical1 kg/100L
SuspensionTopical1 %
LotionTopical1.0 %
SuspensionTopical1.0 %
GelTopical2.0 g/100mL
CreamTopical2.5 mg
ShampooTopical20 mg
SprayTopical2.5 mg
SolutionTopical0.95 g/100g
LiquidTopical
CreamTopical1 mg/1mL
LiquidTopical0.5 g/100mL
ShampooTopical14 mg/1mL
ShampooTopical1.2 g/100g
ShampooTopical12 g/1L
SolutionTopical2.4 mg/500mL
SolutionTopical0.09 g/100mL
ShampooTopical1.2 g/100mL
ShampooTopical10 mL/1000mL
ShampooTopical65.7 g/1000mL
LiquidTopical3 mg/1mL
LiquidTopical0.05 g/1mL
ShampooTopical5.28 mg/1mL
LiquidTopical0.0036 mg/1mL
LiquidTopical0.00528 g/1mL
LiquidTopical0.011 mg/1mL
LiquidTopical0.0034 mg/1mL
ShampooTopical1.0 g
ShampooTopical10 mg/10mL
ShampooTopical1 g/100mL
ShampooTopical1.008 g/100mL
ShampooTopical0.000048 g/100mL
ShampooTopical1.8 mg/300mL
ShampooTopical2 g/100mL
ShampooTopical3.84 mL/384mL
ShampooTopical7.5 mL/750mL
ShampooTopical12 mg/1mL
ShampooTopical2.5 g/250g
ShampooTopical1.68 %
ShampooTopical6 mg/300mL
ShampooTopical0.1 mL/100mL
SolutionTopical0.1 mL/100mL
ShampooTopical0.0095 g/1mL
ShampooTopical0.75 %
LotionTopical0.5 %
ShampooTopical0.5 %
CreamTopical0.75 %
Lotion / shampooTopical10 mg/1mL
LiquidTopical0.1 g/100mL
Lotion / shampooTopical0.5 g/1mL
LotionTopical5 mg/1mL
Lotion / shampooTopical2 g/100mL
Lotion / shampooTopical20 mg/1mL
Lotion / shampooTopical1 g/1mL
ShampooTopical0.01 g/1mL
LotionTopical0.5 mg/100mL
Lotion / shampooTopical.01 g/1mL
Lotion / shampooTopical0.01 g/1mL
Lotion / shampooTopical7.5 mg/1mL
ShampooTopical1.5 g/100g
ShampooTopical15 mg/1mL
EmulsionTopical1.0 g/100g
ShampooTopical15.4 g/1L
ShampooTopical1.0 g/100g
ShampooTopical1.8 %
LiquidTopical1 g/100mL
LotionTopical2 mg/1mL
ShampooTopical1.5 %
LiquidTopical2.1 g/100mL
ShampooTopical0.00336 g/1mL
ShampooTopical1 %
ShampooTopical5 mL/500mL
ShampooTopical0.3 mL/100mL
ShampooTopical.01 g/1g
Shampoo, suspensionTopical.01 g/1g
ShampooTopical1.8 g/100mL
ShampooTopical15.0 g/1.0L
ShampooTopical3.0 g/300g
ShampooTopical1.008 g
LotionTopical10 mg/1mL
ShampooTopical1.20000 mg/240mL
ShampooTopical10.5 mg/1mL
ShampooTopical2.52000 mg/240mL
ShampooTopical10.0 g/500mL
GelTopical0.48 g/100mL
Kit
ShampooTopical10 mg/1mL
LotionTopical0.5 g/100mL
Lotion / shampooTopical1 mg/1mL
LiquidTopical0.97 mg/1mL
Lotion / shampooTopical0.1 g/100mL
SolutionTopical0.1 %
CreamTopical1 mL/100mL
LiquidTopical1 %
LiquidTopical1.0 %
GelTopical2.0 g/100g
ShampooTopical4.04 g/400mL
Shampoo, suspensionTopical0.45 mL/100mL
Shampoo, suspensionTopical1 mL/100mL
CreamTopical3 mg/1000mL
ShampooTopical1 mg/100mL
LiquidTopical29 mg/1mL
ShampooTopical2.41 g/237mL
GelTopical1 %
ShampooTopical1.0 %
ShampooCutaneous0.6 mL/360mL
ShampooTopical2.1 g/100mL
ShampooTopical1 mL/100mL
LiquidTopical10 mg/1mL
LiquidTopical1 mL/100mL
LiquidTopical1.0 mL/100mL
CreamTopical95 mg/1mL
ShampooTopical9.5 mg/1mL
SuspensionTopical0.95 %
ShampooTopical1.9 %
ShampooTopical0.95 %
ShampooTopical5 g/250g
ShampooTopical10 mg/1g
ShampooTopical3 mg/300mL
SolutionTopical0.95 g/100mL
AerosolTopical2 mg
ShampooTopical6 mg/1mL
ShampooTopical1 g
SuspensionTopical0.25 %
ShampooTopical0.5 mL/100mL
ShampooTopical1.0 mL/100mL
SuspensionTopical0.5 mL/100mL
CreamTopical1 mg/1g
Shampoo, suspensionTopical10 mg/1mL
LotionTopical1 mg/1mL
Lotion / shampooTopical1.2 g/1mL
ShampooTopical.01 g/.01g
RinseTopical.005 g/1g
RinseTopical5 mg/1mL
LotionTopical
ShampooTopical10 g
ShampooTopical5 g/500g
CreamTopical250 mg/100g
LiquidTopical.15 %
ShampooTopical2 g/100g
Lotion / shampooTopical20 mg/400mg
ShampooTopical20 mg/400mg
LiquidTopical2 g/100mL
SoapTopical2 g/100g
CreamTopical0.2 %
SprayTopical0.2 %
SoapTopical0.020 g/1
SoapTopical2 %
CreamTopical.5 %
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
boiling point (°C)100 (Zinc salt)MSDS
water solubilitySoluble in cold water (Zinc salt)MSDS
Predicted Properties
PropertyValueSource
Water Solubility3.0 mg/mLALOGPS
logP0.87ALOGPS
logP0.2ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)6.84ChemAxon
pKa (Strongest Basic)0.66ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area26.94 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity34.48 m3·mol-1ChemAxon
Polarizability12.19 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on September 14, 2010 10:21 / Updated on September 17, 2018 20:59