Showing BioInteractions for DB08916 (Afatinib)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Afatinib is a Epidermal growth factor receptor inhibitor
1Epidermal growth factor receptor antagonistsCetuximab, Erlotinib, Gefitinib, Icotinib, Lapatinib, Lidocaine, Necitumumab, Zalutumumab
2Epidermal growth factor receptor suppressorsPanitumumab
3Epidermal growth factor receptor inhibitorsNeratinib, Olmutinib, Osimertinib, Vandetanib
4Epidermal growth factor receptor antibodiesDepatuxizumab mafodotin
Interacting GroupInteracting Drugs
Afatinib is a Receptor tyrosine-protein kinase erbB-2 inhibitor
1Receptor tyrosine-protein kinase erbB-2 antagonistsLapatinib
2Receptor tyrosine-protein kinase erbB-2 antibodiesPertuzumab, Trastuzumab, Trastuzumab emtansine
Interacting GroupInteracting Drugs
Afatinib is a Multidrug resistance protein 1 substrate
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Apixaban, Arsenic trioxide, Atazanavir, Atenolol, Axitinib, Belinostat, Betamethasone, Bosutinib, Brentuximab vedotin, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carbamazepine, Carfilzomib, Ceritinib, Cerivastatin, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Dihydrotestosterone, Diltiazem, Dipyridamole, Docetaxel, Domperidone, Doxorubicin, Edoxaban, Elbasvir, Eletriptan, Enasidenib, Epinastine, Erlotinib, Estradiol, Estriol, Estrone, Ethinyl Estradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluticasone furoate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ketazolam, Ketoconazole, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Osimertinib, Paclitaxel, Panobinostat, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Reserpine, Rifampicin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salicylic acid, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Sorafenib, Sparfloxacin, Sphingosine, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Ulipristal, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Albendazole, Alectinib, Alfentanil, Amantadine, Aminohippuric acid, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Amsacrine, Astemizole, Atazanavir, Atenolol, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Biperiden, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carbamazepine, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorpropamide, Chlorprothixene, Cholesterol, Cilazapril, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Dexamethasone, Dextromethorphan, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Etravirine, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Glycerin, Gramicidin D, Grepafloxacin, Haloperidol, Hydrocortisone, Idelalisib, Imatinib, Imipramine, Indinavir, Indomethacin, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ketamine, Ketoconazole, Lansoprazole, Lapatinib, Letermovir, Levofloxacin, Lidocaine, Lomitapide, Loperamide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Maprotiline, Mebendazole, Mefloquine, Megestrol acetate, Meprobamate, Methadone, Metoprolol, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitomycin, Mitoxantrone, Morphine, Naltrexone, Naringenin, Nelfinavir, Neostigmine, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrazepam, Nitrendipine, Omeprazole, P-Nitrophenol, Paclitaxel, Palmitic Acid, Pantoprazole, Paroxetine, Perindopril, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Pravastatin, Prazosin, Prednisone, Probenecid, Progesterone, Promethazine, Propafenone, Propranolol, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Rifampicin, Rilpivirine, Ritonavir, Rolapitant, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Spironolactone, Staurosporine, Sulfinpyrazone, Sumatriptan, Sunitinib, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Trimipramine, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersBetrixaban, Ledipasvir
Interacting GroupInteracting Drugs
Afatinib is a Multidrug resistance protein 1 inhibitor
1Multidrug resistance protein 1 inducersAldosterone, Amiodarone, Amprenavir, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Midazolam, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifampicin, Ritonavir, Saquinavir, Sirolimus, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2Multidrug resistance protein 1 substratesAbemaciclib, Acebutolol, Acetaminophen, Acetylsalicylic acid, Aldosterone, Alitretinoin, Ambrisentan, Amitriptyline, Apixaban, Arsenic trioxide, Atazanavir, Atenolol, Axitinib, Belinostat, Betamethasone, Bosutinib, Brentuximab vedotin, Bromocriptine, Cabazitaxel, Caffeine, Camptothecin, Canagliflozin, Carbamazepine, Carfilzomib, Ceritinib, Cerivastatin, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dactinomycin, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquin, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Dihydrotestosterone, Diltiazem, Dipyridamole, Docetaxel, Domperidone, Doxorubicin, Edoxaban, Elbasvir, Eletriptan, Enasidenib, Epinastine, Erlotinib, Estradiol, Estriol, Estrone, Ethinyl Estradiol, Etoposide, Ezetimibe, Fesoterodine, Fexofenadine, Fidaxomicin, Fluticasone furoate, Gefitinib, Gemcitabine, Glecaprevir, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ketazolam, Ketoconazole, Lamivudine, Lamotrigine, Lansoprazole, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Losartan, Mannitol, Methotrexate, Methylprednisolone, Metoprolol, Midazolam, Mirabegron, Mitoxantrone, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nizatidine, Odanacatib, Olanzapine, Ombitasvir, Osimertinib, Paclitaxel, Panobinostat, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisone, Progesterone, Propranolol, Quetiapine, Quinidine, Quinine, Ranitidine, Reserpine, Rifampicin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Salicylic acid, Saquinavir, Selexipag, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Sorafenib, Sparfloxacin, Sphingosine, Tacrolimus, Tamoxifen, Taurocholic Acid, Technetium Tc-99m sestamibi, Telaprevir, Temsirolimus, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Trastuzumab emtansine, Ulipristal, Umeclidinium, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vismodegib, Voxilaprevir, Zidovudine
3Multidrug resistance protein 1 inhibitorsAbemaciclib, Acetaminophen, Albendazole, Alectinib, Alfentanil, Amantadine, Aminohippuric acid, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Amsacrine, Astemizole, Atazanavir, Atenolol, Atorvastatin, Azelastine, Azithromycin, Benzocaine, Bepridil, Biperiden, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Caffeine, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carbamazepine, Carvedilol, Caspofungin, Chloroquine, Chlorpromazine, Chlorpropamide, Chlorprothixene, Cholesterol, Cilazapril, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colchicine, Colforsin, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dactinomycin, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Dexamethasone, Dextromethorphan, Diclofenac, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Doxazosin, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Enalapril, Enasidenib, Enzalutamide, Ergonovine, Ergotamine, Erythromycin, Estramustine, Etoposide, Etravirine, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glecaprevir, Glyburide, Glycerin, Gramicidin D, Grepafloxacin, Haloperidol, Hydrocortisone, Idelalisib, Imatinib, Imipramine, Indinavir, Indomethacin, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ketamine, Ketoconazole, Lansoprazole, Lapatinib, Letermovir, Levofloxacin, Lidocaine, Lomitapide, Loperamide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Maprotiline, Mebendazole, Mefloquine, Megestrol acetate, Meprobamate, Methadone, Metoprolol, Mibefradil, Miconazole, Midazolam, Mifepristone, Mitomycin, Mitoxantrone, Morphine, Naltrexone, Naringenin, Nelfinavir, Neostigmine, Nicardipine, Nifedipine, Nilotinib, Nisoldipine, Nitrazepam, Nitrendipine, Omeprazole, P-Nitrophenol, Paclitaxel, Palmitic Acid, Pantoprazole, Paroxetine, Perindopril, Pibrentasvir, Pimozide, Ponatinib, Posaconazole, Pravastatin, Prazosin, Prednisone, Probenecid, Progesterone, Promethazine, Propafenone, Propranolol, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Reboxetine, Regorafenib, Reserpine, Rifampicin, Rilpivirine, Ritonavir, Rolapitant, Saquinavir, Scopolamine, Selegiline, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Spironolactone, Staurosporine, Sulfinpyrazone, Sumatriptan, Sunitinib, Tacrine, Tacrolimus, Tamoxifen, Taurocholic Acid, Telaprevir, Telmisartan, Temsirolimus, Terazosin, Terfenadine, Testosterone, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Trimipramine, Troleandomycin, Velpatasvir, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinorelbine, Voxilaprevir, Zimelidine
4Multidrug resistance protein 1 transportersBetrixaban, Ledipasvir
Interacting GroupInteracting Drugs
Afatinib is a ATP-binding cassette sub-family G member 2 substrate
1ATP-binding cassette sub-family G member 2 substratesAbemaciclib, Alvocidib, Apixaban, Camptothecin, Carboplatin, Cerivastatin, Cholesterol, Cisplatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dactinomycin, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Doxorubicin, Enasidenib, Etoposide, Ezetimibe, Fluorouracil, Folic Acid, Gefitinib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Leflunomide, Lenvatinib, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nilotinib, Nitrofurantoin, Ombitasvir, Osimertinib, Oxaliplatin, Paclitaxel, Pazopanib, Pibrentasvir, Pitavastatin, Ponatinib, Pravastatin, Prazosin, Riluzole, Riociguat, Rosuvastatin, Safinamide, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sumatriptan, Tamoxifen, Teniposide, Teriflunomide, Testosterone, Topotecan, Velpatasvir, Vemurafenib, Venetoclax, Vincristine, Voxilaprevir, Zidovudine
2ATP-binding cassette sub-family G member 2 inhibitorsAbemaciclib, Alectinib, Buprenorphine, Cabazitaxel, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Daidzin, Dasabuvir, Dasatinib, Dexamethasone, Diethylstilbestrol, Doxorubicin, Dronabinol, Elacridar, Enasidenib, Erlotinib, Estradiol, Estrone, Gefitinib, Genistein, Glecaprevir, Glyburide, Hesperetin, Hydrocortisone, Imatinib, Lansoprazole, Letermovir, Mitoxantrone, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Omeprazole, Pantoprazole, Pibrentasvir, Ponatinib, Pravastatin, Prazosin, Quercetin, Rabeprazole, Regorafenib, Rilpivirine, Ritonavir, Rolapitant, Saquinavir, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Taurocholic Acid, Telmisartan, Topiroxostat, Topotecan, Vandetanib, Velpatasvir, Verapamil, Vismodegib, Voxilaprevir
3ATP-binding cassette sub-family G member 2 Antagonist sZafirlukast
4ATP-binding cassette sub-family G member 2 inducersVenlafaxine
5ATP-binding cassette sub-family G member 2 weak inhibitorsCobimetinib
6ATP-binding cassette sub-family G member 2 transportersLedipasvir
Interacting GroupInteracting Drugs
Afatinib is a ATP-binding cassette sub-family G member 2 inhibitor
1ATP-binding cassette sub-family G member 2 substratesAbemaciclib, Alvocidib, Apixaban, Camptothecin, Carboplatin, Cerivastatin, Cholesterol, Cisplatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dactinomycin, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Doxorubicin, Enasidenib, Etoposide, Ezetimibe, Fluorouracil, Folic Acid, Gefitinib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Leflunomide, Lenvatinib, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nilotinib, Nitrofurantoin, Ombitasvir, Osimertinib, Oxaliplatin, Paclitaxel, Pazopanib, Pibrentasvir, Pitavastatin, Ponatinib, Pravastatin, Prazosin, Riluzole, Riociguat, Rosuvastatin, Safinamide, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sumatriptan, Tamoxifen, Teniposide, Teriflunomide, Testosterone, Topotecan, Velpatasvir, Vemurafenib, Venetoclax, Vincristine, Voxilaprevir, Zidovudine
2ATP-binding cassette sub-family G member 2 inhibitorsAbemaciclib, Alectinib, Buprenorphine, Cabazitaxel, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Daidzin, Dasabuvir, Dasatinib, Dexamethasone, Diethylstilbestrol, Doxorubicin, Dronabinol, Elacridar, Enasidenib, Erlotinib, Estradiol, Estrone, Gefitinib, Genistein, Glecaprevir, Glyburide, Hesperetin, Hydrocortisone, Imatinib, Lansoprazole, Letermovir, Mitoxantrone, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Omeprazole, Pantoprazole, Pibrentasvir, Ponatinib, Pravastatin, Prazosin, Quercetin, Rabeprazole, Regorafenib, Rilpivirine, Ritonavir, Rolapitant, Saquinavir, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Taurocholic Acid, Telmisartan, Topiroxostat, Topotecan, Vandetanib, Velpatasvir, Verapamil, Vismodegib, Voxilaprevir
3ATP-binding cassette sub-family G member 2 Antagonist sZafirlukast
4ATP-binding cassette sub-family G member 2 inducersVenlafaxine
5ATP-binding cassette sub-family G member 2 weak inhibitorsCobimetinib
6ATP-binding cassette sub-family G member 2 transportersLedipasvir